Epigenetic programming of adipose-derived stem cells in low birthweight individuals.

abstract：AIMS/HYPOTHESIS:The rs1990760 polymorphism (Ala946Thr) of interferon induced with helicase C domain 1 (IFIH1) has been proposed to associate with type 1 diabetes. In this study, association between IFIH1 Ala946Thr and type 1 diabetes was investigated in two distinct white populations, the Hungarians and Finns. METHODS...

journal_title：Diabetologia

authors： Jermendy A,Szatmári I,Laine AP,Lukács K,Horváth KH,Körner A,Madácsy L,Veijola R,Simell O,Knip M,Ilonen J,Hermann R,Finnish Paediatric Diabetes Registry.,HUNT1DGENES Programme.

更新日期：2010-01-01 00:00:00

abstract：:In pancreatic lesions of non-obese diabetic (NOD) mice the expression of inducible nitric oxide synthase (iNOS) and of the cytokines interferon-gamma and interleukin-4 were studied. Strong iNOS expression as determined at the level of transcription, translation and of enzyme activity was associated with destructive in...

journal_title：Diabetologia

authors： Rothe H,Faust A,Schade U,Kleemann R,Bosse G,Hibino T,Martin S,Kolb H

更新日期：1994-11-01 00:00:00

abstract：:To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibodies and high titre...

journal_title：Diabetologia

authors： Betterle C,Presotto F,Pedini B,Moro L,Slack RS,Zanette F,Zanchetta R

更新日期：1987-05-01 00:00:00

abstract：:The effect of endogenous hyperinsulinaemia, produced by syngeneic transplantation of rat insulinoma at an extrapancreatic site, on pancreatic insulin and pancreatic polypeptide has been examined by radioimmunoassay and immunohistochemistry. Twenty days after subcutaneous transplantation, tumour-bearing rats exhibited ...

journal_title：Diabetologia

authors： O'Hare MM,Shaw C,Swanston-Flatt SK,Marcelli M,Buchanan KD,Flatt PR

更新日期：1985-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data in...

journal_title：Diabetologia

authors： Dawed AY,Ali A,Zhou K,Pearson ER,Franks PW

更新日期：2017-11-01 00:00:00

abstract：:The effects of the aldose reductase inhibitor, sorbinil, on symptomatic symmetrical diabetic polyneuropathy were studied during a 6-month period in a double-blind parallel group placebo-controlled trial. Twenty-seven patients received sorbinil and 28 placebo. The patients were assessed by clinical examination, neuroph...

journal_title：Diabetologia

authors： Fagius J,Brattberg A,Jameson S,Berne C

更新日期：1985-06-01 00:00:00

abstract：:Over a century ago, inquisitive physicians made remarkable discoveries regarding pancreatic pathology in individuals with diabetes, including those who were likely afflicted with the type 1 (autoimmune) form of the disease. Those studies of post-mortem tissues noted unique anatomical changes in islet architecture as w...

journal_title：Diabetologia

authors： Atkinson MA

更新日期：2014-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sympathetic nerves influence islet hormone levels in the circulation. Insights into islet sympathetic innervation and its remodelling in diabetes may impact future therapeutics. However, standard immunohistochemistry and microtome-based microscopy cannot provide an integral view of the islet neurovascul...

journal_title：Diabetologia

authors： Chiu YC,Hua TE,Fu YY,Pasricha PJ,Tang SC

更新日期：2012-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) acts as a cofactor for several nuclear hormone receptors in many tissues and organs implicated in blood pressure regulation. Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension f...

journal_title：Diabetologia

authors： Cheurfa N,Reis AF,Dubois-Laforgue D,Bellanné-Chantelot C,Timsit J,Velho G

更新日期：2004-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis t...

journal_title：Diabetologia

authors： Sutinen J,Kannisto K,Korsheninnikova E,Nyman T,Ehrenborg E,Andrew R,Wake DJ,Hamsten A,Walker BR,Yki-Järvinen H

