Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes.

abstract：AIMS/HYPOTHESIS:Higher habitual coffee drinking has been associated with a lower risk of developing type 2 diabetes. The relation between coffee consumption and risk of cardiovascular disease (CVD) has been examined in many studies, but the issue remains controversial. This study was designed to assess the association ...

journal_title：Diabetologia

authors： Bidel S,Hu G,Qiao Q,Jousilahti P,Antikainen R,Tuomilehto J

更新日期：2006-11-01 00:00:00

abstract：:Potassium homeostasis during a 50-g oral glucose tolerance test was studied in 14 newly diagnosed, untreated Type 2 (non-insulin-dependent) diabetics. They showed a rise in plasma potassium from a mean +/- SEM basal of 3.9 +/- 0.1 to 4.4 +/- 0.1 mmol/l at 60 min and to 4.6 +/- 0.1 mmol/l at 90 min (p less than 0.01), ...

journal_title：Diabetologia

authors： Rosenstock J,Loizou SA,Brajkovich IE,Mashiter K,Joplin GF

更新日期：1982-03-01 00:00:00

abstract：:While the modest reduction in the primary composite outcome of myocardial infarction, stroke or cardiovascular death in the EMPA-REG Outcomes trial was welcome, the 30-40% reductions in heart failure hospitalisation (HFH) and cardiovascular and all-cause deaths in patients treated with empagliflozin were highly impres...

journal_title：Diabetologia

authors： Sattar N,McLaren J,Kristensen SL,Preiss D,McMurray JJ

更新日期：2016-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Maturity onset diabetes of the young type 3 (MODY3) is a monogenic form of diabetes mellitus caused by mutations in the gene encoding for hepatocyte nuclear factor 1 alpha, HNF1 alpha. In this study we have examined the in vivo and in vitro effects of a mutation (L107I) outside the DNA binding and dimer...

journal_title：Diabetologia

authors： Cervin C,Orho-Melander M,Ridderstråle M,Lehto M,Barg S,Groop L,Cilio CM

更新日期：2002-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:We tested the hypothesis that silent coeliac disease is more frequent than expected in both patients with Type I (insulin-dependent) diabetes mellitus and their first-degree relatives. We evaluated how the presence of other autoimmune disorders in diabetic patients and their first-degree relatives is re...

journal_title：Diabetologia

authors： Not T,Tommasini A,Tonini G,Buratti E,Pocecco M,Tortul C,Valussi M,Crichiutti G,Berti I,Trevisiol C,Azzoni E,Neri E,Torre G,Martelossi S,Soban M,Lenhardt A,Cattin L,Ventura A

更新日期：2001-02-01 00:00:00

abstract：:Regeneration of neonatal beta cells after streptozotocin (STZ)-induced destruction may be due to either replication from pre-existing intra-islet beta cells or extra-islet precursor cells. To further investigate this issue, beta-cell growth was analysed in normal and streptozotocin-treated newborn rats (100 micrograms...

journal_title：Diabetologia

authors： Wang RN,Bouwens L,Klöppel G

更新日期：1994-11-01 00:00:00

abstract：:The effects of subclinical vitamin D deficiency and vitamin D supplementation on oral glucose tolerance and secretion of pancreatic hormones were studied in 10 diphenylhydantoin-treated epileptic patients and 15 geriatric patients. Their mean serum concentrations of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 de...

journal_title：Diabetologia

authors： Nyomba BL,Auwerx J,Bormans V,Peeters TL,Pelemans W,Reynaert J,Bouillon R,Vantrappen G,De Moor P

更新日期：1986-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Urinary orosomucoid excretion rate is increased in a substantial proportion of patients with Type II (non-insulin-dependent) diabetes mellitus and normal urinary albumin excretion rate. The aim of this study was to determine whether increased urinary orosomucoid excretion rate is predictive of increased...

journal_title：Diabetologia

authors： Christiansen MS,Hommel E,Magid E,Feldt-Rasmussen B

更新日期：2002-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The islet microcirculation has morphological characteristics resembling those of renal glomeruli. Transcription of the nephrin gene, a highly specific barrier protein of the slit diaphragm of podocyte foot processes, has been reported in the pancreas, although its cellular localisation and function rema...

journal_title：Diabetologia

authors： Zanone MM,Favaro E,Doublier S,Lozanoska-Ochser B,Deregibus MC,Greening J,Huang GC,Klein N,Cavallo Perin P,Peakman M,Camussi G

