FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes.

abstract：:Progressive capillary occlusion often leads to severe retinopathy within 15-20 years of the onset of Type 1 (insulin-dependent) diabetes mellitus. Lipoprotein(a), a complex formed by apolipoprotein(a), apo B-100 and lipids, is considered an independent, genetically determined, predictor of cardiovascular disease. It m...

journal_title：Diabetologia

authors： Maioli M,Tonolo G,Pacifico A,Ciccarese M,Brizzi P,Kohner EM,Porta M

更新日期：1993-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS:We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL acc...

journal_title：Diabetologia

authors： van der Berg JD,Stehouwer CD,Bosma H,van der Velde JH,Willems PJ,Savelberg HH,Schram MT,Sep SJ,van der Kallen CJ,Henry RM,Dagnelie PC,Schaper NC,Koster A

更新日期：2016-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is a serious complication of diabetes mellitus and can lead to blindness. A genetic component, in addition to traditional risk factors, has been well described although strong genetic factors have not yet been identified. Here, we aimed to identify novel genetic risk factors for sig...

journal_title：Diabetologia

authors： Burdon KP,Fogarty RD,Shen W,Abhary S,Kaidonis G,Appukuttan B,Hewitt AW,Sharma S,Daniell M,Essex RW,Chang JH,Klebe S,Lake SR,Pal B,Jenkins A,Govindarjan G,Sundaresan P,Lamoureux EL,Ramasamy K,Pefkianaki M,Hykin PG

更新日期：2015-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:This long-term study was designed to further characterise the retinal safety profile of insulin glargine and human neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes mellitus. METHODS:An open-label, 5 year, randomised (1:1), multicentre, stratified, parallel-group study conducted...

journal_title：Diabetologia

authors： Rosenstock J,Fonseca V,McGill JB,Riddle M,Hallé JP,Hramiak I,Johnston P,Davis M

更新日期：2009-09-01 00:00:00

abstract：:In a population-based survey of 2,930 subjects, prevalence rates for obesity, Type 2 (non-insulin-dependent) diabetes mellitus, impaired glucose tolerance, hypertension, hypertriglyceridaemia, and hypercholesterolaemia were 54.3, 9.3, 11.1, 9.8, 10.3 and 9.2%, respectively. The prevalence, however, of each of these co...

journal_title：Diabetologia

authors： Ferrannini E,Haffner SM,Mitchell BD,Stern MP

更新日期：1991-06-01 00:00:00

abstract：:The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...

journal_title：Diabetologia

authors： Jones PM,Persaud SJ,Bjaaland T,Pearson JD,Howell SL

更新日期：1992-11-01 00:00:00

abstract：:Insulin secretion is stimulated by glucose, hormones and neurotransmitters. Both activation of a non-selective cation current and activation of a Ca2+ current in response to depletion of intracellular Ca2+ stores have been suggested to play a role in this stimulation. The properties of these currents resemble those re...

journal_title：Diabetologia

authors： Sakura H,Ashcroft FM

更新日期：1997-05-01 00:00:00

abstract：:The effect of endogenous hyperinsulinaemia, produced by syngeneic transplantation of rat insulinoma at an extrapancreatic site, on pancreatic insulin and pancreatic polypeptide has been examined by radioimmunoassay and immunohistochemistry. Twenty days after subcutaneous transplantation, tumour-bearing rats exhibited ...

journal_title：Diabetologia

authors： O'Hare MM,Shaw C,Swanston-Flatt SK,Marcelli M,Buchanan KD,Flatt PR

更新日期：1985-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 2 diabetic patients we compared 9 months of combination therapy with insulin glargine and metformin with 9 months of NPH insulin combined with metformin. The primary focus was changes in HbA(1c); secondary focus was diurnal glucose profiles and symptomatic hypoglycaemia. METHODS:In this investi...

journal_title：Diabetologia

authors： Yki-Järvinen H,Kauppinen-Mäkelin R,Tiikkainen M,Vähätalo M,Virtamo H,Nikkilä K,Tulokas T,Hulme S,Hardy K,McNulty S,Hänninen J,Levänen H,Lahdenperä S,Lehtonen R,Ryysy L

更新日期：2006-03-01 00:00:00

abstract：:Phosphoinositide 3-kinase (PI3-kinase) plays a crucial role in insulin signal transduction. We studied the molecular mechanism of the insulin-induced activation of PI3-kinase in rat hepatoma Fao cells using an antibody against the 110-kDa catalytic subunit (p110) and two against the 85-kDa regulatory subunit (p85 alph...

