Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion.

abstract：AIMS/HYPOTHESIS:In our previous studies a low protein diet (8% vs 20%) given during foetal and early postnatal life induced abnormal development of the endocrine pancreas; beta-cell mass and islet-cell proliferation were reduced while apoptosis was increased. Taurine, an important amino acid for development was also re...

journal_title：Diabetologia

authors： Boujendar S,Reusens B,Merezak S,Ahn MT,Arany E,Hill D,Remacle C

更新日期：2002-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is significantly upregulated in the serum of individuals with obesity and diabetes. However, whether elevated PEDF levels contribute to DMED remains unknown. This stu...

journal_title：Diabetologia

authors： Che D,Fang Z,Yan L,Du J,Li F,Xie J,Feng J,Yin P,Qi W,Yang Z,Ma J,Yang X,Gao G,Zhou T

更新日期：2020-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is an autosomal recessive disorder characterised by lipodystrophy and insulin resistance. BSCL2 is caused by loss-of-function mutations in the Seipin gene (also known as Bscl2). Deletion of this gene in mice induces insulin resistance, glucose in...

journal_title：Diabetologia

authors： Xiong J,Sun P,Wang Y,Hua X,Song W,Wang Y,Wu J,Yu W,Liu G,Chen L

更新日期：2020-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single nucleotide polymorphisms (SNPs) in WFS1 have been reproducibly associated with type 2 diabetes. We therefore examined the effects of these variants on diabetes i...

journal_title：Diabetologia

authors： Florez JC,Jablonski KA,McAteer J,Sandhu MS,Wareham NJ,Barroso I,Franks PW,Altshuler D,Knowler WC,Diabetes Prevention Program Research Group.

更新日期：2008-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:A key morphological feature of diabetic nephropathy is the accumulation and deposition of glycogen in renal tubular cells, known as Armanni-Ebstein lesions. While this observation has been consistently reported for many years, the molecular basis of these lesions remains unclear. METHODS:Using biochemi...

journal_title：Diabetologia

authors： Lau X,Zhang Y,Kelly DJ,Stapleton DI

更新日期：2013-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...

journal_title：Diabetologia

authors： Walraven I,van 't Riet E,Stehouwer CD,Polak BC,Moll AC,Dekker JM,Nijpels G

更新日期：2013-05-01 00:00:00

abstract：:The ability of the amino acid leucine and its keto acid, alpha-ketoisocaproate, to induce insulin release, to initiate phosphoinositide hydrolysis, and to amplify the subsequent insulin secretory response to glucose was assessed. In islets whose inositol-containing lipids were prelabelled with myo[2-3H]inositol, the a...

journal_title：Diabetologia

authors： Zawalich WS

更新日期：1988-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Direct infection of beta cells could explain the diabetogenic effect of enteroviruses. Primary adult human beta cells are susceptible to coxsackievirus infections, which could result in impaired beta-cell function or cell death (coxsackieviruses B3, B4, B5) or both, or no apparent immediate adverse effe...

journal_title：Diabetologia

authors： Roivainen M,Ylipaasto P,Savolainen C,Galama J,Hovi T,Otonkoski T

更新日期：2002-05-01 00:00:00

abstract：:75,375 males called to military service were screened to discover the incidence of hypertrophic pyloric stenosis. 49 men gave a history of previous surgery for this condition and were given a 45 g/m2 oral glucose tolerance test. Fourteen had impaired glucose tolerance. In no case was there a family history of diabetes...

journal_title：Diabetologia

authors： Chimènes H,Gautier D,Bon R,Fromantin M

更新日期：1980-06-01 00:00:00

abstract：:Cyclic adenosine 5'diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2+. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly...

journal_title：Diabetologia

authors： Yagui K,Shimada F,Mimura M,Hashimoto N,Suzuki Y,Tokuyama Y,Nata K,Tohgo A,Ikehata F,Takasawa S,Okamoto H,Makino H,Saito Y,Kanatsuka A

更新日期：1998-09-01 00:00:00

abstract：:The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...

