当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice.

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice.

Abstract：

AIMS/HYPOTHESIS:Aggregation of islet amyloid polypeptide (IAPP) to form amyloid contributes to beta cell dysfunction in type 2 diabetes. Human but not non-amyloidogenic rodent IAPP induces islet macrophage proIL-1β synthesis. We evaluated the effect of IL-1 receptor antagonist (IL-1Ra) on islet inflammation and dysfunction in a mouse model of type 2 diabetes with amyloid formation. METHODS:Lean and obese male mice (A/a or A(vy)/A at the agouti locus, respectively) with or without beta cell human IAPP expression (hIAPP(Tg/0)) were treated with PBS or IL-1Ra (50 mg kg(-1) day(-1)) from 16 weeks of age. Intraperitoneal glucose and insulin tolerance tests were performed after 8 weeks. Pancreases were harvested for histology and gene expression analysis. RESULTS:Aggregation of human IAPP was associated with marked upregulation of proinflammatory gene expression in islets of obese hIAPP(Tg/0) mice, together with amyloid deposition and fasting hyperglycaemia. IL-1Ra improved glucose tolerance and reduced plasma proinsulin:insulin in both lean and obese hIAPP(Tg/0) mice with no effect on insulin sensitivity. The severity and prevalence of islet amyloid was reduced by IL-1Ra in lean hIAPP (Tg/0) mice, suggesting a feed-forward mechanism by which islet inflammation promotes islet amyloid at the early stages of disease. IL-1Ra limited Il1a, Il1b, Tnf and Ccl2 expression in islets from obese hIAPP(Tg/0) mice, suggesting an altered islet inflammatory milieu. CONCLUSIONS/INTERPRETATION:These data provide the first in vivo evidence—using a transgenic mouse model with amyloid deposits resembling those found in human islets—that IAPP-induced beta cell dysfunction in type 2 diabetes may be mediated by IL-1. Anti-IL-1 therapies may limit islet inflammation and dysfunction associated with amyloid formation.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Westwell-Roper CY,Chehroudi CA,Denroche HC,Courtade JA,Ehses JA,Verchere CB

doi

10.1007/s00125-014-3447-x

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

575-85

issue

3

eissn

0012-186X

issn

1432-0428

journal_volume

58

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • The effects of insulin and short-term hyperglycaemia on myocardial blood flow in young men with uncomplicated Type I diabetes.

    abstract：AIMS/HYPOTHESIS:Insulin enhances coronary vasodilation in healthy subjects. We tested whether insulin is able to induce coronary vasodilation in Type I (insulin-dependent) diabetic mellitus patients. Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS:Myocardial blood flo...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00125-002-0819-4

    authors： Sundell J,Laine H,Nuutila P,Rönnemaa T,Luotolahti M,Raitakari O,Knuuti J

    更新日期：2002-06-01 00:00:00

  • Incidence, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus in Denmark.

    abstract：:The incidence, sex, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus (j.i.d.m.) were studied retrospectively on one third of the Danish population 1970-1974. The j.i.d.m. incidence remained fairly constant during the study period, the average being 13.2 per 100000 per year. The ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01223266

    authors： Christau B,Kromann H,Andersen OO,Christy M,Buschard K,Arnung K,Kristensen IH,Peitersen B,Steinrud J,Nerup J

    更新日期：1977-08-01 00:00:00

  • Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines.

    abstract：AIMS/HYPOTHESIS:Activin receptor-like kinase 7 (ALK7), a member of the type I receptor serine/threonine kinases of the TGF-beta superfamily, was recently reported to regulate cell proliferation and apoptosis. We hypothesised that ALK7 may play a role in modulating pancreatic beta cell proliferation and/or apoptosis. M...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-0095-1

    authors： Zhang N,Kumar M,Xu G,Ju W,Yoon T,Xu E,Huang X,Gaisano H,Peng C,Wang Q

    更新日期：2006-03-01 00:00:00

  • 15th Golgi lecture: from hyperglycaemia to the dysregulation of vascular remodelling in diabetes.

    abstract：:Hyperglycaemia has been shown to play a central part in diabetic vascular disease, which is also influenced by individual background. Hyperglycaemia initiates the pathogenetic sequence through a series of interrelated biochemical abnormalities, including increased flux through the polyol and hexosamine pathways, oxida...

