Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene.

abstract：AIMS/HYPOTHESIS:Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impaired fibrinolysis and insulin clearance. We examined the association between plasminogen activato...

journal_title：Diabetologia

authors： Lee CC,Lorenzo C,Haffner SM,Wagenknecht LE,Festa A,Goodarzi MO,Stefanovski D,Olson NC,Norris JM,Rewers MJ,Hanley AJ

更新日期：2013-01-01 00:00:00

abstract：:Regeneration of neonatal beta cells after streptozotocin (STZ)-induced destruction may be due to either replication from pre-existing intra-islet beta cells or extra-islet precursor cells. To further investigate this issue, beta-cell growth was analysed in normal and streptozotocin-treated newborn rats (100 micrograms...

journal_title：Diabetologia

authors： Wang RN,Bouwens L,Klöppel G

更新日期：1994-11-01 00:00:00

abstract：:A copy deoxyribonucleic acid (cDNA) clone of the immediate early growth response gene, egr-1 (Krox-24, Zif268, NGFI-1), was isolated through subtractive hybridization screening to identify glucose-induced genes in pancreatic beta cells. Glucose rapidly and transiently induced egr-1 mRNA in the SV40-transformed murine ...

journal_title：Diabetologia

authors： Josefsen K,Sørensen LR,Buschard K,Birkenbach M

更新日期：1999-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS:We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and r...

journal_title：Diabetologia

authors： Qu HQ,Marchand L,Grabs R,Polychronakos C

更新日期：2008-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:As vascular endothelial growth factor (VEGF) plays a pivotal role in the development of diabetic retinopathy, inhibition of angiogenesis induced by VEGF is crucial to treat diabetic retinopathy. HGF (hepatocyte growth factor)/NK4, containing the N-terminal hairpin domain and the four subsequent kringle ...

journal_title：Diabetologia

authors： Nakabayashi M,Morishita R,Nakagami H,Kuba K,Matsumoto K,Nakamura T,Tano Y,Kaneda Y

更新日期：2003-01-01 00:00:00

abstract：:The use of tritiated glucose tracers may result in underestimation of glucose turnover during hyperinsulinaemic clamps giving paradoxical negative endogenous glucose production rates. While mathematical modelling errors in the analysis of tracer data are major determinants of this underestimate in the non-steady state...

journal_title：Diabetologia

authors： Neely RD,Rooney DP,Atkinson AB,Sheridan B,Ennis CN,Trimble ER,Bell PM

更新日期：1990-11-01 00:00:00

abstract：:The effect of hyperglycaemia on islet transplantation in the rat has been examined in two ways, using syngeneic transplantation of 400 islets to the kidney capsule and subsequent measurement of kidney insulin content as a measurement of B-cell survival. Firstly, islets were transplanted into either diabetic or normal ...

journal_title：Diabetologia

authors： Gray DW,Cranston D,McShane P,Sutton R,Morris PJ

更新日期：1989-09-01 00:00:00

abstract：:Of 89 pancreas transplants performed in 77 diabetic patients (43 with and 34 without previous kidney transplants), 53 were from cadaver and 36 from related donors. To date, 64 patients (83%) are alive and 27 (35%) have functioning grafts (14 greater than 1 year), including 0 out of 3 duct-ligated, 3 out of 15 open-duc...

journal_title：Diabetologia

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1984-07-01 00:00:00

abstract：:Severe microvascular disease exists at the stage of clinical diabetic neuropathy. A non-invasive test that will identify those diabetic subjects who will eventually develop neuropathy is essential for early intervention. Sural sensory conduction velocity was recorded (x3) in 12 non-neuropathic diabetic subjects, 15 di...

journal_title：Diabetologia

authors： Tesfaye S,Harris ND,Wilson RM,Ward JD

更新日期：1992-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:This meta-analysis assessed the pooled effect of each genetic variant reproducibly associated with diabetic nephropathy. METHODS:PubMed, EMBASE and Web of Science were searched for articles assessing the association between genes and diabetic nephropathy. All genetic variants statistically associated w...

journal_title：Diabetologia

authors： Mooyaart AL,Valk EJ,van Es LA,Bruijn JA,de Heer E,Freedman BI,Dekkers OM,Baelde HJ

