Mast cells and type VIII collagen in human diabetic nephropathy.

abstract：:Insulin secretion was stimulated and cyclic adenosine 3', 5'-monophosphate (cAMP) levels were elevated in isolated rat islets by 27.5 mmol/l glucose. Alloxan caused a dose-dependent decrease in both variables with complete obliteration of insulin release at a concentration of 1.25 mmol/l. D-glucose, in the presence or...

journal_title：Diabetologia

authors： Zawalich WS,Karl RC,Matschinsky FM

更新日期：1979-02-01 00:00:00

abstract：:Overall D-glucose metabolism and 3-0-methylglucose transport were measured in the perfused heart preparation of lean and genetically obese (fa/fa) rats. Absolute values of basal and insulin-stimulated glucose metabolism were decreased in hearts of 15-week-old obese rats when compared to lean age-matched controls. Basa...

journal_title：Diabetologia

authors： Zaninetti D,Crettaz M,Jeanrenaud B

更新日期：1983-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The therapeutic benefit of physical activity to prevent and treat type 2 diabetes is commonly accepted. However, the impact of the disease on the acute metabolic response is less clear. To this end, we investigated the effect of type 2 diabetes on exercise-induced plasma metabolite changes and the muscu...

journal_title：Diabetologia

authors： Hansen JS,Zhao X,Irmler M,Liu X,Hoene M,Scheler M,Li Y,Beckers J,Hrabĕ de Angelis M,Häring HU,Pedersen BK,Lehmann R,Xu G,Plomgaard P,Weigert C

更新日期：2015-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Simultaneous kidney-pancreas transplantation is an established treatment for patients with type 1 diabetes and end-stage renal failure, even though restored beta cell function may become affected by recurrent islet autoimmunity or graft rejection. We characterised infiltrating lymphocytes isolated from ...

journal_title：Diabetologia

authors： Velthuis JH,Unger WW,van der Slik AR,Duinkerken G,Engelse M,Schaapherder AF,Ringers J,van Kooten C,de Koning EJ,Roep BO

更新日期：2009-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is characterised by leucocyte infiltration of pancreatic islets and a progressive destruction of insulin-producing beta cells. As endothelial nitric oxide production is known to regulate adhesion molecule expression and leucocyte permeation, we examined the a...

journal_title：Diabetologia

authors： Suschek CV,Bonmann E,Kolb-Bachofen V

更新日期：1999-04-01 00:00:00

abstract：:This study analyses 2848 primary major lower limb amputations in diabetic individuals during the period 1982-1993. The male:female sex ratio (mean 1.18) increased, while the mean age at the primary amputation was constant (70.96 years) during the period. The incidence uniformly decreased for both men and women by 0.96...

journal_title：Diabetologia

authors： Ebskov B,Ebskov L

更新日期：1996-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect. Recently, the plant-derived sugar a...

journal_title：Diabetologia

authors： Kishore P,Kehlenbrink S,Hu M,Zhang K,Gutierrez-Juarez R,Koppaka S,El-Maghrabi MR,Hawkins M

更新日期：2012-06-01 00:00:00

abstract：:We have studied the epidemiologic characteristics of insulin-dependent (Type 1) diabetic patients aged 0-19 in a city (San Diego, southern California, USA) characterized by an impressive racial diversity and especially mild and constant climatic conditions. Ascertainment was through retrospective review of medical rec...

journal_title：Diabetologia

authors： Lorenzi M,Cagliero E,Schmidt NJ

更新日期：1985-10-01 00:00:00

abstract：:The ultrastructure of myocardium was examined in short-term diabetic rats. Morphometric analysis showed the volume of myocytic mitochondria, sarcoplasmic reticulum and lipid droplets to be significantly increased compared with those of control animals. Further measurements of mitochondria and sarcoplasmic reticulum in...

journal_title：Diabetologia

authors： Reinilä A,Akerblom HK

更新日期：1984-09-01 00:00:00

abstract：:Rat pups delivered by caesarian section one day before term, either remained attached to (experimental group) or were separated from their placenta (control group). Both groups were transferred into an incubator and their metabolic parameters studied. In the control group, plasma amino acid concentration fell from 11....

