Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin.

abstract：:The interrelationships between fibrinogen, von Willebrand factor, a marker of vascular endothelial cell damage, and serum lipids were explored in well-characterised subjects with insulin-dependent diabetes mellitus. The 2091 subjects were enrolled into a cross-sectional, clinic-based study of complications, from 16 Eu...

journal_title：Diabetologia

authors： Greaves M,Malia RG,Goodfellow K,Mattock M,Stevens LK,Stephenson JM,Fuller JH

更新日期：1997-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the signalling processes and metabolic actions of BDNF. METHODS:We first examined whether exercise induced BDNF expression in humans. Next, C2C12 skeletal muscle ce...

journal_title：Diabetologia

authors： Matthews VB,Aström MB,Chan MH,Bruce CR,Krabbe KS,Prelovsek O,Akerström T,Yfanti C,Broholm C,Mortensen OH,Penkowa M,Hojman P,Zankari A,Watt MJ,Bruunsgaard H,Pedersen BK,Febbraio MA

更新日期：2009-07-01 00:00:00

abstract：:The 497 members of the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics have been followed for mortality from 1975 to 1987. During this period 92 patients died. The most common cause of death was myocardial infarction: 36 (39.1%) deaths, heart disease was responsible for 51.1% of deaths an...

journal_title：Diabetologia

authors： Morrish NJ,Stevens LK,Head J,Fuller JH,Jarrett RJ,Keen H

更新日期：1990-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The humoral part of the immune system, including autoantibodies, is known to predict manifest Type I (insulin-dependent) diabetes mellitus in first-degree relatives but the cell-mediated immune process preceding the manifest disease still is not known. The aim of this investigation was to estimate the i...

journal_title：Diabetologia

authors： Karlsson MG,Lawesson SS,Ludvigsson J

更新日期：2000-06-01 00:00:00

abstract：:The concentrations of zinc, copper, and chromium in liver, kidney, muscle, bone and serum from control normoinsulinaemic and hyperinsulinaemic sand rats (Psammomys obesus) and from untreated spontaneously hyperinsulinaemic-hyperglycaemic sand rats were compared. A chronic hyperinsulinaemic-hyperglycaemic state was ass...

journal_title：Diabetologia

authors： Raz I,Adler JH,Havivi E

更新日期：1988-05-01 00:00:00

abstract：:A representative sample (n = 2140) of the Israeli Jewish population aged 40-70 (excluding known diabetic patients), whose body mass index had been measured 10 years earlier, underwent an oral glucose tolerance test and redetermination of body mass index. Irrespective of weight changes, high concurrent and high past bo...

journal_title：Diabetologia

authors： Modan M,Karasik A,Halkin H,Fuchs Z,Lusky A,Shitrit A,Modan B

更新日期：1986-02-01 00:00:00

abstract：:Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after...

journal_title：Diabetologia

authors： Krentz AJ,Clark PM,Cox L,Williams AC,Nattrass M

更新日期：1992-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:We compared metabolic gene expression in adipose tissue and skeletal muscle from patients with type 2 diabetes and from well-matched healthy control subjects. We hypothesised that gene expression would be discordantly regulated when comparing the two groups. Our secondary aim was to determine the effect...

journal_title：Diabetologia

authors： Carey AL,Petersen EW,Bruce CR,Southgate RJ,Pilegaard H,Hawley JA,Pedersen BK,Febbraio MA

更新日期：2006-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the light of a report suggesting that insulin glargine may increase cancer occurrence, the EASD asked us to perform this study. METHODS:We followed 114,841 individuals who had a prescription dispensed for insulin between 1 July and 31 December 2005. From 1 January 2006 to 31 December 2007, we noted ...

journal_title：Diabetologia

authors： Jonasson JM,Ljung R,Talbäck M,Haglund B,Gudbjörnsdòttir S,Steineck G

更新日期：2009-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Reactive oxygen species (ROS) contribute to diabetes-induced glomerular injury and endoplasmic reticulum (ER) stress-induced beta cell dysfunction, but the source of ROS has not been fully elucidated. Our aim was to determine whether p47(phox)-dependent activation of NADPH oxidase is responsible for hyp...

