Abstract：
:Five healthy volunteers and 6 diabetics were given a mixed test meal on two occasions--once with and once without 10 g guar flour. Addition of guar caused a 47% decrease in maximum post-prandial GIP levels, a 48% decrease in blood glucose and a 48% decrease in plasma insulin in normal subjects. In diabetics, addition of guar caused a 30% reduction in maximum post-prandial GIP and 58% decrease in blood glucose. Four normal and 6 diabetic subjects were given a predominantly carbohydrate meal, again with and without 10 g guar. Addition of guar caused a 78% decrease in blood glucose and a 59% decrease in plasma insulin in normal subjects. In diabetics addition of guar caused a 71% decrease in maximum post-prandial plasma GIP and a 68% decrease in blood glucose. Lowering of post-prandial blood glucose, plasma insulin and GIP levels by guar was statistically significant in every case. Addition of guar to the predominantly carbohydrate meal caused a decrease in total plasma GLI in both normal and diabetic subjects but reached statistical significance only in the normal subjects. There was a highly significant correlation (r = 0.83; p less than 0.0005) between peak post-prandial insulin levels in normal subjects and the corresponding plasma GIP concentration. The reduction of GIP or GLI secretion may, therefore, be partly responsible for the smaller rise in plasma insulin observed in normal volunteers when guar is added to meals.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Morgan LM,Goulder TJ,Tsiolakis D,Marks V,Alberti KGdoi
10.1007/BF01222207subject
Has Abstractpub_date
1979-08-01 00:00:00pages
85-9issue
2eissn
0012-186Xissn
1432-0428journal_volume
17pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract：AIMS/HYPOTHESIS:We aimed to identify microRNAs (miRNAs) associated with type 2 diabetes and risk of developing the disease in skeletal muscle biopsies from phenotypically well-characterised twins. METHODS:We measured muscle miRNA levels in monozygotic (MZ) twins discordant for type 2 diabetes using arrays. Further inv...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3434-2
更新日期：2015-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue. METHODS:Immunohistological analysis was used to determine the distribution of proinsulin and insulin in t...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-020-05115-6
更新日期：2020-06-01 00:00:00
abstract：AIMS/HYPOTHESIS:The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield val...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-018-4568-4
更新日期：2018-05-01 00:00:00
abstract：AIMS/HYPOTHESIS:High intake of carbohydrates, particularly sucrose, in western societies is associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related primarily to the carbohydrate quantity or to the hormonal responses, particularly glucose-dependent...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3423-5
更新日期：2015-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:Cardiovascular disease (CVD) is the most common cause of premature death and disability among patients with type 1 diabetes. Diabetic nephropathy accounts for the increased cardiovascular morbidity and mortality of these patients. We recently showed that the intensity of exercise predicts the incidence ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-016-4189-8
更新日期：2017-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this study was to assess and compare risks of having large- or small-for gestational age (LGA and SGA, respectively) infants born to women with gestational diabetes mellitus (GDM) from ten racial/ethnic groups. METHODS:LGA and SGA were defined as birthweight >90th and <10th percentile, respe...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3420-8
更新日期：2015-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:This study compared the incidence rate of type 1 diabetes in children diagnosed with enterovirus (EV) infections with that in age- and sex-matched children without EV infection in a population-based cohort. In addition, we examined whether the direction or magnitude of the association between EV infecti...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3400-z
更新日期：2015-01-01 00:00:00
abstract：:The effects of the aldose reductase inhibitor, sorbinil, on symptomatic symmetrical diabetic polyneuropathy were studied during a 6-month period in a double-blind parallel group placebo-controlled trial. Twenty-seven patients received sorbinil and 28 placebo. The patients were assessed by clinical examination, neuroph...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章
doi：10.1007/BF00283137
更新日期：1985-06-01 00:00:00
abstract：:The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell funct...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s00125-015-3862-7
更新日期：2016-04-01 00:00:00
abstract：:Isloated rat islets were maintained in vitro in a perifusion system, exposed to alloxan (20 mg/100 ml) for 5 minutes in the presence of agents which affect cAMP metabolism and subsequently stimulated with glucose. The rate of insulin secretion was monitored throughout the period of perifusion. Exposure to alloxan alon...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF01222099
更新日期：1975-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. METHODS:MEDLINE, EMBASE and the Cochrane L...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s00125-020-05295-1
更新日期：2021-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-016-4073-6
更新日期：2016-11-01 00:00:00
abstract：:The ability of the amino acid leucine and its keto acid, alpha-ketoisocaproate, to induce insulin release, to initiate phosphoinositide hydrolysis, and to amplify the subsequent insulin secretory response to glucose was assessed. In islets whose inositol-containing lipids were prelabelled with myo[2-3H]inositol, the a...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00271588
更新日期：1988-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:A high prevalence of diabetes contributes to excess CHD in Indian Asians, but the underlying mechanisms are unclear. Heart rate, heart rate variability (HRV) and baroreflex sensitivity (BRS) are measures of cardiac autonomic function that are disturbed by hyperglycaemia and predict CHD. We compared thes...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-010-1818-5
更新日期：2010-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population. METHODS:Life table modelling was used with simulated follow-...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-019-4875-4
更新日期：2019-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:Neurogenin 3 (NEUROG3), a basic helix-loop-helix transcription factor that is needed for endocrine cell development in the embryonic pancreas, has been shown to induce transdifferentiation of duct cells from adult pancreas towards a neuro-endocrine phenotype. Our study explored the endocrine transdiffer...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-006-0299-z
更新日期：2006-08-01 00:00:00
abstract：:The aim of the present study was to elucidate the pathophysiologic significance of circulating ouabain as a link between insulin resistance (IR) and hypertension (HT) in NIDDM. Euglycaemic (4.5 mmol/l) hyperinsulinaemic (360-580 pmol/l) clamping was performed using an artificial endocrine pancreas. Plasma ouabain-like...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250050354
更新日期：1995-07-01 00:00:00
abstract：:Pancreatic beta cells are clustered in islets of Langerhans together with alpha cells in an arrangement that facilitates the tight coordination of insulin and glucagon secretion at the source of their release. Other secretory cells, including somatostatin-secreting delta cells and pancreatic polypeptide cells, co-loca...
