Short-term moderate sodium restriction induces relative hyperfiltration in normotensive normoalbuminuric Type I diabetes mellitus.

abstract：AIMS/HYPOTHESIS:In the UK, more than one million people have undiagnosed diabetes and an additional five million are at high risk of developing the disease. Given that early identification of these people is key for both primary and secondary prevention, new screening approaches are needed. Since spouses resemble each ...

journal_title：Diabetologia

authors： Nielsen J,Hulman A,Witte DR

更新日期：2018-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repair...

journal_title：Diabetologia

authors： Wägner AM,Cloos P,Bergholdt R,Boissy P,Andersen TL,Henriksen DB,Christiansen C,Christgau S,Pociot F,Nerup J

更新日期：2007-03-01 00:00:00

abstract：:Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...

journal_title：Diabetologia

authors： Crosby SR,Tsigos C,Anderton CD,Gordon C,Young RJ,White A

更新日期：1992-09-01 00:00:00

abstract：:An incidence of 9.0 out of 100,000 children under 19 years of age with Type 1 (insulin-dependent) diabetes was detected in Toronto during a 2 year prospective study. An increased number of cases occurred in the winter months of one of the years but not of the other during the study. The annual incidence was the same i...

journal_title：Diabetologia

authors： Ehrlich RM,Walsh LJ,Falk JA,Middleton PJ,Simpson NE

更新日期：1982-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated the association of variants of the transcription factor 7-like 2 (TCF7L2) gene with: (1) incident diabetes in the Finnish Diabetes Prevention Study (DPS, Study I); (2) type 2 diabetes and impaired glucose regulation (i.e. IGT or IFG) in a cross-sectional study (Study II); and (3) insulin...

journal_title：Diabetologia

authors： Wang J,Kuusisto J,Vänttinen M,Kuulasmaa T,Lindström J,Tuomilehto J,Uusitupa M,Laakso M

更新日期：2007-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is thought that enterovirus infections initiate or facilitate the pathogenetic processes leading to type 1 diabetes. Exposure of cultured human islets to cytolytic enterovirus strains kills beta cells after a protracted period, suggesting a role for secondary virus-induced factors such as cytokines. ...

journal_title：Diabetologia

authors： Ylipaasto P,Kutlu B,Rasilainen S,Rasschaert J,Salmela K,Teerijoki H,Korsgren O,Lahesmaa R,Hovi T,Eizirik DL,Otonkoski T,Roivainen M

更新日期：2005-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:To investigate the incidence of foetal macrosomia (i.e. birth weight >90th percentile) in a non-selected nationwide cohort of women with Type I (insulin-dependent) diabetes mellitus in The Netherlands and to identify risk indicators predictive for macrosomia. METHODS:We conducted a prospective nationwi...

journal_title：Diabetologia

authors： Evers IM,de Valk HW,Mol BW,ter Braak EW,Visser GH

更新日期：2002-11-01 00:00:00

abstract：:Studies were made on the effect of the enteroinsular axis on amino acid-induced insulin and glucagon secretion during hyperglycaemia in man. The responses of plasma immunoreactive insulin, C-peptide, and immunoreactive glucagon to arginine infusion were investigated in nine healthy subjects after induction of hypergly...

journal_title：Diabetologia

authors： Shimizu I,Hirota M,Ohboshi C,Mizuno A,Shima K

更新日期：1987-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The endogenous production of stromal cell-derived factor-1 (SDF-1) in beta cells in transgenic mice attenuates the development of diabetes in response to streptozotocin. Here we propose that beta cell injury induces SDF-1 production, and the SDF-1/chemokine (C-X-C motif) receptor 4 (CXCR4) interaction a...

journal_title：Diabetologia

authors： Liu Z,Stanojevic V,Avadhani S,Yano T,Habener JF

更新日期：2011-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women. METHODS:This was a prospective study of 62,095 middle-aged parous women in Shanghai, China, who had no prior ...

journal_title：Diabetologia

authors： Villegas R,Gao YT,Yang G,Li HL,Elasy T,Zheng W,Shu XO

更新日期：2008-02-01 00:00:00

abstract：:The recently completed diabetes complications and control trial has highlighted the need for improvement of insulin delivery systems for treatment of insulin-dependent diabetes mellitus. Despite steady improvement in methods for islet and whole pancreas transplantation over the past three decades, the broad-scale appl...

