Altered methionine metabolism in streptozotocin-diabetic rats.

abstract：:Previously published Type I (insulin-dependent) diabetes mellitus incidence in 0 to 14-year-old children from 10 countries or areas was compared with the national annual cow milk protein consumption. Countries which were selected for study had appropriate milk protein polymorphism studies, herd breed composition infor...

journal_title：Diabetologia

authors： Elliott RB,Harris DP,Hill JP,Bibby NJ,Wasmuth HE

更新日期：1999-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study compared the incidence rate of type 1 diabetes in children diagnosed with enterovirus (EV) infections with that in age- and sex-matched children without EV infection in a population-based cohort. In addition, we examined whether the direction or magnitude of the association between EV infecti...

journal_title：Diabetologia

authors： Lin HC,Wang CH,Tsai FJ,Hwang KP,Chen W,Lin CC,Li TC

更新日期：2015-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of the study was to analyse how strongly commuting and leisure-time physical activity affect progression to diabetes and to study whether this relationship is different in individuals with isolated impaired fasting glucose (i-IFG) and isolated impaired glucose tolerance (i-IGT). METHODS:We stud...

journal_title：Diabetologia

authors： Engberg S,Glümer C,Witte DR,Jørgensen T,Borch-Johnsen K

更新日期：2010-01-01 00:00:00

abstract：:We have studied the presence of GAD65 autoantibodies in women with insulin-dependent diabetes mellitus (IDDM) (n = 28) or gestational diabetes (GDM) (n = 139) diagnosed during pregnancy and investigated the temporal relationship between these autoantibodies and the subsequent recurrence or development of IDDM. Among t...

journal_title：Diabetologia

authors： Petersen JS,Dyrberg T,Damm P,Kühl C,Mølsted-Pedersen L,Buschard K

更新日期：1996-11-01 00:00:00

abstract：:Renal injury in diabetes mellitus is associated with progressive interstitial fibrosis and extracellular matrix accumulation. However, the phenotypes of cells forming the interstitial infiltrate in diabetic nephropathy have not been precisely defined. There is increasing evidence for the association of mast cells with...

journal_title：Diabetologia

authors： Rüger BM,Hasan Q,Greenhill NS,Davis PF,Dunbar PR,Neale TJ

更新日期：1996-10-01 00:00:00

abstract：:Patients with Type II (non-insulin-dependent) diabetes mellitus manifest abnormalities in insulin action and insulin secretion. It is widely accepted that insulin resistance is an early finding, evident before the onset of hyperglycaemia and predictive of the subsequent development of diabetes. Whether abnormalities i...

journal_title：Diabetologia

authors： Pratley RE,Weyer C

更新日期：2001-08-01 00:00:00

abstract：:The prevalence of diabetes mellitus in 3,145 Tanzanian Africans living in three different areas of the country was studied. Fasting capillary blood glucose concentrations were measured by Dextrometer and if the levels were greater than or equal to 5.5 mmol/l an oral glucose tolerance test was performed. When using the...

journal_title：Diabetologia

authors： Ahrén B,Corrigan CB

更新日期：1984-05-01 00:00:00

abstract：:This review focuses on two paralogue Rab GTPase activating proteins known as TBC1D1 Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 kDa, AS160) and their roles in controlling skeletal muscle glucose transport in response to the independent and combined effects of insulin and exerc...

journal_title：Diabetologia

authors： Cartee GD

更新日期：2015-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures. Here we investigate whether sphingolipid metabolism may contribute to the pathogenesis of human type 1 diabetes ...

journal_title：Diabetologia

authors： Holm LJ,Krogvold L,Hasselby JP,Kaur S,Claessens LA,Russell MA,Mathews CE,Hanssen KF,Morgan NG,Koeleman BPC,Roep BO,Gerling IC,Pociot F,Dahl-Jørgensen K,Buschard K

更新日期：2018-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glomerular mesangial expansion is a characteristic feature of diabetic nephropathy, and the accumulation of AGE in the mesangial lesion has been implicated as one of its potential causes. However, the route for the AGE accumulation in mesangial lesions in diabetic patients is poorly established. METHOD...