journal_title：Diabetologia
pub_type： 评论,杂志文章
doi：10.1007/s00125-015-3567-y
更新日期：2015-06-01 00:00:00
abstract：AIMS/HYPOTHESIS:It is difficult to use HbA(1c) as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA(1c) were compared to evaluate whethe...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-011-2211-8
更新日期：2011-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:The workplace is a potentially important arena for prevention of type 2 diabetes and the first step is to identify occupations where the disease is common and/or risk is high. Therefore, our aim was to analyse incidence and prevalence of type 2 diabetes across all occupational groups in Sweden. METHODS...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-019-04997-5
更新日期：2020-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes. METHODS:Adult male Akita mice (12 weeks old) were treated with insu...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-013-2910-4
更新日期：2013-07-01 00:00:00
abstract：:It is suggested that amylin (islet associated polypeptide), co-secreted with insulin from the pancreatic beta cells acts as a circulating hormone which opposes the action of insulin on muscle and increases hepatic glucose production. We have tested the effect of amylin in human subjects on postabsorptive glucose homeo...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章
doi：10.1007/s001250050088
更新日期：1994-02-01 00:00:00
abstract：:There is now evidence that a single bout of endurance (aerobic) or resistance exercise reduces 24 h post-exercise subcutaneous glucose profiles to the same extent in insulin-resistant humans with or without type 2 diabetes. However, it remains to be determined which group would benefit most from specific exercise prot...
journal_title：Diabetologia
pub_type： 评论,杂志文章
doi：10.1007/s00125-012-2513-5
更新日期：2012-05-01 00:00:00
abstract：:Dementia and non-insulin-dependent diabetes mellitus (NIDDM) are highly prevalent disorders in the elderly. Diabetes has repeatedly been reported to affect cognition, but its relation with dementia is uncertain. We therefore studied the association between diabetes and dementia in the Rotterdam Study, a large populati...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250050588
更新日期：1996-11-01 00:00:00
abstract：:The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00408356
更新日期：1991-11-01 00:00:00
abstract：:In order to examine the permeability of microvessels in diabetic children, the glomerular filtration rate, urinary excretion rates of albumin and beta 2-microglobulin, intravascular mass of albumin, and transcapillary escape rate of albumin were studied in 26 diabetic children without clinical signs of microangiopathy...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF01223619
更新日期：1979-05-01 00:00:00
abstract：AIMS/HYPOTHESIS:Inflammation is associated with obesity and has been implicated in the development of diabetes and atherosclerosis. During gram-negative bacterial infection, lipopolysaccharide causes an inflammatory reaction via toll-like receptor 4 (TLR4), which has an essential function in the induction of innate and...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-007-0654-8
更新日期：2007-06-01 00:00:00
abstract：:In vitro and in vivo studies have suggested that metabolic deterioration can be induced by hyperglycaemia per se. The effect of 53 h of 2.2 mg glucose.kg ideal body weight-1.min-1 was examined in four normal male subjects. This produced overnight hyperglycaemia of 6.0 mmol/l on the two nights of the study compared wit...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00400275
更新日期：1991-08-01 00:00:00
abstract：AIMS/HYPOTHESIS:Endothelial cell (EC) damage is a key mechanism causing retinal microvascular injury in diabetes. Several microRNAs (miRNAs) have been found to regulate sirtuin 1 (SIRT1, which is involved in regulation of the cell cycle, survival and metabolism) in various tissues and disease states, but no studies hav...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3197-9
更新日期：2014-05-01 00:00:00
abstract：:In order to assess the possible progression of neurological abnormalities over time and the value of visual evoked potential alterations in predicting stability and severity of diabetes-related optic pathway disease, a longitudinal study in non-insulin-dependent diabetic patients was performed. Neurological examinatio...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00400726
更新日期：1995-05-01 00:00:00
