Insulin binding and insulin action in rat fat cells after adrenalectomy.

abstract：:Hyperglycaemia has been shown to play a central part in diabetic vascular disease, which is also influenced by individual background. Hyperglycaemia initiates the pathogenetic sequence through a series of interrelated biochemical abnormalities, including increased flux through the polyol and hexosamine pathways, oxida...

journal_title：Diabetologia

authors： Di Mario U,Pugliese G

更新日期：2001-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin-mediated glucose transport and utilisation are decreased in skeletal muscle from type 2 diabetic and glucose-intolerant individuals because of alterations in insulin receptor signalling, GLUT4 translocation to the plasma membrane and microvascular blood flow. Catalytic activity of the muscle-spe...

journal_title：Diabetologia

authors： Mezghenna K,Leroy J,Azay-Milhau J,Tousch D,Castex F,Gervais S,Delgado-Betancourt V,Gross R,Lajoix AD

更新日期：2014-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy is a major debilitating disease causing most cases of blindness in humans in the Western world. Photocoagulation is the established therapy of proliferative diabetic retinopathy, although the molecular mechanisms of its effects are still not known. Recently angiostatin...

journal_title：Diabetologia

authors： Spranger J,Hammes HP,Preissner KT,Schatz H,Pfeiffer AF

更新日期：2000-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to study the incidence of Type I diabetes in 4 countries, Estonia, Latvia, Lithuania and Finland, during 1983-1998, focusing on the two separate periods of 1983-1990 and 1991-1998. METHODS:Population-based incidence data from nationwide diabetes registries were used. Crude and age-standardized...

journal_title：Diabetologia

authors： Podar T,Solntsev A,Karvonen M,Padaiga Z,Brigis G,Urbonaite B,Viik-Kajander M,Reunanen A,Tuomilehto J

更新日期：2001-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We had previously reported that stromal cell-derived factor 1 (SDF-1) mediates chemorepulsion of diabetogenic T cell adhesion to islet microvascular endothelium through unknown mechanisms in NOD mice. Here we report that SDF-1-mediated chemorepulsion occurs through slit homologue (SLIT)2-roundabout, axo...

journal_title：Diabetologia

authors： Glawe JD,Mijalis EM,Davis WC,Barlow SC,Gungor N,McVie R,Kevil CG

更新日期：2013-10-01 00:00:00

abstract：:Insulin antibodies expressed as insulin binding capacity of IgG were determined in 50 Type 1 (insulin-dependent) diabetic children who have been treated with monocomponent porcine insulin from the onset of the disease. During the follow-up period of 0.5-5.5 years (mean +/- SD: 3.2 +/- 1.6 years), 26 out of 50 patients...

journal_title：Diabetologia

authors： Ludvigsson J

更新日期：1984-02-01 00:00:00

abstract：:Platelet aggregation in response to collagen, adenosine diphosphate and arachidonic acid was studied prospectively in 30 children with Type 1 (insulin-dependent) diabetes mellitus. The studies began on admission to hospital and continued throughout the two years following diagnosis. The results were compared with thos...

journal_title：Diabetologia

authors： Kobbah AM,Ewald U,Tuvemo T

更新日期：1989-10-01 00:00:00

abstract：:Insulin secretion was stimulated and cyclic adenosine 3', 5'-monophosphate (cAMP) levels were elevated in isolated rat islets by 27.5 mmol/l glucose. Alloxan caused a dose-dependent decrease in both variables with complete obliteration of insulin release at a concentration of 1.25 mmol/l. D-glucose, in the presence or...

journal_title：Diabetologia

authors： Zawalich WS,Karl RC,Matschinsky FM

更新日期：1979-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes promotes cerebral neovascularisation via increased vascular endothelial growth factor (VEGF) angiogenic signalling. Roundabout-4 (ROBO4) protein is an endogenous inhibitor of VEGF signalling that stabilises the vasculature. Yet, how diabetes affects ROBO4 function remains unknown. We hypothesis...

journal_title：Diabetologia

authors： Abdelsaid M,Coucha M,Hafez S,Yasir A,Johnson MH,Ergul A

更新日期：2017-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies in East Asian populations reported that single nucleotide polymorphisms (SNPs) in KCNQ1 are associated with type 2 diabetes. The aim of this study was to validate this finding in a Chinese population. METHODS:We genotyped four SNPs, rs2074196, rs2237892, rs2237895...

