The postprandial state does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control.

abstract：:Diabetes is an important risk factor for atherosclerosis but the mechanism of the risk is unknown. As endothelial injury is considered to be an early event in the development of atherosclerosis, the effect of glucose on endothelial cell replication was studied. Concentrations of glucose of 11.2, 16.8 and 22.4 mmol/l i...

journal_title：Diabetologia

authors： Stout RW

更新日期：1982-11-01 00:00:00

abstract：:Islet amyloid polypeptide is a 37 amino acid hormone-like peptide which is the major protein component of islet amyloid deposits commonly found in patients with Type 2 (non-insulin-dependent) diabetes mellitus. Recent studies indicate that a physiologically active form of this peptide appears to be carboxyamidated and...

journal_title：Diabetologia

authors： Sowa R,Sanke T,Hirayama J,Tabata H,Furuta H,Nishimura S,Nanjo K

更新日期：1990-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not pro...

journal_title：Diabetologia

authors： Finken MJ,Keijzer-Veen MG,Dekker FW,Frölich M,Hille ET,Romijn JA,Wit JM,Dutch POPS-19 Collaborative Study Group.

更新日期：2006-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We evaluated the secular trend of glycaemic control in individuals with type 2 diabetes in developing countries, where data are limited. METHODS:The International Diabetes Management Practices Study provides real-world evidence of patient profiles and diabetes care practices in developing countries in ...

journal_title：Diabetologia

authors： Aschner P,Gagliardino JJ,Ilkova H,Lavalle F,Ramachandran A,Mbanya JC,Shestakova M,Chantelot JM,Chan JCN

更新日期：2020-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is thought that enterovirus infections initiate or facilitate the pathogenetic processes leading to type 1 diabetes. Exposure of cultured human islets to cytolytic enterovirus strains kills beta cells after a protracted period, suggesting a role for secondary virus-induced factors such as cytokines. ...

journal_title：Diabetologia

authors： Ylipaasto P,Kutlu B,Rasilainen S,Rasschaert J,Salmela K,Teerijoki H,Korsgren O,Lahesmaa R,Hovi T,Eizirik DL,Otonkoski T,Roivainen M

更新日期：2005-08-01 00:00:00

abstract：:The role of islet amyloidosis in the onset and progression of Type 2 diabetes remains obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide which is co-stored and co-released with insulin. Human islet amyloid polypeptide refolds to a beta-conformation and oligomerises to form insoluble fibrils; prol...

journal_title：Diabetologia

authors： Clark A,Nilsson MR

更新日期：2004-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The initial stages of type 1 diabetes are characterised by an aberrant islet inflammation that is in part regulated by the interaction between type 1 diabetes susceptibility genes and environmental factors. Chromosome 16p13 is associated with type 1 diabetes and CLEC16A is thought to be the aetiological...

journal_title：Diabetologia

authors： Dos Santos RS,Marroqui L,Velayos T,Olazagoitia-Garmendia A,Jauregi-Miguel A,Castellanos-Rubio A,Eizirik DL,Castaño L,Santin I

更新日期：2019-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...

journal_title：Diabetologia

authors： Walraven I,van 't Riet E,Stehouwer CD,Polak BC,Moll AC,Dekker JM,Nijpels G

更新日期：2013-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 ...

journal_title：Diabetologia

authors： Yang X,Li M,Haghiac M,Catalano PM,O'Tierney-Ginn P,Hauguel-de Mouzon S

更新日期：2016-11-01 00:00:00

abstract：:Insulin antibodies expressed as insulin binding capacity of IgG were determined in 50 Type 1 (insulin-dependent) diabetic children who have been treated with monocomponent porcine insulin from the onset of the disease. During the follow-up period of 0.5-5.5 years (mean +/- SD: 3.2 +/- 1.6 years), 26 out of 50 patients...

journal_title：Diabetologia

authors： Ludvigsson J

更新日期：1984-02-01 00:00:00

abstract：:A potent high-titre glucagon antibody pool was used to induce a state of acute glucagon deficiency in order to investigate the importance of glucagon in maintaining euglycaemia in the fed and fasted anaesthetised rat. Binding characteristics of the antiserum and evidence of its neutralisation of the biological effects...