journal_title：Diabetologia

authors： Sodoyez-Goffaux F,Sodoyez JC,De Vos CJ

更新日期：1981-05-01 00:00:00

abstract：:We have studied the presence of GAD65 autoantibodies in women with insulin-dependent diabetes mellitus (IDDM) (n = 28) or gestational diabetes (GDM) (n = 139) diagnosed during pregnancy and investigated the temporal relationship between these autoantibodies and the subsequent recurrence or development of IDDM. Among t...

journal_title：Diabetologia

authors： Petersen JS,Dyrberg T,Damm P,Kühl C,Mølsted-Pedersen L,Buschard K

更新日期：1996-11-01 00:00:00

abstract：:Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after...

journal_title：Diabetologia

authors： Krentz AJ,Clark PM,Cox L,Williams AC,Nattrass M

更新日期：1992-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We previously reported the...

journal_title：Diabetologia

authors： Joshi K,Elso C,Motazedian A,Labonne T,Schiesser JV,Cameron F,Mannering SI,Elefanty AG,Stanley EG

更新日期：2019-12-01 00:00:00

abstract：:The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...

journal_title：Diabetologia

authors： Cavallo-Perin P,Chiambretti A,Calefato V,Tomalino M,Urbino R,Cecchini G,Pagano G

更新日期：1991-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Defective beta cell function during lipid oversupply and type 2 diabetes is associated with dysregulation of lysosomal function and autophagy. Whether this dysregulation represents augmentation or inhibition is unclear because of technical limitations in assaying autophagy. The current aim was to determ...

journal_title：Diabetologia

authors： Chu KY,O'Reilly L,Ramm G,Biden TJ

更新日期：2015-09-01 00:00:00

abstract：:The development of proteinuria and its response to insulin therapy in acute experimental diabetes was examined in 11 female rats by sequentially measuring 24 h excretion of glucose and total protein before diabetes, during 5-37 days of acute streptozotocin diabetes, during and after 7-14 days of continuous subcutaneou...

journal_title：Diabetologia

authors： Pennell JP,Millard MM,Ashby MH

更新日期：1981-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Inflammation is associated with obesity and has been implicated in the development of diabetes and atherosclerosis. During gram-negative bacterial infection, lipopolysaccharide causes an inflammatory reaction via toll-like receptor 4 (TLR4), which has an essential function in the induction of innate and...

journal_title：Diabetologia

authors： Poggi M,Bastelica D,Gual P,Iglesias MA,Gremeaux T,Knauf C,Peiretti F,Verdier M,Juhan-Vague I,Tanti JF,Burcelin R,Alessi MC

更新日期：2007-06-01 00:00:00

abstract：:Present-day treatments for people that are insulin dependent require multiple insulin injections, sometimes with an insulin pump, coupled with regular blood glucose monitoring. The availability of modified insulins, each with peaks of activity at varying times, has improved diabetes management. On the other hand, ther...

journal_title：Diabetologia

authors： Melton D

更新日期：2021-01-16 00:00:00

abstract：AIMS/HYPOTHESIS:Platelet activation, endothelial dysfunction and inflammation may be involved in early stages of diabetic microangiopathy. We therefore investigated patients with Type 1 diabetes mellitus, without ( n=19) and with ( n=20) microangiopathy, matched for glycaemic control and duration of disease, and matche...

journal_title：Diabetologia

authors： Yngen M,Östenson CG,Hu H,Li N,Hjemdahl P,Wallén NH

更新日期：2004-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG). METHODS:Peripheral blood m...

journal_title：Diabetologia

authors： Mabilleau G,Petrova NL,Edmonds ME,Sabokbar A

更新日期：2008-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:As one of the key adipokines, retinol binding protein 4 (RBP4) is suggested to positively correlate with insulin resistance; however, not all clinical studies support this association. Although some explanations are proposed for this discrepancy, the temporal aspect of RBP4 secretion has not been consid...

journal_title：Diabetologia

authors： Ma X,Zhou Z,Chen Y,Wu Y,Liu Y

更新日期：2016-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis t...

