Lack of gastrointestinal glucagon response to hypoglycaemia in depancreatized dogs.

abstract：AIMS/HYPOTHESIS:Oxidized LDL is immunogenic and immune complexes formed by oxidized LDL and corresponding antibodies are pro-atherogenic and pro-inflammatory. Considering that macroalbuminuria is a risk factor for coronary heart disease and that common pathogenic factors for atherosclerosis and glomerulosclerosis exist...

journal_title：Diabetologia

authors： Atchley DH,Lopes-Virella MF,Zheng D,Kenny D,Virella G

更新日期：2002-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:We previously reported that exposure to antibodies neutralising serpin B13, a protease inhibitor expressed in exocrine pancreatic ducts, promotes beta cell proliferation, underscoring the importance of a functional relationship between exocrine and endocrine pancreas. The aim of the present study was to...

journal_title：Diabetologia

authors： Lo CW,Kryvalap Y,Sheu TJ,Chang CH,Czyzyk J

更新日期：2019-05-01 00:00:00

abstract：:Use of monoclonal antibodies specific for rat lymphocyte subsets and an anti-insulin marker has allowed us to document the following sequence of events leading to the development of clinical diabetes in this animal model. The first change observed in the pancreas is increased expression of MHC class II molecules on va...

journal_title：Diabetologia

authors： Dean BM,Walker R,Bone AJ,Baird JD,Cooke A

更新日期：1985-07-01 00:00:00

abstract：:Insulin resistance is a significant pathogenetic factor in the development of non-insulin-dependent diabetes mellitus (NIDDM). A new class of drugs, the thiazolidinediones, have been shown to lower blood glucose levels without stimulating insulin secretion. We report the metabolic effect of the thiazolidinedione, darg...

journal_title：Diabetologia

authors： Chaiken RL,Eckert-Norton M,Pasmantier R,Boden G,Ryan I,Gelfand RA,Lebovitz HE

更新日期：1995-11-01 00:00:00

abstract：:We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thro...

journal_title：Diabetologia

authors： Ishizuka T,Taniguchi O,Yamamoto M,Kajita K,Nagashima T,Takeda N,Inouye H,Yasuda K,Miura K

更新日期：1994-06-01 00:00:00

abstract：:In sham-operated rats, intravenous administration of 14C-very low density lipoprotein triglycerides (with labelled esterified fatty acids) caused an initial decrease and subsequent increase in plasma 14C-lipids of both very low density lipoproteins (VLDL) (density less than 1.006) and lipoproteins of density greater t...

journal_title：Diabetologia

authors： Argilés J,Herrera E

更新日期：1983-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesit...

journal_title：Diabetologia

authors： Li H,Kilpeläinen TO,Liu C,Zhu J,Liu Y,Hu C,Yang Z,Zhang W,Bao W,Cha S,Wu Y,Yang T,Sekine A,Choi BY,Yajnik CS,Zhou D,Takeuchi F,Yamamoto K,Chan JC,Mani KR,Been LF,Imamura M,Nakashima E,Lee N,Fujisawa T,Ka

更新日期：2012-04-01 00:00:00

abstract：:Arterial hypertension and poor glycaemic control are central to the development of microalbuminuria in insulin-dependent diabetes mellitus (IDDM). Recent consensus has established sensitive criteria for their detection and treatment, although the proportion of patients who may benefit is unclear. Between 1988 and 1990...

journal_title：Diabetologia

authors： Mangili R,Deferrari G,Di Mario U,Giampietro O,Navalesi R,Nosadini R,Rigamonti G,Spezia R,Crepaldi G

更新日期：1994-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Endothelial cell (EC) damage is a key mechanism causing retinal microvascular injury in diabetes. Several microRNAs (miRNAs) have been found to regulate sirtuin 1 (SIRT1, which is involved in regulation of the cell cycle, survival and metabolism) in various tissues and disease states, but no studies hav...

