Enhanced P-selectin expression and increased soluble CD40 Ligand in patients with Type 1 diabetes mellitus and microangiopathy: evidence for platelet hyperactivity and chronic inflammation.

abstract：AIMS/HYPOTHESIS:Most of the known actions of angiotensin II have been considered primarily to be the result of angiotensin II subtype 1 receptor activation. However, recent data suggest that the angiotensin II subtype 2 receptor (AT(2)R) may modulate key processes linked to atherosclerosis. The aim of this study was to...

journal_title：Diabetologia

authors： Koïtka A,Cao Z,Koh P,Watson AM,Sourris KC,Loufrani L,Soro-Paavonen A,Walther T,Woollard KJ,Jandeleit-Dahm KA,Cooper ME,Allen TJ

更新日期：2010-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic islet transplantation (PIT) offers a physiological treatment for type 1 diabetes, but the failure of islet engraftment hinders its application. The female hormone 17β-oestradiol (E2) favours islet survival and stimulates angiogenesis, raising the possibility that E2 may enhance islet engraftm...

journal_title：Diabetologia

authors： Liu S,Kilic G,Meyers MS,Navarro G,Wang Y,Oberholzer J,Mauvais-Jarvis F

更新日期：2013-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We compared metabolic gene expression in adipose tissue and skeletal muscle from patients with type 2 diabetes and from well-matched healthy control subjects. We hypothesised that gene expression would be discordantly regulated when comparing the two groups. Our secondary aim was to determine the effect...

journal_title：Diabetologia

authors： Carey AL,Petersen EW,Bruce CR,Southgate RJ,Pilegaard H,Hawley JA,Pedersen BK,Febbraio MA

更新日期：2006-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis t...

journal_title：Diabetologia

authors： Sutinen J,Kannisto K,Korsheninnikova E,Nyman T,Ehrenborg E,Andrew R,Wake DJ,Hamsten A,Walker BR,Yki-Järvinen H

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect. Recently, the plant-derived sugar a...

journal_title：Diabetologia

authors： Kishore P,Kehlenbrink S,Hu M,Zhang K,Gutierrez-Juarez R,Koppaka S,El-Maghrabi MR,Hawkins M

更新日期：2012-06-01 00:00:00

abstract：:The binding of 125I-labelled insulin to human adipocytes was studied at 37 degrees C. The precipitability of the 125I-labelled insulin preparation (0.03 nmol/l) in trichloroacetic acid and the concentration of biologically active insulin (7.5 nmol/l) remained constant in buffer incubated with human adipocytes (100 mic...

journal_title：Diabetologia

authors： Andersen O,Gliemann J,Gammeltoft S

更新日期：1977-12-01 00:00:00

abstract：:The accumulation of noradrenaline in constricted sciatic nerves was measured in 6 month diabetic rats (streptozotocin 35 mg/kg) and 4 day diabetic rats (streptozotocin 70 mg/kg) together with two groups of age-matched control animals. There was no alteration in the amount of noradrenaline accumulated in the nerves of ...

journal_title：Diabetologia

authors： Tomlinson DR,Gillon KR,Smith MG

更新日期：1982-03-01 00:00:00

abstract：:Factor VIII-related antigen and von Willebrand factor are synthesised by and released from vascular endothelium. Acute increases in the plasma concentration of these proteins may reflect endothelial cell damage. We have thus measured the plasma concentration of factor VIII-related antigen and von Willebrand factor, to...

journal_title：Diabetologia

authors： Greaves M,Pickering C,Knight G,Boulton AJ,Ball J,Ward JD,Preston FE

更新日期：1987-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is characterised by excessive hepatic glucose production and frequently leads to systemic vascular complications. We therefore analysed the relationship between the gene expression profile in the liver and the pathophysiology of Type 2 diabetes. METHODS:Liver biopsy samples were obtaine...

journal_title：Diabetologia

authors： Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S

更新日期：2004-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular disease in diabetes is linked to increased risk of atherosclerosis, increased levels of triglyceride-rich lipoproteins and enhanced hepatic lipogenesis. The hepatic hexosamine pathway has been implicated in signalling for de novo lipogenesis by the liver. In this study, we assessed if dec...

