Sulfate metabolism in the alloxan-diabetic rat: relationship of altered sulfate pools to proteoglycan sulfation in heart and other tissues.

abstract：:Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points for mature islet functionality, understanding biological variatio...

journal_title：Diabetologia

authors： Arrojo E Drigo R,Roy B,MacDonald PE

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mitochondrial oxidative phosphorylation (OXPHOS) plays an important role in the pathophysiology of type 2 diabetes. Genes involved in OXPHOS have been reported to be down-regulated in skeletal muscle from patients with type 2 diabetes; however, hepatic regulation is unknown. MATERIALS AND METHODS:We an...

journal_title：Diabetologia

authors： Misu H,Takamura T,Matsuzawa N,Shimizu A,Ota T,Sakurai M,Ando H,Arai K,Yamashita T,Honda M,Yamashita T,Kaneko S

更新日期：2007-02-01 00:00:00

abstract：:The basal energy expenditure of 10 Type 1 (insulin-dependent) C-peptide-negative diabetic patients (2042 +/- 62 kcal/24 h) was found to be significantly higher than the 1774 +/- 52 kcal/24 h predicted from their age, sex and body surface area (p less than 0.01). Intravenous insulin treatment significantly reduced ener...

journal_title：Diabetologia

authors： Nair KS,Halliday D,Garrow JS

更新日期：1984-07-01 00:00:00

abstract：:Plasma glucose control and arterial pressure were assessed in 28 Type 1 (insulin-dependent) diabetic patients with different degrees of micro-albuminuria. They were divided into two groups according to their urinary albumin excretion rate: a low micro-albuminuria group (n = 16) with albumin excretion ranging between 1...

journal_title：Diabetologia

authors： Wiseman M,Viberti G,Mackintosh D,Jarrett RJ,Keen H

更新日期：1984-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to study the incidence of Type I diabetes in 4 countries, Estonia, Latvia, Lithuania and Finland, during 1983-1998, focusing on the two separate periods of 1983-1990 and 1991-1998. METHODS:Population-based incidence data from nationwide diabetes registries were used. Crude and age-standardized...

journal_title：Diabetologia

authors： Podar T,Solntsev A,Karvonen M,Padaiga Z,Brigis G,Urbonaite B,Viik-Kajander M,Reunanen A,Tuomilehto J

更新日期：2001-10-01 00:00:00

abstract：:Data are discussed which demonstrate that insulin plays an important role in sodium metabolism. The primary action of insulin on sodium balance is exerted on the kidney. Increases in plasma insulin concentration within the physiological range stimulate sodium reabsorption by the distal nephron segments and this effect...

journal_title：Diabetologia

authors： DeFronzo RA

更新日期：1981-09-01 00:00:00

abstract：:The presence of HLA-DR 3 was analysed in 745 patients with Type 1 (insulin-dependent) diabetes with age at diagnosis between 1-19 years. HLA-DR 3 and/or 4 was found in 678/745 (91%) of the patients. Presence of DR2 with neither DR 3 nor 4 was demonstrated in 15 patients. Patients with HLA-DR 3 without DR 4 presented w...

journal_title：Diabetologia

authors： Ludvigsson J,Samuelsson U,Beauforts C,Deschamps I,Dorchy H,Drash A,Francois R,Herz G,New M,Schober E

更新日期：1986-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is frequently associated with hypertension and type 2 diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the direct contribution of e...

journal_title：Diabetologia

authors： Gangadhariah MH,Dieckmann BW,Lantier L,Kang L,Wasserman DH,Chiusa M,Caskey CF,Dickerson J,Luo P,Gamboa JL,Capdevila JH,Imig JD,Yu C,Pozzi A,Luther JM

更新日期：2017-06-01 00:00:00

abstract：:Severe microvascular disease exists at the stage of clinical diabetic neuropathy. A non-invasive test that will identify those diabetic subjects who will eventually develop neuropathy is essential for early intervention. Sural sensory conduction velocity was recorded (x3) in 12 non-neuropathic diabetic subjects, 15 di...

journal_title：Diabetologia

authors： Tesfaye S,Harris ND,Wilson RM,Ward JD

更新日期：1992-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is linked with a cluster of multiple risk factors and excessive acceleration of atherosclerosis. The underlying mechanism is not, however, fully understood. METHODS:To determine the link between insulin resistance and altered vascular function, we focused on the effect of various non...

