Association of diabetes mellitus and dementia: the Rotterdam Study.

abstract：AIMS/HYPOTHESIS:To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes. MATERIALS AND METHODS:We performed a systematic review and meta-analysis of randomised controlled trials comp...

journal_title：Diabetologia

authors： Hartweg J,Farmer AJ,Perera R,Holman RR,Neil HA

更新日期：2007-08-01 00:00:00

abstract：:The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...

journal_title：Diabetologia

authors： Gill GV,Yudkin JS,Keen H,Beran D

更新日期：2011-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...

journal_title：Diabetologia

authors： Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

更新日期：2012-06-01 00:00:00

abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...

journal_title：Diabetologia

authors： Humphriss DB,Stewart MW,Berrish TS,Barriocanal LA,Trajano LR,Ashworth LA,Brown MD,Miller M,Avery PJ,Alberti KG,Walker M

更新日期：1997-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We determined the response of selected genes to in vivo insulin in adipose tissue in 21 non-diabetic women. MATERIALS AND METHODS:The women were divided into insulin-sensitive and -resistant groups based on their median whole-body insulin sensitivity (8.7+/-0.4 vs 4.2+/-0.3 mg kg(-1) min(-1) for insuli...

journal_title：Diabetologia

authors： Westerbacka J,Cornér A,Kannisto K,Kolak M,Makkonen J,Korsheninnikova E,Nyman T,Hamsten A,Fisher RM,Yki-Järvinen H

更新日期：2006-01-01 00:00:00

abstract：:In order to characterize pancreatic beta cell function in Geneva bred spiny mice (acomys cahirinus), the dynamics of immunoreactive insulin release were examined during perifusion of pancreatic islets isolated from normoglycemic acomys. The initial insulin response of acomys was slow: no clear-cut early (1 to 10 min) ...

journal_title：Diabetologia

authors： Rabinovitch A,Gutzeit A,Kikuchi M,Cerasi E,Renold AE

更新日期：1975-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess whether the diabetogenicity of areca nut (Areca catechu or 'betel-nut'), which has previously been demonstrated experimentally in mice, independently contributes to the risk of hyperglycaemia or type 2 diabetes in men in Taiwan, where the habit has become established ...

journal_title：Diabetologia

authors： Tung TH,Chiu YH,Chen LS,Wu HM,Boucher BJ,Chen TH,Keelung Community-based Integrated Screening programme No. 2.

更新日期：2004-10-01 00:00:00

abstract：:The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...

journal_title：Diabetologia

authors： Dietze G,Wicklmayr M,Mehnert H,Czempiel H,Henftling HG

更新日期：1978-04-01 00:00:00

abstract：:Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...

journal_title：Diabetologia

authors： Qiang X,Satoh J,Sagara M,Fukuzawa M,Masuda T,Sakata Y,Muto G,Muto Y,Takahashi K,Toyota T

更新日期：1998-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance that does not develop diabetes. MATERIALS AND METHODS:NEFA augmen...

journal_title：Diabetologia

authors： Nolan CJ,Leahy JL,Delghingaro-Augusto V,Moibi J,Soni K,Peyot ML,Fortier M,Guay C,Lamontagne J,Barbeau A,Przybytkowski E,Joly E,Masiello P,Wang S,Mitchell GA,Prentki M

更新日期：2006-09-01 00:00:00

abstract：:We performed i.v. insulin tolerance test in 30 non-obese (BMI < 30 male and < 28 female) non-diabetic (by oral glucose tolerance test) subjects and subdivided them into three groups of 10 subjects each, according to their insulin sensitivity (K(itt) values). Then we compared the tyrosine-kinase activity of immunopurif...

journal_title：Diabetologia

authors： Grasso G,Frittitta L,Anello M,Russo P,Sesti G,Trischitta V

更新日期：1995-01-01 00:00:00

abstract：:Oral glucose administration increased plasma noradrenaline concentration significantly in seven normal subjects (p less than 0.02), whereas in six young short-term Type 1 diabetic patients without complications plasma noradrenaline did not change. Basal plasma noradrenaline did not differ between the two groups. In th...

