The low dose streptozotocin murine model of type 1 (insulin-dependent) diabetes mellitus: studies in vivo and in vitro of the modulating effect of sex hormones.

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our understanding of its pathophysiology remains incomplete. The aim of this study was to provide deeper insight into the complex network of molecular and cellular c...

journal_title：Diabetologia

authors： Van Hove I,De Groef L,Boeckx B,Modave E,Hu TT,Beets K,Etienne I,Van Bergen T,Lambrechts D,Moons L,Feyen JHM,Porcu M

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Urinary orosomucoid excretion rate is increased in a substantial proportion of patients with Type II (non-insulin-dependent) diabetes mellitus and normal urinary albumin excretion rate. The aim of this study was to determine whether increased urinary orosomucoid excretion rate is predictive of increased...

journal_title：Diabetologia

authors： Christiansen MS,Hommel E,Magid E,Feldt-Rasmussen B

更新日期：2002-01-01 00:00:00

abstract：:The content of phosphoenolpyruvate (PEP) has been measured in isolated rat islets of Langerhans incubated in vitro. Islet PEP was higher in islets incubated with 16.7 mmol/1 glucose than in islets incubated with zero or 2.8 mmol/1 glucose. Islet PEP content was also increased in islet incubated with 5 mmol/1 D-glycera...

journal_title：Diabetologia

authors： Sugden MC,Ashcroft SJ

更新日期：1977-09-01 00:00:00

abstract：:Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 d...

journal_title：Diabetologia

authors： Comi G,Galardi G,Amadio S,Bianchi E,Secchi A,Martinenghi S,Caldara R,Pozza G,Canal N

更新日期：1991-08-01 00:00:00

abstract：:We examined glomerular basement membrane anionic site distribution identified by cationic gold in seven patients with insulin-dependent and four patients with non-insulin-dependent diabetes mellitus, presenting a spectrum of clinical and glomerular changes. Anionic sites were investigated by pretreatment of tissue wit...

journal_title：Diabetologia

authors： Goode NP,Shires M,Crellin DM,Aparicio SR,Davison AM

更新日期：1995-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to estimate the heritability of quantitative measures of glucose regulation obtained from a tolbutamide-modified frequently sampled IVGTT (t-FSIGT) and to correlate the heritability of the glucose-stimulated beta cell response to the tolbutamide-induced beta cell response. In a...

journal_title：Diabetologia

authors： Gjesing AP,Hornbak M,Allin KH,Ekstrøm CT,Urhammer SA,Eiberg H,Pedersen O,Hansen T

更新日期：2014-06-01 00:00:00

abstract：:The incidence, sex, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus (j.i.d.m.) were studied retrospectively on one third of the Danish population 1970-1974. The j.i.d.m. incidence remained fairly constant during the study period, the average being 13.2 per 100000 per year. The ...

journal_title：Diabetologia

authors： Christau B,Kromann H,Andersen OO,Christy M,Buschard K,Arnung K,Kristensen IH,Peitersen B,Steinrud J,Nerup J

更新日期：1977-08-01 00:00:00

abstract：:Hyperglycaemia has been shown to play a central part in diabetic vascular disease, which is also influenced by individual background. Hyperglycaemia initiates the pathogenetic sequence through a series of interrelated biochemical abnormalities, including increased flux through the polyol and hexosamine pathways, oxida...

journal_title：Diabetologia

authors： Di Mario U,Pugliese G

更新日期：2001-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Direct infection of beta cells could explain the diabetogenic effect of enteroviruses. Primary adult human beta cells are susceptible to coxsackievirus infections, which could result in impaired beta-cell function or cell death (coxsackieviruses B3, B4, B5) or both, or no apparent immediate adverse effe...

journal_title：Diabetologia

authors： Roivainen M,Ylipaasto P,Savolainen C,Galama J,Hovi T,Otonkoski T

更新日期：2002-05-01 00:00:00

abstract：:Hypothalamic and autonomic nervous regulation of carbohydrate and amino acid metabolism in the liver and of lipid metabolism in adipose tissues is described. The direct neural mechanism underlying this regulation has been evaluated. Electrical stimulation of the ventromedial hypothalamic nucleus (VMH)-splanchnic nerve...