journal_title：Diabetologia

authors： Mortuza R,Feng B,Chakrabarti S

更新日期：2014-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this work was to estimate the life expectancy (LE) and disability-free life expectancy (DFLE) for adults with and without diabetes. METHODS:The Chiang method and the adapted Sullivan method were used to estimate LE and DFLE by age and sex. Mortality data in 2011 were available from the Natio...

journal_title：Diabetologia

authors： Huo L,Shaw JE,Wong E,Harding JL,Peeters A,Magliano DJ

更新日期：2016-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several risk stratification systems have been proposed for predicting development of diabetic foot ulcer. However, little has been published that assesses their similarities and disparities, diagnostic accuracy and evidence level. Consequently, we conducted a systematic review of the existing stratifica...

journal_title：Diabetologia

authors： Monteiro-Soares M,Boyko EJ,Ribeiro J,Ribeiro I,Dinis-Ribeiro M

更新日期：2011-05-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. In this issue of Diabetologia (doi: ...

journal_title：Diabetologia

authors： Miele C,Beguinot F

更新日期：2012-05-01 00:00:00

abstract：:In order to examine the permeability of microvessels in diabetic children, the glomerular filtration rate, urinary excretion rates of albumin and beta 2-microglobulin, intravascular mass of albumin, and transcapillary escape rate of albumin were studied in 26 diabetic children without clinical signs of microangiopathy...

journal_title：Diabetologia

authors： Brøchner-Mortensen J,Ditzel J,Mogensen CE,Rødbro P

更新日期：1979-05-01 00:00:00

abstract：:Dementia and non-insulin-dependent diabetes mellitus (NIDDM) are highly prevalent disorders in the elderly. Diabetes has repeatedly been reported to affect cognition, but its relation with dementia is uncertain. We therefore studied the association between diabetes and dementia in the Rotterdam Study, a large populati...

journal_title：Diabetologia

authors： Ott A,Stolk RP,Hofman A,van Harskamp F,Grobbee DE,Breteler MM

更新日期：1996-11-01 00:00:00

abstract：AIM/HYPOTHESIS:Oxidative stress was shown to selectively induce impaired metabolic response to insulin, raising the possible involvement of alterations in Insulin-Receptor-Substrate (IRS) proteins. This study was conducted to assess whether oxidative stress induced IRS protein degradation and enhanced serine phosphoryl...

journal_title：Diabetologia

authors： Potashnik R,Bloch-Damti A,Bashan N,Rudich A

更新日期：2003-05-01 00:00:00

abstract：:We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 1 1973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were greater than age 50 y...

journal_title：Diabetologia

authors： Green A,Hougaard P

更新日期：1983-09-01 00:00:00

abstract：:In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, ...

journal_title：Diabetologia

authors： Gotfredsen CF

更新日期：1976-08-01 00:00:00

abstract：:The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD. Situations in which proteomics could be applied in clinical practice include the identif...

journal_title：Diabetologia

authors： Pena MJ,Mischak H,Heerspink HJ

更新日期：2016-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated of the effects of fatty acid composition of the maternal diet on fetal and postnatal growth, morphology of the pancreas and glucose metabolism and muscle hexosamine concentrations in the adult offspring of rats. METHODS:High-fat diets enriched with either saturated or unsaturated fatty ...

journal_title：Diabetologia

authors： Siemelink M,Verhoef A,Dormans JA,Span PN,Piersma AH

更新日期：2002-10-01 00:00:00

abstract：:From December, 1966 through 1990, 3082 pancreas transplants were reported to the International Registry. A detailed analysis was performed on the 2087 transplants in the 1986-90 data base; during this time the overall one year recipient and graft functional survival rates were 89% and 62%. Univariate analyses showed g...

