Abstract:
AIMS/HYPOTHESIS:Despite the overlap in occurrence of cardiovascular disease (CVD) and type 2 diabetes and their risk factors, family history of these diseases has not yet been investigated simultaneously in relation to cardiometabolic markers in offspring. We examined how a family history of CVD and/or diabetes relates to cardiometabolic markers in offspring, and to what extent these diseases independently contribute to cardiometabolic markers. METHODS:We used data from 1,374 12-year-old children and their parents participating in a birth cohort study in the Netherlands. Family history of CVD (myocardial infarction [MI] and stroke) and diabetes were reported by the parents. Children were classified as 'no', 'moderate' or 'strong' family history, based on early/late onset of disease in parents and grandparents. Cardiometabolic markers were measured at 12 years of age: waist circumference, cholesterol, blood pressure and HbA1c. RESULTS:Compared with those with no family history, children with a strong family history of MI and/or stroke and/or diabetes (29% of the study population) had 0.13 mmol/l higher total cholesterol (TC) (95% CI 0.03, 0.23) and 0.18 higher TC/HDL-cholesterol (HDLC) ratio (95% CI 0.04, 0.32). A strong family history of MI or diabetes was independently associated with unfavourable cardiometabolic markers specific to those diseases. These associations remained after adjusting for BMI. Children with a moderate family history had no unfavourable cardiometabolic markers. CONCLUSIONS/INTERPRETATION:One-third of the children had a strong family history of CVD and/or diabetes. These children had higher TC levels and TC/HDLC ratios than children with no family history. A strong family history of MI or diabetes was independently associated with unfavourable cardiometabolic markers specific to those diseases.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Berentzen NE,Wijga AH,van Rossem L,Koppelman GH,van Nieuwenhuizen B,Gehring U,Spijkerman AM,Smit HAdoi
10.1007/s00125-016-3988-2subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1666-74issue
8eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-016-3988-2journal_volume
59pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract::It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050644
更新日期:1997-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Experimental studies have suggested that apoptosis is involved in diabetic embryopathy through oxidative stress. However, the precise mechanism of diabetic embryopathy is not yet clear. Thioredoxin (TRX) is a small, ubiquitous, multifunctional protein, which has recently been shown to protect cells from...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1784-y
更新日期:2010-09-01 00:00:00
abstract::Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with centra...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05327-w
更新日期:2021-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Experimental studies have suggested that ghrelin, a novel gastrointestinal peptide hormone, could play a role in glucose homeostasis. In addition, ghrelin has been associated with beneficial haemodynamic effects in experimental settings. Since the Arg51Gln mutation changes the carboxyterminal amino acid...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1058-z
更新日期:2003-04-01 00:00:00
abstract::Loss of neurogenic inflammation in response to tissue injury may be an important complication of diabetes mellitus. We studied local neurogenic inflammation in the peripheral nerve trunk of Sprague-Dawley rats 4 months following the induction of diabetes by streptozotocin injection. To assess neurogenic inflammation, ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02743263
更新日期:1993-06-01 00:00:00
abstract::To evaluate the role of mutations in the glucose transporter (GLUT1) gene in Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM), we first conducted a population association study using the XbaI polymorphism of the gene. A polymerase chain reaction (PCR)-based assay was developed and used for the an...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400583
更新日期:1995-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin resistance is recognised as the core factor in the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus, hypertension and atherosclerosis. Several studies indicate the possible role of mutations of the insulin receptor substrate-1 (IRS-1) gene in the pathogenesis of insulin-resistan...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051628
更新日期:2001-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:We assessed the effects of vildagliptin, a novel dipeptidyl peptidase IV inhibitor, on postprandial lipid and lipoprotein metabolism in patients with type 2 diabetes. SUBJECTS, MATERIALS AND METHODS:This was a single-centre, randomised, double-blind study in drug-naive patients with type 2 diabetes. Pa...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-006-0340-2
更新日期:2006-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of metabolic dysregulations across multiple biofluids and over varying timescales of glycaem...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3636-2
更新日期:2015-08-01 00:00:00
abstract::Glucagon-like peptide-1 and glucagon-like peptide-2 are encoded by the m-RNA of pancreatic preproglucagon. They show high conservation in different species and substantial sequence homology to glucagon. Because no definite biological activity of these peptides has been reported, we investigated the effect of synthetic...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00291980
更新日期:1985-09-01 00:00:00
abstract::Fasting (24 h) normal dogs and depancreatized dogs were injected intravenously with highly purified porcine insulin (Actrapid) in the doses of 0.2 U/kg and 0.5 U/kg, respectively. Blood glucose decreased from 152 +/- 41 (SEM) mg/100 ml to 39 +/- 7 mg/100 ml in the depancreatized dog and from 95 +/- 3 mg/100 ml to 42 +...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02342872