journal_title：Diabetologia

authors： Shimazu T

更新日期：1981-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...

journal_title：Diabetologia

authors： Jacobs-Tulleneers-Thevissen D,Bartholomeus K,Suenens K,Vermeulen I,Ling Z,Hellemans KH,In't Veld P,Pipeleers-Marichal M,Pipeleers D

更新日期：2010-08-01 00:00:00

abstract：:Loss of neurogenic inflammation in response to tissue injury may be an important complication of diabetes mellitus. We studied local neurogenic inflammation in the peripheral nerve trunk of Sprague-Dawley rats 4 months following the induction of diabetes by streptozotocin injection. To assess neurogenic inflammation, ...

journal_title：Diabetologia

authors： Zochodne DW,Ho LT

更新日期：1993-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:In order to identify type 2 diabetes disease susceptibility gene(s) in a Japanese population, we applied a region-wide case-control association test to the 20.4 Mb region between D3S1293 and D3S2319 on chromosome 3p24.3-22.1, supported by linkage to type 2 diabetes and its related traits in Japanese and...

journal_title：Diabetologia

authors： Moritani M,Nomura K,Tanahashi T,Osabe D,Fujita Y,Shinohara S,Yamaguchi Y,Keshavarz P,Kudo E,Nakamura N,Yoshikawa T,Ichiishi E,Takata Y,Yasui N,Shiota H,Kunika K,Inoue H,Itakura M

更新日期：2007-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG). METHODS:Peripheral blood m...

journal_title：Diabetologia

authors： Mabilleau G,Petrova NL,Edmonds ME,Sabokbar A

更新日期：2008-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis t...

journal_title：Diabetologia

authors： Sutinen J,Kannisto K,Korsheninnikova E,Nyman T,Ehrenborg E,Andrew R,Wake DJ,Hamsten A,Walker BR,Yki-Järvinen H

更新日期：2004-10-01 00:00:00

abstract：:Diabetes is an important risk factor for atherosclerosis but the mechanism of the risk is unknown. As endothelial injury is considered to be an early event in the development of atherosclerosis, the effect of glucose on endothelial cell replication was studied. Concentrations of glucose of 11.2, 16.8 and 22.4 mmol/l i...

journal_title：Diabetologia

authors： Stout RW

更新日期：1982-11-01 00:00:00

abstract：:Oral glucose administration increased plasma noradrenaline concentration significantly in seven normal subjects (p less than 0.02), whereas in six young short-term Type 1 diabetic patients without complications plasma noradrenaline did not change. Basal plasma noradrenaline did not differ between the two groups. In th...

journal_title：Diabetologia

authors： Hegedüs L,Christensen NJ,Sestoft L

更新日期：1983-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The therapeutic benefit of physical activity to prevent and treat type 2 diabetes is commonly accepted. However, the impact of the disease on the acute metabolic response is less clear. To this end, we investigated the effect of type 2 diabetes on exercise-induced plasma metabolite changes and the muscu...

journal_title：Diabetologia

authors： Hansen JS,Zhao X,Irmler M,Liu X,Hoene M,Scheler M,Li Y,Beckers J,Hrabĕ de Angelis M,Häring HU,Pedersen BK,Lehmann R,Xu G,Plomgaard P,Weigert C

更新日期：2015-08-01 00:00:00

abstract：:The transcription factor SOX9 is regarded as a crucial player in pancreas development, both maintaining progenitors and later being required for beta cell differentiation. However, very little is known about the possible involvement of other SOX family members in such processes. In this issue, the work of Xu et al (DO...

journal_title：Diabetologia

authors： Grapin-Botton A,Seymour PA,Gradwohl G

更新日期：2015-05-01 00:00:00

abstract：:Dementia and non-insulin-dependent diabetes mellitus (NIDDM) are highly prevalent disorders in the elderly. Diabetes has repeatedly been reported to affect cognition, but its relation with dementia is uncertain. We therefore studied the association between diabetes and dementia in the Rotterdam Study, a large populati...

journal_title：Diabetologia

authors： Ott A,Stolk RP,Hofman A,van Harskamp F,Grobbee DE,Breteler MM

更新日期：1996-11-01 00:00:00

abstract：:Employing saline-impregnated cotton threads, an implanted-wick technique was adopted in dogs to obtain specimen from the subcutaneous interstitial compartment in order to estimate its glucose concentration. By measuring the protein, potassium and haemoglobin contents, the centrifuged wick fluid was shown to contain th...