journal_title：Diabetologia

authors： Jones PM,Persaud SJ,Bjaaland T,Pearson JD,Howell SL

更新日期：1992-11-01 00:00:00

abstract：:The present study examined the acute effects of co-ingestion of fat (37.5 g) on the post-prandial metabolic responses to 75 g of carbohydrate which was either slowly absorbed (lentils) or rapidly absorbed (potatoes). Co-ingestion of fat resulted in a significant flattening of the post-prandial glucose curves, the effe...

journal_title：Diabetologia

authors： Collier G,McLean A,O'Dea K

更新日期：1984-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The offspring of mothers with pre-gestational type 1 diabetes (PGDM) may be at increased risk of glucose intolerance and cardiovascular disease in childhood. The underlying causes of these observations, and whether they persist into adulthood, are unknown. The aim of the present study was to test the hy...

journal_title：Diabetologia

authors： Cross JA,Brennan C,Gray T,Temple RC,Dozio N,Hughes JC,Levell NJ,Murphy H,Fowler D,Hughes DA,Sampson MJ

更新日期：2009-02-01 00:00:00

abstract：:Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rats. After 6 weeks of...

journal_title：Diabetologia

authors： Cameron NE,Dines KC,Cotter MA

更新日期：1994-12-01 00:00:00

abstract：:We investigated the regulation of the mRNA expression of the insulin receptor, insulin receptor substrate-1 (IRS-1) and p85alpha-phosphatidylinositol-3-kinase (PI-3K), three major actors of insulin action, in skeletal muscle from 10 healthy lean volunteers, 13 obese patients with Type II (non-insulin-dependent) diabet...

journal_title：Diabetologia

authors： Andreelli F,Laville M,Ducluzeau PH,Vega N,Vallier P,Khalfallah Y,Riou JP,Vidal H

更新日期：1999-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The molecular factors that cause an acute wound in diabetic patients to become chronic have not yet been established. Wound healing is known to require a balance between the accumulation of collagenous and non-collagenous extracellular matrix components and their remodelling by matrix metalloproteinases...

journal_title：Diabetologia

authors： Lobmann R,Ambrosch A,Schultz G,Waldmann K,Schiweck S,Lehnert H

更新日期：2002-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to ...

journal_title：Diabetologia

authors： Mikus CR,Oberlin DJ,Libla J,Boyle LJ,Thyfault JP

更新日期：2012-05-01 00:00:00

abstract：:The M variant of encephalomyocarditis virus (EMC) produces a disease similar to human insulin-dependent diabetes mellitus in some but not all strains of mice. This diabetogenic M variant was found to induce fivefold more interferon than non-diabetogenic strains of EMC in cultures of mouse L 929 fibroblasts. When inter...

journal_title：Diabetologia

authors： Wilson GL,Bellomo SC,Craighead JE

更新日期：1983-01-01 00:00:00

abstract：:The effects of the aldose reductase inhibitor, sorbinil, on symptomatic symmetrical diabetic polyneuropathy were studied during a 6-month period in a double-blind parallel group placebo-controlled trial. Twenty-seven patients received sorbinil and 28 placebo. The patients were assessed by clinical examination, neuroph...

journal_title：Diabetologia

authors： Fagius J,Brattberg A,Jameson S,Berne C

更新日期：1985-06-01 00:00:00

abstract：:We compared urinary albumin excretion during and after pregnancy in 30 insulin-dependent diabetic (IDDM) women with normoalbuminuria and in 12 IDDM women with microalbuminuria (> 15 micrograms.min-1) prior to conception. There was a 6.7-fold increase in the urinary albumin excretion up until the third trimester in the...

journal_title：Diabetologia

authors： Biesenbach G,Zazgornik J,Stöger H,Grafinger P,Hubmann R,Kaiser W,Janko O,Stuby U

更新日期：1994-09-01 00:00:00

abstract：:The relationship between plasma glucose, serum insulin, serum C-peptide and obesity was studied in 320 fasting high school students (13-18 years old), as part of a Busselton population study. For males and females respectively plasma glucose was 4.5 +/- 0.4 and 4.4 +/- 0.5 mmol/l (mean +/- SD), serum insulin 0.51 +/- ...

