当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Systolic time intervals in diabetes.

Systolic time intervals in diabetes.

Abstract：

:The systolic time intervals at rest of 16 Type 1 (insulin-dependent) and 30 Type 2 (non-insulin-dependent) otherwise healthy adult diabetic patients selected from primary health care clinics were compared with those of age- and sex-matched normal subjects by paired analysis. There was no significant difference in prevalence of smoking, body mass index, fasting serum cholesterol or mean blood pressure between the diabetic and control groups. Mean rate-corrected pre-ejection period (diabetic patients: 132.7 +/- 2.1 ms, normal subjects: 134.6 +/- 3.5 ms (+/- SEM), left ventricular ejection time (diabetic patients: 413.9 +/- 3.0 ms, normal subjects: 421.5 +/- 4.7 ms) electromechanical systole (diabetic patients: 544.9 +/- 2.5 ms, normal subjects: 548.0 +/- 3.5 ms) and pre-ejection period/left ventricular ejection time ratio (diabetic patients: 0.36 +/- 0.01, normal subjects: 0.34 +/- 0.01) were not significantly different between the two groups (p greater than 0.05) and systolic time intervals did not correlate with duration of diabetes or type of treatment. Thus, we did not detect subclinical cardiomyopathy in healthy diabetic patients by this technique. However, a statistically significant skew in the distribution of systolic time intervals in the diabetic group (p less than 0.025) suggests the possibility of an 'at risk' population in which a more sensitive technique might demonstrate impaired ventricular performance.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Posner J,Ilya R,Wanderman K,Weitzman S

doi

10.1007/BF00282708

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

249-52

issue

4

eissn

0012-186X

issn

1432-0428

journal_volume

24

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Utilisation of antihyperglycaemic drugs in ten European countries: different developments and different levels.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to compare developments in the utilisation of antihyperglycaemic drugs (AHGDs) in ten European countries. SUBJECTS AND METHODS:Data on the yearly utilisation of insulin and oral AHGDs were collected from public registers in Denmark, Finland, Norway, Sweden, Belgium, England, G...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0331-3

    authors： Melander A,Folino-Gallo P,Walley T,Schwabe U,Groop PH,Klaukka T,Vallano A,Laporte JR,Gallego MR,Schiappa M,Røder M,Kampmann JP,de Swaef A,Aberg M,Månsson NO,Lindblad U

    更新日期：2006-09-01 00:00:00

  • Transition of metabolic phenotypes and risk of subclinical atherosclerosis according to BMI: a prospective study.

    abstract：AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05116-5

    authors： Lin L,Zhang J,Jiang L,Du R,Hu C,Lu J,Wang T,Li M,Zhao Z,Xu Y,Xu M,Bi Y,Ning G,Wang W,Chen Y

    更新日期：2020-07-01 00:00:00

  • Insulin-induced activation of phosphoinositide 3-kinase in Fao cells.

    abstract：:Phosphoinositide 3-kinase (PI3-kinase) plays a crucial role in insulin signal transduction. We studied the molecular mechanism of the insulin-induced activation of PI3-kinase in rat hepatoma Fao cells using an antibody against the 110-kDa catalytic subunit (p110) and two against the 85-kDa regulatory subunit (p85 alph...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00403297

    authors： Hayashi T,Okamoto M,Yoshimasa Y,Inoue G,Yamada K,Kono S,Shigemoto M,Suga J,Kuzuya H,Nakao K

    更新日期：1996-05-01 00:00:00

  • FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes.

    abstract：AIMS/HYPOTHESIS:Fibroblast growth factor 21 (FGF21) is considered to be a promising therapeutic candidate for the treatment of type 2 diabetes. However, as FGF21 levels are elevated in obese and diabetic conditions we aimed to test if exogenous FGF21 is sufficient to prevent diabetes and beta cell loss in New Zealand o...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4389-x

    authors： Laeger T,Baumeier C,Wilhelmi I,Würfel J,Kamitz A,Schürmann A

    更新日期：2017-11-01 00:00:00

  • Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates. The Hoorn Study.

