Surface binding, internalization and degradation by cultured human fibroblasts of low density lipoproteins isolated from type 1 (insulin-dependent) diabetic patients: changes with metabolic control.

abstract：:The prevalence of diabetes mellitus in 3,145 Tanzanian Africans living in three different areas of the country was studied. Fasting capillary blood glucose concentrations were measured by Dextrometer and if the levels were greater than or equal to 5.5 mmol/l an oral glucose tolerance test was performed. When using the...

journal_title：Diabetologia

authors： Ahrén B,Corrigan CB

更新日期：1984-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fractal analysis of the retinal vasculature provides a global measure of the complexity and density of retinal vessels summarised as a single variable: the fractal dimension. We investigated fractal dimensions as long-term predictors of microvasculopathy in type 1 diabetes. METHODS:We included 180 pati...

journal_title：Diabetologia

authors： Broe R,Rasmussen ML,Frydkjaer-Olsen U,Olsen BS,Mortensen HB,Peto T,Grauslund J

更新日期：2014-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Individuals with diabetes have increased mortality rates compared with the general population. In patients with type 2 diabetes depression further contributes to the increased mortality. Depression and mortality rates in patients with type 1 diabetes are an understudied phenomenon. We therefore studied ...

journal_title：Diabetologia

authors： Ahola AJ,Harjutsalo V,Saraheimo M,Forsblom C,Groop PH,FinnDiane Study Group.

更新日期：2012-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. We hypothesised that mannan-binding lectin (MBL) deficiency may confer risk of obesity and insulin resistance. MATERIALS AND METHODS:We performed a cross-sectional study of MBL protein concentratio...

journal_title：Diabetologia

authors： Fernández-Real JM,Straczkowski M,Vendrell J,Soriguer F,Pérez Del Pulgar S,Gallart L,López-Bermejo A,Kowalska I,Manco M,Cardona F,García-Gil MM,Mingrone G,Richart C,Ricart W,Zorzano A

更新日期：2006-10-01 00:00:00

abstract：:We have suggested that the order of cellular vascular perfusion within the islet is important in the regulation of islet hormone secretion. Anatomically, the A and D cells appear to be randomly dispersed throughout the mantle. Although islet capillary blood flow is known to be from the B-cell core to the A- and D-cell...

journal_title：Diabetologia

authors： Stagner JI,Samols E,Marks V

更新日期：1989-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The receptor for AGEs (RAGE) contributes to the development and progression of diabetic nephropathy. In this study, we examined whether the protective effects of RAGE blockade are exerted via modulation of the renal angiotensin II type 2 (AT2) receptor. METHODS:Control and streptozotocin diabetic mice,...

journal_title：Diabetologia

authors： Sourris KC,Morley AL,Koitka A,Samuel P,Coughlan MT,Penfold SA,Thomas MC,Bierhaus A,Nawroth PP,Yamamoto H,Allen TJ,Walther T,Hussain T,Cooper ME,Forbes JM

更新日期：2010-11-01 00:00:00

abstract：:Highly purified insulins offer the possibility of reducing insulin antibody levels and insulin requirement. Those likely to respond cannot be predicted on clinical grounds and a simple laboratory test is recommended for this purpose. This is based on insulin binding capacity (IBC) of plasma and has been used to follow...

journal_title：Diabetologia

authors： Mustaffa BE,Daggett PR,Nabarro JD

更新日期：1977-08-01 00:00:00

abstract：:In the present study we investigated whether glomerular hyperfiltration and albuminuria in streptozotocin-induced diabetic nephropathy in male Wistar-Münich rats are associated with changes in the heparan sulphate content of the glomerular basement membrane. Rats with a diabetes mellitus duration of 8 months, treated ...

journal_title：Diabetologia

authors： van den Born J,van Kraats AA,Bakker MA,Assmann KJ,van den Heuvel LP,Veerkamp JH,Berden JH

更新日期：1995-02-01 00:00:00

abstract：:The involvement of the CNS in pancreatic hormone release has been studied. 1.) It has been shown that one source of vagal efferent fibers capable of facilitating insulin secretion originated in the rostral half of the nucleus ambiguus. 2.) Acute lesions of the ventromedial hypothalamus resulted in hyperinsulinaemia th...

journal_title：Diabetologia

authors： Bereiter DA,Rohner-Jeanrenaud F,Berthoud H-,Jeanrenaud B

更新日期：1981-03-01 00:00:00

abstract：:A differing individual expression of fructosyllysine-specific receptors has been found on the monocytes of 90 insulin-dependent diabetic patients and 101 healthy control subjects. The degree of receptor expression is neither age- nor sex-dependent; however, in the diabetic group it correlates significantly with the se...