journal_title：Diabetologia

authors： Hayashi T,Okamoto M,Yoshimasa Y,Inoue G,Yamada K,Kono S,Shigemoto M,Suga J,Kuzuya H,Nakao K

更新日期：1996-05-01 00:00:00

abstract：:Very low density lipoproteins (VLDL) have an abnormal lipid composition in Type 1 (insulin-dependent) diabetic patients. Since VLDL represent a heterogeneous lipoprotein class, this might be due either to a shift in the distribution or to an abnormal composition of VLDL subclasses or both. In order to investigate thes...

journal_title：Diabetologia

authors： Patti L,Romano G,Di Marino L,Annuzzi G,Mancini M,Riccardi G,Rivellese AA

更新日期：1993-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...

journal_title：Diabetologia

authors： Jacobs-Tulleneers-Thevissen D,Bartholomeus K,Suenens K,Vermeulen I,Ling Z,Hellemans KH,In't Veld P,Pipeleers-Marichal M,Pipeleers D

更新日期：2010-08-01 00:00:00

abstract：:The effects of four sulphonylureas (gliclazide, glibenclamide, chlorpropamide and glipizide) on insulin binding and insulin action were studied in vitro using primary cultured rat hepatocytes. Cells were cultured for 20 h in the absence or presence of the sulphonylurea. The binding of insulin to rat hepatocyte monolay...

journal_title：Diabetologia

authors： Dolais-Kitabgi J,Alengrin F,Freychet P

更新日期：1983-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fenofibrate is a drug used to treat hyperlipidaemia that works by inhibiting hepatic triacylglycerol synthesis. Sterol regulatory element binding protein-1c (SREBP-1c) is a major regulator of the expression of genes involved in hepatic triacylglycerol synthesis. In addition, endoplasmic reticulum (ER)-b...

journal_title：Diabetologia

authors： Min AK,Jeong JY,Go Y,Choi YK,Kim YD,Lee IK,Park KG

更新日期：2013-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Low phosphate and high calcium concentrations have been linked to altered glucose tolerance and reduced insulin sensitivity in non-diabetic individuals. The aim of this study was to examine the relationships of calcium and phosphate levels and the calcium-phosphate product with the development of type 2...

journal_title：Diabetologia

authors： Lorenzo C,Hanley AJ,Rewers MJ,Haffner SM

更新日期：2014-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:MicroRNAs are key regulators of gene expression involved in health and disease. The goal of our study was to investigate the global changes in beta cell microRNA expression occurring in two models of obesity-associated type 2 diabetes and to assess their potential contribution to the development of the ...

journal_title：Diabetologia

authors： Nesca V,Guay C,Jacovetti C,Menoud V,Peyot ML,Laybutt DR,Prentki M,Regazzi R

更新日期：2013-10-01 00:00:00

abstract：:The effects of subclinical vitamin D deficiency and vitamin D supplementation on oral glucose tolerance and secretion of pancreatic hormones were studied in 10 diphenylhydantoin-treated epileptic patients and 15 geriatric patients. Their mean serum concentrations of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 de...

journal_title：Diabetologia

authors： Nyomba BL,Auwerx J,Bormans V,Peeters TL,Pelemans W,Reynaert J,Bouillon R,Vantrappen G,De Moor P

更新日期：1986-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the effects of oxygen consumption-matched short-term interval walking training (IWT) vs continuous walking training (CWT) on glycaemic control, including glycaemic variability, in individuals with type 2 diabetes. We also assessed whether any training-induced improv...

journal_title：Diabetologia

authors： Karstoft K,Clark MA,Jakobsen I,Müller IA,Pedersen BK,Solomon TP,Ried-Larsen M

更新日期：2017-03-01 00:00:00

abstract：:The kidney plays a pivotal role in the clearance and degradation of circulating insulin and is also an important site of insulin action. The kidney clears insulin via two distinct routes. The first route entails glomerular filtration and subsequent luminal reabsorption of insulin by proximal tubular cells by means of ...

