Abstract:
:At St. Mary's Hospital Medical School in London, 22 outpatients, 21 women and 1 man, underwent oral glucose tolerance tests. Carbohydrate intake was standardized for 3 days prior to each test. 13 of the women were on oral contraceptive therapy of the combination type. Tests were performed either at 9 AM after a fast from 10 PM the previous night or at 3 PM after only a light dry breakfast. In the total group, glucose tolerance was found to be impaired in the PM, significant differences (p less than .05 or better) from the AM obtained at 60-150 minutes after glucose. Accompanying the general trend of glucose tolerance impairment in the PM was the finding of delayed and impaired insulin secretion in the PM, the AM and PM values reaching statistically significant differences at 30, 60, and 120 minutes (p less than .05). Measurements of growth hormone indicate fluctuations of this parameter are unlikely to be the cause of the diurnal fluctuations of glucose tolerance. No evidence was obtained to show the impaired carbohydrate tolerance of women on oral contraceptives is due to loss of diurnal rhythm, their pattern of AM and PM tests being very similar to the pattern of the total group. In general, then, the mild abnormalities of the AM tests of oral contraceptors are likely to be exaggerated in the PM tests. It is still undetermined whether the degree of chemical diabetes occurring is harmful to the asymptomatic pill user. The hypothesis that obese subjects lose diurnal rhythm, showing similar AM and PM results, was borne out (p less than .01).
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Oakley NW,Monier D,Wynn Vdoi
10.1007/BF01219788subject
Has Abstractpub_date
1973-06-01 00:00:00pages
235-8issue
3eissn
0012-186Xissn
1432-0428journal_volume
9pub_type
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