In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue.

abstract：:The impact of improved glycaemic control on renal function in newly-presenting Type 2 (non-insulin-dependent) diabetic patients has not been adequately researched. Consequently, glomerular filtration rate and effective renal plasma flow and urinary albumin excretion rates were determined in 76 subjects (age (mean (SD)...

journal_title：Diabetologia

authors： Vora JP,Dolben J,Williams JD,Peters JR,Owens DR

更新日期：1993-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is the most common complication of diabetes and a leading cause of blindness among working-age adults. Anatomical and functional changes occur in the retina and retinal pigment epithelium (RPE) prior to clinical symptoms of the disease. However, the molecular mechanisms responsible ...

journal_title：Diabetologia

authors： Decanini A,Karunadharma PR,Nordgaard CL,Feng X,Olsen TW,Ferrington DA

更新日期：2008-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-2 (GLP-2) is a gut hormone regulating intestinal growth and nutrient absorption. Recently, GLP-2 has been reported to stimulate glucagon secretion in healthy humans. We sought to clarify the mechanism and physiological significance of this endocrine effect. MATERIALS AND METHODS:T...

journal_title：Diabetologia

authors： de Heer J,Pedersen J,Orskov C,Holst JJ

更新日期：2007-10-01 00:00:00

abstract：:The aims of this survey were (1) to estimate the prevalence of known diabetes mellitus in 1988 in Casale Monferrato (Northern Italy); (2) to validate different data sources available in Italy; (3) to identify a population-based cohort of diabetic patients. Multiple independent data sources were used and the capture-re...

journal_title：Diabetologia

authors： Bruno G,Bargero G,Vuolo A,Pisu E,Pagano G

更新日期：1992-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine human enteroviruses (HEVs) and other intestinal viruses derived from children who participated in the Babydiet intervention study and to analyse the findings according to the appearance of islet autoantibodies, dietary intervention, maternal type 1 diabetes and clini...

journal_title：Diabetologia

authors： Simonen-Tikka ML,Pflueger M,Klemola P,Savolainen-Kopra C,Smura T,Hummel S,Kaijalainen S,Nuutila K,Natri O,Roivainen M,Ziegler AG

更新日期：2011-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:High sodium (HS) effects on hypertension are well established. Recent evidence implicates a relationship between HS intake and insulin resistance, even in the absence of hypertension. The aim of the current study was to determine whether loss of the vascular actions of insulin may be the driving factor ...

journal_title：Diabetologia

authors： Premilovac D,Richards SM,Rattigan S,Keske MA

更新日期：2014-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-invasive imaging of the pancreatic beta cell mass (BCM) requires the identification of novel and specific beta cell biomarkers. We have developed a systems biology approach to the identification of promising beta cell markers. METHODS:We followed a functional genomics strategy based on massive para...

journal_title：Diabetologia

authors： Flamez D,Roland I,Berton A,Kutlu B,Dufrane D,Beckers MC,De Waele E,Rooman I,Bouwens L,Clark A,Lonneux M,Jamar JF,Goldman S,Maréchal D,Goodman N,Gianello P,Van Huffel C,Salmon I,Eizirik DL

更新日期：2010-07-01 00:00:00

abstract：:Insulin secretion rates after glucose loading were calculated from peripheral venous IRI concentrations considering half life and distribution space of exogenous insulin in normal men and dogs. The coefficients of multiple linear regression analysis between insulin secretion rates and plasma glucose (level and order a...

journal_title：Diabetologia

authors： Fischer U,Jutzi E,Bombor H,Freyse EJ,Salzieder E,Albrecht G,Besch W,Bruns W

更新日期：1980-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the signalling processes and metabolic actions of BDNF. METHODS:We first examined whether exercise induced BDNF expression in humans. Next, C2C12 skeletal muscle ce...

journal_title：Diabetologia

authors： Matthews VB,Aström MB,Chan MH,Bruce CR,Krabbe KS,Prelovsek O,Akerström T,Yfanti C,Broholm C,Mortensen OH,Penkowa M,Hojman P,Zankari A,Watt MJ,Bruunsgaard H,Pedersen BK,Febbraio MA

更新日期：2009-07-01 00:00:00

abstract：:Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...

