Abstract:
:Eight diabetics were found among 464 children, mean age 11.2 years, of 311 unselected insulin-treated mothers. By a method of age correction the total diabetes prevalence among the children at the age of 25 years was calculated as 3.4%. Three children were non-insulin dependent and these patients and their mothers may belong to the autosomal dominant type of diabetes, so-called MODY. In two of the other five families the fathers also had insulin-dependent diabetes; in two more cases first or second degree paternal relatives were insulin-dependent diabetics. Thus the prevalence of insulin-dependent diabetes among the children of insulin dependent mothers married to non-diabetics is calculated as 1.5% at the age of 25 years.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Köbberling J,Brüggeboes Bdoi
10.1007/BF00261701subject
Has Abstractpub_date
1980-06-01 00:00:00pages
459-62issue
6eissn
0012-186Xissn
1432-0428journal_volume
18pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract::Hypothalamic and autonomic nervous regulation of carbohydrate and amino acid metabolism in the liver and of lipid metabolism in adipose tissues is described. The direct neural mechanism underlying this regulation has been evaluated. Electrical stimulation of the ventromedial hypothalamic nucleus (VMH)-splanchnic nerve...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:
更新日期:1981-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:We studied the gene therapy efficacy of diabetes-associated wound healing disorder with an adeno-associated virus (AAV) vector expressing the 165-amino acid isoform of human vascular endothelial growth factor-A (VEGF-A) by using an incisional skin-wound model produced on the back of female diabetic C57B...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1064-1
更新日期:2003-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, ...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-010-1883-9
更新日期:2011-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1), a polypeptide hormone secreted by the l-cells in the gastrointestinal tract, has shown promising effects as a new treatment modality for patients with Type II (non-insulin-dependent) diabetes mellitus. However, the pharmacokinetic profile of native GLP-1 with a rapid eli...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00125-001-0719-z
更新日期:2002-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:As glycaemia and the incidence of microvascular diabetes complications follow a log-linear relationship, it becomes increasingly difficult to demonstrate a microvascular benefit of glucose-lowering when the HbA1c level is close to normal. METHODS:The Outcome Reduction with an Initial Glargine Intervent...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-014-3238-4
更新日期:2014-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mild cognitive dysfunction is not uncommon in adults with Type 1 diabetes, but its pathogenesis remains unclear. Previous cross-sectional studies had suggested that microangiopathy might affect brain integrity and lead to "central neuropathy." To assess the relationship between changes in cognitive perf...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1128-2
更新日期:2003-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Although insulin resistance has been associated with accumulations of specific intramuscular fatty acids and altered subcellular localisation of lipid droplets, these concepts remain controversial. Therefore, we aimed to identify specific intramuscular fatty acids and subcellular lipid localisations ass...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3169-0
更新日期:2014-04-01 00:00:00
abstract::The antibody response and delayed type hypersensitivity reaction to commercially available trivalent influenza vaccine in 159 patients with diabetes mellitus was compared with response and reaction in 28 healthy volunteers. A correction for prevaccination titres was made. No differences were found between diabetic pat...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00292541
更新日期:1987-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of metabolic dysregulations across multiple biofluids and over varying timescales of glycaem...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3636-2
更新日期:2015-08-01 00:00:00
abstract::Non-insulin-dependent diabetes mellitus (NIDDM) is commonly associated with hypertriglyceridaemia, low serum HDL-cholesterol concentrations, hypertension, obesity and accelerated atherosclerosis (metabolic syndrome X). Since a similar dyslipidaemia occurs with the acute-phase response, we investigated whether elevated...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050822
更新日期:1997-11-01 00:00:00
abstract::Five healthy volunteers and 6 diabetics were given a mixed test meal on two occasions--once with and once without 10 g guar flour. Addition of guar caused a 47% decrease in maximum post-prandial GIP levels, a 48% decrease in blood glucose and a 48% decrease in plasma insulin in normal subjects. In diabetics, addition ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01222207
更新日期:1979-08-01 00:00:00
abstract::The effect of hyperglycaemia on islet transplantation in the rat has been examined in two ways, using syngeneic transplantation of 400 islets to the kidney capsule and subsequent measurement of kidney insulin content as a measurement of B-cell survival. Firstly, islets were transplanted into either diabetic or normal ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00274254
更新日期:1989-09-01 00:00:00
abstract::Four patients with glucagon-producing tumours of the pancreas were investigated. Fasting plasma glucagon concentrations ranged from 209--625 pmol/l. Plasma insulin concentrations were normal except in one patient, where the tumour also produced insulin (558 pmol/l). Intravenous glucose (25 g/m2) depressed the glucagon...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219741
更新日期:1979-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Our aim was to assess regression of albuminuria and its clinical consequences in type 1 diabetes. METHODS:The analysis included 3642 participants from the Finnish Diabetic Nephropathy (FinnDiane) Study with a 24 h urine sample and a history of albuminuria available at baseline. A total of 2729 individu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4564-8
更新日期:2018-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0847-1
更新日期:2008-01-01 00:00:00
abstract::MODY is an early-onset monogenic form of diabetes. Correctly identifying MODY is of considerable importance as diagnosing the specific genetic subtype can inform the optimal treatment, with many patients being able to discontinue unnecessary insulin treatment. Diagnostic molecular genetic testing to confirm MODY is ex...