journal_title：Diabetologia

authors： Newgard CB,Clark S,BeltrandelRio H,Hohmeier HE,Quaade C,Normington K

更新日期：1997-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Circulating fibroblast growth factor 21 (FGF21) levels are often elevated in obesity, dyslipidaemia, insulin resistance and type 2 diabetes. This study investigated the relationship of plasma FGF21 levels with cardiovascular events in patients with type 2 diabetes. METHODS:Plasma FGF21 levels were meas...

journal_title：Diabetologia

authors： Ong KL,Januszewski AS,O'Connell R,Jenkins AJ,Xu A,Sullivan DR,Barter PJ,Hung WT,Scott RS,Taskinen MR,Keech AC,Rye KA

更新日期：2015-03-01 00:00:00

abstract：:Arterial hypertension and poor glycaemic control are central to the development of microalbuminuria in insulin-dependent diabetes mellitus (IDDM). Recent consensus has established sensitive criteria for their detection and treatment, although the proportion of patients who may benefit is unclear. Between 1988 and 1990...

journal_title：Diabetologia

authors： Mangili R,Deferrari G,Di Mario U,Giampietro O,Navalesi R,Nosadini R,Rigamonti G,Spezia R,Crepaldi G

更新日期：1994-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS:Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 ...

journal_title：Diabetologia

authors： Lim EL,Hollingsworth KG,Aribisala BS,Chen MJ,Mathers JC,Taylor R

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hypertension, obesity, impaired glucose tolerance and dyslipidaemia are metabolic abnormalities that often cluster together more often than expected by chance alone. Since these metabolic variables are highly heritable and are at least partially genetically determined, the clustering of defects in these...

journal_title：Diabetologia

authors： Chiu YF,Chuang LM,Kao HY,Ho LT,Ting CT,Hung YJ,Chen YD,Donlon T,Curb JD,Quertermous T,Hsiung CA

更新日期：2007-08-01 00:00:00

abstract：:D600 (2 to 20 muM; alpha-isopropyl-alpha [(N-methyl-N-homoveratril)-gamma-aminopropyl]-3,4,5-trimethoxyphenyl-acetonitril) caused a dose-related, rapid and reversible inhibition of glucose-induced insulin release. It also suppressed the insulinotropic action of a sulphonylurea but failed to affect the enhancing action...

journal_title：Diabetologia

authors： Malaisse WJ,Devis G,Pipeleers DG,Somers G

更新日期：1976-03-01 00:00:00

abstract：:Islet allografts in insulin-dependent diabetic (IDDM) patients exhibit variable survival lengths and low rates of insulin-independence despite treatment with anti-T-cell antibodies and maintenance immunosuppression. Use of poorly characterized freshly isolated preparations makes it difficult to determine whether failu...

journal_title：Diabetologia

authors： Keymeulen B,Ling Z,Gorus FK,Delvaux G,Bouwens L,Grupping A,Hendrieckx C,Pipeleers-Marichal M,Van Schravendijk C,Salmela K,Pipeleers DG

更新日期：1998-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:In this study we investigated whether chronic fetal hypoxia, as indicated by amniotic fluid erythropoietin levels, is associated with perinatal morbidity in type 1 diabetic pregnancies. METHODS:A total of 331 women with type 1 diabetes had at least one childbirth between 1995 and 2000. The amniotic flu...

journal_title：Diabetologia

authors： Teramo K,Kari MA,Eronen M,Markkanen H,Hiilesmaa V

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sleep loss is associated with insulin resistance and an increased risk for type 2 diabetes, yet underlying mechanisms are not understood. Elevation of circulating non-esterified (i.e. free) fatty acid (NEFA) concentrations can lead to insulin resistance and plays a central role in the development of met...

journal_title：Diabetologia

authors： Broussard JL,Chapotot F,Abraham V,Day A,Delebecque F,Whitmore HR,Tasali E

更新日期：2015-04-01 00:00:00

abstract：:This study was performed to evaluate whether L-leucine is able to relieve the structural and functional alterations previously described in pancreatic islets exposed in vitro for a prolonged time to a subnormal glucose concentration (3.3 mM). It was found that both the impairment of secretion and the decreased rate of...