journal_title：Diabetologia

authors： Uvnäs-Wallensten K

更新日期：1981-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sympathetic nerves influence islet hormone levels in the circulation. Insights into islet sympathetic innervation and its remodelling in diabetes may impact future therapeutics. However, standard immunohistochemistry and microtome-based microscopy cannot provide an integral view of the islet neurovascul...

journal_title：Diabetologia

authors： Chiu YC,Hua TE,Fu YY,Pasricha PJ,Tang SC

更新日期：2012-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fetal growth is influenced by genetic factors as well as the intra-uterine environment. We hypothesised that some genetic factors may alter fetal insulin secretion and insulin action. SUBJECTS, MATERIALS AND METHODS:To assess this, we analysed plasma insulin concentration in umbilical cord blood from 6...

journal_title：Diabetologia

authors： Shields BM,Knight B,Turner M,Wilkins-Wall B,Shakespeare L,Powell RJ,Hannemann M,Clark PM,Yajnik CS,Hattersley AT

更新日期：2006-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) acts as a cofactor for several nuclear hormone receptors in many tissues and organs implicated in blood pressure regulation. Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension f...

journal_title：Diabetologia

authors： Cheurfa N,Reis AF,Dubois-Laforgue D,Bellanné-Chantelot C,Timsit J,Velho G

更新日期：2004-11-01 00:00:00

abstract：:Serum insulin response to a single bolus of IV glucose or tolbutamide was measured in eight healthy subjects. Insulin disappearance rate was assessed by deconvolution from the serum insulin levels, using the measured insulin disappearance rate. The mean rate constant of insulin disappearance was 0.238 +/- 0.005 min-1 ...

journal_title：Diabetologia

authors： Asano T,Sasaki H,Okumura M

更新日期：1978-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Activin receptor-like kinase 7 (ALK7), a member of the type I receptor serine/threonine kinases of the TGF-beta superfamily, was recently reported to regulate cell proliferation and apoptosis. We hypothesised that ALK7 may play a role in modulating pancreatic beta cell proliferation and/or apoptosis. M...

journal_title：Diabetologia

authors： Zhang N,Kumar M,Xu G,Ju W,Yoon T,Xu E,Huang X,Gaisano H,Peng C,Wang Q

更新日期：2006-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Single nucleotide polymorphisms (SNPs) in G6PC2 have been reported to be associated with fasting plasma glucose level in several populations of European descent. However, whether G6PC2 variants have a similar effect in other ethnic groups is unknown. The aim of this study was to investigate the effect o...

journal_title：Diabetologia

authors： Hu C,Zhang R,Wang C,Ma X,Wang C,Fang Q,Bao Y,Xiang K,Jia W

更新日期：2009-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is significantly upregulated in the serum of individuals with obesity and diabetes. However, whether elevated PEDF levels contribute to DMED remains unknown. This stu...

journal_title：Diabetologia

authors： Che D,Fang Z,Yan L,Du J,Li F,Xie J,Feng J,Yin P,Qi W,Yang Z,Ma J,Yang X,Gao G,Zhou T

更新日期：2020-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR) P446L variant, associated with inverse modulation of glucose- and lipid-related traits, has been shown to alter the kinetics of glucokinase (GCK) i...

journal_title：Diabetologia

authors： Rees MG,Wincovitch S,Schultz J,Waterstradt R,Beer NL,Baltrusch S,Collins FS,Gloyn AL

更新日期：2012-01-01 00:00:00

abstract：:Microencapsulation has been proposed to protect islets of Langerhans against immune rejection in xenogenic transplantation. However, to achieve glucose homeostasis in human diabetic patients, insulin release by microencapsulated islets must increase in response to a glucose load. We microencapsulated isolated rat isle...

journal_title：Diabetologia

authors： Chicheportiche D,Reach G

更新日期：1988-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance i...

journal_title：Diabetologia

authors： Sayers SR,Beavil RL,Fine NHF,Huang GC,Choudhary P,Pacholarz KJ,Barran PE,Butterworth S,Mills CE,Cruickshank JK,Silvestre MP,Poppitt SD,McGill AT,Lavery GG,Hodson DJ,Caton PW