journal_title：Diabetologia

authors： Yu HY,Inoguchi T,Kakimoto M,Nakashima N,Imamura M,Hashimoto T,Umeda F,Nawata H

更新日期：2001-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is significantly upregulated in the serum of individuals with obesity and diabetes. However, whether elevated PEDF levels contribute to DMED remains unknown. This stu...

journal_title：Diabetologia

authors： Che D,Fang Z,Yan L,Du J,Li F,Xie J,Feng J,Yin P,Qi W,Yang Z,Ma J,Yang X,Gao G,Zhou T

更新日期：2020-09-01 00:00:00

abstract：:The adrenergic regulation of adipose tissue lipolysis in response to insulin-induced hypoglycaemia (intravenous infusion of soluble insulin 0.10 IU.kg body weight-1.h-1 until the arterial plasma glucose fell below 2.8 mmol/l) was investigated directly in vivo in 11 insulin-dependent diabetic (IDDM) patients and 12 con...

journal_title：Diabetologia

authors： Bolinder J,Sjöberg S,Arner P

更新日期：1996-07-01 00:00:00

abstract：:To determine whether increased oxidative stress in diabetes mellitus is due to an impaired free-radical scavenger function in endothelial cells, GSH-dependent H2O2 degradation in human umbilical vein endothelial cells was studied. The GSH-dependent, NaN3-uninhibitable H2O2-degradation in endothelial cells was reduced ...

journal_title：Diabetologia

authors： Kashiwagi A,Asahina T,Ikebuchi M,Tanaka Y,Takagi Y,Nishio Y,Kikkawa R,Shigeta Y

更新日期：1994-03-01 00:00:00

abstract：:75,375 males called to military service were screened to discover the incidence of hypertrophic pyloric stenosis. 49 men gave a history of previous surgery for this condition and were given a 45 g/m2 oral glucose tolerance test. Fourteen had impaired glucose tolerance. In no case was there a family history of diabetes...

journal_title：Diabetologia

authors： Chimènes H,Gautier D,Bon R,Fromantin M

更新日期：1980-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR) P446L variant, associated with inverse modulation of glucose- and lipid-related traits, has been shown to alter the kinetics of glucokinase (GCK) i...

journal_title：Diabetologia

authors： Rees MG,Wincovitch S,Schultz J,Waterstradt R,Beer NL,Baltrusch S,Collins FS,Gloyn AL

更新日期：2012-01-01 00:00:00

abstract：:A method has been developed for the purification of single A, B and D cells and for the isolation of coupled islet cells. Isolated rat islets were dissociated by repeated pipetting in the presence of trypsin and ethylene glycol bis (beta-aminoethyl ether) N,N' tetra-acetic acid (EGTA), and then filtered through nylon ...

journal_title：Diabetologia

authors： Pipeleers DG,Pipeleers-Marichal MA

更新日期：1981-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-g...

journal_title：Diabetologia

authors： Rönn T,Poulsen P,Hansson O,Holmkvist J,Almgren P,Nilsson P,Tuomi T,Isomaa B,Groop L,Vaag A,Ling C

更新日期：2008-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Growth hormone hypersecretion in Type 1 diabetes could exacerbate insulin resistance and contribute to declining glycaemic control. Our aim was to determine the effects of specific growth hormone blockade on insulin sensitivity and lipolysis in young adults with Type 1 diabetes. METHODS:We studied the ...

journal_title：Diabetologia

authors： Williams RM,Amin R,Shojaee-Moradie F,Umpleby AM,Acerini CL,Dunger DB

更新日期：2003-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS:In this single-centre, double-blind, placebo-controlled, ...

journal_title：Diabetologia

authors： Kapitza C,Dahl K,Jacobsen JB,Axelsen MB,Flint A

更新日期：2017-08-01 00:00:00

abstract：:In diabetic nephropathy, expression of glycosaminoglycan side chains of heparan sulphate proteoglycan in the glomerular basement membrane is reduced proportionally to the degree of proteinuria. We performed a cross-sectional study to evaluate whether non-vascular basement membranes also show a decrease in heparan sulp...

journal_title：Diabetologia

authors： van der Pijl JW,Daha MR,van den Born J,Verhagen NA,Lemkes HH,Bucala R,Berden JH,Zwinderman AH,Bruijn JA,van Es LA,van der Woude FJ

