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A novel role for vitamin D: modulation of expression and function of the local renin-angiotensin system in mouse pancreatic islets.

Abstract：

AIMS/HYPOTHESIS:The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function. METHODS:Isolated islets cultured ex vivo under high- or low-glucose conditions and treated with or without calcitriol were examined for changes in RAS component activity and glucose-stimulated insulin secretion (GSIS). Isolated islets from vitamin D receptor knockout (VDR-KO) mice were compared with islets from wild-type (WT) mice for major RAS component expression and RAS protein production. RESULTS:Isolated islets incubated ex vivo under high-glucose conditions showed increased expression and production of major RAS components; this was prevented and reversed by calcitriol in parallel with increases in GSIS. VDR-KO mice displayed increased RAS component mRNA expression and protein production as compared with WT mice, despite comparable glucose homeostasis. CONCLUSIONS:Young mice with vitamin D receptor ablation showed abnormal increases in islet RAS components at mRNA and protein levels, despite unaltered glucose homeostasis. Calcitriol prevents and can correct induction of RAS component production under high-glucose conditions in parallel with the well-known effect of calcitriol on increasing islet beta cell secretory responses to glucose.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Cheng Q,Li YC,Boucher BJ,Leung PS

doi

10.1007/s00125-011-2100-1

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

2077-81

issue

8

eissn

0012-186X

issn

1432-0428

journal_volume

54

pub_type

杂志文章

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