journal_title：Diabetologia

authors： Hegedüs L,Christensen NJ,Sestoft L

更新日期：1983-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:To document the prevalence of typical diabetic symptoms, signs and complications in the diagnosis of type 2 diabetes mellitus, examine their pre-diagnostic duration, and analyse associations with glycaemic level, blood pressure (BP), and weight. METHODS:An epidemiological population-based study of 1137...

journal_title：Diabetologia

authors： Drivsholm T,de Fine Olivarius N,Nielsen AB,Siersma V

更新日期：2005-02-01 00:00:00

abstract：:Using 3H-thymidine labeling techniques, we found that rates of DNA synthesis in islet cells doubled when mouse pancreatic islets were cultured for 1 week with 10 mmol/l nicotinamide, a potent poly(ADP-ribose) synthetase inhibitor. Culture with nicotinamide partially inhibited glucose-stimulated insulin release, wherea...

journal_title：Diabetologia

authors： Sandler S,Andersson A

更新日期：1986-03-01 00:00:00

abstract：:Renal tubular lesions have been studied in streptozotocin-diabetic rats after 50 days of diabetes and compared with age-matched controls. The kidney weight increased by 67% in the diabetic animals and the length of the proximal tubules increased by 22%, but no abnormalities were found. The length of the distal tubules...

journal_title：Diabetologia

authors： Rasch R

更新日期：1984-07-01 00:00:00

abstract：:Demographic and biological data were collected from all Caucasian Type 1 diabetic patients (n = 279) who were recruited at clinical onset by the Belgian Diabetes Registry over 34 months. The male/female ratio was significantly higher for onset between age 20 and 40 years (2.4) than before age 20 years (1.0); no age-or...

journal_title：Diabetologia

authors： Vandewalle CL,Decraene T,Schuit FC,De Leeuw IH,Pipeleers DG,Gorus FK

更新日期：1993-11-01 00:00:00

abstract：:Glycation of long-lived proteins is an inevitable consequence of aging that is accelerated in patients with diabetes mellitus. Treatment of demineralized bone matrix particles from 35-week-old normal Long-Evans rats with glycoaldehyde, a precursor of advanced glycation end-products, was used to assess the effects of b...

journal_title：Diabetologia

authors： Fong Y,Edelstein D,Wang EA,Brownlee M

更新日期：1993-09-01 00:00:00

abstract：:The adrenergic regulation of adipose tissue lipolysis in response to insulin-induced hypoglycaemia (intravenous infusion of soluble insulin 0.10 IU.kg body weight-1.h-1 until the arterial plasma glucose fell below 2.8 mmol/l) was investigated directly in vivo in 11 insulin-dependent diabetic (IDDM) patients and 12 con...

journal_title：Diabetologia

authors： Bolinder J,Sjöberg S,Arner P

更新日期：1996-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to evaluate if the cellular localisation and molecular species of diacylglycerol (DAG) were related to insulin sensitivity in human skeletal muscle. METHODS:Healthy sedentary obese controls (Ob; n = 6; mean±SEM age 39.5 ± 2.3 years; mean ± SEM BMI 33.3 ± 1.4 kg/m(2)), individuals with type 2 ...

journal_title：Diabetologia

authors： Bergman BC,Hunerdosse DM,Kerege A,Playdon MC,Perreault L

更新日期：2012-04-01 00:00:00

abstract：:The interrelationships between fibrinogen, von Willebrand factor, a marker of vascular endothelial cell damage, and serum lipids were explored in well-characterised subjects with insulin-dependent diabetes mellitus. The 2091 subjects were enrolled into a cross-sectional, clinic-based study of complications, from 16 Eu...

journal_title：Diabetologia

authors： Greaves M,Malia RG,Goodfellow K,Mattock M,Stevens LK,Stephenson JM,Fuller JH

更新日期：1997-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We analysed the factors that determine the outcomes of surgical treatment of osteomyelitis of the foot in diabetic patients given early surgical treatment within 12 h of admission and treated with prioritisation of foot-sparing surgery and avoidance of amputation. METHODS:A consecutive series of 185 di...