journal_title：Diabetologia

authors： Babaei-Jadidi R,Karachalias N,Kupich C,Ahmed N,Thornalley PJ

更新日期：2004-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The receptor tyrosine kinase, c-Kit, and its ligand, stem cell factor, control a variety of cellular processes, including pancreatic beta cell survival and differentiation as revealed in c-Kit ( Wv ) mice, which have a p...

journal_title：Diabetologia

authors： Feng ZC,Li J,Turco BA,Riopel M,Yee SP,Wang R

更新日期：2012-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Accurate prevalence estimates for gestational diabetes mellitus (GDM) among pregnant women in Europe are lacking owing to the use of a multitude of diagnostic criteria and screening strategies in both high-risk women and the general pregnant population. Our aims were to report important risk factors for...

journal_title：Diabetologia

authors： Egan AM,Vellinga A,Harreiter J,Simmons D,Desoye G,Corcoy R,Adelantado JM,Devlieger R,Van Assche A,Galjaard S,Damm P,Mathiesen ER,Jensen DM,Andersen L,Lapolla A,Dalfrà MG,Bertolotto A,Mantaj U,Wender-Ozegowska E,Zawi

更新日期：2017-10-01 00:00:00

abstract：:The development of diabetic glomerulopathy in kidneys transplanted to diabetic patients was estimated in transplant biopsies and evaluated in relation to suspected clinical risk factors for diabetic nephropathy. Surgical biopsies were taken at baseline and at 24-36 months post-transplantation in 16 Type 1 (insulin-dep...

journal_title：Diabetologia

authors： Osterby R,Nyberg G,Hedman L,Karlberg I,Persson H,Svalander C

更新日期：1991-09-01 00:00:00

abstract：:This study estimates the direct health care costs of the incidence of insulin-dependent diabetes mellitus (IDDM) in Spain. A discrete event simulation model was developed to approximate the natural history of a cohort of newly diagnosed patients in a given year and used to calculate the average costs which would accum...

journal_title：Diabetologia

authors： Hart WM,Espinosa C,Rovira J

更新日期：1997-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Differences in seasonality of birth patterns between the general population and the group who develop Type I (insulin-dependent) diabetes mellitus indicate that environmental factors operating around the antenatal and perinatal period could be important. We investigated whether the same unsual patterns ...

journal_title：Diabetologia

authors： McKinney PA,EURODIAB Seasonality Of Birth Group. Europe and Diabetes.

更新日期：2001-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model ...

journal_title：Diabetologia

authors： Zhou T,Zhou KK,Lee K,Gao G,Lyons TJ,Kowluru R,Ma JX

更新日期：2011-02-01 00:00:00

abstract：:Little is known about the immunological impact of insulin administration other than it can boost insulin autoantibody levels. In particular, while the subcutaneous administration of a soluble foreign antigen (without adjuvant) is generally only weakly immunogenic in a naive animal, it is unknown what effect the subcut...

journal_title：Diabetologia

authors： Tian J,Chau C,Kaufman DL

更新日期：1998-02-01 00:00:00

abstract：:To study the effect of E. Coli L-asparaginase on glucose tolerance and insulin release, 6 patients with neoplastic disease were subjected to 3 hour oral glucose tolerance tests with simultaneous measurement of serum immunoreactive insulin (IRI) levels before and following the intravenous administration of 5000 I. U. L...

journal_title：Diabetologia

authors： Lavine RL,Brodsky I,Garofano CD,Rose LI

更新日期：1978-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cre-loxP systems are frequently used in mouse genetics as research tools for studying tissue-specific functions of numerous genes/proteins. However, the expression of Cre recombinase in a tissue-specific manner often produces undesirable changes in mouse biology that can confound data interpretation whe...

journal_title：Diabetologia

authors： Al Batran R,Gopal K,Martin MD,Ho KL,Almutairi M,Aburasayn H,Eaton F,Campbell JE,Ussher JR

更新日期：2018-08-01 00:00:00

abstract：:In postnatal organisms, insulin is well known as an essential anabolic hormone responsible for maintaining glucose homeostasis. Its biosynthesis by the pancreatic beta cell has been considered a model of tissue-specific gene expression. However, proinsulin mRNA and protein have been found in embryonic stages before th...

