Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis.

abstract：:The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (GLUT 4) level in ...

journal_title：Diabetologia

authors： Bader S,Scholz R,Kellerer M,Tippmer S,Rett K,Mathaei S,Freund P,Häring HU

更新日期：1992-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the prevalence and nature of mutations in HNF4alpha/MODY1, GCK/MODY2 and HNF-1alpha/MODY3 genes in Czech subjects with clinical diagnosis of MODY. METHODS:We studied 61 unrelated index probands of Czech origin (28 males, 33 females) with a clinical diagnosis of MODY...

journal_title：Diabetologia

authors： Pruhova S,Ek J,Lebl J,Sumnik Z,Saudek F,Andel M,Pedersen O,Hansen T

更新日期：2003-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proinsulin C-peptide has been implicated in reducing complications associated with diabetes and also in improving blood flow. We hypothesised that incubation of erythrocytes with C-peptide would improve the ability of these cells to release ATP, a stimulus for nitric oxide production. METHODS:Erythrocy...

journal_title：Diabetologia

authors： Meyer JA,Froelich JM,Reid GE,Karunarathne WK,Spence DM

更新日期：2008-01-01 00:00:00

abstract：:Oral glucose administration increased plasma noradrenaline concentration significantly in seven normal subjects (p less than 0.02), whereas in six young short-term Type 1 diabetic patients without complications plasma noradrenaline did not change. Basal plasma noradrenaline did not differ between the two groups. In th...

journal_title：Diabetologia

authors： Hegedüs L,Christensen NJ,Sestoft L

更新日期：1983-09-01 00:00:00

abstract：:Human crude and recombinant interleukin 1 (IL-1) was found to dose- and time-dependently affect the biosynthesis of (pro)insulin in isolated rat islets of Langerhans. Incubation of rat islets with either 0.5 U/ml or 5 U/ml of crude IL-1 for 1 h had no detectable effect on (pro)insulin biosynthesis. After 24 hours of e...

journal_title：Diabetologia

authors： Spinas GA,Hansen BS,Linde S,Kastern W,Mølvig J,Mandrup-Poulsen T,Dinarello CA,Nielsen JH,Nerup J

更新日期：1987-07-01 00:00:00

abstract：:The effect of oral vanadate on intestinal sodium-dependent glucose transport and 6-phosphofructo-1-kinase (EC 2.7.1.11) activity was examined in male Sprague-Dawley rats following a 30-day period of non-treated streptozotocin-induced diabetes. Non-treated diabetic rats were hyperglycaemic and demonstrated increased in...

journal_title：Diabetologia

authors： Madsen KL,Ariano D,Fedorak RN

更新日期：1995-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-year disease risk, which to date has been...

journal_title：Diabetologia

authors： De Grijse J,Asanghanwa M,Nouthe B,Albrecher N,Goubert P,Vermeulen I,Van Der Meeren S,Decochez K,Weets I,Keymeulen B,Lampasona V,Wenzlau J,Hutton JC,Pipeleers D,Gorus FK,Belgian Diabetes Registry.

更新日期：2010-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Direct infection of beta cells could explain the diabetogenic effect of enteroviruses. Primary adult human beta cells are susceptible to coxsackievirus infections, which could result in impaired beta-cell function or cell death (coxsackieviruses B3, B4, B5) or both, or no apparent immediate adverse effe...

journal_title：Diabetologia

authors： Roivainen M,Ylipaasto P,Savolainen C,Galama J,Hovi T,Otonkoski T

更新日期：2002-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:As glycaemia and the incidence of microvascular diabetes complications follow a log-linear relationship, it becomes increasingly difficult to demonstrate a microvascular benefit of glucose-lowering when the HbA1c level is close to normal. METHODS:The Outcome Reduction with an Initial Glargine Intervent...

journal_title：Diabetologia

authors： ORIGIN trial investigators.,Gilbert RE,Mann JF,Hanefeld M,Spinas G,Bosch J,Yusuf S,Gerstein HC

更新日期：2014-07-01 00:00:00

abstract：:The aim of the study was to evaluate an acute decrease in NEFA levels during an oral glucose tolerance test and its effects on glucose tolerance, muscle glucose uptake and muscle indirect calorimetry in ten lean non-insulin-dependent diabetic subjects. Two 75-g oral glucose tolerance tests were performed in random ord...

