Abstract:
:In perifused pancreatic islets, the fluorescence of oxidized flavoproteins (FAD) was recorded continuously. Elevation of glucose concentration in the medium form 0 or 5 mM to 20 mM led to decrease in FAD-fluorescence beginning 10 sec after change of medium. L-leucine (10 mM), (+/-)-B-BCH (20 mM) and alpha-ketoisocaproic acid (10 mM) caused typical kinetics of FAD-fluorescence decrease. The results are interpreted to indicate rapid changes of the functional state of B-cell mitochondria induced by the above-mentioned stimulators of insulin release.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Panten U,Ishida Hdoi
10.1007/BF01222108subject
Has Abstractpub_date
1975-12-01 00:00:00pages
569-73issue
6eissn
0012-186Xissn
1432-0428journal_volume
11pub_type
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