journal_title：Diabetologia

authors： Hernández-Sánchez C,Mansilla A,de la Rosa EJ,de Pablo F

更新日期：2006-06-01 00:00:00

abstract：:Five healthy volunteers and 6 diabetics were given a mixed test meal on two occasions--once with and once without 10 g guar flour. Addition of guar caused a 47% decrease in maximum post-prandial GIP levels, a 48% decrease in blood glucose and a 48% decrease in plasma insulin in normal subjects. In diabetics, addition ...

journal_title：Diabetologia

authors： Morgan LM,Goulder TJ,Tsiolakis D,Marks V,Alberti KG

更新日期：1979-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS:Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 ...

journal_title：Diabetologia

authors： Lim EL,Hollingsworth KG,Aribisala BS,Chen MJ,Mathers JC,Taylor R

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The process of islet isolation can cause chemical and mechanical injury to beta cells. In addition, hyperglycaemia after islet transplantation can compromise beta cell function. The aim of this experiment was to evaluate changes in gene expression in endogenous islets using laser-capture microdissection...

journal_title：Diabetologia

authors： Ahn YB,Xu G,Marselli L,Toschi E,Sharma A,Bonner-Weir S,Sgroi DC,Weir GC

更新日期：2007-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of cancer in a large population-based cohort study. METHODS:Data for ...

journal_title：Diabetologia

authors： Ruiter R,Visser LE,van Herk-Sukel MP,Coebergh JW,Haak HR,Geelhoed-Duijvestijn PH,Straus SM,Herings RM,Stricker BH

更新日期：2012-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Currently, three categories of measures are used to assess cardiovascular autonomic dysfunction: measures of the Ewing-test, measures of heart-rate variability, and measures of baroreflex sensitivity. We studied the determinants of these measures obtained from cardiovascular autonomic function tests in ...

journal_title：Diabetologia

authors： Gerritsen J,Dekker JM,TenVoorde BJ,Bertelsmann FW,Kostense PJ,Stehouwer CD,Heine RJ,Nijpels G,Heethaar RM,Bouter LM

更新日期：2000-05-01 00:00:00

abstract：:Mitochondrial DNA is maternally inherited. Mitochondrial DNA mutations could contribute to the excess of maternal over paternal inheritance of non-insulin-dependent diabetes mellitus (NIDDM). We therefore investigated the relationship between this variant, insulin resistance and other risk factors in a cohort which ha...

journal_title：Diabetologia

authors： Poulton J,Brown MS,Cooper A,Marchington DR,Phillips DI

更新日期：1998-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...

journal_title：Diabetologia

authors： Treweeke AT,Winterburn TJ,Mackenzie I,Barrett F,Barr C,Rushworth GF,Dransfield I,MacRury SM,Megson IL

更新日期：2012-11-01 00:00:00

abstract：:To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibodies and high titre...

journal_title：Diabetologia

authors： Betterle C,Presotto F,Pedini B,Moro L,Slack RS,Zanette F,Zanchetta R

更新日期：1987-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We describe a novel model of insulin-deficient diabetes with a single copy of the gene encoding insulin 1 (Ins1) and no gene encoding insulin 2 (Ins2). MATERIALS AND METHODS:We constructed five lines of mice: mice with two copies of Ins1 (NOD( Ins1+/+,Ins2-/-)), mice with a single copy of Ins1 (NOD( In...

journal_title：Diabetologia

authors： Babaya N,Nakayama M,Moriyama H,Gianani R,Still T,Miao D,Yu L,Hutton JC,Eisenbarth GS

更新日期：2006-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Neuronal dorsal root ganglion (DRG) cells seem to be vulnerable in diabetes. The aim of this study was to determine whether the p75 neurotrophin receptor stimulates perikaryal shrinkage and neuronal death, and further accelerates neuronal DRG cell loss after axotomy in a mouse model of diabetes. METHOD...

journal_title：Diabetologia

authors： Jiang Y,Jakobsen J

更新日期：2004-09-01 00:00:00