journal_title：Diabetologia

authors： Brandt R,Landmesser C,Vogt L,Hehmke B,Hanschke R,Kasbohm J,Hartmann K,Jäger B,Krantz S,Michaelis D

更新日期：1996-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:According to the consensus criteria developed for type 1 diabetes, an individual can be diagnosed with insulitis when ≥ 15 CD45+ cells are found within the parenchyma or in the islet-exocrine interface in ≥ 3 islets. The aim of this study was to determine the frequency of individuals with type 2 diabete...

journal_title：Diabetologia

authors： Lundberg M,Seiron P,Ingvast S,Korsgren O,Skog O

更新日期：2017-02-01 00:00:00

abstract：:Plasma immunoreactive secretin and insulin concentrations were measured in fasting normal humans after intraduodenal infusions of hydrochloric acid, isotonic or hypertonic glucose. The effect of intraduodenal acidification or intravenous bolus injections of secretin on plasma insulin concentrations during infusions of...

journal_title：Diabetologia

authors： Fahrenkrug J,Schaffalitzky de Muckadell OB,Kühl C

更新日期：1978-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. METHODS:A case-cohort study within the European Pros...

journal_title：Diabetologia

authors： Wittenbecher C,Kuxhaus O,Boeing H,Stefan N,Schulze MB

更新日期：2019-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sleep loss is associated with insulin resistance and an increased risk for type 2 diabetes, yet underlying mechanisms are not understood. Elevation of circulating non-esterified (i.e. free) fatty acid (NEFA) concentrations can lead to insulin resistance and plays a central role in the development of met...

journal_title：Diabetologia

authors： Broussard JL,Chapotot F,Abraham V,Day A,Delebecque F,Whitmore HR,Tasali E

更新日期：2015-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is characterised by morphological lesions related to disturbances in retinal blood flow. It has previously been shown that the early development of retinal lesions temporal to the fovea may predict the development of treatment-requiring diabetic maculopathy. The aim of this study wa...

journal_title：Diabetologia

authors： Ometto G,Assheton P,Calivá F,Chudzik P,Al-Diri B,Hunter A,Bek T

更新日期：2017-12-01 00:00:00

abstract：:Since glucose control and glycosylated haemoglobin varies asyncroneously, we have studied the steady-state relationship between these two factors. In Type 1 (insulin-dependent) diabetic patients with a constant haemoglobin A1c during the preceding 2 years, 15 ambulatory blood glucose profiles during a 5-week period sh...

journal_title：Diabetologia

authors： Svendsen PA,Lauritzen T,Søegaard U,Nerup J

更新日期：1982-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study compared the incidence rate of type 1 diabetes in children diagnosed with enterovirus (EV) infections with that in age- and sex-matched children without EV infection in a population-based cohort. In addition, we examined whether the direction or magnitude of the association between EV infecti...

journal_title：Diabetologia

authors： Lin HC,Wang CH,Tsai FJ,Hwang KP,Chen W,Lin CC,Li TC

更新日期：2015-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Clinical trials are in progress to test thiazolidinediones in neurodegenerative diseases such as Alzheimer's disease that involve deficiencies in brain glucose metabolism. While thiazolidinediones enhance glucose uptake in non-cerebral tissues, their impact on brain energy metabolism has not been invest...

journal_title：Diabetologia

authors： Galea E,Feinstein DL,Lacombe P

更新日期：2006-09-01 00:00:00

abstract：:Diabetes mellitus in Macaca mulatta rhesus monkeys is preceded by phases of obesity and hyperinsulinaemia and is similar to Type 2 (non-insulin-dependent) diabetes mellitus in man. To relate the progression of the disease to quantitative changes in islet morphology, post-mortem pancreatic tissue from 26 monkeys was ex...

journal_title：Diabetologia

authors： de Koning EJ,Bodkin NL,Hansen BC,Clark A

更新日期：1993-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to assess whether persistence of C-peptide secretion is associated with less glucose variability and fewer low-glucose events in adults with type 1 diabetes who use flash monitoring. METHODS:We performed a cross-sectional study of 290 adults attending a university teaching hospital diabetes cl...

journal_title：Diabetologia

authors： Gibb FW,McKnight JA,Clarke C,Strachan MWJ

更新日期：2020-05-01 00:00:00

abstract：:D600 (2 to 20 muM; alpha-isopropyl-alpha [(N-methyl-N-homoveratril)-gamma-aminopropyl]-3,4,5-trimethoxyphenyl-acetonitril) caused a dose-related, rapid and reversible inhibition of glucose-induced insulin release. It also suppressed the insulinotropic action of a sulphonylurea but failed to affect the enhancing action...