更新日期：2011-03-01 00:00:00

abstract：:This study was performed to evaluate whether L-leucine is able to relieve the structural and functional alterations previously described in pancreatic islets exposed in vitro for a prolonged time to a subnormal glucose concentration (3.3 mM). It was found that both the impairment of secretion and the decreased rate of...

journal_title：Diabetologia

authors： Andersson A,Höiriis-Nielsen J,Borg LA

更新日期：1977-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The paucity of information on the epigenetic barriers that are blocking reprogramming protocols, and on what makes a beta cell unique, has hampered efforts to develop novel beta cell sources. Here, we aimed to identify enhancers in pancreatic islets, to understand their developmental ontologies, and to ...

journal_title：Diabetologia

authors： Tennant BR,Robertson AG,Kramer M,Li L,Zhang X,Beach M,Thiessen N,Chiu R,Mungall K,Whiting CJ,Sabatini PV,Kim A,Gottardo R,Marra MA,Lynn FC,Jones SJ,Hoodless PA,Hoffman BG

更新日期：2013-03-01 00:00:00

abstract：:The binding of 125I-labelled insulin to human adipocytes was studied at 37 degrees C. The precipitability of the 125I-labelled insulin preparation (0.03 nmol/l) in trichloroacetic acid and the concentration of biologically active insulin (7.5 nmol/l) remained constant in buffer incubated with human adipocytes (100 mic...

journal_title：Diabetologia

authors： Andersen O,Gliemann J,Gammeltoft S

更新日期：1977-12-01 00:00:00

abstract：:We examined changes in guanosine triphosphate-dependent signal transduction mechanisms in the retina from the early stages of the streptozotocin-diabetic rat, a model for Type 1 (insulin-dependent) diabetes mellitus. Guanosine triphosphate binding, guanosine triphosphatase activity, and binding of (azido) guanosine tr...

journal_title：Diabetologia

authors： Kowluru A,Kowluru RA,Yamazaki A

更新日期：1992-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The role of infections in the aetiology of Type I diabetes is controversial. Certain enteroviral infections might be involved in triggering the beta-cell destruction but insufficient exposure to early infections might increase the risk. We studied how the number of infections experienced during several ...

journal_title：Diabetologia

authors： Pundziute-Lyckå A,Urbonaite B,Dahlquist G

更新日期：2000-10-01 00:00:00

abstract：:The role of islet amyloidosis in the onset and progression of Type 2 diabetes remains obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide which is co-stored and co-released with insulin. Human islet amyloid polypeptide refolds to a beta-conformation and oligomerises to form insoluble fibrils; prol...

journal_title：Diabetologia

authors： Clark A,Nilsson MR

更新日期：2004-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The enzyme hormone-sensitive lipase (HSL) is produced and is active in pancreatic beta cells. Because lipids are known to play a crucial role in normal control of insulin release and in the deterioration of beta cell function, as observed in type 2 diabetes, actions of HSL in beta cells may be critical....

journal_title：Diabetologia

authors： Fex M,Haemmerle G,Wierup N,Dekker-Nitert M,Rehn M,Ristow M,Zechner R,Sundler F,Holm C,Eliasson L,Mulder H

更新日期：2009-02-01 00:00:00

abstract：:Mortality among 4740 diabetic men and women aged 35-55 years participating in the WHO Multinational Study of Vascular Disease in Diabetics has been studied. Ten of the original centres (Warsaw, Berlin, Havana, Arizona, Oklahoma, Hong Kong, Switzerland, London, Tokyo, Zagreb) were able to identify the life/death status...

journal_title：Diabetologia

authors： Head J,Fuller JH

更新日期：1990-08-01 00:00:00

abstract：:AbstractIn Table 1 the data for age group, sex and Townsend index were incorrectly identified as mean ± SD instead of n (%). The table is corrected here. ...

journal_title：Diabetologia

authors： Nirantharakumar K,Mohammed N,Toulis KA,Thomas GN,Narendran P

更新日期：2018-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We examined features of the metabolic syndrome to see if they modified the risk of chronic diabetic complications in patients with Type II (non-insulin-dependent) diabetes mellitus. METHODS:A total of 85 randomly selected patients with the metabolic syndrome (WHO definition) were compared with 85 Type ...