journal_title：Diabetologia

authors： Piatti PM,Monti LD,Davis SN,Conti M,Brown MD,Pozza G,Alberti KG

更新日期：1996-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) have been shown to abrogate in vitro the proinflammatory response in type 1 diabetes. The mechanism involves paracrine factors, which may include microvesicles (MVs). We evaluated whether MVs derived from heterologous bone-marrow MSCs exert an immunomodulatory effect on T c...

journal_title：Diabetologia

authors： Favaro E,Carpanetto A,Lamorte S,Fusco A,Caorsi C,Deregibus MC,Bruno S,Amoroso A,Giovarelli M,Porta M,Perin PC,Tetta C,Camussi G,Zanone MM

更新日期：2014-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Contemporary data for the association of diabetes with haematological malignancies are lacking. We evaluated the risk of developing haematological malignancies and subsequent mortality in individuals with diabetes compared with those without diabetes. METHODS:We conducted a population-based observation...

journal_title：Diabetologia

authors： Gong IY,Cheung MC,Read S,Na Y,Lega IC,Lipscombe LL

更新日期：2021-01-06 00:00:00

abstract：:A series of recent experimental findings are reviewed to indicate that glucokinase does not represent the pancreatic B-cell glucoreceptor. Whether in liver, pancreatic islet or insulin-producing tumoral cell homogenates, glucokinase fails to yield a higher reaction velocity with alpha-than beta-D-glucose. At a high gl...

journal_title：Diabetologia

authors： Malaisse WJ,Sener A

更新日期：1985-08-01 00:00:00

abstract：:In healthy subjects hypoglycaemia causes a fall in body temperature through increased sweating and limb blood flow, and despite increased metabolic heat production. We studied thermoregulatory responses to hyperinsulinaemic (100 mU.m-2.min-1) (a) hypoglycaemia (2.5 mmol/l) and (b) euglycaemia (4.5 mmol/l) in insulin-d...

journal_title：Diabetologia

authors： Maggs DG,Macdonald IA,Tattersall RB

更新日期：1994-07-01 00:00:00

abstract：:The involvement of the CNS in pancreatic hormone release has been studied. 1.) It has been shown that one source of vagal efferent fibers capable of facilitating insulin secretion originated in the rostral half of the nucleus ambiguus. 2.) Acute lesions of the ventromedial hypothalamus resulted in hyperinsulinaemia th...

journal_title：Diabetologia

authors： Bereiter DA,Rohner-Jeanrenaud F,Berthoud H-,Jeanrenaud B

更新日期：1981-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...

journal_title：Diabetologia

authors： Walraven I,van 't Riet E,Stehouwer CD,Polak BC,Moll AC,Dekker JM,Nijpels G

更新日期：2013-05-01 00:00:00

abstract：:Rat pups delivered by caesarian section one day before term, either remained attached to (experimental group) or were separated from their placenta (control group). Both groups were transferred into an incubator and their metabolic parameters studied. In the control group, plasma amino acid concentration fell from 11....

journal_title：Diabetologia

authors： Sodoyez-Goffaux F,Sodoyez JC,De Vos CJ

更新日期：1981-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. METHODS:Sixty-three...

journal_title：Diabetologia

authors： Göbl CS,Bozkurt L,Tura A,Leutner M,Andrei L,Fahr L,Husslein P,Eppel W,Kautzky-Willer A

更新日期：2017-12-01 00:00:00

abstract：:The aim of this study was to evaluate factors related to the markedly increased risk of dying from diabetic renal disease in Japanese insulin-dependent diabetic patients compared to those in the USA. The study was based on two population-based cohorts consisting of 1374 cases from Japan and 995 cases from Allegheny Co...

journal_title：Diabetologia

authors： Matsushima M,Tajima N,LaPorte RE,Orchard TJ,Tull ES,Gower IF,Kitagawa T

更新日期：1995-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of m...

journal_title：Diabetologia

authors： Thorens B,Tarussio D,Maestro MA,Rovira M,Heikkilä E,Ferrer J

更新日期：2015-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes is induced by multiple low doses of streptozotocin (MLD-STZ) in male mice of susceptible strains. In this model beta-cell injury and T-cell-mediated inflammatory reactions are induced. Probably, reactive oxygen species (ROS) participate in the destruction of beta cells. The effects of ROS can b...