journal_title：Diabetologia

authors： Garcia-Webb P,Bonser A,Wearne KL,Gracey M

更新日期：1980-09-01 00:00:00

abstract：:Highly purified insulins offer the possibility of reducing insulin antibody levels and insulin requirement. Those likely to respond cannot be predicted on clinical grounds and a simple laboratory test is recommended for this purpose. This is based on insulin binding capacity (IBC) of plasma and has been used to follow...

journal_title：Diabetologia

authors： Mustaffa BE,Daggett PR,Nabarro JD

更新日期：1977-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Effects of the transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MAFA) on the regulation of beta cell gene expression and function were investigated. MATERIALS AND METHODS:INS-1 stable cell lines permitting inducible up- or downregulation of this transcription factor were...

journal_title：Diabetologia

authors： Wang H,Brun T,Kataoka K,Sharma AJ,Wollheim CB

更新日期：2007-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The first clinical manifestation of diabetes is polyuria. The prostaglandin E2 (PGE2) receptor EP3 antagonises arginine vasopressin (AVP)-mediated water reabsorption and its expression is increased in the diabetic kidney. The purpose of this work was to study the contribution of EP3 to diabetic polyuria...

journal_title：Diabetologia

authors： Hassouneh R,Nasrallah R,Zimpelmann J,Gutsol A,Eckert D,Ghossein J,Burns KD,Hébert RL

更新日期：2016-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus is a heterogeneous disorder characterised by impaired insulin secretion and action. Our aim was to study whether autoimmunity, variations in genes affecting insulin secretion and action, or both, contribute to the development of gestational diabetes and whether the pathogen...

journal_title：Diabetologia

authors： Shaat N,Ekelund M,Lernmark A,Ivarsson S,Nilsson A,Perfekt R,Berntorp K,Groop L

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study aimed to assess, in multiple populations, the role of HLA alleles on early and late age at onset of type 1 diabetes. METHODS:Stepwise linear regression models were used to determine which HLA class I and class II risk alleles to include. High-resolution genotyping data for patients from the T...

journal_title：Diabetologia

authors： Valdes AM,Erlich HA,Carlson J,Varney M,Moonsamy PV,Noble JA

更新日期：2012-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302, and allelic variation of the T cell regulatory gene cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) and of the T cell activation gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22) have been associated with type 1 diabetes...

journal_title：Diabetologia

authors： Howson JM,Dunger DB,Nutland S,Stevens H,Wicker LS,Todd JA

更新日期：2007-04-01 00:00:00

abstract：:The aim of the present study was to elucidate the pathophysiologic significance of circulating ouabain as a link between insulin resistance (IR) and hypertension (HT) in NIDDM. Euglycaemic (4.5 mmol/l) hyperinsulinaemic (360-580 pmol/l) clamping was performed using an artificial endocrine pancreas. Plasma ouabain-like...

journal_title：Diabetologia

authors： Wasada T,Kuroki H,Naruse M,Arii H,Maruyama A,Katsumori K,Saito S,Watanabe Y,Naruse K,Demura H

更新日期：1995-07-01 00:00:00

abstract：:Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes,...

journal_title：Diabetologia

authors： Grønbaek H,Nielsen B,Osterby R,Harris A,Orskov H,Flyvbjerg A

更新日期：1995-02-01 00:00:00

abstract：:This study aimed at verifying whether thiamine, a co-enzyme which decreases intracellular glycolysis metabolites by allowing pyruvate and glyceraldheyde 3-phosphate to enter the Krebs cycle and the pentose-phosphate shunt, respectively, corrects delayed replication caused by high glucose concentrations in cultured hum...

journal_title：Diabetologia

authors： La Selva M,Beltramo E,Pagnozzi F,Bena E,Molinatti PA,Molinatti GM,Porta M

更新日期：1996-11-01 00:00:00