Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: impli

abstract：AIMS/HYPOTHESIS:The role of infections in the aetiology of Type I diabetes is controversial. Certain enteroviral infections might be involved in triggering the beta-cell destruction but insufficient exposure to early infections might increase the risk. We studied how the number of infections experienced during several ...

journal_title：Diabetologia

authors： Pundziute-Lyckå A,Urbonaite B,Dahlquist G

更新日期：2000-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine whether impaired glucose tolerance is associated with reduced suppression of glucagon concentrations. METHODS:Eighty-four non-diabetic women of Caucasian origin and 61 years of age, of whom 48 had normal glucose tolerance (NGT) and 36 had IGT, underwent a 75 g OGTT and a hyperinsuli...

journal_title：Diabetologia

authors： Ahrén B,Larsson H

更新日期：2001-11-01 00:00:00

abstract：:The effects of subclinical vitamin D deficiency and vitamin D supplementation on oral glucose tolerance and secretion of pancreatic hormones were studied in 10 diphenylhydantoin-treated epileptic patients and 15 geriatric patients. Their mean serum concentrations of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 de...

journal_title：Diabetologia

authors： Nyomba BL,Auwerx J,Bormans V,Peeters TL,Pelemans W,Reynaert J,Bouillon R,Vantrappen G,De Moor P

更新日期：1986-01-01 00:00:00

abstract：:Little is known about the immunological impact of insulin administration other than it can boost insulin autoantibody levels. In particular, while the subcutaneous administration of a soluble foreign antigen (without adjuvant) is generally only weakly immunogenic in a naive animal, it is unknown what effect the subcut...

journal_title：Diabetologia

authors： Tian J,Chau C,Kaufman DL

更新日期：1998-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...

journal_title：Diabetologia

authors： Rozo AV,Vijayvargia R,Weiss HR,Ruan H

更新日期：2008-08-01 00:00:00

abstract：:Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8+ T cells. While both hallmarks are n...

journal_title：Diabetologia

authors： Carré A,Richardson SJ,Larger E,Mallone R

更新日期：2021-01-01 00:00:00

abstract：:Several thrombogenic abnormalities are associated with diabetes. To investigate the underlying molecular mechanisms, we examined the effects of advanced glycation endproducts (AGE), non-enzymatically glycated protein derivatives, on the production of prostacyclin (PGI2), an anti-thrombogenic prostanoid, and of plasmin...

journal_title：Diabetologia

authors： Yamagishi S,Fujimori H,Yonekura H,Yamamoto Y,Yamamoto H

更新日期：1998-12-01 00:00:00

abstract：:Using 3H-thymidine labeling techniques, we found that rates of DNA synthesis in islet cells doubled when mouse pancreatic islets were cultured for 1 week with 10 mmol/l nicotinamide, a potent poly(ADP-ribose) synthetase inhibitor. Culture with nicotinamide partially inhibited glucose-stimulated insulin release, wherea...

journal_title：Diabetologia

authors： Sandler S,Andersson A

更新日期：1986-03-01 00:00:00

abstract：:Non-obese diabetic mice aged 30 to 60 days were treated orally with Cyclosporin at doses of 25, 15 and 2.5 mg/kg every 2 days until 160 days of age. Diabetes developed in 12 out of 18 oil-treated mice (67%), with partial to complete Langerhans' islet destruction associated with lymphocytic infiltration. The non-obese ...

journal_title：Diabetologia

authors： Mori Y,Suko M,Okudaira H,Matsuba I,Tsuruoka A,Sasaki A,Yokoyama H,Tanase T,Shida T,Nishimura M

更新日期：1986-04-01 00:00:00

abstract：:Since glucose control and glycosylated haemoglobin varies asyncroneously, we have studied the steady-state relationship between these two factors. In Type 1 (insulin-dependent) diabetic patients with a constant haemoglobin A1c during the preceding 2 years, 15 ambulatory blood glucose profiles during a 5-week period sh...

journal_title：Diabetologia

authors： Svendsen PA,Lauritzen T,Søegaard U,Nerup J

更新日期：1982-11-01 00:00:00

abstract：:Nicotinamide, the amide derivative of nicotinic acid, has over the past forty years been given at high doses for a variety of therapeutic applications. It is currently in trial as a potential means of preventing the onset of Type I (insulin-dependent) diabetes mellitus in high-risk, first-degree relatives. Nicotinamid...

journal_title：Diabetologia

authors： Knip M,Douek IF,Moore WP,Gillmor HA,McLean AE,Bingley PJ,Gale EA,European Nicotinamide Diabetes Intervention Trial Group.

