Abstract:
:Light and electron microscopic studies of diploid, tetraploid and octaploid B-cells in the islets of normal C57BL/KsJ mice revealed that polyploid cells were characterized by a wider range of granulated states than diploid B-cells. The maximum granule densities were similar for polyploid and diploid cells; however, some polyploid cells were almost devoid of granules, while the least granulated diploid cells contained intermediate granule densities. The tetraploid cell also appeared to be characterized by an increased mitochondrial stage which suggests compensation for the greater degree of degranulation. These observations were confirmed by morphometric analysis. Two interpretations of the apparent polyploidy are discussed; that polyploid B-cells may be more responsive to insulin releasing stimuli than diploid B-cells and that tetraploid cells may only be diploid cells in the G2 phase of the mitotic cycle.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Bowen RE,Swartz FJdoi
10.1007/BF00428985subject
Has Abstractpub_date
1976-05-01 00:00:00pages
171-80issue
2eissn
0012-186Xissn
1432-0428journal_volume
12pub_type
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