更新日期:1978-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repair...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0556-1
更新日期:2007-03-01 00:00:00
abstract::The migration of Tokelauans from a traditional atoll in the Pacific to urban New Zealand is associated with an increased prevalence and incidence of Type 2 (non-insulin-dependent) diabetes mellitus over the period 1968-1982. During the same period, a lesser but definite increase is seen among non-migrants in Tokelau. ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00285332
更新日期:1989-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2546-9
更新日期:2012-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:African-Americans with type 2 diabetes and access to adequate healthcare are at lower risk of clinical coronary artery disease than are white diabetic patients. We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0017-2
更新日期:2005-12-01 00:00:00
abstract::The pO2 at which haemoglobin is half-saturated with oxygen (p50) was determined at fixed pCO2 (45 mmHg) and without altering the resulting pH and the level of organic phosphates in heparinized whole blood samples from 26 diabetic patients and 24 normal subjects of both sexes. Diabetic blood p50 was higher (29.79 +/- 1...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00260950
更新日期:1982-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this work was to examine the associations of average weight and weight velocity in three growth periods from birth through adolescence with type 2 diabetes incidence. METHODS:Child participants were selected from a 43 year longitudinal study of American Indians to represent three growth peri...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05165-w
更新日期:2020-09-01 00:00:00
abstract:AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0841-7
更新日期:2008-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The conversion of D-[3-(3)H]glucose to (3) HOH is currently measured to assess D-glucose utilisation. The validity of such a procedure was re-evaluated. METHODS:The conversion of D-[3-(3)H]glucose and D-[5-(3)H]glucose to (3) HOH was measured in rat pancreatic islets, parotid cells and erythrocytes. Th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0907-5
更新日期:2002-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS:In this single-centre, double-blind, placebo-controlled, ...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-017-4289-0
更新日期:2017-08-01 00:00:00
abstract::Using 3H-thymidine labeling techniques, we found that rates of DNA synthesis in islet cells doubled when mouse pancreatic islets were cultured for 1 week with 10 mmol/l nicotinamide, a potent poly(ADP-ribose) synthetase inhibitor. Culture with nicotinamide partially inhibited glucose-stimulated insulin release, wherea...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02427093
更新日期:1986-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4073-6
更新日期:2016-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Increased oxidative-nitrosative stress, poly(ADP-ribose) polymerase (PARP) activation and subsequent cellular damage play important roles in the complications of both diabetes mellitus and pregnancy. Our aim was to investigate nitrative stress and PARP activity levels during normal and gestational diabe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1435-3
更新日期:2009-09-01 00:00:00
abstract::Epigenetics encapsulates a group of molecular mechanisms including DNA methylation, histone modification and microRNAs (miRNAs). Gestational diabetes (GDM) increases the risk of adverse perinatal outcomes and is associated with future offspring risk of obesity and type 2 diabetes. It has been hypothesised that epigene...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-019-05011-8
更新日期:2019-12-01 00:00:00
abstract::Diabetes affects 4 to 5% of the population worldwide and is the most common metabolic disorder. The number of individuals diagnosed with diabetes is rapidly increasing, especially in the developed countries and the disorder frequently leads to secondary complications such as retinopathy, nephropathy, neuropathy and ca...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250100623
更新日期:2001-09-01 00:00:00
abstract::The mechanisms which underlie the development of Charcot joints and foot ulceration are poorly understood. The present study using non-invasive Doppler techniques demonstrates that in the neuropathic leg, the arteries are rigid, peripheral blood flow is increased and associated with arteriovenous shunting. We studied ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00253862
更新日期:1982-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glomerular hyperfiltration is a well-established phenomenon occurring early in some patients with type 1 diabetes. However, there is no consistent answer regarding whether hyperfiltration predicts later development of nephropathy. We performed a systematic review and meta-analysis of observational studi...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析
doi:10.1007/s00125-009-1268-0
更新日期:2009-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-g...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1018-8
更新日期:2008-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:This study compared the incidence rate of type 1 diabetes in children diagnosed with enterovirus (EV) infections with that in age- and sex-matched children without EV infection in a population-based cohort. In addition, we examined whether the direction or magnitude of the association between EV infecti...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3400-z
更新日期:2015-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Low-grade inflammation has been implicated in the development of Type 2 diabetes and cardiovascular disease, but its role in the pathogenesis of the metabolic syndrome is unclear. We investigated the association between C-reactive protein (CRP) levels and the development of the metabolic syndrome and di...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1472-x
更新日期:2004-08-01 00:00:00