A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy is a major debilitating disease causing most cases of blindness in humans in the Western world. Photocoagulation is the established therapy of proliferative diabetic retinopathy, although the molecular mechanisms of its effects are still not known. Recently angiostatin...

journal_title：Diabetologia

authors： Spranger J,Hammes HP,Preissner KT,Schatz H,Pfeiffer AF

更新日期：2000-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess whether the diabetogenicity of areca nut (Areca catechu or 'betel-nut'), which has previously been demonstrated experimentally in mice, independently contributes to the risk of hyperglycaemia or type 2 diabetes in men in Taiwan, where the habit has become established ...

journal_title：Diabetologia

authors： Tung TH,Chiu YH,Chen LS,Wu HM,Boucher BJ,Chen TH,Keelung Community-based Integrated Screening programme No. 2.

更新日期：2004-10-01 00:00:00

abstract：:To examine differences among pregnant diabetic and nondiabetic subjects, serum glucose, and immunoreactivity of C-peptide, free and total insulin were measured at hourly intervals during a 24--h third trimester metabolic ward evaluation. Six normals, three mild, and four juvenile-onset type diabetics were studied. Die...

journal_title：Diabetologia

authors： Lewis SB,Wallin JD,Kuzuya H,Murray WK,Coustan DR,Daane TA,Rubenstein AH

更新日期：1976-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is characterised by excessive hepatic glucose production and frequently leads to systemic vascular complications. We therefore analysed the relationship between the gene expression profile in the liver and the pathophysiology of Type 2 diabetes. METHODS:Liver biopsy samples were obtaine...

journal_title：Diabetologia

authors： Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S

更新日期：2004-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin control of glucose output is a major mechanism by which appropriate amounts of glucose are produced to supply energy to the central nervous system, without causing long-term increases of the plasma glucose concentration. It is hypothesised that the primary route by which insulin maintains contro...

journal_title：Diabetologia

authors： Bergman RN

更新日期：2000-07-01 00:00:00

abstract：:A copy deoxyribonucleic acid (cDNA) clone of the immediate early growth response gene, egr-1 (Krox-24, Zif268, NGFI-1), was isolated through subtractive hybridization screening to identify glucose-induced genes in pancreatic beta cells. Glucose rapidly and transiently induced egr-1 mRNA in the SV40-transformed murine ...

journal_title：Diabetologia

authors： Josefsen K,Sørensen LR,Buschard K,Birkenbach M

更新日期：1999-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Activin receptor-like kinase 7 (ALK7), a member of the type I receptor serine/threonine kinases of the TGF-beta superfamily, was recently reported to regulate cell proliferation and apoptosis. We hypothesised that ALK7 may play a role in modulating pancreatic beta cell proliferation and/or apoptosis. M...

journal_title：Diabetologia

authors： Zhang N,Kumar M,Xu G,Ju W,Yoon T,Xu E,Huang X,Gaisano H,Peng C,Wang Q

更新日期：2006-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance i...

journal_title：Diabetologia

authors： Sayers SR,Beavil RL,Fine NHF,Huang GC,Choudhary P,Pacholarz KJ,Barran PE,Butterworth S,Mills CE,Cruickshank JK,Silvestre MP,Poppitt SD,McGill AT,Lavery GG,Hodson DJ,Caton PW

更新日期：2020-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Thickening of the basement membrane and selective loss of pericytes occur early in diabetic retinopathy. As we showed previously that pericyte adhesion is impaired on extracellular matrix produced by endothelial cells in high hexose concentrations, we aimed to verify if altered adhesion could influence ...

journal_title：Diabetologia

authors： Beltramo E,Buttiglieri S,Pomero F,Allione A,D'Alù F,Ponte E,Porta M

更新日期：2003-03-01 00:00:00

abstract：:Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...

journal_title：Diabetologia

authors： Rossing P,Hommel E,Smidt UM,Parving HH

更新日期：1994-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the signalling processes and metabolic actions of BDNF. METHODS:We first examined whether exercise induced BDNF expression in humans. Next, C2C12 skeletal muscle ce...

