Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes.

abstract：:Insulin antibodies expressed as insulin binding capacity of IgG were determined in 50 Type 1 (insulin-dependent) diabetic children who have been treated with monocomponent porcine insulin from the onset of the disease. During the follow-up period of 0.5-5.5 years (mean +/- SD: 3.2 +/- 1.6 years), 26 out of 50 patients...

journal_title：Diabetologia

authors： Ludvigsson J

更新日期：1984-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield val...

journal_title：Diabetologia

authors： Tura A,Chemello G,Szendroedi J,Göbl C,Færch K,Vrbíková J,Pacini G,Ferrannini E,Roden M

更新日期：2018-05-01 00:00:00

abstract：:The effect of interference with diacylglycerol metabolism was investigated in pancreatic mouse islets. In the presence of the diacylglycerol lipase inhibitor RHC 80,267, glucose-induced insulin secretion was reduced 50-60%; whereas carbacholin-induced insulin secretion was unaffected. Addition of the diacylglycerol ki...

journal_title：Diabetologia

authors： Capito K,Hansen SE,Hedeskov CJ,Thams P

更新日期：1989-02-01 00:00:00

abstract：:Plasma insulin, intact proinsulin and 32-33 split proinsulin measured by specific immunoradiometric assays and insulin and C-peptide measured by radioimmunoassay were measured during a constant infusion of glucose test in ten diet-treated subjects with a history of Type 2 (non-insulin-dependent) diabetes (termed diabe...

journal_title：Diabetologia

authors： Clark PM,Levy JC,Cox L,Burnett M,Turner RC,Hales CN

更新日期：1992-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The effect of renin inhibition on type 2 diabetes is still unclear. The present study was undertaken to examine the efficacy of aliskiren, a direct renin inhibitor, on cardiovascular injuries, glucose intolerance and pancreatic injury in a mouse model of type 2 diabetes. METHODS:Groups of db/db mice, w...

journal_title：Diabetologia

authors： Dong YF,Liu L,Kataoka K,Nakamura T,Fukuda M,Tokutomi Y,Nako H,Ogawa H,Kim-Mitsuyama S

更新日期：2010-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated receptor-gamma agonist that induces adipocyte differentiation and, hence, lipid accumulation. This is in apparent contrast to the long-term glucose-lowering, insulin-sensitising effect of rosiglitazone. We tested whether th...

journal_title：Diabetologia

authors： Wang P,Renes J,Bouwman F,Bunschoten A,Mariman E,Keijer J

更新日期：2007-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between geneticall...

journal_title：Diabetologia

authors： Larsson SC,Michaëlsson K,Burgess S

更新日期：2020-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and ...

journal_title：Diabetologia

authors： Ohlsson B,Melander O,Thorsson O,Olsson R,Ekberg O,Sundkvist G

更新日期：2006-09-01 00:00:00

abstract：:Families (n = 14) with more than 1 sibling with insulin dependent diabetes were matched with families of similar size and age distribution containing only 1 affected child. The distribution of HLA haplotypes, age of onset of disease, and seasonal onset of disease were compared in the two groups. The data are not consi...

journal_title：Diabetologia

authors： Jaworski MA,Colle E,Guttmann RD,Belmonte MM,Taylor B,Crepeau MP,Wilkins J,Poirier R

更新日期：1980-08-01 00:00:00

abstract：:A controlled trial of oral nicotinamide to prevent the onset of diabetes mellitus in high risk children was conducted in two centres. The selection criteria were age less than 16 years, islet cell antibody greater than or equal to 80 IUs, and first phase insulin release less than 5th percentile. All of eight untreated...

journal_title：Diabetologia

authors： Elliott RB,Chase HP

更新日期：1991-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular disease (CVD) is the most common cause of premature death and disability among patients with type 1 diabetes. Diabetic nephropathy accounts for the increased cardiovascular morbidity and mortality of these patients. We recently showed that the intensity of exercise predicts the incidence ...

journal_title：Diabetologia

authors： Tikkanen-Dolenc H,Wadén J,Forsblom C,Harjutsalo V,Thorn LM,Saraheimo M,Elonen N,Rosengård-Bärlund M,Gordin D,Tikkanen HO,Groop PH,FinnDiane Study Group.