更新日期：2000-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:This multicentre randomised double-blind placebo-controlled clinical trial assessed the efficacy and safety of a methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib, in individuals with obesity (BMI ≥30 kg/m2) and type 2 diabetes (HbA1c 53-97 mmol/mol [7-11%] and fasting glucose <15.6 mmol/l). ME...

journal_title：Diabetologia

authors： Proietto J,Malloy J,Zhuang D,Arya M,Cohen ND,de Looze FJ,Gilfillan C,Griffin P,Hall S,Nathow T,Oldfield GS,O'Neal DN,Roberts A,Stuckey BGA,Yue D,Taylor K,Kim D

更新日期：2018-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Perinatal exposure to bisphenol A (BPA), a widely distributed environmental endocrine disruptor, is associated with insulin resistance and diabetes in offspring. The underlying molecular mechanisms could involve epigenetics, as adverse effects induced by environmental exposure in early life are suggeste...

journal_title：Diabetologia

authors： Ma Y,Xia W,Wang DQ,Wan YJ,Xu B,Chen X,Li YY,Xu SQ

更新日期：2013-09-01 00:00:00

abstract：:Very low density lipoproteins (VLDL) have an abnormal lipid composition in Type 1 (insulin-dependent) diabetic patients. Since VLDL represent a heterogeneous lipoprotein class, this might be due either to a shift in the distribution or to an abnormal composition of VLDL subclasses or both. In order to investigate thes...

journal_title：Diabetologia

authors： Patti L,Romano G,Di Marino L,Annuzzi G,Mancini M,Riccardi G,Rivellese AA

更新日期：1993-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, independently of the hormonal changes, is controversial. We tested whether an exogenous GLP-1 infusio...

journal_title：Diabetologia

authors： Seghieri M,Rebelos E,Gastaldelli A,Astiarraga BD,Casolaro A,Barsotti E,Pocai A,Nauck M,Muscelli E,Ferrannini E

更新日期：2013-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Defective beta cell function during lipid oversupply and type 2 diabetes is associated with dysregulation of lysosomal function and autophagy. Whether this dysregulation represents augmentation or inhibition is unclear because of technical limitations in assaying autophagy. The current aim was to determ...

journal_title：Diabetologia

authors： Chu KY,O'Reilly L,Ramm G,Biden TJ

更新日期：2015-09-01 00:00:00

abstract：:Cyclic adenosine 5'diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2+. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly...

journal_title：Diabetologia

authors： Yagui K,Shimada F,Mimura M,Hashimoto N,Suzuki Y,Tokuyama Y,Nata K,Tohgo A,Ikehata F,Takasawa S,Okamoto H,Makino H,Saito Y,Kanatsuka A

更新日期：1998-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q/11) but the signallin...

journal_title：Diabetologia

authors： Ferdaoussi M,Bergeron V,Zarrouki B,Kolic J,Cantley J,Fielitz J,Olson EN,Prentki M,Biden T,MacDonald PE,Poitout V

更新日期：2012-10-01 00:00:00

abstract：AIM/HYPOTHESIS:Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comorbidities are poorly ...

journal_title：Diabetologia

authors： Rouault C,Marcelin G,Adriouch S,Rose C,Genser L,Ambrosini M,Bichet JC,Zhang Y,Marquet F,Aron-Wisnewsky J,Poitou C,André S,Dérumeaux G,Guerre-Millo M,Clément K

更新日期：2021-01-01 00:00:00

abstract：:Microencapsulation has been proposed to protect islets of Langerhans against immune rejection in xenogenic transplantation. However, to achieve glucose homeostasis in human diabetic patients, insulin release by microencapsulated islets must increase in response to a glucose load. We microencapsulated isolated rat isle...