    abstract：AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-2864-6

    authors： Walraven I,van 't Riet E,Stehouwer CD,Polak BC,Moll AC,Dekker JM,Nijpels G

    更新日期：2013-05-01 00:00:00

  • Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study.

    abstract：AIMS/HYPOTHESIS:We determined the effects of 6 years of lifestyle intervention in persons with impaired glucose tolerance (IGT) on the development of retinopathy, nephropathy and neuropathy over a 20 year period. METHODS:In 1986, 577 adults with IGT from 33 clinics in Da Qing, China were randomly assigned by clinic to...

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-010-1948-9

    authors： Gong Q,Gregg EW,Wang J,An Y,Zhang P,Yang W,Li H,Li H,Jiang Y,Shuai Y,Zhang B,Zhang J,Gerzoff RB,Roglic G,Hu Y,Li G,Bennett PH

    更新日期：2011-02-01 00:00:00

  • On line continuous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis.

    abstract：:For the normalisation of blood glucose levels in diabetic patients by feedback controlled insulin delivery, a self-manageable and reliable method for continuous glucose estimation is still not available. By combining a commercially available needle type dialysis probe (molecular cutoff 20,000 Da) with a sensitive gluc...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF02221686

    authors： Meyerhoff C,Bischof F,Sternberg F,Zier H,Pfeiffer EF

    更新日期：1992-11-01 00:00:00

  • Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse.

    abstract：AIMS/HYPOTHESIS:Reactive oxygen species (ROS) contribute to diabetes-induced glomerular injury and endoplasmic reticulum (ER) stress-induced beta cell dysfunction, but the source of ROS has not been fully elucidated. Our aim was to determine whether p47(phox)-dependent activation of NADPH oxidase is responsible for hyp...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2586-1

    authors： Liu GC,Fang F,Zhou J,Koulajian K,Yang S,Lam L,Reich HN,John R,Herzenberg AM,Giacca A,Oudit GY,Scholey JW

    更新日期：2012-09-01 00:00:00

  • Diabetic background retinopathy is associated with impaired coronary vasoreactivity in people with Type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:We examined whether diabetic background retinopathy is associated with reduced coronary vasoreactivity in people with Type 1 diabetes. METHODS:A total of 21 men with Type 1 diabetes were investigated, including 9 men with background retinopathy and 12 men without retinopathy. In addition, 12 non-diabet...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00125-004-1340-8

    authors： Sundell J,Janatuinen T,Rönnemaa T,Raitakari OT,Toikka J,Nuutila P,Knuuti J

    更新日期：2004-04-01 00:00:00

  • Duration of breast-feeding and the incidence of type 2 diabetes mellitus in the Shanghai Women's Health Study.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women. METHODS:This was a prospective study of 62,095 middle-aged parous women in Shanghai, China, who had no prior ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0885-8

    authors： Villegas R,Gao YT,Yang G,Li HL,Elasy T,Zheng W,Shu XO

    更新日期：2008-02-01 00:00:00

  • Type I (insulin dependent) diabetes mellitus. Is there strong evidence for a non-HLA linked gene?

    abstract：:A recent investigation of families containing two and three consecutive generations affected with Type I (insulin dependent) diabetes mellitus has led to speculation that there is a second susceptibility gene, not linked to the major histocompatibility complex. These families differ in important respects from families...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00252759

    authors： Suarez BK,Van Eerdewegh P

    更新日期：1981-05-01 00:00:00

  • The effects of glucose-induced oxidative stress on growth and extracellular matrix gene expression of vascular smooth muscle cells.