journal_title：Diabetologia

authors： Hu C,Wang C,Zhang R,Ma X,Wang J,Lu J,Qin W,Bao Y,Xiang K,Jia W

更新日期：2009-07-01 00:00:00

abstract：:Using an antiserum raised to a recombinant coxsackie virus B 3 capsid protein, VP1, an immunocytochemical technique was developed which was capable of detecting the presence of all coxsackie B viruses in formalin fixed paraffin embedded infected tissue culture cells. This technique was tested on autopsy heart and panc...

journal_title：Diabetologia

authors： Foulis AK,Farquharson MA,Cameron SO,McGill M,Schönke H,Kandolf R

更新日期：1990-05-01 00:00:00

abstract：:Under strict balance conditions we studied the effect of phenformin in 5 patients with diabetes mellitus. In all cases phenformin lowered the blood glucose values, and all patients showed a reduction of glycosuria. Contrary to other reports body weight increased during phenformin treatment. This was accompanied by pos...

journal_title：Diabetologia

authors： Geldermans CA,Terpstra J,Krans HM

更新日期：1975-10-01 00:00:00

abstract：:Following prolonged administration of tolbutamide the DNA- and protein content per islet was enhanced but the IRI content per islet was diminished. Glucose-induced (2.0, 8.0 or 16.6 mM) and leucine-induced (12.5 or 25.0 mM) IRI release from isolated islets, as well as 14C02-production from U-14C glucose, were decrease...

journal_title：Diabetologia

authors： Schauder P,Frerichs H

更新日期：1975-08-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) in the gut-brain-pancreatic axis are key players in the postprandial control of metabolism and food intake. A number of intestinally located receptors have been implicated in the chemo-detection of ingested nutrients, and in the pancreatic islets and nervous system GPCRs play essent...

journal_title：Diabetologia

authors： Reimann F,Gribble FM

更新日期：2016-02-01 00:00:00

abstract：AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...

journal_title：Diabetologia

authors： Perrini S,Laviola L,Cignarelli A,Melchiorre M,De Stefano F,Caccioppoli C,Natalicchio A,Orlando MR,Garruti G,De Fazio M,Catalano G,Memeo V,Giorgino R,Giorgino F

更新日期：2008-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of the study was to analyse how strongly commuting and leisure-time physical activity affect progression to diabetes and to study whether this relationship is different in individuals with isolated impaired fasting glucose (i-IFG) and isolated impaired glucose tolerance (i-IGT). METHODS:We stud...

journal_title：Diabetologia

authors： Engberg S,Glümer C,Witte DR,Jørgensen T,Borch-Johnsen K

更新日期：2010-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...

journal_title：Diabetologia

authors： Niersmann C,Carstensen-Kirberg M,Maalmi H,Holleczek B,Roden M,Brenner H,Herder C,Schöttker B

更新日期：2020-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Rosiglitazone, an insulin sensitiser, not only improves insulin sensitivity but also enhances insulin secretory capacity by ameliorating gluco- and lipotoxicity in beta cells. Rosiglitazone can stimulate insulin secretion at basal and high glucose levels via a phosphatidylinositol 3-kinase (PI3K)-depend...

journal_title：Diabetologia

authors： Chang TJ,Chen WP,Yang C,Lu PH,Liang YC,Su MJ,Lee SC,Chuang LM

更新日期：2009-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...

journal_title：Diabetologia

authors： Lutgers HL,Gerrits EG,Graaff R,Links TP,Sluiter WJ,Gans RO,Bilo HJ,Smit AJ

更新日期：2009-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We determined the response of selected genes to in vivo insulin in adipose tissue in 21 non-diabetic women. MATERIALS AND METHODS:The women were divided into insulin-sensitive and -resistant groups based on their median whole-body insulin sensitivity (8.7+/-0.4 vs 4.2+/-0.3 mg kg(-1) min(-1) for insuli...

journal_title：Diabetologia

authors： Westerbacka J,Cornér A,Kannisto K,Kolak M,Makkonen J,Korsheninnikova E,Nyman T,Hamsten A,Fisher RM,Yki-Järvinen H