更新日期：1998-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glutamic acid decarboxylase autoantibodies (GADA) are the most frequent beta-cell-specific autoantibodies in type 1 diabetes and in latent autoimmune diabetes in adults (LADA). The autoimmune attack on pancreatic islet cells is associated with a T helper 1 cell (T(h)1) response, mainly represented by Ig...

journal_title：Diabetologia

authors： Hillman M,Törn C,Thorgeirsson H,Landin-Olsson M

更新日期：2004-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Animal studies have indicated that disturbed diurnal rhythms of clock gene expression in adipose tissue can induce obesity and type 2 diabetes. The importance of the circadian timing system for energy metabolism is well established, but little is known about the diurnal regulation of (clock) gene expres...

journal_title：Diabetologia

authors： Stenvers DJ,Jongejan A,Atiqi S,Vreijling JP,Limonard EJ,Endert E,Baas F,Moerland PD,Fliers E,Kalsbeek A,Bisschop PH

更新日期：2019-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. ...

journal_title：Diabetologia

authors： Taverna MJ,Sola A,Guyot-Argenton C,Pacher N,Bruzzo F,Slama G,Reach G,Selam JL

更新日期：2002-03-01 00:00:00

abstract：:Amylin is a 37-amino acid pancreatic polypeptide, probably involved in the pathophysiology of Type 2 (non-insulin-dependent) diabetes mellitus. We have determined amylin in human plasma by extraction-based radioimmunoassay (Sep-Pak C18). Of 23 healthy control subjects plasma amylin was determined as 11.9 +/- 3.5 ng/l....

journal_title：Diabetologia

authors： Hartter E,Svoboda T,Ludvik B,Schuller M,Lell B,Kuenburg E,Brunnbauer M,Woloszczuk W,Prager R

更新日期：1991-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Despite the overlap in occurrence of cardiovascular disease (CVD) and type 2 diabetes and their risk factors, family history of these diseases has not yet been investigated simultaneously in relation to cardiometabolic markers in offspring. We examined how a family history of CVD and/or diabetes relates...

journal_title：Diabetologia

authors： Berentzen NE,Wijga AH,van Rossem L,Koppelman GH,van Nieuwenhuizen B,Gehring U,Spijkerman AM,Smit HA

更新日期：2016-08-01 00:00:00

abstract：:Studying 239 Type 1 (insulin-dependent) diabetic patients and 144 of their first-degree relatives, we found a significant prevalence of autoimmune manifestations in both groups, compared with sex- and age-matched control subjects (p less than 0.001). In particular, in diabetic patients we found a high frequency of aut...

journal_title：Diabetologia

authors： Betterle C,Zanette F,Pedini B,Presotto F,Rapp LB,Monciotti CM,Rigon F

更新日期：1984-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Uncoupling protein-2 (UCP2) is thought to play a role in insulin secretion and the development of obesity. In this study, we investigated the effects of genetic variation in UCP2 on type 2 diabetes and obesity, as well as on metabolic phenotypes related to these diseases, in Pima Indians. METHODS:The c...

journal_title：Diabetologia

authors： Kovacs P,Ma L,Hanson RL,Franks P,Stumvoll M,Bogardus C,Baier LJ

更新日期：2005-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Platelet activation, endothelial dysfunction and inflammation may be involved in early stages of diabetic microangiopathy. We therefore investigated patients with Type 1 diabetes mellitus, without ( n=19) and with ( n=20) microangiopathy, matched for glycaemic control and duration of disease, and matche...

journal_title：Diabetologia

authors： Yngen M,Östenson CG,Hu H,Li N,Hjemdahl P,Wallén NH

更新日期：2004-03-01 00:00:00

abstract：:The eyes, kidneys and pancreas of mice (SJL/J) infected with encephalomyocarditis virus were examined by light and electron microscopy. Diabetic mice with the longest duration (6 months) of diabetes showed marked renal and ocular alterations. Fasting blood glucose levels were 17.8-21.9 mmol/l and glycosuria was presen...

journal_title：Diabetologia

authors： Rodrigues M,Currier C,Yoon J

更新日期：1983-04-01 00:00:00

abstract：:For the normalisation of blood glucose levels in diabetic patients by feedback controlled insulin delivery, a self-manageable and reliable method for continuous glucose estimation is still not available. By combining a commercially available needle type dialysis probe (molecular cutoff 20,000 Da) with a sensitive gluc...

journal_title：Diabetologia

authors： Meyerhoff C,Bischof F,Sternberg F,Zier H,Pfeiffer EF

更新日期：1992-11-01 00:00:00