Tubular lesions in streptozotocin-diabetic rats.

abstract：AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...

journal_title：Diabetologia

authors： Karlsson P,Gylfadottir SS,Kristensen AG,Ramirez JD,Cruz P,Le N,Shillo PR,Tesfaye S,Rice ASC,Tankisi H,Finnerup NB,Nyengaard JR,Jensen TS,Bennett DLH,Themistocleous AC

更新日期：2021-01-23 00:00:00

abstract：:The Neurometer is a variable constant current sine wave stimulator, and has recently been proposed as a simple non-invasive and quantitative measure of peripheral nerve function. The device is portable and battery operated; assessment of upper and lower extremities takes only a few min, in contrast to conventional ass...

journal_title：Diabetologia

authors： Masson EA,Veves A,Fernando D,Boulton AJ

更新日期：1989-10-01 00:00:00

abstract：:Insulin release and 86Rb efflux were studied in perifused rat islets exposed in vitro to alloxan (2 mmol/l) for 5 min. At a low glucose concentration, alloxan transiently increased 86Rb efflux. Alloxan immediately and completely abolished the secretory response to glucose (15 mmol/l) and markedly delayed the reduction...

journal_title：Diabetologia

authors： Henquin JC,Malvaux P,Lambert AE

更新日期：1979-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the relationship between benign prostatic hyperplasia (BPH) and arteriosclerosis shown in a model of type 2 diabetes in a trans-sectional population study using contrast-enhanced colour Doppler ultrasound for exact assessment of prostatic blood flow. METHODS:Contra...

journal_title：Diabetologia

authors： Berger AP,Deibl M,Halpern EJ,Lechleitner M,Bektic J,Horninger W,Fritsche G,Steiner H,Pelzer A,Bartsch G,Frauscher F

更新日期：2005-04-01 00:00:00

abstract：:Studying 239 Type 1 (insulin-dependent) diabetic patients and 144 of their first-degree relatives, we found a significant prevalence of autoimmune manifestations in both groups, compared with sex- and age-matched control subjects (p less than 0.001). In particular, in diabetic patients we found a high frequency of aut...

journal_title：Diabetologia

authors： Betterle C,Zanette F,Pedini B,Presotto F,Rapp LB,Monciotti CM,Rigon F

更新日期：1984-06-01 00:00:00

abstract：:Type I diabetes mellitus may represent a heterogeneous disorder with a distinct pathogenesis in patients with young and adult onset of the disease. To investigate whether serological markers directed to different autoantigens have the potential to distinguish acute onset from slowly progressive Type I diabetes we anal...

journal_title：Diabetologia

authors： Seissler J,de Sonnaville JJ,Morgenthaler NG,Steinbrenner H,Glawe D,Khoo-Morgenthaler UY,Lan MS,Notkins AL,Heine RJ,Scherbaum WA

更新日期：1998-08-01 00:00:00

abstract：:Glycogen phosphorylase regulates the breakdown of glycogen into glucose, but as previous studies have demonstrated, the control of glycogen metabolism becomes deregulated in diabetes mellitus. Messenger RNA levels encoding several different proteins are altered in skeletal muscle biopsies of patients with insulin-depe...

journal_title：Diabetologia

authors： Reynet C,Kahn CR,Loeken MR

更新日期：1996-02-01 00:00:00

abstract：:The prevalence of Type 2 (non-insulin-dependent) diabetes mellitus is high in Mauritius, a multiethnic island nation in the southwestern Indian Ocean. Evaluation of candidate genes in the different ethnic groups represents a means of assessing the genetic component. As glucokinase is known to be a key regulator of glu...

journal_title：Diabetologia

authors： Chiu KC,Province MA,Dowse GK,Zimmet PZ,Wagner G,Serjeantson S,Permutt MA

更新日期：1992-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The transcription factor upstream stimulatory factor 1 (USF1) regulates the expression of genes involved in glucose and lipid metabolism and has been associated with familial combined hyperlipidaemia. USF1 is located on chromosome 1q22-23, a region with evidence for linkage to type 2 diabetes and variou...