journal_title：Diabetologia

authors： Nakajou K,Horiuchi S,Sakai M,Haraguchi N,Tanaka M,Takeya M,Otagiri M

更新日期：2005-02-01 00:00:00

abstract：:Non-obese diabetic mice were treated daily with a mixture of gangliosides from day 30 until day 250 of life or until the mice became diabetic. Ganglioside treatment reduced diabetes incidence from 80-90% to 47% and from 20-30% to zero in female and male mice respectively. Gangliosides did not affect the frequency of p...

journal_title：Diabetologia

authors： Wilberz S,Herberg L,Renold AE

更新日期：1988-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. We hypothesised that mannan-binding lectin (MBL) deficiency may confer risk of obesity and insulin resistance. MATERIALS AND METHODS:We performed a cross-sectional study of MBL protein concentratio...

journal_title：Diabetologia

authors： Fernández-Real JM,Straczkowski M,Vendrell J,Soriguer F,Pérez Del Pulgar S,Gallart L,López-Bermejo A,Kowalska I,Manco M,Cardona F,García-Gil MM,Mingrone G,Richart C,Ricart W,Zorzano A

更新日期：2006-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties. METHODS:Male par...

journal_title：Diabetologia

authors： Broekhuizen LN,Lemkes BA,Mooij HL,Meuwese MC,Verberne H,Holleman F,Schlingemann RO,Nieuwdorp M,Stroes ES,Vink H

更新日期：2010-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cholesterol absorption inhibitor ezetimibe has been shown to ameliorate non-alcoholic fatty liver disease (NAFLD) pathology in a single-armed clinical study and in experimental animal models. In this study, we investigated the efficacy of ezetimibe on NAFLD pathology in an open-label randomised cont...

journal_title：Diabetologia

authors： Takeshita Y,Takamura T,Honda M,Kita Y,Zen Y,Kato K,Misu H,Ota T,Nakamura M,Yamada K,Sunagozaka H,Arai K,Yamashita T,Mizukoshi E,Kaneko S

更新日期：2014-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The main objective of this work was to discover new drugs that can activate the differentiation of multipotent pancreatic progenitors into endocrine cells. METHODS:In vitro experiments were performed using fetal pancreatic explants from rats and mice. In this assay, we examined the actions on pancreati...

journal_title：Diabetologia

authors： Zertal-Zidani S,Busiah K,Edelman A,Polak M,Scharfmann R

更新日期：2013-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Maternal Type I (insulin-dependent) diabetes mellitus is associated with an increased risk for fetal malformations and spontaneous abortions. Although the pathogenic mechanism is not fully understood, reactive oxygen species have been shown to contribute to the pathogenesis in experimental studies. By m...

journal_title：Diabetologia

authors： Cederberg J,Basu S,Eriksson UJ

更新日期：2001-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...

journal_title：Diabetologia

authors： Retnakaran R,Hanley AJ,Raif N,Hirning CR,Connelly PW,Sermer M,Kahn SE,Zinman B

更新日期：2005-05-01 00:00:00

abstract：:Using a prospective randomised double-blind crossover design, the effect of the angiotensin converting enzyme inhibitor enalapril compared to a placebo was studied in 18 normotensive, normoalbuminuric Type 1 (insulin-dependent) diabetic children. Each patient had a high normal or clearly elevated glomerular filtration...

journal_title：Diabetologia

authors： Drummond K,Levy-Marchal C,Laborde K,Kindermans C,Wright C,Dechaux M,Czernichow P

更新日期：1989-04-01 00:00:00

abstract：:The impact of improved glycaemic control on renal function in newly-presenting Type 2 (non-insulin-dependent) diabetic patients has not been adequately researched. Consequently, glomerular filtration rate and effective renal plasma flow and urinary albumin excretion rates were determined in 76 subjects (age (mean (SD)...

journal_title：Diabetologia

authors： Vora JP,Dolben J,Williams JD,Peters JR,Owens DR

更新日期：1993-08-01 00:00:00

abstract：:The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic disorders. Furthermore, it was also revealed that brown adipose tissue (BAT) in humans may consist of so-calle...

journal_title：Diabetologia

authors： Schrauwen P,van Marken Lichtenbelt WD,Spiegelman BM

更新日期：2015-08-01 00:00:00

abstract：:Hyperglycaemia has been shown to play a central part in diabetic vascular disease, which is also influenced by individual background. Hyperglycaemia initiates the pathogenetic sequence through a series of interrelated biochemical abnormalities, including increased flux through the polyol and hexosamine pathways, oxida...