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although the variable number tandem repeat (VNTR) minisatellite 5' to the insulin gene is among the most studied polymorphisms in diabetes, the relationships between VNTR variation, diabetes-related traits and predisposition to type 2 diabetes remain unclear. Since inadequate sample size is likely to ha...

journal_title：Diabetologia

authors： Bennett A,Sovio U,Ruokonen A,Martikainen H,Pouta A,Taponen S,Hartikainen AL,Franks S,Peltonen L,Elliott P,Järvelin MR,McCarthy MI

更新日期：2005-05-01 00:00:00

abstract：:Screening and diagnostic criteria for gestational diabetes (GDM) are inconsistent across Europe, and the development of a uniform GDM screening strategy is necessary. Such a strategy would create opportunities for more women to receive timely treatment for GDM. Developing a consensus on screening for GDM in Europe is ...

journal_title：Diabetologia

authors： Benhalima K,Mathieu C,Damm P,Van Assche A,Devlieger R,Desoye G,Corcoy R,Mahmood T,Nizard J,Savona-Ventura C,Dunne F

更新日期：2015-07-01 00:00:00

abstract：:Very low density lipoproteins (VLDL) have an abnormal lipid composition in Type 1 (insulin-dependent) diabetic patients. Since VLDL represent a heterogeneous lipoprotein class, this might be due either to a shift in the distribution or to an abnormal composition of VLDL subclasses or both. In order to investigate thes...

journal_title：Diabetologia

authors： Patti L,Romano G,Di Marino L,Annuzzi G,Mancini M,Riccardi G,Rivellese AA

更新日期：1993-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, ...

journal_title：Diabetologia

authors： Jacobson AM,Ryan CM,Cleary PA,Waberski BH,Weinger K,Musen G,Dahms W,Diabetes Control and Complications Trial\/EDIC Research Group.

更新日期：2011-02-01 00:00:00

abstract：:There is ample evidence that environmental factors are involved in the aetiology of type 1 diabetes, but the nature and timing of the interactions are poorly understood. The intrauterine environment is known to play a role in the later development of type 2 diabetes, and this review considers a possible role in type 1...

journal_title：Diabetologia

authors： Stene LC,Gale EA

更新日期：2013-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:We studied the gene therapy efficacy of diabetes-associated wound healing disorder with an adeno-associated virus (AAV) vector expressing the 165-amino acid isoform of human vascular endothelial growth factor-A (VEGF-A) by using an incisional skin-wound model produced on the back of female diabetic C57B...

journal_title：Diabetologia

authors： Galeano M,Deodato B,Altavilla D,Cucinotta D,Arsic N,Marini H,Torre V,Giacca M,Squadrito F

更新日期：2003-04-01 00:00:00

abstract：:Insulin and somatostatin reportedly affect pancreatic acinar cell function via specific receptor binding. Theoretically peri-insular levels depend on the islet-acinar portal system, but the actual hormone levels have never been demonstrated. Rat pancreata were perfused anterogradely or retrogradely with 125I-insulin, ...

journal_title：Diabetologia

authors： Nakagawa A,Stagner JI,Samols E

更新日期：1995-03-01 00:00:00

abstract：:Hybridomas producing proinsulin antibodies were cloned by limiting dilution of cell cultures obtained by fusion of splenocytes of immunized mice with immortal myeloma cells. Some proinsulin monoclonal antibodies crossreacted with labelled insulin but none did with labelled C-peptide indicating that the involved epitop...

journal_title：Diabetologia

authors： Sodoyez JC,Koch M,Lemaire I,Sodoyez-Goffaux F,Rapaille A,François-Gérard C,Sondag D

更新日期：1991-07-01 00:00:00

abstract：:Little is known about the immunological impact of insulin administration other than it can boost insulin autoantibody levels. In particular, while the subcutaneous administration of a soluble foreign antigen (without adjuvant) is generally only weakly immunogenic in a naive animal, it is unknown what effect the subcut...

journal_title：Diabetologia

authors： Tian J,Chau C,Kaufman DL

更新日期：1998-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Elevated circulating adipocyte fatty acid-binding protein (AFABP) levels have been found to correlate with diabetic nephropathy staging in cross-sectional studies. However, it remains unclear whether these higher serum levels reflect a role of AFABP in the development of diabetic kidney disease (DKD), o...

