Glucocorticoids and the fate of exogenous insulin in insulin-immunized guinea pigs.

Abstract:

:Groups of normal rats and of normal and insulin-immunized guinea pigs were injected intravasculary with mixtures of radio-iodinated and unlabelled porcine insulins. No differences could be discerned between the fates of radio-iodinated and unlabelled insulins in normal or immune guinea pigs except with respect to the kidneys of normal animals, which seemed to accumlate TCA-precipitable radioactive substances devoid of immunoreactivity. The abnormally slow disappearance of insulin from the plasma and its persistent accumulation in the livers and spleens of immune guinea pigs were not affected by prior treatment for three days with large daily doses (ca 20 mg/kg body wt.) of hydrocortisone acetate.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Wright PH,Gingerich RL,Oliver JR

doi

10.1007/BF00422391

subject

Has Abstract

pub_date

1975-08-01 00:00:00

pages

273-8

issue

4

eissn

0012-186X

issn

1432-0428

journal_volume

11

pub_type

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