journal_title：Diabetologia

authors： Sutinen J,Kannisto K,Korsheninnikova E,Nyman T,Ehrenborg E,Andrew R,Wake DJ,Hamsten A,Walker BR,Yki-Järvinen H

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study estimated the economic efficiency (1) of intensive blood glucose control and tight blood pressure control in patients with type 2 diabetes who also had hypertension, and (2) of metformin therapy in type 2 diabetic patients who were overweight. METHODS:We conducted cost-utility analysis based...

journal_title：Diabetologia

authors： Clarke PM,Gray AM,Briggs A,Stevens RJ,Matthews DR,Holman RR,UKPDS 72 United Kingdom Prospective Diabetes Study.

更新日期：2005-05-01 00:00:00

abstract：:The effects of four sulphonylureas (gliclazide, glibenclamide, chlorpropamide and glipizide) on insulin binding and insulin action were studied in vitro using primary cultured rat hepatocytes. Cells were cultured for 20 h in the absence or presence of the sulphonylurea. The binding of insulin to rat hepatocyte monolay...

journal_title：Diabetologia

authors： Dolais-Kitabgi J,Alengrin F,Freychet P

更新日期：1983-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to establish if stem cells contained in cord blood cell allografts have the capacity to differentiate into insulin-expressing beta cells in humans. METHODS:We studied pancreases obtained at autopsy from individuals (n = 11) who had prior opposite-sex cord blood transplants to reconstitute hae...

journal_title：Diabetologia

authors： Huang CJ,Butler AE,Moran A,Rao PN,Wagner JE,Blazar BR,Rizza RA,Manivel JC,Butler PC

更新日期：2011-05-01 00:00:00

abstract：:C-peptide was determined in 24-h urine collections and in fasting plasma of 27 Type 1 (insulin-dependent) diabetic children (duration of disease 0-6 years) and in 11 matched normal children. Grouping the patients according to duration of disease from onset to 6 years, it was found that in the first year of disease the...

journal_title：Diabetologia

authors： Aurbach-Klipper J,Sharph-Dor R,Heding LG,Karp M,Laron Z

更新日期：1983-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hypertension, obesity, impaired glucose tolerance and dyslipidaemia are metabolic abnormalities that often cluster together more often than expected by chance alone. Since these metabolic variables are highly heritable and are at least partially genetically determined, the clustering of defects in these...

journal_title：Diabetologia

authors： Chiu YF,Chuang LM,Kao HY,Ho LT,Ting CT,Hung YJ,Chen YD,Donlon T,Curb JD,Quertermous T,Hsiung CA

更新日期：2007-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:An isoform of glutamic acid decarboxylase, (GAD)65 has been identified as a pancreatic beta-cell autoantigen in Type I (insulin dependent) diabetes mellitus. We investigated the expression of GAD isoforms among single rat beta cells in culture, under different conditions and the correlation between GAD6...

journal_title：Diabetologia

authors： Sánchez-Soto MC,Larrieta ME,Vidaltamayo R,Hiriart M

更新日期：1999-09-01 00:00:00

abstract：:An in vitro method for detecting IgE insulin antibody using the principle of the radioallergosorbent test (RAST) is described. In six patients with insulin allergy, the RAST values were higher than in normal persons or insulin-treated diabetics without insulin-allergy. No differences were observed between normal perso...

journal_title：Diabetologia

authors： Nakagawa S,Saito N,Nakayama H,Sasaki T,Watanabe T,Aoki S

更新日期：1978-01-14 00:00:00

abstract：AIMS/HYPOTHESIS:Impaired central vision has been shown to predict diabetic peripheral neuropathy (DPN). Several studies have demonstrated diffuse retinal neurodegenerative changes in diabetic patients prior to retinopathy development, raising the prospect that non-central vision may also be compromised by primary neura...

journal_title：Diabetologia

authors： Sampson GP,Shahidi AM,Vagenas D,Pritchard N,Edwards K,Russell AW,Malik RA,Efron N

更新日期：2012-04-01 00:00:00