journal_title：Diabetologia

authors： Tan K,Tsiolakis D,Marks V

更新日期：1985-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Serum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults. METHODS:We used data from the Coronary Arter...

journal_title：Diabetologia

authors： Chatterjee R,Colangelo LA,Yeh HC,Anderson CA,Daviglus ML,Liu K,Brancati FL

更新日期：2012-05-01 00:00:00

abstract：AIM/HYPOTHESIS:A strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant et al. We ai...

journal_title：Diabetologia

authors： van Vliet-Ostaptchouk JV,Shiri-Sverdlov R,Zhernakova A,Strengman E,van Haeften TW,Hofker MH,Wijmenga C

更新日期：2007-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased plasma plasminogen activator inhibitor-1 (PAI-1) concentrations are characteristic for subjects with insulin resistance and could contribute to the increased cardiovascular risk in this state. In this study, we investigated the effect of troglitazone, a ligand of the nuclear receptor peroxisom...

journal_title：Diabetologia

authors： Gottschling-Zeller H,Röhrig K,Hauner H

更新日期：2000-03-01 00:00:00

abstract：:Serum high density lipoprotein cholesterol, total cholesterol, triglyceride and apolipoproteins A-I and B were studied at diagnosis and after 12 months conventional treatment in a group of Type 2 (non-insulin-dependent) diabetic patients. No significant deleterious effect on serum lipids and apolipoproteins was seen i...

journal_title：Diabetologia

authors： Taylor KG,John WG,Matthews KA,Wright AD

更新日期：1982-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS:Wom...

journal_title：Diabetologia

authors： d'Emden MC,Jenkins AJ,Li L,Zannino D,Mann KP,Best JD,Stuckey BG,Park K,Saltevo J,Keech AC,FIELD Study Investigators.

更新日期：2014-11-01 00:00:00

abstract：:The antiprotozoal drug pentamidine can be toxic to islet cells in vivo and in vitro. Rat islets were exposed to pentamidine (mesylate and isethionate salts) and six other structurally related diamidines. The beta-cell response to arginine + theophylline was suppressed by pentamidine (10(-2) mmol/l) while the glucagon ...

journal_title：Diabetologia

authors： Boillot D,in't Veld P,Sai P,Feutren G,Gepts W,Assan R

更新日期：1985-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner. The PPARG proline for alanine substitution at position 12 (Pro12Al...

journal_title：Diabetologia

authors： Franks PW,Jablonski KA,Delahanty L,Hanson RL,Kahn SE,Altshuler D,Knowler WC,Florez JC,Diabetes Prevention Program Research Group.

更新日期：2007-12-01 00:00:00

abstract：:[Nepsilon-palmitoyl Lys (B29)] human insulin is a fatty acid-acylated derivative of insulin with extended action compared to unmodified insulin when infused intravenously (i.v.) secondary to its binding to circulating albumin. The duration and activity profile of the acylated (A) and NPH (B) insulins were assessed fol...

journal_title：Diabetologia

authors： Radziuk J,Pye S,Bradley B,Braaten J,Vignati L,Roach P,Bowsher R,DiMarchi R,Chance R

更新日期：1998-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The benefits of moderate alcohol consumption for type 2 diabetes have been postulated to involve a mechanism of improved insulin sensitivity. Fetuin-A, which is known to inhibit insulin signalling, has emerged as a biomarker for diabetes risk. Alcohol consumption may influence circulating fetuin-A conce...

journal_title：Diabetologia

authors： Ley SH,Sun Q,Jimenez MC,Rexrode KM,Manson JE,Jensen MK,Rimm EB,Hu FB

更新日期：2014-01-01 00:00:00

abstract：:Oral glucose administration increased plasma noradrenaline concentration significantly in seven normal subjects (p less than 0.02), whereas in six young short-term Type 1 diabetic patients without complications plasma noradrenaline did not change. Basal plasma noradrenaline did not differ between the two groups. In th...