journal_title：Diabetologia

authors： Aragón-Sánchez FJ,Cabrera-Galván JJ,Quintana-Marrero Y,Hernández-Herrero MJ,Lázaro-Martínez JL,García-Morales E,Beneit-Montesinos JV,Armstrong DG

更新日期：2008-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to test the hypothesis that intensive glycaemic control (INT) and higher plasma C-peptide levels in patients with poorly controlled diabetes would be associated with better eye outcomes. METHODS:The incidence and progression of diabetic retinopathy (DR) was assessed by grading...

journal_title：Diabetologia

authors： Azad N,Agrawal L,Emanuele NV,Klein R,Bahn GD,Reaven P,VADT Study Group.

更新日期：2014-06-01 00:00:00

abstract：:The effect of hyperglycaemia on islet transplantation in the rat has been examined in two ways, using syngeneic transplantation of 400 islets to the kidney capsule and subsequent measurement of kidney insulin content as a measurement of B-cell survival. Firstly, islets were transplanted into either diabetic or normal ...

journal_title：Diabetologia

authors： Gray DW,Cranston D,McShane P,Sutton R,Morris PJ

更新日期：1989-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The stress-activated nuclear protein transcription regulator 1 (NUPR1) is induced in response to glucose and TNF-α, both of which are elevated in type 2 diabetes, and Nupr1 has been implicated in cell proliferation and apoptosis cascades. We used Nupr1(-/-) mice to study the role of Nupr1 in glucose hom...

journal_title：Diabetologia

authors： Barbosa-Sampaio HC,Liu B,Drynda R,Rodriguez de Ledesma AM,King AJ,Bowe JE,Malicet C,Iovanna JL,Jones PM,Persaud SJ,Muller DS

更新日期：2013-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:A high prevalence of diabetes contributes to excess CHD in Indian Asians, but the underlying mechanisms are unclear. Heart rate, heart rate variability (HRV) and baroreflex sensitivity (BRS) are measures of cardiac autonomic function that are disturbed by hyperglycaemia and predict CHD. We compared thes...

journal_title：Diabetologia

authors： Bathula R,Hughes AD,Panerai R,Potter J,Thom SA,Francis DP,Shore AC,Kooner J,Chaturvedi N

更新日期：2010-10-01 00:00:00

abstract：:It has been proposed that the development of diabetic complications may involve a depletion of cellular myo-inositol due to an increase in polyol (sorbitol) formation. We therefore initially examined the effect of diabetes on levels of these metabolites in isolated cerebral microvessels. Compared with microvessels fro...

journal_title：Diabetologia

authors： Sussman I,Carson MP,Schultz V,Wu XP,McCall AL,Ruderman NB,Tornheim K

更新日期：1988-10-01 00:00:00

abstract：:The effect of early antihypertensive treatment on survival of patients with diabetic nephropathy was evaluated by studying two cohorts of Type 1 (insulin-dependent) diabetic patients developing persistent proteinuria in I: 1957-1973 (late treatment group n = 49) and II: 1979-1983 (early treatment group n = 71). At ons...

journal_title：Diabetologia

authors： Mathiesen ER,Borch-Johnsen K,Jensen DV,Deckert T

更新日期：1989-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...

journal_title：Diabetologia

authors： Yajnik CS,Joglekar CV,Lubree HG,Rege SS,Naik SS,Bhat DS,Uradey B,Raut KN,Shetty P,Yudkin JS

更新日期：2008-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with...

journal_title：Diabetologia

authors： Mahendran Y,Jonsson A,Have CT,Allin KH,Witte DR,Jørgensen ME,Grarup N,Pedersen O,Kilpeläinen TO,Hansen T

更新日期：2017-05-01 00:00:00

abstract：:Hyperglycaemia may enhance insulin resistance typical of non-insulin dependent diabetes mellitus, as well as insulin dependent diabetes mellitus, and thus initiate a vicious pathogenetic cycle. We sought to test the hypothesis that reduction in chronic hyperglycaemia in the diabetic dog by methods that do not employ i...

journal_title：Diabetologia

authors： Koffler M,Imamura T,Santeusanio F,Helderman JH

更新日期：1988-04-01 00:00:00