journal_title：Diabetologia

authors： Sutherland DE

更新日期：1991-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The gene encoding the beta(3)-subunit (GPIIIa) of the platelet alpha(2)beta(3)-integrin (fibrinogen receptor) shows a polymorphism PlA1/A2 with the A2 allele putatively associated with an increased risk of acute ischaemic events. This study investigated whether Type 2 diabetes as a particular macrovascu...

journal_title：Diabetologia

authors： Tschoepe D,Menart B,Ferber P,Altmann C,Haude M,Haastert B,Roesen P

更新日期：2003-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:A shift towards younger age at onset of diabetes in susceptible people has been suggested as a possible explanation for the increasing temporal trend in incidence of type 1 diabetes. We aimed to test this hypothesis by assessing trends in incidence rates in the period 1984-2004 in children and young adu...

journal_title：Diabetologia

authors： Bruno G,Novelli G,Panero F,Perotto M,Monasterolo F,Bona G,Perino A,Rabbone I,Cavallo-Perin P,Cerutti F,Piedmont Study Group for Diabetes Epidemiology.

更新日期：2009-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial. METHODS:In 62 non-diabetic women and men (age 24-69 years, BMI 21-39 kg/m2), we measured VAT and subcutaneous ...

journal_title：Diabetologia

authors： Gastaldelli A,Sironi AM,Ciociaro D,Positano V,Buzzigoli E,Giannessi D,Lombardi M,Mari A,Ferrannini E

更新日期：2005-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this work was to estimate the impact of birthweight on early-onset (age <40 years) type 2 diabetes. METHODS:A longitudinal study of American Indians, aged ≥5 years, was conducted from 1965 to 2007. Participants who had a recorded birthweight were followed until they developed diabetes or the...

journal_title：Diabetologia

authors： Olaiya MT,Wedekind LE,Hanson RL,Sinha M,Kobes S,Nelson RG,Baier LJ,Knowler WC

更新日期：2019-09-01 00:00:00

abstract：:Downregulation of insulin receptor tyrosine kinase (IRK) activity yields to impaired insulin signalling and contributes to the pathogenesis of cellular insulin resistance. Activation of protein kinase C (PKC) by different agents is associated with an inhibition of IRK activity in various cell types. There is evidence ...

journal_title：Diabetologia

authors： Bossenmaier B,Mosthaf L,Mischak H,Ullrich A,Häring HU

更新日期：1997-07-01 00:00:00

abstract：:To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibodies and high titre...

journal_title：Diabetologia

authors： Betterle C,Presotto F,Pedini B,Moro L,Slack RS,Zanette F,Zanchetta R

更新日期：1987-05-01 00:00:00

abstract：:IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulo-interstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three...

journal_title：Diabetologia

authors： Schaefer L,Schaefer RM,Ling H,Teschner M,Heidland A

更新日期：1994-06-01 00:00:00

abstract：:Amylin is a 37-amino acid pancreatic polypeptide, probably involved in the pathophysiology of Type 2 (non-insulin-dependent) diabetes mellitus. We have determined amylin in human plasma by extraction-based radioimmunoassay (Sep-Pak C18). Of 23 healthy control subjects plasma amylin was determined as 11.9 +/- 3.5 ng/l....

journal_title：Diabetologia

authors： Hartter E,Svoboda T,Ludvik B,Schuller M,Lell B,Kuenburg E,Brunnbauer M,Woloszczuk W,Prager R

更新日期：1991-01-01 00:00:00

abstract：:Blood glucose screening results, obtained using two different screening procedures, are reported from two occupational groups. Post-prandial blood glucose levels were measured in 3346 subjects aged 45 years or more employed by the Greater London Council/Inner London Education Authority. In women, mean blood glucose le...

journal_title：Diabetologia

authors： Jarrett RJ,Murrells TJ,Shipley MJ,Hall T

更新日期：1984-12-01 00:00:00

abstract：:The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...

journal_title：Diabetologia

authors： Jones PM,Persaud SJ,Bjaaland T,Pearson JD,Howell SL

更新日期：1992-11-01 00:00:00