journal_title：Diabetologia

authors： Hegedüs L,Christensen NJ,Sestoft L

更新日期：1983-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:No previous studies on the association between salt intake and the risk of type 2 diabetes have been reported. The aim of this study was to assess whether high salt intake, measured by 24-h urinary sodium excretion, is an independent risk factor for type 2 diabetes. METHODS:We followed prospectively 93...

journal_title：Diabetologia

authors： Hu G,Jousilahti P,Peltonen M,Lindström J,Tuomilehto J

更新日期：2005-08-01 00:00:00

abstract：:Endothelium-derived nitric oxide plays a major role in the regulation of vascular tone and in the maintenance of vascular homeostasis. Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) dia...

journal_title：Diabetologia

authors： Chan NN,Chan JC

更新日期：2002-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Neurogenin 3 (NEUROG3), a basic helix-loop-helix transcription factor that is needed for endocrine cell development in the embryonic pancreas, has been shown to induce transdifferentiation of duct cells from adult pancreas towards a neuro-endocrine phenotype. Our study explored the endocrine transdiffer...

journal_title：Diabetologia

authors： Harb G,Heremans Y,Heimberg H,Korbutt GS

更新日期：2006-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We assessed the effects of vildagliptin, a novel dipeptidyl peptidase IV inhibitor, on postprandial lipid and lipoprotein metabolism in patients with type 2 diabetes. SUBJECTS, MATERIALS AND METHODS:This was a single-centre, randomised, double-blind study in drug-naive patients with type 2 diabetes. Pa...

journal_title：Diabetologia

authors： Matikainen N,Mänttäri S,Schweizer A,Ulvestad A,Mills D,Dunning BE,Foley JE,Taskinen MR

更新日期：2006-09-01 00:00:00

abstract：:We aimed to assess prandial responses, basal glucose turnover and insulin action (euglycaemic clamp) in a very low-dose neonatal streptozotocin model of Type 2 (non-insulin-dependent) diabetes mellitus. Male Wistar rats were injected at 2 days of age with 45 mg/kg streptozotocin or vehicle (control). At 8 weeks, the g...

journal_title：Diabetologia

authors： Pascoe WS,Jenkins AB,Kusunoki M,Storlien LH

更新日期：1992-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Islet autoantibodies are important in diabetes classification and risk assessment, and as endpoints in observational studies. The Diabetes Autoantibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type 1 diabetes. We report results for glut...

journal_title：Diabetologia

authors： Törn C,Mueller PW,Schlosser M,Bonifacio E,Bingley PJ,Participating Laboratories.

更新日期：2008-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The prognostic importance of the ankle-brachial index (ABI) in individuals with diabetes is controversial. We aimed to evaluate the relationship between the ABI and the occurrence of micro- and macrovascular complications in individuals with type 2 diabetes. METHODS:The ABI was measured at baseline in ...

journal_title：Diabetologia

authors： Cardoso CRL,Melo JV,Salles GC,Leite NC,Salles GF

更新日期：2018-11-01 00:00:00

abstract：:The content of phosphoenolpyruvate (PEP) has been measured in isolated rat islets of Langerhans incubated in vitro. Islet PEP was higher in islets incubated with 16.7 mmol/1 glucose than in islets incubated with zero or 2.8 mmol/1 glucose. Islet PEP content was also increased in islet incubated with 5 mmol/1 D-glycera...

journal_title：Diabetologia

authors： Sugden MC,Ashcroft SJ

更新日期：1977-09-01 00:00:00

abstract：:The nerve fibre loss, atrophy and injury of diabetic peripheral polyneuropathy and their responses to metabolic intervention have been studied by morphometric analysis of sural nerve biopsies. The magnitudes and sources of intra- and inter-individual variation in these morphometric measures have not been investigated ...

journal_title：Diabetologia

authors： Sima AA,Brown MB,Prashar A,Chakrabarti S,Laudadio C,Greene DA

更新日期：1992-06-01 00:00:00