journal_title：Diabetologia

authors： Fischer U,Ertle R,Abel P,Rebrin K,Brunstein E,Hahn von Dorsche H,Freyse EJ

更新日期：1987-12-01 00:00:00

abstract：:An autoimmune basis for the pathogenesis of insulin-dependent diabetes mellitus (IDDM) is supported by the frequent presence of autoantibodies - islet cell antibodies (ICAs) and GAD antibodies (GADab). However, in Chinese patients with clinical IDDM, a low prevalence of ICAs was observed. In non-insulin-dependent diab...

journal_title：Diabetologia

authors： Thai AC,Ng WY,Loke KY,Lee WR,Lui KF,Cheah JS

更新日期：1997-12-01 00:00:00

abstract：:Severe microvascular disease exists at the stage of clinical diabetic neuropathy. A non-invasive test that will identify those diabetic subjects who will eventually develop neuropathy is essential for early intervention. Sural sensory conduction velocity was recorded (x3) in 12 non-neuropathic diabetic subjects, 15 di...

journal_title：Diabetologia

authors： Tesfaye S,Harris ND,Wilson RM,Ward JD

更新日期：1992-02-01 00:00:00

abstract：:Restriction fragment length polymorphism of the human insulin receptor gene was analyzed with a 4.2 Kb cDNA probe in Japanese normal subjects and Type 2 (non-insulin-dependent) diabetic patients. Restriction endonuclease Rsa I digestion showed polymorphism of the human insulin receptor gene, with a band at 6.7 Kb, 6.2...

journal_title：Diabetologia

authors： Takeda J,Seino Y,Yoshimasa Y,Fukumoto H,Koh G,Kuzuya H,Imura H,Seino S

更新日期：1986-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...

journal_title：Diabetologia

authors： Lin L,Zhang J,Jiang L,Du R,Hu C,Lu J,Wang T,Li M,Zhao Z,Xu Y,Xu M,Bi Y,Ning G,Wang W,Chen Y

更新日期：2020-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Adiponectin is a circulating peptide derived from adipose tissue. It mediates its insulin-sensitising and anti-atherogenic effects on target tissues through two known receptors, adiponectin receptors 1 and 2 (ADIPOR1; ADIPOR2), which are encoded by the genes ADIPOR1 and ADIPOR2. Our aim was to study the...

journal_title：Diabetologia

authors： Siitonen N,Pulkkinen L,Mager U,Lindström J,Eriksson JG,Valle TT,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Tuomilehto J,Laakso M,Uusitupa M

更新日期：2006-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with traditional cardiovascular risk factors and incident cardiovascular events in older people with type 2 diabetes. METHODS:In the prospective phase of the Edinburgh Type 2 Diabetes Study,...

journal_title：Diabetologia

authors： Price AH,Welsh P,Weir CJ,Feinkohl I,Robertson CM,Morling JR,McLachlan S,Strachan MW,Sattar N,Price JF

更新日期：2014-12-01 00:00:00

abstract：AIMS/OBJECTIVE:Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a ...

journal_title：Diabetologia

authors： Hara M,Yamagata K,Tomino Y,Saito A,Hirayama Y,Ogasawara S,Kurosawa H,Sekine S,Yan K

更新日期：2012-11-01 00:00:00

abstract：:The relation between urinary albumin excretion rate (UAE), transcapillary escape rate of albumin (TERalb), haemostatic factors, ambulatory blood pressure, and metabolic variables was investigated in 45 Type II (non-insulin-dependent) diabetic patients without overt nephropathy or uncontrolled blood pressure. We enroll...

journal_title：Diabetologia

authors： Nielsen S,Schmitz A,Bacher T,Rehling M,Ingerslev J,Mogensen CE

更新日期：1999-01-01 00:00:00

abstract：:To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibodies and high titre...

journal_title：Diabetologia

authors： Betterle C,Presotto F,Pedini B,Moro L,Slack RS,Zanette F,Zanchetta R

更新日期：1987-05-01 00:00:00