更新日期：2020-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:G-protein-coupled receptor kinases (GRKs) play a key role in agonist-induced desensitisation of G-protein-coupled receptors (GPCRs) that are involved in metabolic regulation and glucose homeostasis. Our aim was to examine whether small peptides derived from the catalytic domain of GRK2 and -3 would amel...

journal_title：Diabetologia

authors： Anis Y,Leshem O,Reuveni H,Wexler I,Ben Sasson R,Yahalom B,Laster M,Raz I,Ben Sasson S,Shafrir E,Ziv E

更新日期：2004-07-01 00:00:00

abstract：:There is ample evidence that environmental factors are involved in the aetiology of type 1 diabetes, but the nature and timing of the interactions are poorly understood. The intrauterine environment is known to play a role in the later development of type 2 diabetes, and this review considers a possible role in type 1...

journal_title：Diabetologia

authors： Stene LC,Gale EA

更新日期：2013-09-01 00:00:00

abstract：:Multiple epidemiological studies have documented an association between metformin, used for treatment of type 2 diabetes, and reduced cancer incidence and mortality. Cell line models may not accurately reflect the effects of metformin in the clinical setting. Moreover, findings from animal model studies have been inco...

journal_title：Diabetologia

authors： Heckman-Stoddard BM,DeCensi A,Sahasrabuddhe VV,Ford LG

更新日期：2017-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of IRS2 in the liver of ...

journal_title：Diabetologia

authors： Krause C,Geißler C,Tackenberg H,El Gammal AT,Wolter S,Spranger J,Mann O,Lehnert H,Kirchner H

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function. METHODS:Isolated islets cultured ex vivo under high- or low-glucose conditions and treated with or witho...

journal_title：Diabetologia

authors： Cheng Q,Li YC,Boucher BJ,Leung PS

更新日期：2011-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes promotes cerebral neovascularisation via increased vascular endothelial growth factor (VEGF) angiogenic signalling. Roundabout-4 (ROBO4) protein is an endogenous inhibitor of VEGF signalling that stabilises the vasculature. Yet, how diabetes affects ROBO4 function remains unknown. We hypothesis...

journal_title：Diabetologia

authors： Abdelsaid M,Coucha M,Hafez S,Yasir A,Johnson MH,Ergul A

更新日期：2017-04-01 00:00:00

abstract：:The eyes, kidneys and pancreas of mice (SJL/J) infected with encephalomyocarditis virus were examined by light and electron microscopy. Diabetic mice with the longest duration (6 months) of diabetes showed marked renal and ocular alterations. Fasting blood glucose levels were 17.8-21.9 mmol/l and glycosuria was presen...

journal_title：Diabetologia

authors： Rodrigues M,Currier C,Yoon J

更新日期：1983-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells have highly developed endoplasmic reticulum (ER) due to their role in insulin secretion. Since ER stress has been associated with beta cell dysfunction, we studied several features of beta cell ER in human type 2 diabetes. METHODS:Pancreatic samples and/or isolated islets from non...

journal_title：Diabetologia

authors： Marchetti P,Bugliani M,Lupi R,Marselli L,Masini M,Boggi U,Filipponi F,Weir GC,Eizirik DL,Cnop M

更新日期：2007-12-01 00:00:00

abstract：:Lack of insulin receptors in mice is associated with near-normal intrauterine growth, unlike patients with leprechaunism, in whom growth deficiency is a prominent clinical feature. Genetic crosses of insulin receptor- and insulin-like growth-factor-1 (IGF-1) receptor-deficient mice indicate, however, that insulin rece...

journal_title：Diabetologia

authors： Cinti S,Eberbach S,Castellucci M,Accili D

更新日期：1998-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The effects of successful pancreas transplant alone (PTA) on chronic complications of diabetes, in particular diabetic retinopathy, remain disputed. We prospectively studied the course of diabetic retinopathy in PTA recipients and in non-transplanted (non-PTA) type 1 diabetic patients. METHODS:The PTA ...

journal_title：Diabetologia

authors： Giannarelli R,Coppelli A,Sartini MS,Del Chiaro M,Vistoli F,Rizzo G,Barsotti M,Del Prato S,Mosca F,Boggi U,Marchetti P

更新日期：2006-12-01 00:00:00