Abstract：
:The antibody response and delayed type hypersensitivity reaction to commercially available trivalent influenza vaccine in 159 patients with diabetes mellitus was compared with response and reaction in 28 healthy volunteers. A correction for prevaccination titres was made. No differences were found between diabetic patients and control subjects with respect to antibody response to the three vaccine strains as measured by the difference between geometric mean titres of post- and prevaccination sera. In Type 1 (insulin-dependent) diabetic patients the incidence of non-responders to two vaccine components was significantly increased (p less than 0.05). The delayed type hypersensitivity reaction to influenza antigen was significantly decreased in patients with high concentrations of glycosylated haemoglobin (p less than 0.01). These findings suggest a role for impaired immune response in the increased influenza morbidity and mortality in patients with diabetes mellitus. Implications for therapy and vaccination strategy are discussed.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Diepersloot RJ,Bouter KP,Beyer WE,Hoekstra JB,Masurel Ndoi
10.1007/BF00292541subject
Has Abstractpub_date
1987-06-01 00:00:00pages
397-401issue
6eissn
0012-186Xissn
1432-0428journal_volume
30pub_type
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