Genetic heterogeneity in the major histocompatibility complex of various BB rat sublines.

Abstract:

:Fragments of cloned rat class I transplantation antigen genes were used to define the polymorphism detected between two lines of closely related BB rats. One line, BB-Hagedorn (BB/H), is prone to diabetes, and the other (BB control) is resistant. A cDNA probe representing part of the second extracellular domain of a class I antigen detected several DNA fragments and revealed a 2kb fragment present in resistant, but absent in diabetes-prone, BB/H rat DNA following digestion with BamH1. A 40 bp cDNA probe from the same domain showed a further simplified pattern in the DNA hybridization analysis. Only two fragments, 15 kb and 7 kb, were present in the resistant rats; the diabetes-prone BB/H rats lacked the 7 kb fragment. Several lines of evidence suggest that the gene contained in this 7 kb fragment may be deleted. Analysis of other diabetic BB rats and in the F2 generation of intercross offspring of F1 hybrid parents following crossbreeding between the resistant (BB-control) and diabetes-prone (BB/H) line demonstrate that the class I polymorphism was not linked directly to diabetes. Examination of various other BB lines and sublines indicate that these polymorphisms can be traced back to at least one other subline (Worcester) in the parent colony.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Kryspin-Sørensen I,Dyrberg T,Kastern W

doi

10.1007/BF00452068

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

307-12

issue

5

eissn

0012-186X

issn

1432-0428

journal_volume

29

pub_type

杂志文章
  • Oxidative DNA damage in diabetes mellitus: its association with diabetic complications.

    abstract:AIMS/HYPOTHESIS:Augmented oxidative stress induced by hyperglycaemia possibly contributes to the pathogenesis of diabetic complications. Oxidative stress is known to increase the conversion of deoxyguanosine to 8-oxo, 2'-deoxyguanosine in DNA. To investigate the possible contribution of oxidative DNA damage to the path...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051258

    authors: Hinokio Y,Suzuki S,Hirai M,Chiba M,Hirai A,Toyota T

    更新日期:1999-08-01 00:00:00

  • Vitreous metabolomics profiling of proliferative diabetic retinopathy.

    abstract:AIMS/HYPOTHESIS:Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabo...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05309-y

    authors: Tomita Y,Cagnone G,Fu Z,Cakir B,Kotoda Y,Asakage M,Wakabayashi Y,Hellström A,Joyal JS,Talukdar S,Smith LEH,Usui Y

    更新日期:2021-01-01 00:00:00

  • Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes.

    abstract:AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-008-1036-6

    authors: Rozo AV,Vijayvargia R,Weiss HR,Ruan H

    更新日期:2008-08-01 00:00:00

  • Electron microscopy of renal and ocular changes in virus-induced diabetes mellitus in mice.

    abstract::The eyes, kidneys and pancreas of mice (SJL/J) infected with encephalomyocarditis virus were examined by light and electron microscopy. Diabetic mice with the longest duration (6 months) of diabetes showed marked renal and ocular alterations. Fasting blood glucose levels were 17.8-21.9 mmol/l and glycosuria was presen...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00282717

    authors: Rodrigues M,Currier C,Yoon J

    更新日期:1983-04-01 00:00:00

  • Marine lipids normalize cholesteryl ester transfer in IDDM.

    abstract::Patients with insulin-dependent diabetes mellitus (IDDM) have a pathological increase in cholesteryl ester transfer (CET) that enriches the apolipoprotein B-containing lipoproteins with cholesteryl ester and increases their atherogenicity. Since we have shown earlier that omega-3 (n-3) fatty acids present in marine li...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00400682

    authors: Bagdade JD,Ritter M,Subbaiah PV

    更新日期:1996-04-01 00:00:00

  • The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance.

    abstract:AIMS/HYPOTHESIS:Insulin resistance is recognised as the core factor in the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus, hypertension and atherosclerosis. Several studies indicate the possible role of mutations of the insulin receptor substrate-1 (IRS-1) gene in the pathogenesis of insulin-resistan...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051628

    authors: Baroni MG,Arca M,Sentinelli F,Buzzetti R,Capici F,Lovari S,Vitale M,Romeo S,Di Mario U