journal_title：Diabetologia

authors： Malaisse WJ,Devis G,Pipeleers DG,Somers G

更新日期：1976-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The AERx insulin Diabetes Management system (AERx iDMS) is a liquid aerosol device that enables insulin to be administered to the peripheral parts of the lung. This study aimed to compare the pharmacokinetic and pharmacodynamic properties of insulin which is inhaled using AERx iDMS with insulin which is...

journal_title：Diabetologia

authors： Brunner GA,Balent B,Ellmerer M,Schaupp L,Siebenhofer A,Jendle JH,Okikawa J,Pieber TR

更新日期：2001-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Intensive glucose control reduces the risk of vascular complications while increasing the risk of severe hypoglycaemia at a group level. We sought to estimate individual beneficial and adverse effects of intensive glucose control in patients with type 2 diabetes. METHODS:We performed a post hoc analysi...

journal_title：Diabetologia

authors： van der Leeuw J,Visseren FL,Woodward M,van der Graaf Y,Grobbee DE,Harrap S,Heller S,Mancia G,Marre M,Poulter N,Zoungas S,Chalmers J

更新日期：2016-12-01 00:00:00

abstract：:The accumulation of noradrenaline in constricted sciatic nerves was measured in 6 month diabetic rats (streptozotocin 35 mg/kg) and 4 day diabetic rats (streptozotocin 70 mg/kg) together with two groups of age-matched control animals. There was no alteration in the amount of noradrenaline accumulated in the nerves of ...

journal_title：Diabetologia

authors： Tomlinson DR,Gillon KR,Smith MG

更新日期：1982-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the signalling processes and metabolic actions of BDNF. METHODS:We first examined whether exercise induced BDNF expression in humans. Next, C2C12 skeletal muscle ce...

journal_title：Diabetologia

authors： Matthews VB,Aström MB,Chan MH,Bruce CR,Krabbe KS,Prelovsek O,Akerström T,Yfanti C,Broholm C,Mortensen OH,Penkowa M,Hojman P,Zankari A,Watt MJ,Bruunsgaard H,Pedersen BK,Febbraio MA

更新日期：2009-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies in East Asian populations reported that single nucleotide polymorphisms (SNPs) in KCNQ1 are associated with type 2 diabetes. The aim of this study was to validate this finding in a Chinese population. METHODS:We genotyped four SNPs, rs2074196, rs2237892, rs2237895...

journal_title：Diabetologia

authors： Hu C,Wang C,Zhang R,Ma X,Wang J,Lu J,Qin W,Bao Y,Xiang K,Jia W

更新日期：2009-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We previously reported the...

journal_title：Diabetologia

authors： Joshi K,Elso C,Motazedian A,Labonne T,Schiesser JV,Cameron F,Mannering SI,Elefanty AG,Stanley EG

更新日期：2019-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the current study, the effect of a highly specific peptide inhibitor of glycogen synthase kinase 3 (GSK3) (L803-mts) on glucose metabolism and BP was examined in a high-fat (HF) fed mouse model of diabetes. METHODS:C57/BL6J mice were placed on an HF diet for 3 months and treated with L803-mts for 20...

journal_title：Diabetologia

authors： Rao R,Hao CM,Redha R,Wasserman DH,McGuinness OP,Breyer MD

更新日期：2007-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:This multicentre randomised double-blind placebo-controlled clinical trial assessed the efficacy and safety of a methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib, in individuals with obesity (BMI ≥30 kg/m2) and type 2 diabetes (HbA1c 53-97 mmol/mol [7-11%] and fasting glucose <15.6 mmol/l). ME...

journal_title：Diabetologia

authors： Proietto J,Malloy J,Zhuang D,Arya M,Cohen ND,de Looze FJ,Gilfillan C,Griffin P,Hall S,Nathow T,Oldfield GS,O'Neal DN,Roberts A,Stuckey BGA,Yue D,Taylor K,Kim D

更新日期：2018-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the UK, more than one million people have undiagnosed diabetes and an additional five million are at high risk of developing the disease. Given that early identification of these people is key for both primary and secondary prevention, new screening approaches are needed. Since spouses resemble each ...

journal_title：Diabetologia

authors： Nielsen J,Hulman A,Witte DR

更新日期：2018-07-01 00:00:00