journal_title：Diabetologia

authors： Liu GC,Fang F,Zhou J,Koulajian K,Yang S,Lam L,Reich HN,John R,Herzenberg AM,Giacca A,Oudit GY,Scholey JW

更新日期：2012-09-01 00:00:00

abstract：:The authors have been made aware that the following sentence is incorrect: 'Like IIK7, both ramelteon and tasimelteon have a greater affinity for the MT2 receptor [162].' ...

journal_title：Diabetologia

authors： Forrestel AC,Miedlich SU,Yurcheshen M,Wittlin SD,Sellix MT

更新日期：2018-05-01 00:00:00

abstract：:Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...

journal_title：Diabetologia

authors： Uvnäs-Wallensten K

更新日期：1981-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance that does not develop diabetes. MATERIALS AND METHODS:NEFA augmen...

journal_title：Diabetologia

authors： Nolan CJ,Leahy JL,Delghingaro-Augusto V,Moibi J,Soni K,Peyot ML,Fortier M,Guay C,Lamontagne J,Barbeau A,Przybytkowski E,Joly E,Masiello P,Wang S,Mitchell GA,Prentki M

更新日期：2006-09-01 00:00:00

abstract：:Diabetes is an important risk factor for atherosclerosis but the mechanism of the risk is unknown. As endothelial injury is considered to be an early event in the development of atherosclerosis, the effect of glucose on endothelial cell replication was studied. Concentrations of glucose of 11.2, 16.8 and 22.4 mmol/l i...

journal_title：Diabetologia

authors： Stout RW

更新日期：1982-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Regulation of insulin secretion along the secretory pathway is incompletely understood. We addressed the expression of SIL1, a nucleotide exchange factor for the endoplasmic reticulum (ER) chaperone glucose-regulated protein 78 kD (GRP78), in pancreatic beta cells and investigated whether or not SIL1 is...

journal_title：Diabetologia

authors： Ittner AA,Bertz J,Chan TY,van Eersel J,Polly P,Ittner LM

更新日期：2014-07-01 00:00:00

abstract：:The impact of improved glycaemic control on renal function in newly-presenting Type 2 (non-insulin-dependent) diabetic patients has not been adequately researched. Consequently, glomerular filtration rate and effective renal plasma flow and urinary albumin excretion rates were determined in 76 subjects (age (mean (SD)...

journal_title：Diabetologia

authors： Vora JP,Dolben J,Williams JD,Peters JR,Owens DR

更新日期：1993-08-01 00:00:00

abstract：:Decreased release of nitric oxide from damaged endothelium is responsible for the impaired endothelium-dependent vasodilator responses found in animal models of vascular disease. Dietary supplementation with fish oils has been shown to augment endothelium-dependent relaxations, principally by improving the release of ...

journal_title：Diabetologia

authors： McVeigh GE,Brennan GM,Johnston GD,McDermott BJ,McGrath LT,Henry WR,Andrews JW,Hayes JR

更新日期：1993-01-01 00:00:00

abstract：:The aim of the present study was to elucidate the pathophysiologic significance of circulating ouabain as a link between insulin resistance (IR) and hypertension (HT) in NIDDM. Euglycaemic (4.5 mmol/l) hyperinsulinaemic (360-580 pmol/l) clamping was performed using an artificial endocrine pancreas. Plasma ouabain-like...

journal_title：Diabetologia

authors： Wasada T,Kuroki H,Naruse M,Arii H,Maruyama A,Katsumori K,Saito S,Watanabe Y,Naruse K,Demura H

更新日期：1995-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. In this study we evaluated whether diabetic conditions in ...

journal_title：Diabetologia

authors： Shanmugam N,Todorov IT,Nair I,Omori K,Reddy MA,Natarajan R

更新日期：2006-01-01 00:00:00

abstract：:Insulin binding and the effect of insulin on the transport of 3-O-methylglucose, lipogenesis from glucose, glucose oxidation and lipolysis was studied in fat cells of adrenalectomised rats and of a control group of sham-operated rats. The serum insulin level of the adrenalectomised rats (0.7 ng/ml) was lower than that...

