Abstract:
:The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell function. To this end, each individual beta cell can be viewed as a sensor of a multitude of stimuli that are integrated to determine the extent of glucose-dependent insulin release. This review discusses recent advances in our understanding of inter-organ communications that regulate beta cell insulin release in response to elevated glucose levels.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Hussain MA,Akalestou E,Song WJdoi
10.1007/s00125-015-3862-7subject
Has Abstractpub_date
2016-04-01 00:00:00pages
659-67issue
4eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-015-3862-7journal_volume
59pub_type
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