    更新日期:2001-03-01 00:00:00

  • Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells.

    abstract:AIMS/HYPOTHESIS:Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hIPSCs) offer unique opportunities for regenerative medicine and for the study of mammalian development. However, developing methods to differentiate hESCs/hIPSCs into specific cell types following a natural pathway of developm...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2687-x

    authors: Cho CH,Hannan NR,Docherty FM,Docherty HM,Joåo Lima M,Trotter MW,Docherty K,Vallier L

    更新日期:2012-12-01 00:00:00

  • The increase in albuminuria induced by exercise is not associated with preferential excretion of glycated albumin in type 1 (insulin-dependent) diabetic patients.

    abstract::The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00408356

    authors: Cavallo-Perin P,Chiambretti A,Calefato V,Tomalino M,Urbino R,Cecchini G,Pagano G

    更新日期:1991-11-01 00:00:00

  • Absence of an adipogenic effect of rosiglitazone on mature 3T3-L1 adipocytes: increase of lipid catabolism and reduction of adipokine expression.

    abstract:AIMS/HYPOTHESIS:The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated receptor-gamma agonist that induces adipocyte differentiation and, hence, lipid accumulation. This is in apparent contrast to the long-term glucose-lowering, insulin-sensitising effect of rosiglitazone. We tested whether th...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-006-0565-0

    authors: Wang P,Renes J,Bouwman F,Bunschoten A,Mariman E,Keijer J

    更新日期:2007-03-01 00:00:00

  • Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:Hyperglycaemia in diabetes is associated with increased glycation, oxidative stress and nitrosative stress. Proteins modified consequently contain glycation, oxidation and nitration adduct residues, and undergo cellular proteolysis with release of corresponding free adducts. These free adducts leak into...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-005-1810-7

    authors: Ahmed N,Babaei-Jadidi R,Howell SK,Beisswenger PJ,Thornalley PJ

    更新日期:2005-08-01 00:00:00

  • Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis.

    abstract:AIMS/HYPOTHESIS:Acute hyperglycaemia rapidly suppresses endogenous glucose production (EGP) in non-diabetic individuals, mainly by inhibiting glycogenolysis. Loss of this 'glucose effectiveness' contributes to fasting hyperglycaemia in type 2 diabetes. Elevated NEFA levels characteristic of type 2 diabetes impair gluco...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2662-6

    authors: Kehlenbrink S,Koppaka S,Martin M,Relwani R,Cui MH,Hwang JH,Li Y,Basu R,Hawkins M,Kishore P

    更新日期:2012-11-01 00:00:00

  • Inter-organ communication and regulation of beta cell function.

    abstract::The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell funct...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-015-3862-7

    authors: Hussain MA,Akalestou E,Song WJ

    更新日期:2016-04-01 00:00:00

  • 11beta-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes.

    abstract::Obesity and Type 2 diabetes mellitus are associated with abnormal regulation of glucocorticoid metabolism that are highlighted by clinical similarities between the sequelae of insulin resistance and Cushing's syndrome, as well as glucocorticoids' functional antagonism to insulin. 11beta-hydroxysteroid dehydrogenase ty...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-003-1284-4

    authors: Stulnig TM,Waldhäusl W

    更新日期:2004-01-01 00:00:00

  • Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels.

    abstract:AIMS/HYPOTHESIS:Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-017-4222-6

    authors: Mahendran Y,Jonsson A,Have CT,Allin KH,Witte DR,Jørgensen ME,Grarup N,Pedersen O,Kilpeläinen TO,Hansen T

    更新日期:2017-05-01 00:00:00

  • No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort.

    abstract:AIMS/HYPOTHESIS:Although the variable number tandem repeat (VNTR) minisatellite 5' to the insulin gene is among the most studied polymorphisms in diabetes, the relationships between VNTR variation, diabetes-related traits and predisposition to type 2 diabetes remain unclear. Since inadequate sample size is likely to ha...