    abstract：:Vascular smooth muscle cell (VSMC) dysfunction plays a role in diabetic macrovasculopathy and this may include abnormalities in growth characteristics and the extracellular matrix. As the actual mechanisms by which glucose induces VSMC dysfunction remain unclear, the aim of this study was to assess the potential role ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051054

    authors： Sharpe PC,Yue KK,Catherwood MA,McMaster D,Trimble ER

    更新日期：1998-10-01 00:00:00

  • Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men.

    abstract：AIMS/HYPOTHESIS:Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050028

    authors： Boquist S,Hamsten A,Karpe F,Ruotolo G

    更新日期：2000-02-01 00:00:00

  • Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium.

    abstract：:It has been proposed that the development of diabetic complications may involve a depletion of cellular myo-inositol due to an increase in polyol (sorbitol) formation. We therefore initially examined the effect of diabetes on levels of these metabolites in isolated cerebral microvessels. Compared with microvessels fro...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00274782

    authors： Sussman I,Carson MP,Schultz V,Wu XP,McCall AL,Ruderman NB,Tornheim K

    更新日期：1988-10-01 00:00:00

  • Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4.

    abstract：:In pancreatic lesions of non-obese diabetic (NOD) mice the expression of inducible nitric oxide synthase (iNOS) and of the cytokines interferon-gamma and interleukin-4 were studied. Strong iNOS expression as determined at the level of transcription, translation and of enzyme activity was associated with destructive in...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00418380

    authors： Rothe H,Faust A,Schade U,Kleemann R,Bosse G,Hibino T,Martin S,Kolb H

    更新日期：1994-11-01 00:00:00

  • Adiposity, inflammation and hyperglycaemia in rural and urban Indian men: Coronary Risk of Insulin Sensitivity in Indian Subjects (CRISIS) Study.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0847-1

    authors： Yajnik CS,Joglekar CV,Lubree HG,Rege SS,Naik SS,Bhat DS,Uradey B,Raut KN,Shetty P,Yudkin JS

    更新日期：2008-01-01 00:00:00

  • Assessment of urinary microparticles in normotensive patients with type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 d...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-016-4190-2

    authors： Lytvyn Y,Xiao F,Kennedy CR,Perkins BA,Reich HN,Scholey JW,Cherney DZ,Burger D

    更新日期：2017-03-01 00:00:00

  • Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin.

    abstract：AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2546-9

    authors： Hauge-Evans AC,Anderson RL,Persaud SJ,Jones PM

    更新日期：2012-07-01 00:00:00

  • Spatial distribution of early red lesions is a risk factor for development of vision-threatening diabetic retinopathy.

    abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is characterised by morphological lesions related to disturbances in retinal blood flow. It has previously been shown that the early development of retinal lesions temporal to the fovea may predict the development of treatment-requiring diabetic maculopathy. The aim of this study wa...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4424-y

    authors： Ometto G,Assheton P,Calivá F,Chudzik P,Al-Diri B,Hunter A,Bek T

    更新日期：2017-12-01 00:00:00

  • Meta-analysis of the effects of n-3 polyunsaturated fatty acids on lipoproteins and other emerging lipid cardiovascular risk markers in patients with type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes. MATERIALS AND METHODS:We performed a systematic review and meta-analysis of randomised controlled trials comp...

    journal_title：Diabetologia

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00125-007-0695-z

    authors： Hartweg J,Farmer AJ,Perera R,Holman RR,Neil HA

    更新日期：2007-08-01 00:00:00

  • Effects of semaglutide on beta cell function and glycaemic control in participants with type 2 diabetes: a randomised, double-blind, placebo-controlled trial.

    abstract：AIMS/HYPOTHESIS:Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS:In this single-centre, double-blind, placebo-controlled, ...

