Oxidized LDL-anti-oxidized LDL immune complexes and diabetic nephropathy.

abstract：AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...

journal_title：Diabetologia

authors： Treweeke AT,Winterburn TJ,Mackenzie I,Barrett F,Barr C,Rushworth GF,Dransfield I,MacRury SM,Megson IL

更新日期：2012-11-01 00:00:00

abstract：:The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. ...

journal_title：Diabetologia

authors： Tomlinson DR

更新日期：1999-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to identify microRNAs (miRNAs) associated with type 2 diabetes and risk of developing the disease in skeletal muscle biopsies from phenotypically well-characterised twins. METHODS:We measured muscle miRNA levels in monozygotic (MZ) twins discordant for type 2 diabetes using arrays. Further inv...

journal_title：Diabetologia

authors： Bork-Jensen J,Scheele C,Christophersen DV,Nilsson E,Friedrichsen M,Fernandez-Twinn DS,Grunnet LG,Litman T,Holmstrøm K,Vind B,Højlund K,Beck-Nielsen H,Wojtaszewski J,Ozanne SE,Pedersen BK,Poulsen P,Vaag A

更新日期：2015-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Exposure to sunlight has the potential to suppress metabolic dysfunction and obesity. We previously demonstrated that regular exposure to low-doses of ultraviolet radiation (UVR) reduced weight gain and signs of diabetes in male mice fed a high-fat diet, in part via release of nitric oxide from skin. He...

journal_title：Diabetologia

authors： Dhamrait GK,Panchal K,Fleury NJ,Abel TN,Ancliffe MK,Crew RC,Croft K,Fernandez BO,Minnion M,Hart PH,Lucas RM,Mark PJ,Feelisch M,Weller RB,Matthews V,Gorman S

更新日期：2020-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to study the incidence of Type I diabetes in 4 countries, Estonia, Latvia, Lithuania and Finland, during 1983-1998, focusing on the two separate periods of 1983-1990 and 1991-1998. METHODS:Population-based incidence data from nationwide diabetes registries were used. Crude and age-standardized...

journal_title：Diabetologia

authors： Podar T,Solntsev A,Karvonen M,Padaiga Z,Brigis G,Urbonaite B,Viik-Kajander M,Reunanen A,Tuomilehto J

更新日期：2001-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. ...

journal_title：Diabetologia

authors： Taverna MJ,Sola A,Guyot-Argenton C,Pacher N,Bruzzo F,Slama G,Reach G,Selam JL

更新日期：2002-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose-lowering therapy with dipeptidyl peptidase-4 (DPP-4) inhibitors is associated with a low risk of hypoglycaemia. We hypothesise that DPP-4 inhibition prevents hypoglycaemia via increased glucagon counterregulation through the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). M...

journal_title：Diabetologia

authors： Malmgren S,Ahrén B

更新日期：2015-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Patients with glucokinase mutations are characterised by mild, persistent fasting hyperglycaemia, a small increment in glucose in response to an oral load and a dominant family history. These patients frequently present with gestational diabetes and often require insulin treatment during pregnancy. We a...

journal_title：Diabetologia

authors： Ellard S,Beards F,Allen LI,Shepherd M,Ballantyne E,Harvey R,Hattersley AT

更新日期：2000-02-01 00:00:00

abstract：:A method has been developed for the purification of single A, B and D cells and for the isolation of coupled islet cells. Isolated rat islets were dissociated by repeated pipetting in the presence of trypsin and ethylene glycol bis (beta-aminoethyl ether) N,N' tetra-acetic acid (EGTA), and then filtered through nylon ...

journal_title：Diabetologia

authors： Pipeleers DG,Pipeleers-Marichal MA

更新日期：1981-06-01 00:00:00

abstract：:Light and electron microscopic studies of diploid, tetraploid and octaploid B-cells in the islets of normal C57BL/KsJ mice revealed that polyploid cells were characterized by a wider range of granulated states than diploid B-cells. The maximum granule densities were similar for polyploid and diploid cells; however, so...

journal_title：Diabetologia

authors： Bowen RE,Swartz FJ

更新日期：1976-05-01 00:00:00

abstract：:Measurement of insulin autoantibodies (IAA) with a novel micro radiobinding assay which requires only 20 microl of serum was compared with that in a conventional radiobinding assay which uses 600 microl of serum. IAA were measured with both assays in samples from 94 new onset insulin-dependent diabetes mellitus (IDDM)...