journal_title：Diabetologia

authors： Matthews VB,Aström MB,Chan MH,Bruce CR,Krabbe KS,Prelovsek O,Akerström T,Yfanti C,Broholm C,Mortensen OH,Penkowa M,Hojman P,Zankari A,Watt MJ,Bruunsgaard H,Pedersen BK,Febbraio MA

更新日期：2009-07-01 00:00:00

abstract：:Insulin binding and the effect of insulin on the transport of 3-O-methylglucose, lipogenesis from glucose, glucose oxidation and lipolysis was studied in fat cells of adrenalectomised rats and of a control group of sham-operated rats. The serum insulin level of the adrenalectomised rats (0.7 ng/ml) was lower than that...

journal_title：Diabetologia

authors： Häring H,Calle C,Bug A,Renner R,Hepp KD,Kemmler W

更新日期：1980-10-01 00:00:00

abstract：:Specific insulin receptors are present in the liver and brain of the lizard Anolis carolinesis. In this study, the specific binding of 125I-insulin to the receptors showed time, temperature and pH dependency. Specific binding to crude membranes prepared from brain was 1-2% of the total radioactivity added compared to ...

journal_title：Diabetologia

authors： Shemer J,Penhos JC,LeRoith D

更新日期：1986-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glomerular hyperfiltration is a well-established phenomenon occurring early in some patients with type 1 diabetes. However, there is no consistent answer regarding whether hyperfiltration predicts later development of nephropathy. We performed a systematic review and meta-analysis of observational studi...

journal_title：Diabetologia

authors： Magee GM,Bilous RW,Cardwell CR,Hunter SJ,Kee F,Fogarty DG

更新日期：2009-04-01 00:00:00

abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

journal_title：Diabetologia

authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

更新日期：1984-08-01 00:00:00

abstract：:Diabetic polyneuropathy is a common, disabling chronic complication of diabetes mellitus. Previous studies have suggested that combined pancreas-kidney transplantation can ameliorate nerve conduction. The relative contribution of the correction of hyperglycaemia and uraemia on nerve function is still a matter of debat...

journal_title：Diabetologia

authors： Martinenghi S,Comi G,Galardi G,Di Carlo V,Pozza G,Secchi A

更新日期：1997-09-01 00:00:00

abstract：:The effect of metergoline on insulin secretion has been evaluated in normal subjects and in patients with chemical diabetes. The repeated administration of metergoline, 2 mg at four-hour intervals to give a total of 24 mg, has enhanced insulin secretion in response to i.v. glucose in normal subjects but not in chemica...

journal_title：Diabetologia

authors： Pontiroli AE,Viberti GC,Tognetti A,Pozza G

更新日期：1975-04-01 00:00:00

abstract：:Pancreatic beta cells differ in terms of glucose responsiveness, insulin secretion and proliferative capacity; however, the molecular pathways that regulate this cellular heterogeneity are unknown. We have identified the Wnt-planar cell polarity (PCP) effector Flattop (FLTP) as a biomarker that identifies mature beta ...

journal_title：Diabetologia

authors： Migliorini A,Roscioni SS,Lickert H

更新日期：2016-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The role of infections in the aetiology of Type I diabetes is controversial. Certain enteroviral infections might be involved in triggering the beta-cell destruction but insufficient exposure to early infections might increase the risk. We studied how the number of infections experienced during several ...

journal_title：Diabetologia

authors： Pundziute-Lyckå A,Urbonaite B,Dahlquist G

更新日期：2000-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:To investigate whether proinsulin C peptide influences sympathetic nerve activity directly or indirectly through parasympathetic nerve activity. METHODS:The proliferative response of splenic lymphocytes to Concanavalin A (ConA response) which is known to be suppressed by subjection of rats to footshock...

journal_title：Diabetologia

authors： Okamoto S,Kimura K,Kitamura T,Cañas X,Yoshida T,Saito M

更新日期：2000-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect on any component of the immune system, including dendritic cells (DCs), by direct contact, the release of soluble markers and extracellular vesicles (EVs). We evaluated whether MSCs and MSC-derived EVs have an immunomodulatory effect on...

journal_title：Diabetologia

authors： Favaro E,Carpanetto A,Caorsi C,Giovarelli M,Angelini C,Cavallo-Perin P,Tetta C,Camussi G,Zanone MM