更新日期：2005-09-01 00:00:00

abstract：:Isloated rat islets were maintained in vitro in a perifusion system, exposed to alloxan (20 mg/100 ml) for 5 minutes in the presence of agents which affect cAMP metabolism and subsequently stimulated with glucose. The rate of insulin secretion was monitored throughout the period of perifusion. Exposure to alloxan alon...

journal_title：Diabetologia

authors： Lacy PE,McDaniel ML,Fink CJ,Roth C

更新日期：1975-12-01 00:00:00

abstract：:Insulin secretion from pancreatic beta cells is dependent on membrane potential changes that result from the concerted regulation of multiple ion channels. Among the distinct K+ channels known to be expressed in beta cells, large conductance Ca(2+)-activated K+ channels have been suggested to play an important role in...

journal_title：Diabetologia

authors： Ferrer J,Wasson J,Salkoff L,Permutt MA

更新日期：1996-08-01 00:00:00

abstract：AIM/HYPOTHESIS:Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comorbidities are poorly ...

journal_title：Diabetologia

authors： Rouault C,Marcelin G,Adriouch S,Rose C,Genser L,Ambrosini M,Bichet JC,Zhang Y,Marquet F,Aron-Wisnewsky J,Poitou C,André S,Dérumeaux G,Guerre-Millo M,Clément K

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hypertension, obesity, impaired glucose tolerance and dyslipidaemia are metabolic abnormalities that often cluster together more often than expected by chance alone. Since these metabolic variables are highly heritable and are at least partially genetically determined, the clustering of defects in these...

journal_title：Diabetologia

authors： Chiu YF,Chuang LM,Kao HY,Ho LT,Ting CT,Hung YJ,Chen YD,Donlon T,Curb JD,Quertermous T,Hsiung CA

更新日期：2007-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proinsulin C-peptide has been implicated in reducing complications associated with diabetes and also in improving blood flow. We hypothesised that incubation of erythrocytes with C-peptide would improve the ability of these cells to release ATP, a stimulus for nitric oxide production. METHODS:Erythrocy...

journal_title：Diabetologia

authors： Meyer JA,Froelich JM,Reid GE,Karunarathne WK,Spence DM

更新日期：2008-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the action of the glucose-lowering compound sodium tungstate on glucose transport in muscle myotubes and to unravel the molecular events underlying the effects observed. METHODS:We studied the effects of tungstate on 2-deoxy-D: -glucose uptake, levels and transl...

journal_title：Diabetologia

authors： Girón MD,Sevillano N,Vargas AM,Domínguez J,Guinovart JJ,Salto R

更新日期：2008-07-01 00:00:00

abstract：AIM/HYPOTHESIS:The renin-angiotensin-aldosterone system is important in diabetic nephropathy, with the angiotensin-converting-enzyme DD-genotype being a renal risk factor. The D-allele is associated with higher ACE concentrations, but functional consequences in diabetes mellitus are not known. To analyse these conseque...

journal_title：Diabetologia

authors： Luik PT,Hoogenberg K,Kerstens MN,Beusekamp BJ,De Jong PE,Dullaart RP,Navis GJ

更新日期：2003-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine the effects of bariatric surgery on microvascular complications in patients with type 2 diabetes using objective measures. METHODS:Prospective case-control study of 70 obese surgical patients with type 2 diabetes undergoing gastric bypass surgery matched for age, sex and duration of...

journal_title：Diabetologia

authors： Miras AD,Chuah LL,Khalil N,Nicotra A,Vusirikala A,Baqai N,Graham C,Ravindra S,Lascaratos G,Oliver N,le Roux CW

更新日期：2015-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fetal growth is influenced by genetic factors as well as the intra-uterine environment. We hypothesised that some genetic factors may alter fetal insulin secretion and insulin action. SUBJECTS, MATERIALS AND METHODS:To assess this, we analysed plasma insulin concentration in umbilical cord blood from 6...

journal_title：Diabetologia

authors： Shields BM,Knight B,Turner M,Wilkins-Wall B,Shakespeare L,Powell RJ,Hannemann M,Clark PM,Yajnik CS,Hattersley AT

更新日期：2006-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...

journal_title：Diabetologia

authors： Lundqvist MH,Almby K,Wiklund U,Abrahamsson N,Kamble PG,Pereira MJ,Eriksson JW