journal_title：Diabetologia

authors： Lee CH,Cheung CYY,Woo YC,Lui DTW,Yuen MMA,Fong CHY,Chow WS,Xu A,Lam KSL

更新日期：2019-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG). METHODS:Peripheral blood m...

journal_title：Diabetologia

authors： Mabilleau G,Petrova NL,Edmonds ME,Sabokbar A

更新日期：2008-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Few data are available about intakes and food sources of trans-fatty acids (TFAs) or their associations with cardiometabolic outcomes in Asian people who consume a prudent diet but are experiencing rapid nutritional transitions. We aimed to investigate the relationships between TFA biomarkers and type 2...

journal_title：Diabetologia

authors： Yu DX,Sun Q,Ye XW,Pan A,Zong G,Zhou YH,Li HX,Hu FB,Lin X

更新日期：2012-11-01 00:00:00

abstract：:Freshly isolated and primary cultured adult rat cardiomyocytes were used to elucidate the mechanism of action of the new oral antidiabetic agent (+/-)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethyl-chroman-2-yl-methoxy)benzyl]-2,4-thiazolidinedione (troglitazone) on the heart. Interaction with protein kinase C (PKC) and regul...

journal_title：Diabetologia

authors： Bähr M,Spelleken M,Bock M,von Holtey M,Kiehn R,Eckel J

更新日期：1996-07-01 00:00:00

abstract：:The prevalence of Type 2 (non-insulin-dependent) diabetes mellitus is high in Mauritius, a multiethnic island nation in the southwestern Indian Ocean. Evaluation of candidate genes in the different ethnic groups represents a means of assessing the genetic component. As glucokinase is known to be a key regulator of glu...

journal_title：Diabetologia

authors： Chiu KC,Province MA,Dowse GK,Zimmet PZ,Wagner G,Serjeantson S,Permutt MA

更新日期：1992-07-01 00:00:00

abstract：:There is now evidence that a single bout of endurance (aerobic) or resistance exercise reduces 24 h post-exercise subcutaneous glucose profiles to the same extent in insulin-resistant humans with or without type 2 diabetes. However, it remains to be determined which group would benefit most from specific exercise prot...

journal_title：Diabetologia

authors： Roden M

更新日期：2012-05-01 00:00:00

abstract：:The content of phosphoenolpyruvate (PEP) has been measured in isolated rat islets of Langerhans incubated in vitro. Islet PEP was higher in islets incubated with 16.7 mmol/1 glucose than in islets incubated with zero or 2.8 mmol/1 glucose. Islet PEP content was also increased in islet incubated with 5 mmol/1 D-glycera...

journal_title：Diabetologia

authors： Sugden MC,Ashcroft SJ

更新日期：1977-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS:We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL acc...

journal_title：Diabetologia

authors： van der Berg JD,Stehouwer CD,Bosma H,van der Velde JH,Willems PJ,Savelberg HH,Schram MT,Sep SJ,van der Kallen CJ,Henry RM,Dagnelie PC,Schaper NC,Koster A

更新日期：2016-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We previously reported the...

journal_title：Diabetologia

authors： Joshi K,Elso C,Motazedian A,Labonne T,Schiesser JV,Cameron F,Mannering SI,Elefanty AG,Stanley EG

更新日期：2019-12-01 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is commonly associated with hypertriglyceridaemia, low serum HDL-cholesterol concentrations, hypertension, obesity and accelerated atherosclerosis (metabolic syndrome X). Since a similar dyslipidaemia occurs with the acute-phase response, we investigated whether elevated...

journal_title：Diabetologia

authors： Pickup JC,Mattock MB,Chusney GD,Burt D

更新日期：1997-11-01 00:00:00

abstract：:Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the pancreas as a whole, emerging evidence may implicate a role for cysti...

journal_title：Diabetologia

authors： Koivula FNM,McClenaghan NH,Harper AGS,Kelly C

更新日期：2016-07-01 00:00:00