Abstract:
:Platelet aggregation in response to collagen, adenosine diphosphate and arachidonic acid was studied prospectively in 30 children with Type 1 (insulin-dependent) diabetes mellitus. The studies began on admission to hospital and continued throughout the two years following diagnosis. The results were compared with those in 44 health control children. Collagen-induced aggregation was significantly decreased in the diabetic children on admission in comparison to the healthy children. In contrast, the aggregation induced by adenosine diphosphate (1.1 mumols/l, p less than 0.05) and arachidonic acid (0.25 mmol/l, p less than 0.05) was increased on admission. The magnitude of the platelet shape change after adenosine diphosphate stimulation was small at the onset of the disease but was significantly increased towards normal during the two years of follow-up. On admission, the primary wave aggregation induced by adenosine diphosphate was positively and significantly correlated to some of the lipoprotein fractions that were disturbed at that time, especially triglycerides in high-density lipoproteins. After two years of treatment the platelet aggregability in the diabetic children had been restored to normal.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Kobbah AM,Ewald U,Tuvemo Tdoi
10.1007/BF00274532subject
Has Abstractpub_date
1989-10-01 00:00:00pages
729-35issue
10eissn
0012-186Xissn
1432-0428journal_volume
32pub_type
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