    journal_title：Diabetologia

    pub_type：

    doi：10.1007/s001250051676

    authors： Di Mario U,Pugliese G

    更新日期：2001-06-01 00:00:00

  • SDF-1-CXCR4 differentially regulates autoimmune diabetogenic T cell adhesion through ROBO1-SLIT2 interactions in mice.

    abstract：AIMS/HYPOTHESIS:We had previously reported that stromal cell-derived factor 1 (SDF-1) mediates chemorepulsion of diabetogenic T cell adhesion to islet microvascular endothelium through unknown mechanisms in NOD mice. Here we report that SDF-1-mediated chemorepulsion occurs through slit homologue (SLIT)2-roundabout, axo...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-2978-x

    authors： Glawe JD,Mijalis EM,Davis WC,Barlow SC,Gungor N,McVie R,Kevil CG

    更新日期：2013-10-01 00:00:00

  • Short-term moderate sodium restriction induces relative hyperfiltration in normotensive normoalbuminuric Type I diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is associated with an increased extracellular volume. Sodium restriction might seem a logical form of treatment but data on its renal effects is conflicting. We therefore studied the effects of sodium restriction on renal haemodynamics in uncomplicated Type I...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00125-001-0763-8

    authors： Luik PT,Hoogenberg K,Van Der Kleij FG,Beusekamp BJ,Kerstens MN,De Jong PE,Dullaart RP,Navis GJ

    更新日期：2002-04-01 00:00:00

  • Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin.

    abstract：AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2546-9

    authors： Hauge-Evans AC,Anderson RL,Persaud SJ,Jones PM

    更新日期：2012-07-01 00:00:00

  • Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels.

    abstract：AIMS/HYPOTHESIS:Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4222-6

    authors： Mahendran Y,Jonsson A,Have CT,Allin KH,Witte DR,Jørgensen ME,Grarup N,Pedersen O,Kilpeläinen TO,Hansen T

    更新日期：2017-05-01 00:00:00

  • Risk factors for diabetes mellitus by age and sex: results of the National Population Health Survey.

    abstract：AIMS/HYPOTHESIS:We aimed to assess the risk factors for diabetes mellitus, by age and sex in Canada and to recommend prevention and control strategies. METHODS:This study was based on the Canadian 1996-1997 National Population Health Survey which comprised 69 494 participants aged 12 years and over. The prevalence of ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250100648

    authors： Choi BC,Shi F

    更新日期：2001-10-01 00:00:00

  • Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells.

    abstract：:Several thrombogenic abnormalities are associated with diabetes. To investigate the underlying molecular mechanisms, we examined the effects of advanced glycation endproducts (AGE), non-enzymatically glycated protein derivatives, on the production of prostacyclin (PGI2), an anti-thrombogenic prostanoid, and of plasmin...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051089

    authors： Yamagishi S,Fujimori H,Yonekura H,Yamamoto Y,Yamamoto H

    更新日期：1998-12-01 00:00:00

  • Report from the International Pancreas Transplant Registry.

    abstract：:From December, 1966 through 1990, 3082 pancreas transplants were reported to the International Registry. A detailed analysis was performed on the 2087 transplants in the 1986-90 data base; during this time the overall one year recipient and graft functional survival rates were 89% and 62%. Univariate analyses showed g...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00587615

    authors： Sutherland DE

    更新日期：1991-08-01 00:00:00

  • Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice.

    abstract：AIMS/HYPOTHESIS:Sphingolipid metabolism regulates beta cell biology and inflammation and is abnormal at the onset of type 1 diabetes. Fenofibrate, a regulator of sphingolipid metabolism, is known to prevent diabetes in NOD mice. Here, we aimed to investigate the effects of fenofibrate on the pancreatic lipidome, pancre...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-04973-z

    authors： Holm LJ,Haupt-Jorgensen M,Giacobini JD,Hasselby JP,Bilgin M,Buschard K

    更新日期：2019-12-01 00:00:00

  • High saturated fat and low starch and fibre are associated with hyperinsulinaemia in a non-diabetic population: the San Luis Valley Diabetes Study.

    abstract：:A geographically based sample of 1069 Hispanic and non-Hispanic white persons aged 20-74 years, living in southern Colorado and who tested normal on an oral glucose tolerance test (World Health Organization criteria) were evaluated to determine associations of dietary factors with fasting serum insulin concentrations....