journal_title：Diabetologia

authors： Häring H,Calle C,Bug A,Renner R,Hepp KD,Kemmler W

更新日期：1980-10-01 00:00:00

abstract：:Very low density lipoproteins (VLDL) have an abnormal lipid composition in Type 1 (insulin-dependent) diabetic patients. Since VLDL represent a heterogeneous lipoprotein class, this might be due either to a shift in the distribution or to an abnormal composition of VLDL subclasses or both. In order to investigate thes...

journal_title：Diabetologia

authors： Patti L,Romano G,Di Marino L,Annuzzi G,Mancini M,Riccardi G,Rivellese AA

更新日期：1993-02-01 00:00:00

abstract：:We aimed to assess prandial responses, basal glucose turnover and insulin action (euglycaemic clamp) in a very low-dose neonatal streptozotocin model of Type 2 (non-insulin-dependent) diabetes mellitus. Male Wistar rats were injected at 2 days of age with 45 mg/kg streptozotocin or vehicle (control). At 8 weeks, the g...

journal_title：Diabetologia

authors： Pascoe WS,Jenkins AB,Kusunoki M,Storlien LH

更新日期：1992-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular disease in diabetes is linked to increased risk of atherosclerosis, increased levels of triglyceride-rich lipoproteins and enhanced hepatic lipogenesis. The hepatic hexosamine pathway has been implicated in signalling for de novo lipogenesis by the liver. In this study, we assessed if dec...

journal_title：Diabetologia

authors： Babaei-Jadidi R,Karachalias N,Kupich C,Ahmed N,Thornalley PJ

更新日期：2004-12-01 00:00:00

abstract：:Three members of the angiopoietin-like (ANGPTL) family of proteins, ANGPTL3, ANGPTL4 and ANGPTL8, are known regulators of plasma triacylglycerol levels. Recently, these three proteins have garnered considerable interest as potential targets for therapeutically reducing plasma triacylglycerol levels and improving cardi...

journal_title：Diabetologia

authors： Davies BSJ

更新日期：2018-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of IRS2 in the liver of ...

journal_title：Diabetologia

authors： Krause C,Geißler C,Tackenberg H,El Gammal AT,Wolter S,Spranger J,Mann O,Lehnert H,Kirchner H

更新日期：2020-10-01 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and function due to hypergly...

journal_title：Diabetologia

authors： Catrina SB,Zheng X

更新日期：2021-01-26 00:00:00

abstract：:In the present study the antepartum relationship between maternal diabetic glucose control and fetal hypoxaemia was examined in 44 Type 1 (insulin-dependent) diabetic and 23 non-diabetic control pregnancies. Maternal HbA1C was used to assess maternal integrated blood glucose control while fetal metabolic control was e...

journal_title：Diabetologia

authors： Widness JA,Teramo KA,Clemons GK,Voutilainen P,Stenman UH,McKinlay SM,Schwartz R

更新日期：1990-06-01 00:00:00

abstract：:The effect of pregnancy on pancreatic insulin content and relative B-cell volume has been studied in normoglycaemic Wistar rats treated with streptozotocin 14 days before mating. A single intravenous injection of streptozotocin (30 mg/kg body weight) caused a significant reduction of pancreatic insulin content and B-c...

journal_title：Diabetologia

authors： Ziegler B,Lucke S,Besch W,Hahn HJ

更新日期：1985-03-01 00:00:00

abstract：:This study was performed to evaluate whether L-leucine is able to relieve the structural and functional alterations previously described in pancreatic islets exposed in vitro for a prolonged time to a subnormal glucose concentration (3.3 mM). It was found that both the impairment of secretion and the decreased rate of...

journal_title：Diabetologia

authors： Andersson A,Höiriis-Nielsen J,Borg LA

更新日期：1977-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The glomerular endothelial layer is coated by the endothelial surface layer (ESL), which is suggested to play a role in regulation of the permselectivity of macromolecules. Production of heparanase, a degrading enzyme of the ESL, is induced by reactive oxygen species (ROS). We hypothesised that oxidativ...

journal_title：Diabetologia

authors： Kuwabara A,Satoh M,Tomita N,Sasaki T,Kashihara N

更新日期：2010-09-01 00:00:00