journal_title：Diabetologia

authors： Ohly P,Dohle C,Abel J,Seissler J,Gleichmann H

更新日期：2000-08-01 00:00:00

abstract：AIM/HYPOTHESIS:Mitochondria and the endoplasmic reticulum (ER) physically interact by close structural juxtaposition, via the mitochondria-associated ER membrane. Inter-organelle communication between the ER and mitochondria has been shown to regulate energy metabolism and to be central to the modulation of various key...

journal_title：Diabetologia

authors： Wang L,Ishihara T,Ibayashi Y,Tatsushima K,Setoyama D,Hanada Y,Takeichi Y,Sakamoto S,Yokota S,Mihara K,Kang D,Ishihara N,Takayanagi R,Nomura M

更新日期：2015-10-01 00:00:00

abstract：:The presence of immunoreactive insulin in saliva and its relationship to plasma immunoreactive insulin was investigated in healthy subjects, newly diagnosed non-obese Type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects, basally and after an oral glucose tolerance test. The mean +/- SEM fas...

journal_title：Diabetologia

authors： Marchetti P,Benzi L,Masoni A,Cecchetti P,Giannarelli R,Di Cianni G,Ciccarone AM,Navalesi R

更新日期：1986-10-01 00:00:00

abstract：:The characteristics, progressivity and reversibility of the changes in glucose homeostasis brought about by chronic protein-calorie malnutrition were studied in the rat. Four-week-old male rats received a control diet (15% protein) or a low-protein diet (5% protein) until the age of 28 weeks. Other rats received the l...

journal_title：Diabetologia

authors： Okitolonda W,Brichard SM,Henquin JC

更新日期：1987-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:A high prevalence of diabetes contributes to excess CHD in Indian Asians, but the underlying mechanisms are unclear. Heart rate, heart rate variability (HRV) and baroreflex sensitivity (BRS) are measures of cardiac autonomic function that are disturbed by hyperglycaemia and predict CHD. We compared thes...

journal_title：Diabetologia

authors： Bathula R,Hughes AD,Panerai R,Potter J,Thom SA,Francis DP,Shore AC,Kooner J,Chaturvedi N

更新日期：2010-10-01 00:00:00

abstract：:A prominent feature of Type 2 (non-insulin-dependent) diabetes mellitus is the inability of insulin to appropriately increase the transport of glucose into target tissue. In adipocytes from individuals with Type 2 diabetes, insulin resistance has been shown to be associated with a depletion of glucose transporters. Si...

journal_title：Diabetologia

authors： Handberg A,Vaag A,Damsbo P,Beck-Nielsen H,Vinten J

更新日期：1990-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study sought to identify genes and regions in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American participants from the Insulin Resistance Atherosclerosis Family Study (IRAS FS). METHODS:A two-stage...

journal_title：Diabetologia

authors： Rich SS,Goodarzi MO,Palmer ND,Langefeld CD,Ziegler J,Haffner SM,Bryer-Ash M,Norris JM,Taylor KD,Haritunians T,Rotter JI,Chen YD,Wagenknecht LE,Bowden DW,Bergman RN

更新日期：2009-07-01 00:00:00

abstract：:The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...

journal_title：Diabetologia

authors： Gill GV,Yudkin JS,Keen H,Beran D

更新日期：2011-01-01 00:00:00

abstract：:We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thro...

journal_title：Diabetologia

authors： Ishizuka T,Taniguchi O,Yamamoto M,Kajita K,Nagashima T,Takeda N,Inouye H,Yasuda K,Miura K

更新日期：1994-06-01 00:00:00

abstract：:Freshly isolated and primary cultured adult rat cardiomyocytes were used to elucidate the mechanism of action of the new oral antidiabetic agent (+/-)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethyl-chroman-2-yl-methoxy)benzyl]-2,4-thiazolidinedione (troglitazone) on the heart. Interaction with protein kinase C (PKC) and regul...

journal_title：Diabetologia

authors： Bähr M,Spelleken M,Bock M,von Holtey M,Kiehn R,Eckel J

更新日期：1996-07-01 00:00:00