Abstract:
:Groups of normal rats and of normal and insulin-immunized guinea pigs were injected intravasculary with mixtures of radio-iodinated and unlabelled porcine insulins. No differences could be discerned between the fates of radio-iodinated and unlabelled insulins in normal or immune guinea pigs except with respect to the kidneys of normal animals, which seemed to accumlate TCA-precipitable radioactive substances devoid of immunoreactivity. The abnormally slow disappearance of insulin from the plasma and its persistent accumulation in the livers and spleens of immune guinea pigs were not affected by prior treatment for three days with large daily doses (ca 20 mg/kg body wt.) of hydrocortisone acetate.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Wright PH,Gingerich RL,Oliver JRdoi
10.1007/BF00422391subject
Has Abstractpub_date
1975-08-01 00:00:00pages
273-8issue
4eissn
0012-186Xissn
1432-0428journal_volume
11pub_type
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