journal_title：Diabetologia

authors： Ng MC,Miyake K,So WY,Poon EW,Lam VK,Li JK,Cox NJ,Bell GI,Chan JC

更新日期：2005-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The newly identified liver- and fat-derived hormone, betatrophin, has recently been linked to insulin resistance and pancreatic beta cell growth in mice. These preclinical findings have suggested betatrophin as a potential candidate for novel glucose-lowering treatment concepts involving beta cell regen...

journal_title：Diabetologia

authors： Fenzl A,Itariu BK,Kosi L,Fritzer-Szekeres M,Kautzky-Willer A,Stulnig TM,Kiefer FW

更新日期：2014-06-01 00:00:00

abstract：:The plasma concentration of 1,5-anhydro-D-glucitol(AG)(1-deoxyglucose) is known to decrease in diabetic patients. In order to evaluate the usefulness of this polyol as a diabetic marker, we examined the specificity of the plasma AG reduction in various diseases: the plasma AG level was determined in 108 newly diagnose...

journal_title：Diabetologia

authors： Yamanouchi T,Akanuma H,Nakamura T,Akaoka I,Akanuma Y

更新日期：1988-01-01 00:00:00

abstract：:The presence of HLA-DR 3 was analysed in 745 patients with Type 1 (insulin-dependent) diabetes with age at diagnosis between 1-19 years. HLA-DR 3 and/or 4 was found in 678/745 (91%) of the patients. Presence of DR2 with neither DR 3 nor 4 was demonstrated in 15 patients. Patients with HLA-DR 3 without DR 4 presented w...

journal_title：Diabetologia

authors： Ludvigsson J,Samuelsson U,Beauforts C,Deschamps I,Dorchy H,Drash A,Francois R,Herz G,New M,Schober E

更新日期：1986-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between environmental pollution and both prediabetes and diabetes. METHODS:Associations of serum levels of five persistent organic pollutants (POPs), namely polychlorinated biphen...

journal_title：Diabetologia

authors： Ukropec J,Radikova Z,Huckova M,Koska J,Kocan A,Sebokova E,Drobna B,Trnovec T,Susienkova K,Labudova V,Gasperikova D,Langer P,Klimes I

更新日期：2010-05-01 00:00:00

abstract：:Freshly isolated and primary cultured adult rat cardiomyocytes were used to elucidate the mechanism of action of the new oral antidiabetic agent (+/-)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethyl-chroman-2-yl-methoxy)benzyl]-2,4-thiazolidinedione (troglitazone) on the heart. Interaction with protein kinase C (PKC) and regul...

journal_title：Diabetologia

authors： Bähr M,Spelleken M,Bock M,von Holtey M,Kiehn R,Eckel J

更新日期：1996-07-01 00:00:00

abstract：:Phosphoinositide 3-kinase (PI3-kinase) plays a crucial role in insulin signal transduction. We studied the molecular mechanism of the insulin-induced activation of PI3-kinase in rat hepatoma Fao cells using an antibody against the 110-kDa catalytic subunit (p110) and two against the 85-kDa regulatory subunit (p85 alph...

journal_title：Diabetologia

authors： Hayashi T,Okamoto M,Yoshimasa Y,Inoue G,Yamada K,Kono S,Shigemoto M,Suga J,Kuzuya H,Nakao K

更新日期：1996-05-01 00:00:00

abstract：:Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...

journal_title：Diabetologia

authors： Uvnäs-Wallensten K

更新日期：1981-03-01 00:00:00

abstract：:Non-obese diabetic mice were treated daily with a mixture of gangliosides from day 30 until day 250 of life or until the mice became diabetic. Ganglioside treatment reduced diabetes incidence from 80-90% to 47% and from 20-30% to zero in female and male mice respectively. Gangliosides did not affect the frequency of p...

journal_title：Diabetologia

authors： Wilberz S,Herberg L,Renold AE

更新日期：1988-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies in East Asian populations reported that single nucleotide polymorphisms (SNPs) in KCNQ1 are associated with type 2 diabetes. The aim of this study was to validate this finding in a Chinese population. METHODS:We genotyped four SNPs, rs2074196, rs2237892, rs2237895...

journal_title：Diabetologia

authors： Hu C,Wang C,Zhang R,Ma X,Wang J,Lu J,Qin W,Bao Y,Xiang K,Jia W

更新日期：2009-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to assess the risk factors for diabetes mellitus, by age and sex in Canada and to recommend prevention and control strategies. METHODS:This study was based on the Canadian 1996-1997 National Population Health Survey which comprised 69 494 participants aged 12 years and over. The prevalence of ...