更新日期：2016-02-01 00:00:00

abstract：AIM/HYPOTHESIS:Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown. METHODS:We...

journal_title：Diabetologia

authors： Kim YK,Joung KH,Ryu MJ,Kim SJ,Kim H,Chung HK,Lee MH,Lee SE,Choi MJ,Chang JY,Hong HJ,Kim KS,Lee SH,Kweon GR,Kim H,Lee CH,Kim HJ,Shong M

更新日期：2015-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Clinical trials are in progress to test thiazolidinediones in neurodegenerative diseases such as Alzheimer's disease that involve deficiencies in brain glucose metabolism. While thiazolidinediones enhance glucose uptake in non-cerebral tissues, their impact on brain energy metabolism has not been invest...

journal_title：Diabetologia

authors： Galea E,Feinstein DL,Lacombe P

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The Cost of Diabetes in Europe-Type II study is the first coordinated attempt to assess the total costs of Type II (non-insulin-dependent) diabetes mellitus in Europe. Although gaining a clearer understanding of the economics of diabetes was the goal of the study, a secondary objective was to consider t...

journal_title：Diabetologia

authors： Koopmanschap M

更新日期：2002-07-01 00:00:00

abstract：:We examined changes in guanosine triphosphate-dependent signal transduction mechanisms in the retina from the early stages of the streptozotocin-diabetic rat, a model for Type 1 (insulin-dependent) diabetes mellitus. Guanosine triphosphate binding, guanosine triphosphatase activity, and binding of (azido) guanosine tr...

journal_title：Diabetologia

authors： Kowluru A,Kowluru RA,Yamazaki A

更新日期：1992-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:An isoform of glutamic acid decarboxylase, (GAD)65 has been identified as a pancreatic beta-cell autoantigen in Type I (insulin dependent) diabetes mellitus. We investigated the expression of GAD isoforms among single rat beta cells in culture, under different conditions and the correlation between GAD6...

journal_title：Diabetologia

authors： Sánchez-Soto MC,Larrieta ME,Vidaltamayo R,Hiriart M

更新日期：1999-09-01 00:00:00

abstract：:The oscillatory potential of the electroretinogram and the initial 2-min phase of dark-adaptation were studied in seven newly diagnosed Type 1 (insulin-dependent) diabetic patients before and during initial insulin treatment. Strict metabolic control was achieved in all seven patients using multiple subcutaneous injec...

journal_title：Diabetologia

authors： Frost-Larsen K,Christiansen JS,Parving HH

更新日期：1983-03-01 00:00:00

abstract：:Screening and diagnostic criteria for gestational diabetes (GDM) are inconsistent across Europe, and the development of a uniform GDM screening strategy is necessary. Such a strategy would create opportunities for more women to receive timely treatment for GDM. Developing a consensus on screening for GDM in Europe is ...

journal_title：Diabetologia

authors： Benhalima K,Mathieu C,Damm P,Van Assche A,Devlieger R,Desoye G,Corcoy R,Mahmood T,Nizard J,Savona-Ventura C,Dunne F

更新日期：2015-07-01 00:00:00

abstract：:We have recently shown that leptin mimicks insulin effects on glucose transport and glycogen synthesis through a phosphatidylinositol-3 (PI) kinase dependent pathway in C2C12 myotubes. The aim of the present study was to identify the signalling path from the leptin receptor to the PI-3 kinase. We stimulated C2C12 myot...

journal_title：Diabetologia

authors： Kellerer M,Koch M,Metzinger E,Mushack J,Capp E,Häring HU

更新日期：1997-11-01 00:00:00

abstract：:Diabetic retinopathy was found to be present in 12 out of a group of 67 diabetic patients supervised by us during 92 pregnancies, and 3 further pregnant diabetics were referred to us because of retinopathy. The mean duration of diabetes was 13 years (range 3--25 years). Nine patients had minimal retinopathy, 2 had bac...

journal_title：Diabetologia

authors： Cassar J,Kohner EM,Hamilton AM,Gordon H,Joplin GF

更新日期：1978-08-01 00:00:00