Abstract:
AIMS/HYPOTHESIS:Decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. We hypothesised that mannan-binding lectin (MBL) deficiency may confer risk of obesity and insulin resistance. MATERIALS AND METHODS:We performed a cross-sectional study of MBL protein concentration (n=434) and MBL2 gene mutations (exon 1) (n=759) in association with obesity, markers of inflammation and insulin action (euglycaemic clamp, n=113), and a longitudinal study of MBL protein before and after weight loss in obese patients (n=10). We also studied the effects of MBL in vitro in muscle cells and circulating MBL-A (mouse equivalent of human MBL) in a mouse model. RESULTS:Among 434 consecutive non-diabetic men, the age-adjusted serum MBL concentration was lower in obese subjects than in lean subjects (median: 959 microg/ml [interquartile range: 116.8-2,044 microg/ml] vs 1,365 [467-2,513] microg/ml; p=0.01) and was accompanied by increased serum inflammatory markers. Insulin action correlated significantly with serum MBL (r=0.49, p<0.0001). Serum MBL concentration increased by a median of 110.2% after weight loss. The change in serum concentration of MBL was positively associated with the increase in insulin sensitivity (r=0.713, p=0.021). At least one MBL2 gene mutation was present in 48.2% of obese vs 39.3% of non-obese subjects (p=0.037). The plasma concentration of MBL-A was lower in insulin-resistant obese ob/ob mice, as was the glucose/insulin ratio. Incubation of rat soleus muscle with human MBL markedly increased fatty acid oxidation. CONCLUSIONS/INTERPRETATION:These findings suggest that MBL, previously thought only to be involved in inflammation and immune system function, affects metabolic pathways.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Fernández-Real JM,Straczkowski M,Vendrell J,Soriguer F,Pérez Del Pulgar S,Gallart L,López-Bermejo A,Kowalska I,Manco M,Cardona F,García-Gil MM,Mingrone G,Richart C,Ricart W,Zorzano Adoi
10.1007/s00125-006-0381-6subject
Has Abstractpub_date
2006-10-01 00:00:00pages
2402-11issue
10eissn
0012-186Xissn
1432-0428journal_volume
49pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:An isoform of glutamic acid decarboxylase, (GAD)65 has been identified as a pancreatic beta-cell autoantigen in Type I (insulin dependent) diabetes mellitus. We investigated the expression of GAD isoforms among single rat beta cells in culture, under different conditions and the correlation between GAD6...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051275
更新日期:1999-09-01 00:00:00
abstract::At St. Mary's Hospital Medical School in London, 22 outpatients, 21 women and 1 man, underwent oral glucose tolerance tests. Carbohydrate intake was standardized for 3 days prior to each test. 13 of the women were on oral contraceptive therapy of the combination type. Tests were performed either at 9 AM after a fas...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219788
更新日期:1973-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hIPSCs) offer unique opportunities for regenerative medicine and for the study of mammalian development. However, developing methods to differentiate hESCs/hIPSCs into specific cell types following a natural pathway of developm...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2687-x
更新日期:2012-12-01 00:00:00
abstract::The 10-year follow-up of the Munich General Practitioner Project was designed as a long-term prospective study to evaluate factors predicting macrovascular and overall mortality in a random cohort of non-insulin-dependent diabetic (NIDDM) patients. Of the original 290 patients (103 males, 187 females, median age 65 ye...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050612
更新日期:1996-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:This study aimed to explore the infancy growth trajectories of 'recent' and 'earlier' offspring of mothers with gestational diabetes mellitus (OGDM), each compared with the same control infants, and investigate whether 'recent' OGDM still exhibit a classical phenotype, with macrosomia and increased adip...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-4970-6
更新日期:2019-11-01 00:00:00
abstract::Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00587632
更新日期:1991-08-01 00:00:00
abstract::We examined glomerular basement membrane anionic site distribution identified by cationic gold in seven patients with insulin-dependent and four patients with non-insulin-dependent diabetes mellitus, presenting a spectrum of clinical and glomerular changes. Anionic sites were investigated by pretreatment of tissue wit...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400607
更新日期:1995-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The glomerular endothelial layer is coated by the endothelial surface layer (ESL), which is suggested to play a role in regulation of the permselectivity of macromolecules. Production of heparanase, a degrading enzyme of the ESL, is induced by reactive oxygen species (ROS). We hypothesised that oxidativ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1810-0
更新日期:2010-09-01 00:00:00
abstract::We have suggested that the order of cellular vascular perfusion within the islet is important in the regulation of islet hormone secretion. Anatomically, the A and D cells appear to be randomly dispersed throughout the mantle. Although islet capillary blood flow is known to be from the B-cell core to the A- and D-cell...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00265095
更新日期:1989-03-01 00:00:00
abstract::The impact of improved glycaemic control on renal function in newly-presenting Type 2 (non-insulin-dependent) diabetic patients has not been adequately researched. Consequently, glomerular filtration rate and effective renal plasma flow and urinary albumin excretion rates were determined in 76 subjects (age (mean (SD)...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00401144
更新日期:1993-08-01 00:00:00
abstract::Plasma corticosterone concentrations in diabetic (db) mice maintained on two different inbred backgrounds were found to be elevated significantly when compared to normal controls. These data are similar to that reported with the phenotypically similar obese (ob) mouse. These results suggest that the hyperadrenolcortic...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00996323
更新日期:1977-01-01 00:00:00
abstract::In the present study the antepartum relationship between maternal diabetic glucose control and fetal hypoxaemia was examined in 44 Type 1 (insulin-dependent) diabetic and 23 non-diabetic control pregnancies. Maternal HbA1C was used to assess maternal integrated blood glucose control while fetal metabolic control was e...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404643