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-017-4289-0

    authors： Kapitza C,Dahl K,Jacobsen JB,Axelsen MB,Flint A

    更新日期：2017-08-01 00:00:00

  • Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors.

    abstract：AIMS/HYPOTHESIS:This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. METHODS:A case-cohort study within the European Pros...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-04978-8

    authors： Wittenbecher C,Kuxhaus O,Boeing H,Stefan N,Schulze MB

    更新日期：2019-12-01 00:00:00

  • Genetic risk scores ascertained in early adulthood and the prediction of type 2 diabetes later in life.

    abstract：:It is hoped that information garnered from studies on population genetics will one day be translated into a form in which it meaningfully improves the prediction, prevention or treatment of type 2 diabetes. Type 2 diabetes genetics researchers have made extraordinary progress in identifying common genetic variants tha...

    journal_title：Diabetologia

    pub_type： 评论,杂志文章

    doi：10.1007/s00125-012-2683-1

    authors： Franks PW

    更新日期：2012-10-01 00:00:00

  • Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs.

    abstract：:Employing saline-impregnated cotton threads, an implanted-wick technique was adopted in dogs to obtain specimen from the subcutaneous interstitial compartment in order to estimate its glucose concentration. By measuring the protein, potassium and haemoglobin contents, the centrifuged wick fluid was shown to contain th...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00295878

    authors： Fischer U,Ertle R,Abel P,Rebrin K,Brunstein E,Hahn von Dorsche H,Freyse EJ

    更新日期：1987-12-01 00:00:00

  • Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells.

    abstract：AIMS/HYPOTHESIS:Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hIPSCs) offer unique opportunities for regenerative medicine and for the study of mammalian development. However, developing methods to differentiate hESCs/hIPSCs into specific cell types following a natural pathway of developm...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2687-x

    authors： Cho CH,Hannan NR,Docherty FM,Docherty HM,Joåo Lima M,Trotter MW,Docherty K,Vallier L

    更新日期：2012-12-01 00:00:00

  • The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity.

    abstract：:Impaired lipolysis has been proposed as a pathogenic factor contributing to clustering of abdominal obesity and dyslipidaemia in Type II (non-insulin-dependent) diabetes mellitus--that is, the metabolic syndrome (MSDR). As this syndrome clusters in families, alterations in the hormone-sensitive lipase (HSL) gene could...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051099

    authors： Klannemark M,Orho M,Langin D,Laurell H,Holm C,Reynisdottir S,Arner P,Groop L

    更新日期：1998-12-01 00:00:00

  • The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men.

    abstract：AIMS/HYPOTHESIS:The relationship of androgens to the metabolic syndrome has not been resolved. The polymorphic number of CAG repeats within the androgen receptor gene is inversely associated with the transcriptional activity of target genes. This polymorphism might thus influence testosterone effects on body fat conten...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-002-0980-9

    authors： Zitzmann M,Gromoll J,von Eckardstein A,Nieschlag E

    更新日期：2003-01-01 00:00:00

  • A population-based prevalence survey of known diabetes mellitus in northern Italy based upon multiple independent sources of ascertainment.

    abstract：:The aims of this survey were (1) to estimate the prevalence of known diabetes mellitus in 1988 in Casale Monferrato (Northern Italy); (2) to validate different data sources available in Italy; (3) to identify a population-based cohort of diabetic patients. Multiple independent data sources were used and the capture-re...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00399931

    authors： Bruno G,Bargero G,Vuolo A,Pisu E,Pagano G

    更新日期：1992-09-01 00:00:00

  • Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1308-9

    authors： Lutgers HL,Gerrits EG,Graaff R,Links TP,Sluiter WJ,Gans RO,Bilo HJ,Smit AJ

    更新日期：2009-05-01 00:00:00

  • Genetic predisposition to obesity leads to increased risk of type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:Obesity is a major risk factor for type 2 diabetes. Recent genome-wide association (GWA) studies have identified multiple loci robustly associated with BMI and risk of obesity. However, information on their associations with type 2 diabetes is limited. Such information could help increase our understand...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-011-2044-5

    authors： Li S,Zhao JH,Luan J,Langenberg C,Luben RN,Khaw KT,Wareham NJ,Loos RJ

    更新日期：2011-04-01 00:00:00