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050697

    authors： Marshall JA,Bessesen DH,Hamman RF

    更新日期：1997-04-01 00:00:00

  • Elevated GLUT 1 level in crude muscle membranes from diabetic Zucker rats despite a normal GLUT 1 level in perineurial sheaths.

    abstract：:Recently, we demonstrated that approximately 60% of GLUT 1 in a crude membrane fraction of rat skeletal muscle originates from perineurial sheaths. To study the in vivo regulation of GLUT 1 expression in different tissues in muscles, we measured the level of GLUT 1 in crude muscle membranes and in perineurial sheaths ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050130

    authors： Handberg A,Kayser L,Høyer PE,Micheelsen J,Vinten J

    更新日期：1994-05-01 00:00:00

  • Glucose induces early growth response gene (Egr-1) expression in pancreatic beta cells.

    abstract：:A copy deoxyribonucleic acid (cDNA) clone of the immediate early growth response gene, egr-1 (Krox-24, Zif268, NGFI-1), was isolated through subtractive hybridization screening to identify glucose-induced genes in pancreatic beta cells. Glucose rapidly and transiently induced egr-1 mRNA in the SV40-transformed murine ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051139

    authors： Josefsen K,Sørensen LR,Buschard K,Birkenbach M

    更新日期：1999-02-01 00:00:00

  • Assessment of urinary microparticles in normotensive patients with type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 d...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-016-4190-2

    authors： Lytvyn Y,Xiao F,Kennedy CR,Perkins BA,Reich HN,Scholey JW,Cherney DZ,Burger D

    更新日期：2017-03-01 00:00:00

  • Insulin receptor tyrosine-kinase activity is altered in both muscle and adipose tissue from non-obese normoglycaemic insulin-resistant subjects.

    abstract：:We performed i.v. insulin tolerance test in 30 non-obese (BMI < 30 male and < 28 female) non-diabetic (by oral glucose tolerance test) subjects and subdivided them into three groups of 10 subjects each, according to their insulin sensitivity (K(itt) values). Then we compared the tyrosine-kinase activity of immunopurif...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF02369353

    authors： Grasso G,Frittitta L,Anello M,Russo P,Sesti G,Trischitta V

    更新日期：1995-01-01 00:00:00

  • Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey.

    abstract：AIMS/HYPOTHESIS:Cardiac autonomic nervous dysfunction (CAND) raises the risk of mortality, but the glycaemic threshold at which it develops is unclear. We aimed to determine the prevalence of, risk factors for and impact of CAND in glucose intolerance and diabetes. METHODS:Among 1,332 eligible participants aged 55-74 ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3534-7

    authors： Ziegler D,Voss A,Rathmann W,Strom A,Perz S,Roden M,Peters A,Meisinger C,KORA Study Group.

    更新日期：2015-05-01 00:00:00

  • The effect of metabolic regulation on microvascular permeability to small and large molecules in short-term juvenile diabetics.

    abstract：:The microvascular permeability to small and large molecules was studied during good and poor metabolic regulation in ten short duration juvenile diabetics. The following variables were measured; daily urinary albumin and beta2-microglobulin-excretion rates, whole body transcapillary escape rate of albumin (TER), glome...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00428983

    authors： Parving HH,Noer I,Deckert T,Evrin PE,Nielsen SL,Lyngsoe J,Mogensen CE,Rorth M,Svendsen PA,Trap-Jensen J,Lassen NA

    更新日期：1976-05-01 00:00:00

  • Racial and ethnic disparities in extremes of fetal growth after gestational diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to assess and compare risks of having large- or small-for gestational age (LGA and SGA, respectively) infants born to women with gestational diabetes mellitus (GDM) from ten racial/ethnic groups. METHODS:LGA and SGA were defined as birthweight >90th and <10th percentile, respe...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3420-8

    authors： Xiang AH,Black MH,Li BH,Martinez MP,Sacks DA,Lawrence JM,Buchanan TA,Jacobsen SJ

    更新日期：2015-02-01 00:00:00

  • Case fatality rates after first acute coronary syndrome in persons treated for type 2 diabetes show an improving trend.