journal_title:Diabetologia
pub_type: 评论,社论
doi:10.1007/s00125-017-4213-7
更新日期:2017-04-01 00:00:00
abstract::This study aimed at evaluating the influence of furosemide upon insulin and glucagon responses to arginine in healthy subjects. For this purpose, six normal subjects received two consecutive arginine pulses (3 g), 60 min apart, before and after the administration of furosemide (40 mg, IV). The acute insulin response (...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00251008
更新日期:1980-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Endothelial-endocrine cell interactions and vascular endothelial growth factor (VEGF)-A signalling are deemed essential for maternal islet vascularisation, glucose control and beta cell expansion during mouse pregnancy. The aim of this study was to assess whether pregnancy-associated beta cell expansion...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4243-1
更新日期:2017-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not pro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0118-y
更新日期:2006-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:This study compared the incidence rate of type 1 diabetes in children diagnosed with enterovirus (EV) infections with that in age- and sex-matched children without EV infection in a population-based cohort. In addition, we examined whether the direction or magnitude of the association between EV infecti...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3400-z
更新日期:2015-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1721-0
更新日期:2010-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4190-2
更新日期:2017-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Non-alcoholic fatty liver disease (NAFLD) is common in type 2 diabetes but it is unknown whether NAFLD is prevalent in European women at risk of type 2 diabetes. We studied the prevalence of, and risk factors for, NAFLD in European women with previous gestational diabetes (GDM) at high risk of type 2 di...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-2009-0
更新日期:2011-03-01 00:00:00
abstract::Highly purified insulins offer the possibility of reducing insulin antibody levels and insulin requirement. Those likely to respond cannot be predicted on clinical grounds and a simple laboratory test is recommended for this purpose. This is based on insulin binding capacity (IBC) of plasma and has been used to follow...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01223271
更新日期:1977-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, independently of the hormonal changes, is controversial. We tested whether an exogenous GLP-1 infusio...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-012-2738-3
更新日期:2013-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302, and allelic variation of the T cell regulatory gene cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) and of the T cell activation gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22) have been associated with type 1 diabetes...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0603-6
更新日期:2007-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Improvements in islet transplantation require clinical series large enough to implement controlled new strategies. The goal of this study was to demonstrate the feasibility of a multicentre network for islet transplantation in Type I (insulin-dependent) diabetic patients. METHODS:The five centres (Besa...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s001250100571
更新日期:2001-07-01 00:00:00
abstract::The systolic time intervals at rest of 16 Type 1 (insulin-dependent) and 30 Type 2 (non-insulin-dependent) otherwise healthy adult diabetic patients selected from primary health care clinics were compared with those of age- and sex-matched normal subjects by paired analysis. There was no significant difference in prev...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00282708
更新日期:1983-04-01 00:00:00
abstract::The recently completed diabetes complications and control trial has highlighted the need for improvement of insulin delivery systems for treatment of insulin-dependent diabetes mellitus. Despite steady improvement in methods for islet and whole pancreas transplantation over the past three decades, the broad-scale appl...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250051398
更新日期:1997-07-01 00:00:00
abstract::Despite its anabolic effects on protein balance, acute administration of insulin has been reported to have no effect on skeletal muscle or whole body protein synthesis in man. However, insulin also reduces plasma and intramuscular amino acid availability, which may limit protein synthesis. We have therefore measured t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00586460
更新日期:1990-01-01 00:00:00