journal_title：Diabetologia

authors： Naserke HE,Dozio N,Ziegler AG,Bonifacio E

更新日期：1998-06-01 00:00:00

abstract：:Fragments of cloned rat class I transplantation antigen genes were used to define the polymorphism detected between two lines of closely related BB rats. One line, BB-Hagedorn (BB/H), is prone to diabetes, and the other (BB control) is resistant. A cDNA probe representing part of the second extracellular domain of a c...

journal_title：Diabetologia

authors： Kryspin-Sørensen I,Dyrberg T,Kastern W

更新日期：1986-05-01 00:00:00

abstract：:Plasma immunoreactive secretin and insulin concentrations were measured in fasting normal humans after intraduodenal infusions of hydrochloric acid, isotonic or hypertonic glucose. The effect of intraduodenal acidification or intravenous bolus injections of secretin on plasma insulin concentrations during infusions of...

journal_title：Diabetologia

authors： Fahrenkrug J,Schaffalitzky de Muckadell OB,Kühl C

更新日期：1978-04-01 00:00:00

abstract：:In sham-operated rats, intravenous administration of 14C-very low density lipoprotein triglycerides (with labelled esterified fatty acids) caused an initial decrease and subsequent increase in plasma 14C-lipids of both very low density lipoproteins (VLDL) (density less than 1.006) and lipoproteins of density greater t...

journal_title：Diabetologia

authors： Argilés J,Herrera E

更新日期：1983-04-01 00:00:00

abstract：:The insulin receptor has been proposed as a candidate gene for the inherited defect in Type 2 (non-insulin-dependent) diabetes mellitus and we therefore studied three restriction fragment length polymorphic sites, two revealed with the enzyme Sst1 and one by Rsa1, using two insulin receptor cDNA probes in 131 Caucasia...

journal_title：Diabetologia

authors： Oelbaum RS,Bouloux PM,Li SR,Baroni MG,Stocks J,Galton DJ

更新日期：1991-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine time trends in national perinatal outcomes in pregnancies complicated by pre-existing type 1 or type 2 diabetes. METHODS:We analysed episode-level data on all obstetric inpatient delivery events (live or stillbirth) between 1 April 1998 and 31 March 2013 (n = 813,921) using the Scot...

journal_title：Diabetologia

authors： Mackin ST,Nelson SM,Kerssens JJ,Wood R,Wild S,Colhoun HM,Leese GP,Philip S,Lindsay RS,SDRN Epidemiology Group.

更新日期：2018-05-01 00:00:00

abstract：:The objective of the present study was to assess the prevalence of familial aggregation of Type 1 (insulin-dependent) diabetes mellitus among Danish families with a diabetic child aged 20 years or less and to compare epidemiological data for familial and sporadic cases. We attempted to identify all patients with Type ...

journal_title：Diabetologia

authors： Pociot F,Nørgaard K,Hobolth N,Andersen O,Nerup J

更新日期：1993-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The main objective of this work was to discover new drugs that can activate the differentiation of multipotent pancreatic progenitors into endocrine cells. METHODS:In vitro experiments were performed using fetal pancreatic explants from rats and mice. In this assay, we examined the actions on pancreati...

journal_title：Diabetologia

authors： Zertal-Zidani S,Busiah K,Edelman A,Polak M,Scharfmann R

更新日期：2013-02-01 00:00:00

abstract：:Under strict balance conditions we studied the effect of phenformin in 5 patients with diabetes mellitus. In all cases phenformin lowered the blood glucose values, and all patients showed a reduction of glycosuria. Contrary to other reports body weight increased during phenformin treatment. This was accompanied by pos...

journal_title：Diabetologia

authors： Geldermans CA,Terpstra J,Krans HM

更新日期：1975-10-01 00:00:00

abstract：:Circulating somatomedin-C/insulin-like growth factor-I levels are low in the diabetic rat and unresponsive to exogenous growth hormone. However, the nature of this defect in growth hormone action remains unclear and there is little data on insulin-like growth factor-I gene expression in response to other stimuli and i...