    abstract：AIMS/HYPOTHESIS:We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. METHODS:We used national registers to identify all patients with clinically known type 2 diabetes in Finlan...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1606-2

    authors： Winell KM,Pääkkönen R,Pietilä A,Niemi MK,Reunanen AR,Salomaa VV

    更新日期：2010-03-01 00:00:00

  • Insulin antibodies in diabetic children treated with monocomponent porcine insulin from the onset: relationship to B-cell function and partial remission.

    abstract：:Insulin antibodies expressed as insulin binding capacity of IgG were determined in 50 Type 1 (insulin-dependent) diabetic children who have been treated with monocomponent porcine insulin from the onset of the disease. During the follow-up period of 0.5-5.5 years (mean +/- SD: 3.2 +/- 1.6 years), 26 out of 50 patients...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00281121

    authors： Ludvigsson J

    更新日期：1984-02-01 00:00:00

  • VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.

    abstract：AIMS/HYPOTHESIS:Rho GTPases (Ras-related C3 botulinum toxin substrate 1 [Rac1] and cell division cycle 42 [Cdc42]) have been shown to regulate glucose-stimulated insulin secretion (GSIS) via cytoskeletal remodelling, trafficking and fusion of insulin-secretory granules with the plasma membrane. GTP loading of these G p...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3707-4

    authors： Veluthakal R,Tunduguru R,Arora DK,Sidarala V,Syeda K,Vlaar CP,Thurmond DC,Kowluru A

    更新日期：2015-11-01 00:00:00

  • The effect of improvement in diabetic control on plasma and whole blood viscosity.

    abstract：:Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean home capillary blood glucose...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00280518

    authors： Paisey RB,Harkness J,Hartog M,Chadwick T

    更新日期：1980-10-01 00:00:00

  • Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents.

    abstract：AIMS/HYPOTHESIS:High levels of inflammation locally in the graft during the initial days after transplantation can cause primary non-function (PNF) of grafted xenogeneic islets in NOD mice. The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-003-1154-0

    authors： Gysemans C,Stoffels K,Giulietti A,Overbergh L,Waer M,Lannoo M,Feige U,Mathieu C

    更新日期：2003-08-01 00:00:00

  • Birthweight and early-onset type 2 diabetes in American Indians: differential effects in adolescents and young adults and additive effects of genotype, BMI and maternal diabetes.

    abstract：AIMS/HYPOTHESIS:The aim of this work was to estimate the impact of birthweight on early-onset (age <40 years) type 2 diabetes. METHODS:A longitudinal study of American Indians, aged ≥5 years, was conducted from 1965 to 2007. Participants who had a recorded birthweight were followed until they developed diabetes or the...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-4899-9

    authors： Olaiya MT,Wedekind LE,Hanson RL,Sinha M,Kobes S,Nelson RG,Baier LJ,Knowler WC

    更新日期：2019-09-01 00:00:00

  • The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet.

    abstract：:We have suggested that the order of cellular vascular perfusion within the islet is important in the regulation of islet hormone secretion. Anatomically, the A and D cells appear to be randomly dispersed throughout the mantle. Although islet capillary blood flow is known to be from the B-cell core to the A- and D-cell...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00265095

    authors： Stagner JI,Samols E,Marks V

    更新日期：1989-03-01 00:00:00

  • Prevention or delay of type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide.

    abstract：:A controlled trial of oral nicotinamide to prevent the onset of diabetes mellitus in high risk children was conducted in two centres. The selection criteria were age less than 16 years, islet cell antibody greater than or equal to 80 IUs, and first phase insulin release less than 5th percentile. All of eight untreated...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00405010

    authors： Elliott RB,Chase HP

    更新日期：1991-05-01 00:00:00

  • Altered tissue content of trace metals in diabetic hyperinsulinaemic sand rats (Psammomys obesus).

    abstract：:The concentrations of zinc, copper, and chromium in liver, kidney, muscle, bone and serum from control normoinsulinaemic and hyperinsulinaemic sand rats (Psammomys obesus) and from untreated spontaneously hyperinsulinaemic-hyperglycaemic sand rats were compared. A chronic hyperinsulinaemic-hyperglycaemic state was ass...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00277416

    authors： Raz I,Adler JH,Havivi E

    更新日期：1988-05-01 00:00:00

  • Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1308-9

    authors： Lutgers HL,Gerrits EG,Graaff R,Links TP,Sluiter WJ,Gans RO,Bilo HJ,Smit AJ

    更新日期：2009-05-01 00:00:00