更新日期：2006-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci (including African-specific variants) and fine-map association signals by performing genetic ...

journal_title：Diabetologia

authors： Chen J,Sun M,Adeyemo A,Pirie F,Carstensen T,Pomilla C,Doumatey AP,Chen G,Young EH,Sandhu M,Morris AP,Barroso I,McCarthy MI,Mahajan A,Wheeler E,Rotimi CN,Motala AA

更新日期：2019-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated of the effects of fatty acid composition of the maternal diet on fetal and postnatal growth, morphology of the pancreas and glucose metabolism and muscle hexosamine concentrations in the adult offspring of rats. METHODS:High-fat diets enriched with either saturated or unsaturated fatty ...

journal_title：Diabetologia

authors： Siemelink M,Verhoef A,Dormans JA,Span PN,Piersma AH

更新日期：2002-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Both obesity and genetics contribute to cardiovascular disease (CVD). We examined whether a genetic risk score (GRS) prospectively predicted cardiovascular morbidity and mortality among overweight/obese individuals with type 2 diabetes and whether behavioural weight loss could diminish this association....

journal_title：Diabetologia

authors： Look AHEAD Research Group.

更新日期：2015-08-01 00:00:00

abstract：:Fragments of cloned rat class I transplantation antigen genes were used to define the polymorphism detected between two lines of closely related BB rats. One line, BB-Hagedorn (BB/H), is prone to diabetes, and the other (BB control) is resistant. A cDNA probe representing part of the second extracellular domain of a c...

journal_title：Diabetologia

authors： Kryspin-Sørensen I,Dyrberg T,Kastern W

更新日期：1986-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data in...

journal_title：Diabetologia

authors： Dawed AY,Ali A,Zhou K,Pearson ER,Franks PW

更新日期：2017-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fat balance is critical in the aetiology of obesity and related diseases. Lipoprotein lipase is of major importance in lipid metabolism. The aim of this study was to investigate the long-term effects of the lipoprotein lipase activator, NO-1886, on substrate utilisation, adiposity and insulin action in ...

journal_title：Diabetologia

authors： Kusunoki M,Hara T,Tsutsumi K,Nakamura T,Miyata T,Sakakibara F,Sakamoto S,Ogawa H,Nakaya Y,Storlien LH

更新日期：2000-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Brain natriuretic peptide (BNP) is a potent vasorelaxing and natriuretic peptide that is secreted from the heart and has cardioprotective properties. We have previously generated hypotensive transgenic mice (BNP-Tg mice) that overproduce BNP in the liver, which is released into the circulation. Using th...

journal_title：Diabetologia

authors： Makino H,Mukoyama M,Mori K,Suganami T,Kasahara M,Yahata K,Nagae T,Yokoi H,Sawai K,Ogawa Y,Suga S,Yoshimasa Y,Sugawara A,Tanaka I,Nakao K

更新日期：2006-10-01 00:00:00

abstract：:Circulating somatomedin-C/insulin-like growth factor-I levels are low in the diabetic rat and unresponsive to exogenous growth hormone. However, the nature of this defect in growth hormone action remains unclear and there is little data on insulin-like growth factor-I gene expression in response to other stimuli and i...

journal_title：Diabetologia

authors： Murphy LJ

更新日期：1988-11-01 00:00:00

abstract：:Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8+ T cells. While both hallmarks are n...

journal_title：Diabetologia

authors： Carré A,Richardson SJ,Larger E,Mallone R

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Evidence suggests that bacterial components in blood could play an early role in events leading to diabetes. To test this hypothesis, we studied the capacity of a broadly specific bacterial marker (16S rDNA) to predict the onset of diabetes and obesity in a general population. METHODS:Data from an Epid...

journal_title：Diabetologia

authors： Amar J,Serino M,Lange C,Chabo C,Iacovoni J,Mondot S,Lepage P,Klopp C,Mariette J,Bouchez O,Perez L,Courtney M,Marre M,Klopp P,Lantieri O,Doré J,Charles M,Balkau B,Burcelin R,D.E.S.I.R. Study Group.

更新日期：2011-12-01 00:00:00