journal_title：Diabetologia

authors： Isomaa B,Henricsson M,Almgren P,Tuomi T,Taskinen MR,Groop L

更新日期：2001-09-01 00:00:00

abstract：:Is the course leading to diabetic end-stage renal disease similar for Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus? We identified all diabetic end-stage renal disease patients starting renal replacement therapy from 1989 to 1991 in two urban counties in Texas. Three ethnic/racial gro...

journal_title：Diabetologia

authors： Pugh JA,Medina R,Ramirez M

更新日期：1993-10-01 00:00:00

abstract：:A rapid chromatography method for separating glycosylated protein from non-glycosylated protein, using a boronate-agarose affinity medium which selectively binds the cis-diol groups of glycoproteins, was used to quantitate plasma glycoprotein as well as glycohaemoglobin. The results were found to be independent of: (1...

journal_title：Diabetologia

authors： Willey DG,Rosenthal MA,Caldwell S

更新日期：1984-07-01 00:00:00

abstract：:MODY is an early-onset monogenic form of diabetes. Correctly identifying MODY is of considerable importance as diagnosing the specific genetic subtype can inform the optimal treatment, with many patients being able to discontinue unnecessary insulin treatment. Diagnostic molecular genetic testing to confirm MODY is ex...

journal_title：Diabetologia

authors： Shields B,Colclough K

更新日期：2017-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:To investigate the incidence of foetal macrosomia (i.e. birth weight >90th percentile) in a non-selected nationwide cohort of women with Type I (insulin-dependent) diabetes mellitus in The Netherlands and to identify risk indicators predictive for macrosomia. METHODS:We conducted a prospective nationwi...

journal_title：Diabetologia

authors： Evers IM,de Valk HW,Mol BW,ter Braak EW,Visser GH

更新日期：2002-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The abnormal intrauterine milieu of intrauterine growth retardation (IUGR) permanently alters gene expression and function of pancreatic beta cells leading to the development of diabetes in adulthood. Expression of the pancreatic homeobox transcription factor Pdx1 is permanently reduced in IUGR islets s...

journal_title：Diabetologia

authors： Pinney SE,Jaeckle Santos LJ,Han Y,Stoffers DA,Simmons RA

更新日期：2011-10-01 00:00:00

abstract：:The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metabolism of triglyceride-rich lipoproteins of intestinal origin was assessed by measuring the retinyl palmitate c...

journal_title：Diabetologia

authors： Jeppesen J,Zhou MY,Chen YD,Reaven GM

更新日期：1994-08-01 00:00:00

abstract：AIM/HYPOTHESIS:Diabetic neuropathy is accompanied by a range of positive (paresthaesia, dysesthaesia, pain) and negative (hypesthaesia, anesthaesia) neurological symptoms suggesting widespread alterations in axonal excitability. The nature and the mechanisms underlying these alterations in axonal excitability are not w...

journal_title：Diabetologia

authors： Kriz J,Padjen AL

更新日期：2003-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine whether impaired glucose tolerance is associated with reduced suppression of glucagon concentrations. METHODS:Eighty-four non-diabetic women of Caucasian origin and 61 years of age, of whom 48 had normal glucose tolerance (NGT) and 36 had IGT, underwent a 75 g OGTT and a hyperinsuli...

journal_title：Diabetologia

authors： Ahrén B,Larsson H

更新日期：2001-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of the study was to evaluate the relationship between insulin sensitivity, beta cell function and glucose tolerance, and its dependence on variants in the newly identified Type 2 diabetes susceptibility gene, calpain-10 ( CAPN10). METHODS:We studied 203 men of the same age but with varying degr...

journal_title：Diabetologia

authors： Tripathy D,Eriksson KF,Orho-Melander M,Fredriksson J,Ahlqvist G,Groop L

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study aimed to elucidate the mechanism of increased proliferation of alpha cells in recent-onset type 1 diabetes. Pancreatic beta cells express GAD and produce γ-aminobutyric acid (GABA), which inhibits alpha cell secretion of glucagon. We explored the roles of GABA in alpha cell proliferation in c...

journal_title：Diabetologia

authors： Feng AL,Xiang YY,Gui L,Kaltsidis G,Feng Q,Lu WY

更新日期：2017-06-01 00:00:00