更新日期：2017-03-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. In this issue of Diabetologia (doi: ...

journal_title：Diabetologia

authors： Miele C,Beguinot F

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:High intake of carbohydrates, particularly sucrose, in western societies is associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related primarily to the carbohydrate quantity or to the hormonal responses, particularly glucose-dependent...

journal_title：Diabetologia

authors： Keyhani-Nejad F,Irmler M,Isken F,Wirth EK,Beckers J,Birkenfeld AL,Pfeiffer AF

更新日期：2015-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue. METHODS:Immunohistological analysis was used to determine the distribution of proinsulin and insulin in t...

journal_title：Diabetologia

authors： Leete P,Oram RA,McDonald TJ,Shields BM,Ziller C,TIGI study team.,Hattersley AT,Richardson SJ,Morgan NG

更新日期：2020-06-01 00:00:00

abstract：:Hybridomas producing proinsulin antibodies were cloned by limiting dilution of cell cultures obtained by fusion of splenocytes of immunized mice with immortal myeloma cells. Some proinsulin monoclonal antibodies crossreacted with labelled insulin but none did with labelled C-peptide indicating that the involved epitop...

journal_title：Diabetologia

authors： Sodoyez JC,Koch M,Lemaire I,Sodoyez-Goffaux F,Rapaille A,François-Gérard C,Sondag D

更新日期：1991-07-01 00:00:00

abstract：:The interrelationships between fibrinogen, von Willebrand factor, a marker of vascular endothelial cell damage, and serum lipids were explored in well-characterised subjects with insulin-dependent diabetes mellitus. The 2091 subjects were enrolled into a cross-sectional, clinic-based study of complications, from 16 Eu...

journal_title：Diabetologia

authors： Greaves M,Malia RG,Goodfellow K,Mattock M,Stevens LK,Stephenson JM,Fuller JH

更新日期：1997-06-01 00:00:00

abstract：:Very low density lipoproteins (VLDL) have an abnormal lipid composition in Type 1 (insulin-dependent) diabetic patients. Since VLDL represent a heterogeneous lipoprotein class, this might be due either to a shift in the distribution or to an abnormal composition of VLDL subclasses or both. In order to investigate thes...

journal_title：Diabetologia

authors： Patti L,Romano G,Di Marino L,Annuzzi G,Mancini M,Riccardi G,Rivellese AA

更新日期：1993-02-01 00:00:00

abstract：:Non-obese diabetic mice aged 30 to 60 days were treated orally with Cyclosporin at doses of 25, 15 and 2.5 mg/kg every 2 days until 160 days of age. Diabetes developed in 12 out of 18 oil-treated mice (67%), with partial to complete Langerhans' islet destruction associated with lymphocytic infiltration. The non-obese ...

journal_title：Diabetologia

authors： Mori Y,Suko M,Okudaira H,Matsuba I,Tsuruoka A,Sasaki A,Yokoyama H,Tanase T,Shida T,Nishimura M

更新日期：1986-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose and the peptide growth factors insulin, IGF-I and IGF-II strongly regulate beta cell mass. Furthermore, beta cell expression of IGF-I receptor (Igf1r) and insulin receptor (Insr) is mandatory for several steps of insulin secretion. MATERIALS AND METHODS:We hypothesised that glucose concentratio...

journal_title：Diabetologia

authors： Raile K,Klammt J,Laue S,Garten A,Blüher M,Kralisch S,Klöting N,Kiess W

更新日期：2005-09-01 00:00:00

abstract：:Cyclic adenosine 5'diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2+. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly...

