Long-term effects of exposure of pancreatic islets to nicotinamide in vitro on DNA synthesis, metabolism and B-cell function.

abstract：AIMS/HYPOTHESIS:To investigate whether proinsulin C peptide influences sympathetic nerve activity directly or indirectly through parasympathetic nerve activity. METHODS:The proliferative response of splenic lymphocytes to Concanavalin A (ConA response) which is known to be suppressed by subjection of rats to footshock...

journal_title：Diabetologia

authors： Okamoto S,Kimura K,Kitamura T,Cañas X,Yoshida T,Saito M

更新日期：2000-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Despite the overlap in occurrence of cardiovascular disease (CVD) and type 2 diabetes and their risk factors, family history of these diseases has not yet been investigated simultaneously in relation to cardiometabolic markers in offspring. We examined how a family history of CVD and/or diabetes relates...

journal_title：Diabetologia

authors： Berentzen NE,Wijga AH,van Rossem L,Koppelman GH,van Nieuwenhuizen B,Gehring U,Spijkerman AM,Smit HA

更新日期：2016-08-01 00:00:00

abstract：:The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...

journal_title：Diabetologia

authors： Cavallo-Perin P,Chiambretti A,Calefato V,Tomalino M,Urbino R,Cecchini G,Pagano G

更新日期：1991-11-01 00:00:00

abstract：:The purpose of this study was to investigate whether young insulin-dependent diabetic patients still develop peripheral nerve dysfunction when using modern multiple insulin injection therapy and to elucidate if this correlated with various disease parameters. Seventy-five patients, 7 to 20 years old with a duration of...

journal_title：Diabetologia

authors： Hyllienmark L,Brismar T,Ludvigsson J

更新日期：1995-06-01 00:00:00

abstract：:Plasma glucose control and arterial pressure were assessed in 28 Type 1 (insulin-dependent) diabetic patients with different degrees of micro-albuminuria. They were divided into two groups according to their urinary albumin excretion rate: a low micro-albuminuria group (n = 16) with albumin excretion ranging between 1...

journal_title：Diabetologia

authors： Wiseman M,Viberti G,Mackintosh D,Jarrett RJ,Keen H

更新日期：1984-06-01 00:00:00

abstract：:Immunoelectrophoresis of glomerular basement membrane antigens in the urine of 20 Type 1 (insulin-dependent) diabetic and 10 healthy children was performed. In 10 of the diabetic children, there was altered alpha-1-mobility, while the other diabetic and normal children showed alpha-2-mobility. After incubation with gl...

journal_title：Diabetologia

authors： Schober E,Pollak A,Coradello H,Lubec G

更新日期：1982-12-01 00:00:00

abstract：:The effects of the aldose reductase inhibitor, sorbinil, on symptomatic symmetrical diabetic polyneuropathy were studied during a 6-month period in a double-blind parallel group placebo-controlled trial. Twenty-seven patients received sorbinil and 28 placebo. The patients were assessed by clinical examination, neuroph...

journal_title：Diabetologia

authors： Fagius J,Brattberg A,Jameson S,Berne C

更新日期：1985-06-01 00:00:00

abstract：:To examine differences among pregnant diabetic and nondiabetic subjects, serum glucose, and immunoreactivity of C-peptide, free and total insulin were measured at hourly intervals during a 24--h third trimester metabolic ward evaluation. Six normals, three mild, and four juvenile-onset type diabetics were studied. Die...

journal_title：Diabetologia

authors： Lewis SB,Wallin JD,Kuzuya H,Murray WK,Coustan DR,Daane TA,Rubenstein AH

更新日期：1976-08-01 00:00:00

abstract：:Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rats. After 6 weeks of...

journal_title：Diabetologia

authors： Cameron NE,Dines KC,Cotter MA

更新日期：1994-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this work was to estimate the life expectancy (LE) and disability-free life expectancy (DFLE) for adults with and without diabetes. METHODS:The Chiang method and the adapted Sullivan method were used to estimate LE and DFLE by age and sex. Mortality data in 2011 were available from the Natio...