更新日期：2020-11-26 00:00:00

abstract：:It is suggested that amylin (islet associated polypeptide), co-secreted with insulin from the pancreatic beta cells acts as a circulating hormone which opposes the action of insulin on muscle and increases hepatic glucose production. We have tested the effect of amylin in human subjects on postabsorptive glucose homeo...

journal_title：Diabetologia

authors： Wilding JP,Khandan-Nia N,Bennet WM,Gilbey SG,Beacham J,Ghatei MA,Bloom SR

更新日期：1994-02-01 00:00:00

abstract：:Hypoglycaemic sulphonamides stimulate net uptake of 45Ca++ and insulin release in isolated pancreatic islets. These effects are antagonized by organic calcium-antagonists (e.g. suloctidil). In an artificial system, hypoglycaemic sulphonamides, such as gliclazide, stimulate the translocation of calcium into or across a...

journal_title：Diabetologia

authors： Couturier E,Malaisse WJ

更新日期：1980-10-01 00:00:00

abstract：:It has been suggested that bradykinin stimulates glucose uptake in experiments in vivo and in cultured cells. However, its mechanism has not yet been fully elucidated. In this study, the effects of bradykinin on the insulin signalling pathway were evaluated in isolated dog adipocytes. The bradykinin receptor binding s...

journal_title：Diabetologia

authors： Isami S,Kishikawa H,Araki E,Uehara M,Kaneko K,Shirotani T,Todaka M,Ura S,Motoyoshi S,Matsumoto K,Miyamura N,Shichiri M

更新日期：1996-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...

journal_title：Diabetologia

authors： Yajnik CS,Joglekar CV,Lubree HG,Rege SS,Naik SS,Bhat DS,Uradey B,Raut KN,Shetty P,Yudkin JS

更新日期：2008-01-01 00:00:00

abstract：:The incorporation of [35S]sulfate into heart proteoglycans has been studied in normal and alloxan-diabetic rats by perfusion and in vivo administration of the isotope; in the latter situation, comparison was also made of radiolabeled sulfate utilization by several other tissues (kidney, liver, lung, muscle, testes and...

journal_title：Diabetologia

authors： Spiro MJ

更新日期：1987-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...

journal_title：Diabetologia

authors： Jacobs-Tulleneers-Thevissen D,Bartholomeus K,Suenens K,Vermeulen I,Ling Z,Hellemans KH,In't Veld P,Pipeleers-Marichal M,Pipeleers D

更新日期：2010-08-01 00:00:00

abstract：:The global nutrition transition, which embraces major changes in how food is produced, distributed and consumed, is associated with rapid increases in the prevalence of obesity, but the implications for diabetes differ between populations. A simple conceptual model treats diabetes risk as the function of two interacti...

journal_title：Diabetologia

authors： Wells JCK

更新日期：2019-10-01 00:00:00

abstract：:The transcription factor SOX9 is regarded as a crucial player in pancreas development, both maintaining progenitors and later being required for beta cell differentiation. However, very little is known about the possible involvement of other SOX family members in such processes. In this issue, the work of Xu et al (DO...

journal_title：Diabetologia

authors： Grapin-Botton A,Seymour PA,Gradwohl G

更新日期：2015-05-01 00:00:00

abstract：:The incidence, prevalence, and ages and dates of onset of diabetes, were studied in 184 families with 2 or more affected children. Results suggested that the siblings of children who developed diabetes before the age of 16 years were 26 times more likely to develop diabetes than other children. Of all siblings surveye...

journal_title：Diabetologia

authors： Gamble DR

更新日期：1980-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cre-loxP systems are frequently used in mouse genetics as research tools for studying tissue-specific functions of numerous genes/proteins. However, the expression of Cre recombinase in a tissue-specific manner often produces undesirable changes in mouse biology that can confound data interpretation whe...

journal_title：Diabetologia

authors： Al Batran R,Gopal K,Martin MD,Ho KL,Almutairi M,Aburasayn H,Eaton F,Campbell JE,Ussher JR

更新日期：2018-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes mellitus is associated with reduced incretin effects. Although previous studies have shown that hyperglycaemia contributes to impaired incretin responses in beta cells, it is largely unknown how hyperlipidaemia, another feature of type 2 diabetes, contributes to impaired glucagon-like pe...

journal_title：Diabetologia

authors： Kang ZF,Deng Y,Zhou Y,Fan RR,Chan JC,Laybutt DR,Luzuriaga J,Xu G

更新日期：2013-02-01 00:00:00