    journal_title:Diabetologia

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00125-005-1737-z

    authors: Bennett A,Sovio U,Ruokonen A,Martikainen H,Pouta A,Taponen S,Hartikainen AL,Franks S,Peltonen L,Elliott P,Järvelin MR,McCarthy MI

    更新日期:2005-05-01 00:00:00

  • Elevated plasma insulin-like growth factor binding protein-1 levels in type 1 (insulin-dependent) diabetic patients with peripheral neuropathy.

    abstract::Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00399934

    authors: Crosby SR,Tsigos C,Anderton CD,Gordon C,Young RJ,White A

    更新日期:1992-09-01 00:00:00

  • Role of insulin resistance in the pathogenesis of NIDDM.

    abstract::The above discussion illustrating the multitude of variables which influence insulin sensitivity in normal subjects challenges the prevailing view that insulin sensitivity is genetically determined in patients with NIDDM. The lack of accurate quantitation of all determinants of insulin sensitivity in the cross-section...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/BF00400597

    authors: Yki-Järvinen H

    更新日期:1995-12-01 00:00:00

  • Impaired estrogen-induced uterine insulin-like growth factor-I gene expression in the streptozotocin diabetic rat.

    abstract::Circulating somatomedin-C/insulin-like growth factor-I levels are low in the diabetic rat and unresponsive to exogenous growth hormone. However, the nature of this defect in growth hormone action remains unclear and there is little data on insulin-like growth factor-I gene expression in response to other stimuli and i...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00277488

    authors: Murphy LJ

    更新日期:1988-11-01 00:00:00

  • Reversibility of insulin resistance in obese diabetic patients: role of plasma lipids.

    abstract::The aim of the present study was to measure whole body glucose uptake (M) and oxidation rate by euglycaemic hyperinsulinaemic clamp and indirect calorimetry in 7 morbidly obese subjects (BMI > 40 kg/m2) at three time points: before bilio-pancreatic diversion (BPD) surgery (Ob); 3 months after surgery POI; and after re...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050721

    authors: Mingrone G,DeGaetano A,Greco AV,Capristo E,Benedetti G,Castagneto M,Gasbarrini G

    更新日期:1997-05-01 00:00:00

  • Proinsulin C peptide obviates sympathetically mediated suppression of splenic lymphocyte activity in rats.

    abstract:AIMS/HYPOTHESIS:To investigate whether proinsulin C peptide influences sympathetic nerve activity directly or indirectly through parasympathetic nerve activity. METHODS:The proliferative response of splenic lymphocytes to Concanavalin A (ConA response) which is known to be suppressed by subjection of rats to footshock...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051562

    authors: Okamoto S,Kimura K,Kitamura T,Cañas X,Yoshida T,Saito M

    更新日期:2000-12-01 00:00:00

  • Preserved C-peptide secretion is associated with fewer low-glucose events and lower glucose variability on flash glucose monitoring in adults with type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:We aimed to assess whether persistence of C-peptide secretion is associated with less glucose variability and fewer low-glucose events in adults with type 1 diabetes who use flash monitoring. METHODS:We performed a cross-sectional study of 290 adults attending a university teaching hospital diabetes cl...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05099-3

    authors: Gibb FW,McKnight JA,Clarke C,Strachan MWJ

    更新日期:2020-05-01 00:00:00

  • Recent experience with 89 pancreas transplants at a single institution.

    abstract::Of 89 pancreas transplants performed in 77 diabetic patients (43 with and 34 without previous kidney transplants), 53 were from cadaver and 36 from related donors. To date, 64 patients (83%) are alive and 27 (35%) have functioning grafts (14 greater than 1 year), including 0 out of 3 duct-ligated, 3 out of 15 open-duc...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00275675

    authors: Sutherland DE,Goetz FC,Najarian JS

    更新日期:1984-07-01 00:00:00

  • HepG2/erythrocyte glucose transporter (GLUT1) gene in NIDDM: a population association study and molecular scanning in Japanese subjects.