journal_title：Diabetologia

authors： Huo L,Shaw JE,Wong E,Harding JL,Peeters A,Magliano DJ

更新日期：2016-07-01 00:00:00

abstract：:Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused b...

journal_title：Diabetologia

authors： Ziegler M,Hahn HJ,Ziegler B,Köhler E,Fiedler H

更新日期：1975-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic islet transplantation (PIT) offers a physiological treatment for type 1 diabetes, but the failure of islet engraftment hinders its application. The female hormone 17β-oestradiol (E2) favours islet survival and stimulates angiogenesis, raising the possibility that E2 may enhance islet engraftm...

journal_title：Diabetologia

authors： Liu S,Kilic G,Meyers MS,Navarro G,Wang Y,Oberholzer J,Mauvais-Jarvis F

更新日期：2013-02-01 00:00:00

abstract：:Neurotrophin-3 (NT-3) acts as a target-derived neurotrophic factor for large calibre sensory neurones and plays a role in the maintenance of the adult phenotype of proprioceptive and mechanoreceptive fibres. Large fibre sensory neuropathy is common in diabetes mellitus and the aim of this study was to determine whethe...

journal_title：Diabetologia

authors： Fernyhough P,Diemel LT,Tomlinson DR

更新日期：1998-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to elucidate whether excess glucocorticoids and increased dietary lipids act synergistically to impair glucose tolerance and, if so, whether activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has an adverse or beneficial effect on glucose tolerance. METHODS:Dexamethaso...

journal_title：Diabetologia

authors： Holness MJ,Smith ND,Greenwood GK,Sugden MC

更新日期：2005-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. METHODS:We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m(2) [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA(1c) 7.1 ± 0.5% ...

journal_title：Diabetologia

authors： Camastra S,Gastaldelli A,Mari A,Bonuccelli S,Scartabelli G,Frascerra S,Baldi S,Nannipieri M,Rebelos E,Anselmino M,Muscelli E,Ferrannini E

更新日期：2011-08-01 00:00:00

abstract：:The relationship between plasma glucose, serum insulin, serum C-peptide and obesity was studied in 320 fasting high school students (13-18 years old), as part of a Busselton population study. For males and females respectively plasma glucose was 4.5 +/- 0.4 and 4.4 +/- 0.5 mmol/l (mean +/- SD), serum insulin 0.51 +/- ...

journal_title：Diabetologia

authors： Garcia-Webb P,Bonser A,Wearne KL,Gracey M

更新日期：1980-09-01 00:00:00

abstract：:We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...

journal_title：Diabetologia

authors： Ma Z,Westermark GT,Li ZC,Engström U,Westermark P

更新日期：1997-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The newly identified liver- and fat-derived hormone, betatrophin, has recently been linked to insulin resistance and pancreatic beta cell growth in mice. These preclinical findings have suggested betatrophin as a potential candidate for novel glucose-lowering treatment concepts involving beta cell regen...

journal_title：Diabetologia

authors： Fenzl A,Itariu BK,Kosi L,Fritzer-Szekeres M,Kautzky-Willer A,Stulnig TM,Kiefer FW

更新日期：2014-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Coronary heart disease is the leading cause of mortality among people with type 1 diabetes. Diet is an important lifestyle factor that relates to risk of CHD. The aim of this study was to examine how diet and adherence to dietary guidelines differ between adults with and without type 1 diabetes, and the...

journal_title：Diabetologia

authors： Snell-Bergeon JK,Chartier-Logan C,Maahs DM,Ogden LG,Hokanson JE,Kinney GL,Eckel RH,Ehrlich J,Rewers M

更新日期：2009-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We previously reported the...

journal_title：Diabetologia

authors： Joshi K,Elso C,Motazedian A,Labonne T,Schiesser JV,Cameron F,Mannering SI,Elefanty AG,Stanley EG