更新日期:1990-06-01 00:00:00
abstract::It is suggested that amylin (islet associated polypeptide), co-secreted with insulin from the pancreatic beta cells acts as a circulating hormone which opposes the action of insulin on muscle and increases hepatic glucose production. We have tested the effect of amylin in human subjects on postabsorptive glucose homeo...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s001250050088
更新日期:1994-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes. METHODS:Adult male Akita mice (12 weeks old) were treated with insu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2910-4
更新日期:2013-07-01 00:00:00
abstract::Insulin resistance is a significant pathogenetic factor in the development of non-insulin-dependent diabetes mellitus (NIDDM). A new class of drugs, the thiazolidinediones, have been shown to lower blood glucose levels without stimulating insulin secretion. We report the metabolic effect of the thiazolidinedione, darg...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/BF00401763
更新日期:1995-11-01 00:00:00
abstract::Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rats. After 6 weeks of...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00399794
更新日期:1994-12-01 00:00:00
abstract::Glycation of long-lived proteins is an inevitable consequence of aging that is accelerated in patients with diabetes mellitus. Treatment of demineralized bone matrix particles from 35-week-old normal Long-Evans rats with glycoaldehyde, a precursor of advanced glycation end-products, was used to assess the effects of b...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400353
更新日期:1993-09-01 00:00:00
abstract::The effect of interference with diacylglycerol metabolism was investigated in pancreatic mouse islets. In the presence of the diacylglycerol lipase inhibitor RHC 80,267, glucose-induced insulin secretion was reduced 50-60%; whereas carbacholin-induced insulin secretion was unaffected. Addition of the diacylglycerol ki...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00505183
更新日期:1989-02-01 00:00:00
abstract:AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0841-7
更新日期:2008-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:African-Americans with type 2 diabetes and access to adequate healthcare are at lower risk of clinical coronary artery disease than are white diabetic patients. We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0017-2
更新日期:2005-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The relevance of the OGTT in predicting type 2 diabetes is unclear. We assessed the performance of 14 OGTT glucose traits in type 2 diabetes prediction. METHODS:We studied 2,603 and 2,386 Europeans from the Botnia study and Malmö Prevention Project (MPP) cohorts with baseline OGTT data. Over a follow-u...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3390-x
更新日期:2015-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The effect of renin inhibition on type 2 diabetes is still unclear. The present study was undertaken to examine the efficacy of aliskiren, a direct renin inhibitor, on cardiovascular injuries, glucose intolerance and pancreatic injury in a mouse model of type 2 diabetes. METHODS:Groups of db/db mice, w...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1575-5
更新日期:2010-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin resistance is linked with a cluster of multiple risk factors and excessive acceleration of atherosclerosis. The underlying mechanism is not, however, fully understood. METHODS:To determine the link between insulin resistance and altered vascular function, we focused on the effect of various non...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051668
更新日期:2001-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:In early type 1 diabetes mellitus, renal salt handling is dysregulated, so that the glomerular filtration rate becomes inversely proportional to salt intake. The salt paradox occurs in both humans and rats and, with low salt intake, results in diabetic hyperfiltration. We tested whether increased salt i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2569-2
更新日期:2012-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to examine whether impaired glucose tolerance is associated with reduced suppression of glucagon concentrations. METHODS:Eighty-four non-diabetic women of Caucasian origin and 61 years of age, of whom 48 had normal glucose tolerance (NGT) and 36 had IGT, underwent a 75 g OGTT and a hyperinsuli...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250100003
更新日期:2001-11-01 00:00:00
abstract::There is now evidence that a single bout of endurance (aerobic) or resistance exercise reduces 24 h post-exercise subcutaneous glucose profiles to the same extent in insulin-resistant humans with or without type 2 diabetes. However, it remains to be determined which group would benefit most from specific exercise prot...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-012-2513-5
更新日期:2012-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Obesity is a major risk factor for type 2 diabetes. Recent genome-wide association (GWA) studies have identified multiple loci robustly associated with BMI and risk of obesity. However, information on their associations with type 2 diabetes is limited. Such information could help increase our understand...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2044-5
更新日期:2011-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Our aim was to assess regression of albuminuria and its clinical consequences in type 1 diabetes. METHODS:The analysis included 3642 participants from the Finnish Diabetic Nephropathy (FinnDiane) Study with a 24 h urine sample and a history of albuminuria available at baseline. A total of 2729 individu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4564-8
更新日期:2018-05-01 00:00:00
abstract::Of 89 pancreas transplants performed in 77 diabetic patients (43 with and 34 without previous kidney transplants), 53 were from cadaver and 36 from related donors. To date, 64 patients (83%) are alive and 27 (35%) have functioning grafts (14 greater than 1 year), including 0 out of 3 duct-ligated, 3 out of 15 open-duc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00275675
更新日期:1984-07-01 00:00:00
abstract::Over a century ago, inquisitive physicians made remarkable discoveries regarding pancreatic pathology in individuals with diabetes, including those who were likely afflicted with the type 1 (autoimmune) form of the disease. Those studies of post-mortem tissues noted unique anatomical changes in islet architecture as w...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-013-3159-7
更新日期:2014-04-01 00:00:00