journal_title：Diabetologia

authors： Yagui K,Shimada F,Mimura M,Hashimoto N,Suzuki Y,Tokuyama Y,Nata K,Tohgo A,Ikehata F,Takasawa S,Okamoto H,Makino H,Saito Y,Kanatsuka A

更新日期：1998-09-01 00:00:00

abstract：:A diabetes prevalence study on an isolated urbanized Central Pacific Island has established a prevalence rate of 34.4% in individuals aged 15 years and over. Of these, 10.4% had previously known diabetes; in the others the diagnosis was made on the basis of a plasma glucose level of at least 160 mg/100 ml 2h after a 7...

journal_title：Diabetologia

authors： Zimmet P,Taft P,Guinea A,Guthrie W,Thoma K

更新日期：1977-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 1 diabetes, selective beta cell loss occurs within the inflamed milieu of insulitic islets. This milieu is generated via the enhanced secretion of proinflammatory cytokines and by the loss of anti-inflammatory molecules such as IL-4 and IL-13. While the actions of proinflammatory cytokines have ...

journal_title：Diabetologia

authors： Leslie KA,Russell MA,Taniguchi K,Richardson SJ,Morgan NG

更新日期：2019-01-01 00:00:00

abstract：UNLABELLED:AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also exists in Belgian patients, is specific for immune-mediated diabetes, remains genotype-restricted after adjustment for age at diagnosis, and is associate...

journal_title：Diabetologia

authors： Weets I,Van Autreve J,Van der Auwera BJ,Schuit FC,Du Caju MV,Decochez K,De Leeuw IH,Keymeulen B,Mathieu C,Rottiers R,Dorchy H,Quartier E,Gorus FK,Belgian Diabetes Registry.

更新日期：2001-01-01 00:00:00

abstract：:In order to establish a model for the in vivo assessment of islet function we have used the Rowett nude rat with transplantation of allogeneic and xenogeneic (mouse) islets into the renal subcapsular space following a minimal period of diabetic induction. Thirty-one nude rats were given streptozotocin and 30 became di...

journal_title：Diabetologia

authors： Lake SP,Chamberlain J,Husken P,Bell PR,James RF

更新日期：1988-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...

journal_title：Diabetologia

authors： Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

更新日期：2012-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly ...

journal_title：Diabetologia

authors： Sparsø T,Andersen G,Nielsen T,Burgdorf KS,Gjesing AP,Nielsen AL,Albrechtsen A,Rasmussen SS,Jørgensen T,Borch-Johnsen K,Sandbaek A,Lauritzen T,Madsbad S,Hansen T,Pedersen O

更新日期：2008-01-01 00:00:00

abstract：:The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic disorders. Furthermore, it was also revealed that brown adipose tissue (BAT) in humans may consist of so-calle...

journal_title：Diabetologia

authors： Schrauwen P,van Marken Lichtenbelt WD,Spiegelman BM

更新日期：2015-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved...

journal_title：Diabetologia

authors： Strey CH,Young J,Collier M,Florkowski CM,Shand BI,Scott RS

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study aimed to elucidate the mechanism of increased proliferation of alpha cells in recent-onset type 1 diabetes. Pancreatic beta cells express GAD and produce γ-aminobutyric acid (GABA), which inhibits alpha cell secretion of glucagon. We explored the roles of GABA in alpha cell proliferation in c...

journal_title：Diabetologia

authors： Feng AL,Xiang YY,Gui L,Kaltsidis G,Feng Q,Lu WY

更新日期：2017-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic cardiomyopathy (DCM) is associated with suppressed autophagy and augmented apoptosis in the heart although the interplay between the two remains elusive. The ability of mammalian sterile 20-like kinase 1 to regulate both autophagy and apoptosis prompted us to investigate it as a possible candid...

journal_title：Diabetologia

authors： Zhang M,Zhang L,Hu J,Lin J,Wang T,Duan Y,Man W,Feng J,Sun L,Jia H,Li C,Zhang R,Wang H,Sun D

更新日期：2016-11-01 00:00:00