Abstract:
:G protein-coupled receptors (GPCRs) in the gut-brain-pancreatic axis are key players in the postprandial control of metabolism and food intake. A number of intestinally located receptors have been implicated in the chemo-detection of ingested nutrients, and in the pancreatic islets and nervous system GPCRs play essential roles in the detection of many hormones and neurotransmitters. Because of the diversity, cell-specific expression and 'druggability' of the GPCR superfamily, these receptors are popular targets for therapeutic development. This review will outline current and potential future approaches to develop GPCR agonists for the treatment of type 2 diabetes. This review summarises a presentation given at the 'Novel approaches to treating type 2 diabetes' symposium at the 2015 annual meeting of the EASD. It is accompanied by a commentary by the Session Chair, Michael Nauck (DOI: 10.1007/s00125-015-3823-1 ).
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Reimann F,Gribble FMdoi
10.1007/s00125-015-3825-zsubject
Has Abstractpub_date
2016-02-01 00:00:00pages
229-33issue
2eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-015-3825-zjournal_volume
59pub_type
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