journal_title：Diabetologia

authors： Choi BC,Shi F

更新日期：2001-10-01 00:00:00

abstract：:Vasoactive intestinal polypeptide is a pancreatic neurotransmitter which augments insulin release. To obtain more detailed information on its mode of action on the pancreatic beta cell we studied the effect of vasoactive intestinal polypeptide on 86Rb+ efflux, 45Ca2+ uptake, electrical activity and second messenger sy...

journal_title：Diabetologia

authors： Wahl MA,Straub SG,Ammon HP

更新日期：1993-10-01 00:00:00

abstract：:Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused b...

journal_title：Diabetologia

authors： Ziegler M,Hahn HJ,Ziegler B,Köhler E,Fiedler H

更新日期：1975-02-01 00:00:00

abstract：:A radioreceptor-assay for glucagon was developed employing pig liver plasma membranes isolated by means of an aqueous two-phase polymer system. The assay is simple, precise, and has a detection limit of 40 pg/ml. Acid-ethanol extracts of porcine intestinal mucosa and entero-glucagon purified by affinity chromatography...

journal_title：Diabetologia

authors： Holst JJ

更新日期：1975-06-01 00:00:00

abstract：:75,375 males called to military service were screened to discover the incidence of hypertrophic pyloric stenosis. 49 men gave a history of previous surgery for this condition and were given a 45 g/m2 oral glucose tolerance test. Fourteen had impaired glucose tolerance. In no case was there a family history of diabetes...

journal_title：Diabetologia

authors： Chimènes H,Gautier D,Bon R,Fromantin M

更新日期：1980-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Maturity onset diabetes of the young type 3 (MODY3) is a monogenic form of diabetes mellitus caused by mutations in the gene encoding for hepatocyte nuclear factor 1 alpha, HNF1 alpha. In this study we have examined the in vivo and in vitro effects of a mutation (L107I) outside the DNA binding and dimer...

journal_title：Diabetologia

authors： Cervin C,Orho-Melander M,Ridderstråle M,Lehto M,Barg S,Groop L,Cilio CM

更新日期：2002-12-01 00:00:00

abstract：:Short- and long-term regulation of hepatic carbohydrate metabolism by insulin-like growth factor II was studied in primary cultures of adult rat hepatocytes and compared to the metabolic potency of insulin. Insulin-like growth factor II stimulated glycogen synthesis from [14C]glucose, uptake of [3H]aminoisobutyric aci...

journal_title：Diabetologia

authors： Hartmann H,Meyer-Alber A,Braulke T

更新日期：1992-03-01 00:00:00

abstract：:While the modest reduction in the primary composite outcome of myocardial infarction, stroke or cardiovascular death in the EMPA-REG Outcomes trial was welcome, the 30-40% reductions in heart failure hospitalisation (HFH) and cardiovascular and all-cause deaths in patients treated with empagliflozin were highly impres...

journal_title：Diabetologia

authors： Sattar N,McLaren J,Kristensen SL,Preiss D,McMurray JJ

更新日期：2016-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS:We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and r...

journal_title：Diabetologia

authors： Qu HQ,Marchand L,Grabs R,Polychronakos C

更新日期：2008-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Both obesity and genetics contribute to cardiovascular disease (CVD). We examined whether a genetic risk score (GRS) prospectively predicted cardiovascular morbidity and mortality among overweight/obese individuals with type 2 diabetes and whether behavioural weight loss could diminish this association....

journal_title：Diabetologia

authors： Look AHEAD Research Group.

更新日期：2015-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sphingolipid metabolism regulates beta cell biology and inflammation and is abnormal at the onset of type 1 diabetes. Fenofibrate, a regulator of sphingolipid metabolism, is known to prevent diabetes in NOD mice. Here, we aimed to investigate the effects of fenofibrate on the pancreatic lipidome, pancre...

journal_title：Diabetologia

authors： Holm LJ,Haupt-Jorgensen M,Giacobini JD,Hasselby JP,Bilgin M,Buschard K

更新日期：2019-12-01 00:00:00

abstract：:Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with centra...

journal_title：Diabetologia

authors： Nogueiras R,Sabio G

更新日期：2021-02-01 00:00:00