journal_title：Diabetologia

authors： Chicheportiche D,Reach G

更新日期：1988-01-01 00:00:00

abstract：:The glycaemic control of infants and of their mothers was studied at delivery and on day 7 after birth in 11 control and 20 insulin-dependent diabetic women. At delivery, venous blood glucose was lower in infants of diabetic mothers compared with control infants (p less than 0.02). Seven days after birth, no significa...

journal_title：Diabetologia

authors： Gouédard HA,Ménez JF,Meskar A,Caroff J,Lucas D,Legendre JM

更新日期：1984-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Experimental studies have suggested that apoptosis is involved in diabetic embryopathy through oxidative stress. However, the precise mechanism of diabetic embryopathy is not yet clear. Thioredoxin (TRX) is a small, ubiquitous, multifunctional protein, which has recently been shown to protect cells from...

journal_title：Diabetologia

authors： Kamimoto Y,Sugiyama T,Kihira T,Zhang L,Murabayashi N,Umekawa T,Nagao K,Ma N,Toyoda N,Yodoi J,Sagawa N

更新日期：2010-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sleep loss is associated with insulin resistance and an increased risk for type 2 diabetes, yet underlying mechanisms are not understood. Elevation of circulating non-esterified (i.e. free) fatty acid (NEFA) concentrations can lead to insulin resistance and plays a central role in the development of met...

journal_title：Diabetologia

authors： Broussard JL,Chapotot F,Abraham V,Day A,Delebecque F,Whitmore HR,Tasali E

更新日期：2015-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:To investigate the incidence of foetal macrosomia (i.e. birth weight >90th percentile) in a non-selected nationwide cohort of women with Type I (insulin-dependent) diabetes mellitus in The Netherlands and to identify risk indicators predictive for macrosomia. METHODS:We conducted a prospective nationwi...

journal_title：Diabetologia

authors： Evers IM,de Valk HW,Mol BW,ter Braak EW,Visser GH

更新日期：2002-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Circulating levels of adiponectin are negatively associated with multiple indices of insulin resistance, and the concentration is reduced in humans with insulin resistance and type 2 diabetes. However, the mechanisms by which adiponectin improves insulin sensitivity remain unclear. SUBJECTS AND METHODS...

journal_title：Diabetologia

authors： Højlund K,Frystyk J,Levin K,Flyvbjerg A,Wojtaszewski JF,Beck-Nielsen H

更新日期：2006-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Intensive glucose control reduces the risk of vascular complications while increasing the risk of severe hypoglycaemia at a group level. We sought to estimate individual beneficial and adverse effects of intensive glucose control in patients with type 2 diabetes. METHODS:We performed a post hoc analysi...

journal_title：Diabetologia

authors： van der Leeuw J,Visseren FL,Woodward M,van der Graaf Y,Grobbee DE,Harrap S,Heller S,Mancia G,Marre M,Poulter N,Zoungas S,Chalmers J

更新日期：2016-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the effects of a secondary renal insult, due to chronic infusion of AGEs on renal function, and on early pathological markers in rats with a developmental nephron deficit. METHODS:Female Wistar-Kyoto rats were fed a low-protein diet (LPD; 8.7% casein) or a norma...

journal_title：Diabetologia

authors： Zimanyi MA,Denton KM,Forbes JM,Thallas-Bonke V,Thomas MC,Poon F,Black MJ

更新日期：2006-04-01 00:00:00

abstract：:The objective of the present study was to assess the prevalence of familial aggregation of Type 1 (insulin-dependent) diabetes mellitus among Danish families with a diabetic child aged 20 years or less and to compare epidemiological data for familial and sporadic cases. We attempted to identify all patients with Type ...

journal_title：Diabetologia

authors： Pociot F,Nørgaard K,Hobolth N,Andersen O,Nerup J

更新日期：1993-09-01 00:00:00

abstract：:For the normalisation of blood glucose levels in diabetic patients by feedback controlled insulin delivery, a self-manageable and reliable method for continuous glucose estimation is still not available. By combining a commercially available needle type dialysis probe (molecular cutoff 20,000 Da) with a sensitive gluc...

journal_title：Diabetologia

authors： Meyerhoff C,Bischof F,Sternberg F,Zier H,Pfeiffer EF

更新日期：1992-11-01 00:00:00

abstract：:The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...

journal_title：Diabetologia

authors： Gill GV,Yudkin JS,Keen H,Beran D

更新日期：2011-01-01 00:00:00