journal_title：Diabetologia

authors： Murphy LJ

更新日期：1988-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-alcoholic fatty liver disease (NAFLD) is common in type 2 diabetes but it is unknown whether NAFLD is prevalent in European women at risk of type 2 diabetes. We studied the prevalence of, and risk factors for, NAFLD in European women with previous gestational diabetes (GDM) at high risk of type 2 di...

journal_title：Diabetologia

authors： Forbes S,Taylor-Robinson SD,Patel N,Allan P,Walker BR,Johnston DG

更新日期：2011-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the action of the glucose-lowering compound sodium tungstate on glucose transport in muscle myotubes and to unravel the molecular events underlying the effects observed. METHODS:We studied the effects of tungstate on 2-deoxy-D: -glucose uptake, levels and transl...

journal_title：Diabetologia

authors： Girón MD,Sevillano N,Vargas AM,Domínguez J,Guinovart JJ,Salto R

更新日期：2008-07-01 00:00:00

abstract：:Non-obese diabetic mice aged 30 to 60 days were treated orally with Cyclosporin at doses of 25, 15 and 2.5 mg/kg every 2 days until 160 days of age. Diabetes developed in 12 out of 18 oil-treated mice (67%), with partial to complete Langerhans' islet destruction associated with lymphocytic infiltration. The non-obese ...

journal_title：Diabetologia

authors： Mori Y,Suko M,Okudaira H,Matsuba I,Tsuruoka A,Sasaki A,Yokoyama H,Tanase T,Shida T,Nishimura M

更新日期：1986-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin enhances coronary vasodilation in healthy subjects. We tested whether insulin is able to induce coronary vasodilation in Type I (insulin-dependent) diabetic mellitus patients. Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS:Myocardial blood flo...

journal_title：Diabetologia

authors： Sundell J,Laine H,Nuutila P,Rönnemaa T,Luotolahti M,Raitakari O,Knuuti J

更新日期：2002-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Serum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults. METHODS:We used data from the Coronary Arter...

journal_title：Diabetologia

authors： Chatterjee R,Colangelo LA,Yeh HC,Anderson CA,Daviglus ML,Liu K,Brancati FL

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Abnormal rheological properties of erythrocytes, leucocytes and plasma may have a role in the development of diabetic microangiopathy. We hypothesized that changed haemorrheological variables may already be found in children with onset diabetes. METHODS:Erythrocyte deformation (rheoscope), neutrophil d...

journal_title：Diabetologia

authors： Linderkamp O,Ruef P,Zilow EP,Hoffmann GF

更新日期：1999-07-01 00:00:00

abstract：:The Schwabing Insulin Prophylaxis Trial is a randomised, controlled pilot study designed to examine whether insulin therapy can delay or prevent the clinical onset of Type I diabetes in high risk first degree relatives of people with the disease. First degree relatives of patients with Type I diabetes, who were aged 4...

journal_title：Diabetologia

authors： Füchtenbusch M,Rabl W,Grassl B,Bachmann W,Standl E,Ziegler AG

更新日期：1998-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Experimental studies have suggested that apoptosis is involved in diabetic embryopathy through oxidative stress. However, the precise mechanism of diabetic embryopathy is not yet clear. Thioredoxin (TRX) is a small, ubiquitous, multifunctional protein, which has recently been shown to protect cells from...

journal_title：Diabetologia

authors： Kamimoto Y,Sugiyama T,Kihira T,Zhang L,Murabayashi N,Umekawa T,Nagao K,Ma N,Toyoda N,Yodoi J,Sagawa N

更新日期：2010-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:As one of the key adipokines, retinol binding protein 4 (RBP4) is suggested to positively correlate with insulin resistance; however, not all clinical studies support this association. Although some explanations are proposed for this discrepancy, the temporal aspect of RBP4 secretion has not been consid...

journal_title：Diabetologia

authors： Ma X,Zhou Z,Chen Y,Wu Y,Liu Y

更新日期：2016-02-01 00:00:00

abstract：:The introduction of new techniques and the access to clonal lines of insulin-secreting cells have enabled re-evaluation of glucose effects on Ca2+ movements in pancreatic beta cells. It became evident that glucose, in addition to stimulating the entry of Ca2+, also promotes active sequestration of the ion in intracell...

journal_title：Diabetologia

authors： Hellman B

更新日期：1985-08-01 00:00:00