journal_title：Diabetologia

authors： Di Mario U,Pugliese G

更新日期：2001-06-01 00:00:00

abstract：:Glycogen phosphorylase regulates the breakdown of glycogen into glucose, but as previous studies have demonstrated, the control of glycogen metabolism becomes deregulated in diabetes mellitus. Messenger RNA levels encoding several different proteins are altered in skeletal muscle biopsies of patients with insulin-depe...

journal_title：Diabetologia

authors： Reynet C,Kahn CR,Loeken MR

更新日期：1996-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is the most common complication of diabetes and a leading cause of blindness among working-age adults. Anatomical and functional changes occur in the retina and retinal pigment epithelium (RPE) prior to clinical symptoms of the disease. However, the molecular mechanisms responsible ...

journal_title：Diabetologia

authors： Decanini A,Karunadharma PR,Nordgaard CL,Feng X,Olsen TW,Ferrington DA

更新日期：2008-06-01 00:00:00

abstract：:We aimed to assess prandial responses, basal glucose turnover and insulin action (euglycaemic clamp) in a very low-dose neonatal streptozotocin model of Type 2 (non-insulin-dependent) diabetes mellitus. Male Wistar rats were injected at 2 days of age with 45 mg/kg streptozotocin or vehicle (control). At 8 weeks, the g...

journal_title：Diabetologia

authors： Pascoe WS,Jenkins AB,Kusunoki M,Storlien LH

更新日期：1992-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We examined features of the metabolic syndrome to see if they modified the risk of chronic diabetic complications in patients with Type II (non-insulin-dependent) diabetes mellitus. METHODS:A total of 85 randomly selected patients with the metabolic syndrome (WHO definition) were compared with 85 Type ...

journal_title：Diabetologia

authors： Isomaa B,Henricsson M,Almgren P,Tuomi T,Taskinen MR,Groop L

更新日期：2001-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:We had previously reported that stromal cell-derived factor 1 (SDF-1) mediates chemorepulsion of diabetogenic T cell adhesion to islet microvascular endothelium through unknown mechanisms in NOD mice. Here we report that SDF-1-mediated chemorepulsion occurs through slit homologue (SLIT)2-roundabout, axo...

journal_title：Diabetologia

authors： Glawe JD,Mijalis EM,Davis WC,Barlow SC,Gungor N,McVie R,Kevil CG

更新日期：2013-10-01 00:00:00

abstract：:Glycosylated haemoglobin (HbA1) was measured serially by microcolumn chromatography in 38 children with newly diagnosed insulin-dependent diabetes. Initial HbA1 levels of 13.6 +/- 0.5% fell signficiantly from day 0 (prior to therapy) both to day 1 (1.6 +/- 0.2% decrease) and to day 3-5 (2.6 +/- 0.4% decrease) (P < 0.0...

journal_title：Diabetologia

authors： Daneman D,Tsalikian E,Hengstenberg F,Becker DJ,Drash AL

更新日期：1980-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:To study if people with Type I (insulin-dependent) or Type II (non-insulin-dependent) diabetes mellitus have increased risk of hip fracture. METHODS:The study population consisted of 35,444 people 50 years of age and older, attending a health screening in a Norwegian county. They were followed up with ...

journal_title：Diabetologia

authors： Forsén L,Meyer HE,Midthjell K,Edna TH

更新日期：1999-08-01 00:00:00

abstract：:Blood glucose values close to normal reduce the microvascular complications of insulin-dependent diabetes mellitus. The Stockholm study of this effect continued after the initial 7.5-year period in order to see what happened when intensively treated patients were left to control their own treatment while treatment was...

journal_title：Diabetologia

authors： Reichard P,Pihl M,Rosenqvist U,Sule J

更新日期：1996-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:We describe a novel model of insulin-deficient diabetes with a single copy of the gene encoding insulin 1 (Ins1) and no gene encoding insulin 2 (Ins2). MATERIALS AND METHODS:We constructed five lines of mice: mice with two copies of Ins1 (NOD( Ins1+/+,Ins2-/-)), mice with a single copy of Ins1 (NOD( In...

journal_title：Diabetologia

authors： Babaya N,Nakayama M,Moriyama H,Gianani R,Still T,Miao D,Yu L,Hutton JC,Eisenbarth GS

更新日期：2006-06-01 00:00:00