journal_title：Diabetologia

authors： Rabkin R,Ryan MP,Duckworth WC

更新日期：1984-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although maternal hyperglycaemia is associated with increased risk of adverse pregnancy outcome, the mechanisms of postprandial hyperglycaemia during pregnancy are poorly understood. We aimed to describe glucose turnover in pregnant women with type 1 diabetes, according to stage of gestation (early vs l...

journal_title：Diabetologia

authors： Murphy HR,Elleri D,Allen JM,Harris J,Simmons D,Rayman G,Temple RC,Umpleby AM,Dunger DB,Haidar A,Nodale M,Wilinska ME,Hovorka R

更新日期：2012-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:To identify the possible causes of the lengthening of the action potential duration described in patients affected by diabetes mellitus. METHODS:We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising potassium currents It(o), IK, Iss and IK1 in enzymaticall...

journal_title：Diabetologia

authors： Casis O,Gallego M,Iriarte M,Sánchez-Chapula JA

更新日期：2000-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...

journal_title：Diabetologia

authors： Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

更新日期：2012-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Maturity onset diabetes of the young type 3 (MODY3) is a monogenic form of diabetes mellitus caused by mutations in the gene encoding for hepatocyte nuclear factor 1 alpha, HNF1 alpha. In this study we have examined the in vivo and in vitro effects of a mutation (L107I) outside the DNA binding and dimer...

journal_title：Diabetologia

authors： Cervin C,Orho-Melander M,Ridderstråle M,Lehto M,Barg S,Groop L,Cilio CM

更新日期：2002-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this work was to estimate the impact of birthweight on early-onset (age <40 years) type 2 diabetes. METHODS:A longitudinal study of American Indians, aged ≥5 years, was conducted from 1965 to 2007. Participants who had a recorded birthweight were followed until they developed diabetes or the...

journal_title：Diabetologia

authors： Olaiya MT,Wedekind LE,Hanson RL,Sinha M,Kobes S,Nelson RG,Baier LJ,Knowler WC

更新日期：2019-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...

journal_title：Diabetologia

authors： Retnakaran R,Hanley AJ,Raif N,Hirning CR,Connelly PW,Sermer M,Kahn SE,Zinman B

更新日期：2005-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The AERx insulin Diabetes Management system (AERx iDMS) is a liquid aerosol device that enables insulin to be administered to the peripheral parts of the lung. This study aimed to compare the pharmacokinetic and pharmacodynamic properties of insulin which is inhaled using AERx iDMS with insulin which is...

journal_title：Diabetologia

authors： Brunner GA,Balent B,Ellmerer M,Schaupp L,Siebenhofer A,Jendle JH,Okikawa J,Pieber TR

更新日期：2001-03-01 00:00:00

abstract：:The purpose of this study was to investigate whether young insulin-dependent diabetic patients still develop peripheral nerve dysfunction when using modern multiple insulin injection therapy and to elucidate if this correlated with various disease parameters. Seventy-five patients, 7 to 20 years old with a duration of...

journal_title：Diabetologia

authors： Hyllienmark L,Brismar T,Ludvigsson J

更新日期：1995-06-01 00:00:00

abstract：UNLABELLED:AIMS/HYPOTHESIS; The aim of the Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying Type II (non-insulin-dependent) diabetes mellitus in subjects with impaired glucose tolerance, to evaluate the effects of the intervention programme on cardiov...

journal_title：Diabetologia

authors： Eriksson J,Lindström J,Valle T,Aunola S,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Laakso M,Lauhkonen M,Lehto P,Lehtonen A,Louheranta A,Mannelin M,Martikkala V,Rastas M,Sundvall J,Turpeinen A,Viljanen T,Uus

更新日期：1999-07-01 00:00:00

abstract：:The validity of the new diagnostic criteria for diabetes mellitus for Japanese subjects was assessed by the long-term prognosis of 501 patients, found in an epidemiological survey of 6,681 people in a Japanese town. Ten-year relative survival rates were examined in relation to the 50 g oral glucose tolerance test (ser...

journal_title：Diabetologia

authors： Sasaki A

更新日期：1981-03-01 00:00:00

abstract：:Diabetic patients exhibit a higher incidence of post-surgical sepsis, as well as a higher rate of mortality from sepsis, than their non-diabetic counterparts. This may be a result of cardiovascular deterioration associated with diabetes mellitus. This study was designed to characterize the cardiovascular sequelae asso...

journal_title：Diabetologia

authors： Law WR,Moriarty MT,McLane MP

更新日期：1991-10-01 00:00:00