更新日期：2019-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Paraoxonase is a member of a multigene family of three genes. Paraoxonase2 gene polymorphisms have been associated with coronary heart disease in non-diabetic patients and with an increased fasting glycaemia in patients with Type II (non-insulin-dependent) diabetes mellitus. We tested the hypothesis of ...

journal_title：Diabetologia

authors： Pinizzotto M,Castillo E,Fiaux M,Temler E,Gaillard RC,Ruiz J

更新日期：2001-01-01 00:00:00

abstract：:Large-scale, centrally-coordinated screening for undiagnosed type 2 diabetes is an attractive option to reduce the mortality and morbidity resulting from inadequately controlled diabetes. However, there is limited research examining the direct consequences of such screening programmes on outcomes such as cardiovascula...

journal_title：Diabetologia

authors： Shaw JE

更新日期：2017-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Microvascular complications in the heart and kidney are strongly associated with an overall rise in inflammation. Annexin A1 (ANXA1) is an endogenous anti-inflammatory molecule that limits and resolves inflammation. In this study, we have used a bedside to bench approach to investigate: (1) ANXA1 levels...

journal_title：Diabetologia

authors： Purvis GSD,Chiazza F,Chen J,Azevedo-Loiola R,Martin L,Kusters DHM,Reutelingsperger C,Fountoulakis N,Gnudi L,Yaqoob MM,Collino M,Thiemermann C,Solito E

更新日期：2018-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Previous studies have implicated the glycoxidative modification of low-density lipoprotein (LDL) by glucose and aldehydes (apparently comprising both glycation and oxidation), as a causative factor in the elevated levels of atherosclerosis observed in diabetic patients. Such LDL modification can result ...

journal_title：Diabetologia

authors： Brown BE,Dean RT,Davies MJ

更新日期：2005-02-01 00:00:00

abstract：:The insulin-like growth factor I receptor and the activity of its associated tyrosine kinase activity were characterised in wheat germ agglutinin extracts from skeletal muscle biopsies from nine control and ten obese Type 2 (non-insulin-dependent) diabetic subjects, who had marked peripheral in vivo insulin resistance...

journal_title：Diabetologia

authors： Livingston N,Pollare T,Lithell H,Arner P

更新日期：1988-12-01 00:00:00

abstract：:A recent investigation of families containing two and three consecutive generations affected with Type I (insulin dependent) diabetes mellitus has led to speculation that there is a second susceptibility gene, not linked to the major histocompatibility complex. These families differ in important respects from families...

journal_title：Diabetologia

authors： Suarez BK,Van Eerdewegh P

更新日期：1981-05-01 00:00:00

abstract：:498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermitte...

journal_title：Diabetologia

authors： Herman JB,Medalie JH,Goldbourt U

更新日期：1977-05-01 00:00:00

abstract：:Diabetes is an important risk factor for atherosclerosis but the mechanism of the risk is unknown. As endothelial injury is considered to be an early event in the development of atherosclerosis, the effect of glucose on endothelial cell replication was studied. Concentrations of glucose of 11.2, 16.8 and 22.4 mmol/l i...

journal_title：Diabetologia

authors： Stout RW

更新日期：1982-11-01 00:00:00

abstract：:In order to examine the permeability of microvessels in diabetic children, the glomerular filtration rate, urinary excretion rates of albumin and beta 2-microglobulin, intravascular mass of albumin, and transcapillary escape rate of albumin were studied in 26 diabetic children without clinical signs of microangiopathy...

journal_title：Diabetologia

authors： Brøchner-Mortensen J,Ditzel J,Mogensen CE,Rødbro P

更新日期：1979-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We analysed the cost-effectiveness of intensified prevention in diabetic patients with different risks for foot ulcers and lower extremity amputations. Specifically, we examined whether the additional prevention costs associated with present recommendations would be offset by reduced costs of future foo...

journal_title：Diabetologia

authors： Ragnarson Tennvall G,Apelqvist J

更新日期：2001-11-01 00:00:00