journal_title：Diabetologia

authors： Andersson A,Höiriis-Nielsen J,Borg LA

更新日期：1977-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We compared metabolic gene expression in adipose tissue and skeletal muscle from patients with type 2 diabetes and from well-matched healthy control subjects. We hypothesised that gene expression would be discordantly regulated when comparing the two groups. Our secondary aim was to determine the effect...

journal_title：Diabetologia

authors： Carey AL,Petersen EW,Bruce CR,Southgate RJ,Pilegaard H,Hawley JA,Pedersen BK,Febbraio MA

更新日期：2006-05-01 00:00:00

abstract：:Kwashiorkor, the human disease of protein-energy malnutrition, has been implicated in the aetiology of malnutrition-related diabetes mellitus, a form of diabetes not uncommon in developing countries. We have previously demonstrated that temporary protein-energy malnutrition in young rats causes a persisting impairment...

journal_title：Diabetologia

authors： Swenne I,Borg LA,Crace CJ,Schnell Landström A

更新日期：1992-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Currently, three categories of cardiovascular autonomic nervous function measures are used: classic Ewing-test measures, measures of heart-rate variability (HRV), and measures of baroreflex sensitivity (BRS). Little is known about the agreement between these measures, and reference and reproducibility v...

journal_title：Diabetologia

authors： Gerritsen J,TenVoorde BJ,Dekker JM,Kingma R,Kostense PJ,Bouter LM,Heethaar RM

更新日期：2003-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly ...

journal_title：Diabetologia

authors： Sparsø T,Andersen G,Nielsen T,Burgdorf KS,Gjesing AP,Nielsen AL,Albrechtsen A,Rasmussen SS,Jørgensen T,Borch-Johnsen K,Sandbaek A,Lauritzen T,Madsbad S,Hansen T,Pedersen O

更新日期：2008-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study estimated the economic efficiency (1) of intensive blood glucose control and tight blood pressure control in patients with type 2 diabetes who also had hypertension, and (2) of metformin therapy in type 2 diabetic patients who were overweight. METHODS:We conducted cost-utility analysis based...

journal_title：Diabetologia

authors： Clarke PM,Gray AM,Briggs A,Stevens RJ,Matthews DR,Holman RR,UKPDS 72 United Kingdom Prospective Diabetes Study.

更新日期：2005-05-01 00:00:00

abstract：:Use of monoclonal antibodies specific for rat lymphocyte subsets and an anti-insulin marker has allowed us to document the following sequence of events leading to the development of clinical diabetes in this animal model. The first change observed in the pancreas is increased expression of MHC class II molecules on va...

journal_title：Diabetologia

authors： Dean BM,Walker R,Bone AJ,Baird JD,Cooke A

更新日期：1985-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental functio...

journal_title：Diabetologia

authors： Salbaum JM,Kruger C,Zhang X,Delahaye NA,Pavlinkova G,Burk DH,Kappen C

更新日期：2011-07-01 00:00:00

abstract：:In 1971, 107 newly diagnosed black diabetics admitted to Harare Central Hospital, Rhodesia, were studied. Nine died before discharge. In 1977, 93 of the 98 patients discharged alive were traced but of these 38 (41%) had since died. Of 18 autopsies performed the cause of death was hypoglycaemia in 8 patients and hyperg...

journal_title：Diabetologia

authors： Castle WM,Wicks AC

更新日期：1980-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to establish if stem cells contained in cord blood cell allografts have the capacity to differentiate into insulin-expressing beta cells in humans. METHODS:We studied pancreases obtained at autopsy from individuals (n = 11) who had prior opposite-sex cord blood transplants to reconstitute hae...

journal_title：Diabetologia

authors： Huang CJ,Butler AE,Moran A,Rao PN,Wagner JE,Blazar BR,Rizza RA,Manivel JC,Butler PC

更新日期：2011-05-01 00:00:00

abstract：:Of 89 pancreas transplants performed in 77 diabetic patients (43 with and 34 without previous kidney transplants), 53 were from cadaver and 36 from related donors. To date, 64 patients (83%) are alive and 27 (35%) have functioning grafts (14 greater than 1 year), including 0 out of 3 duct-ligated, 3 out of 15 open-duc...

journal_title：Diabetologia

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1984-07-01 00:00:00