    abstract::To evaluate the role of mutations in the glucose transporter (GLUT1) gene in Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM), we first conducted a population association study using the XbaI polymorphism of the gene. A polymerase chain reaction (PCR)-based assay was developed and used for the an...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00400583

    authors: Tao T,Tanizawa Y,Matsutani A,Matsubara A,Kaneko T,Kaku K

    更新日期:1995-08-01 00:00:00

  • Residual B cell function in diabetic children as determined by urinary C-peptide.

    abstract::C-peptide was determined in 24-h urine collections and in fasting plasma of 27 Type 1 (insulin-dependent) diabetic children (duration of disease 0-6 years) and in 11 matched normal children. Grouping the patients according to duration of disease from onset to 6 years, it was found that in the first year of disease the...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00297387

    authors: Aurbach-Klipper J,Sharph-Dor R,Heding LG,Karp M,Laron Z

    更新日期:1983-02-01 00:00:00

  • Islet amyloid polypeptide amide causes peripheral insulin resistance in vivo in dogs.

    abstract::Islet amyloid polypeptide is a 37 amino acid hormone-like peptide which is the major protein component of islet amyloid deposits commonly found in patients with Type 2 (non-insulin-dependent) diabetes mellitus. Recent studies indicate that a physiologically active form of this peptide appears to be carboxyamidated and...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00401051

    authors: Sowa R,Sanke T,Hirayama J,Tabata H,Furuta H,Nishimura S,Nanjo K

    更新日期:1990-02-01 00:00:00

  • Obesity and insulin secretion in fasting high school students.

    abstract::The relationship between plasma glucose, serum insulin, serum C-peptide and obesity was studied in 320 fasting high school students (13-18 years old), as part of a Busselton population study. For males and females respectively plasma glucose was 4.5 +/- 0.4 and 4.4 +/- 0.5 mmol/l (mean +/- SD), serum insulin 0.51 +/- ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00275268

    authors: Garcia-Webb P,Bonser A,Wearne KL,Gracey M

    更新日期:1980-09-01 00:00:00

  • Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.

    abstract:AIMS/HYPOTHESIS:Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single nucleotide polymorphisms (SNPs) in WFS1 have been reproducibly associated with type 2 diabetes. We therefore examined the effects of these variants on diabetes i...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-007-0891-x

    authors: Florez JC,Jablonski KA,McAteer J,Sandhu MS,Wareham NJ,Barroso I,Franks PW,Altshuler D,Knowler WC,Diabetes Prevention Program Research Group.

    更新日期:2008-03-01 00:00:00

  • Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids.

    abstract:AIMS/HYPOTHESIS:According to the foetal origins hypothesis, there is a relation between foetal nutrition and adult glucose intolerance. In adults, insulin resistance has been associated with dietary polyunsaturated fatty acids. We examined whether the availability of polyunsaturated fatty acids during foetal life, as i...

    journal_title:Diabetologia

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00125-001-0764-7

    authors: Rump P,Popp-Snijders C,Heine RJ,Hornstra G

    更新日期:2002-03-01 00:00:00

  • Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirub

    abstract:AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) is a risk factor for perinatal complications. In several countries, the criteria for the diagnosis of GDM have been in flux, the American Diabetes Association (ADA) thresholds recommended in 2000 being lower than those of the National Diabetes Data Group (NDDG) that h...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-006-0517-8

    authors: Ferrara A,Weiss NS,Hedderson MM,Quesenberry CP Jr,Selby JV,Ergas IJ,Peng T,Escobar GJ,Pettitt DJ,Sacks DA

    更新日期:2007-02-01 00:00:00

  • Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) have been shown to abrogate in vitro the proinflammatory response in type 1 diabetes. The mechanism involves paracrine factors, which may include microvesicles (MVs). We evaluated whether MVs derived from heterologous bone-marrow MSCs exert an immunomodulatory effect on T c...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-014-3262-4

    authors: Favaro E,Carpanetto A,Lamorte S,Fusco A,Caorsi C,Deregibus MC,Bruno S,Amoroso A,Giovarelli M,Porta M,Perin PC,Tetta C,Camussi G,Zanone MM

    更新日期:2014-08-01 00:00:00