Gangliosides in vivo reduce diabetes incidence in non-obese diabetic mice.

Abstract:

:Non-obese diabetic mice were treated daily with a mixture of gangliosides from day 30 until day 250 of life or until the mice became diabetic. Ganglioside treatment reduced diabetes incidence from 80-90% to 47% and from 20-30% to zero in female and male mice respectively. Gangliosides did not affect the frequency of perivasculitis. It is concluded that gangliosides can reduce diabetes incidence in non-obese diabetic mice.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Wilberz S,Herberg L,Renold AE

doi

10.1007/BF00277490

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

855-7

issue

11

eissn

0012-186X

issn

1432-0428

journal_volume

31

pub_type

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