Enalapril does not alter renal function in normotensive, normoalbuminuric, hyperfiltering type 1 (insulin-dependent) diabetic children.

abstract：AIMS/HYPOTHESIS:We evaluated the secular trend of glycaemic control in individuals with type 2 diabetes in developing countries, where data are limited. METHODS:The International Diabetes Management Practices Study provides real-world evidence of patient profiles and diabetes care practices in developing countries in ...

journal_title：Diabetologia

authors： Aschner P,Gagliardino JJ,Ilkova H,Lavalle F,Ramachandran A,Mbanya JC,Shestakova M,Chantelot JM,Chan JCN

更新日期：2020-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an angiotensin converting enzyme inhibitor (ACEI). METHODS:We examined the effects of olmesartan, an ARB, on primary compo...

journal_title：Diabetologia

authors： Imai E,Chan JC,Ito S,Yamasaki T,Kobayashi F,Haneda M,Makino H,ORIENT study investigators.

更新日期：2011-12-01 00:00:00

abstract：:Isloated rat islets were maintained in vitro in a perifusion system, exposed to alloxan (20 mg/100 ml) for 5 minutes in the presence of agents which affect cAMP metabolism and subsequently stimulated with glucose. The rate of insulin secretion was monitored throughout the period of perifusion. Exposure to alloxan alon...

journal_title：Diabetologia

authors： Lacy PE,McDaniel ML,Fink CJ,Roth C

更新日期：1975-12-01 00:00:00

abstract：:Islet amyloid polypeptide is a 37 amino acid hormone-like peptide which is the major protein component of islet amyloid deposits commonly found in patients with Type 2 (non-insulin-dependent) diabetes mellitus. Recent studies indicate that a physiologically active form of this peptide appears to be carboxyamidated and...

journal_title：Diabetologia

authors： Sowa R,Sanke T,Hirayama J,Tabata H,Furuta H,Nishimura S,Nanjo K

更新日期：1990-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:A high prevalence of diabetes contributes to excess CHD in Indian Asians, but the underlying mechanisms are unclear. Heart rate, heart rate variability (HRV) and baroreflex sensitivity (BRS) are measures of cardiac autonomic function that are disturbed by hyperglycaemia and predict CHD. We compared thes...

journal_title：Diabetologia

authors： Bathula R,Hughes AD,Panerai R,Potter J,Thom SA,Francis DP,Shore AC,Kooner J,Chaturvedi N

更新日期：2010-10-01 00:00:00

abstract：:The immune response of diabetic patients to influenza vaccination was examined in 31 patients, 10 with Type 1 (insulin-dependent) diabetes and 21 with Type 2 (non-insulin-dependent diabetes), and in 19 normal subjects. Each received a single intramuscular injection of the 3 virus strains (A/Chile,A/Philippines,B/USSR)...

journal_title：Diabetologia

authors： Pozzilli P,Gale EA,Visalli N,Baroni M,Crovari P,Frighi V,Cavallo MG,Andreani D

更新日期：1986-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Soluble CD163 (sCD163) was recently identified as a strong risk marker for developing type 2 diabetes. We hypothesised that sCD163 independently associates with insulin resistance. METHODS:This cross-sectional study includes 234 participants: 96 with type 2 diabetes, 34 with impaired glucose tolerance ...

journal_title：Diabetologia

authors： Parkner T,Sørensen LP,Nielsen AR,Fischer CP,Bibby BM,Nielsen S,Pedersen BK,Møller HJ

更新日期：2012-06-01 00:00:00

abstract：:In vitro and in vivo studies have suggested that metabolic deterioration can be induced by hyperglycaemia per se. The effect of 53 h of 2.2 mg glucose.kg ideal body weight-1.min-1 was examined in four normal male subjects. This produced overnight hyperglycaemia of 6.0 mmol/l on the two nights of the study compared wit...

journal_title：Diabetologia

authors： Flax H,Matthews DR,Levy JC,Coppack SW,Turner RC

更新日期：1991-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women. METHODS:This was a prospective study of 62,095 middle-aged parous women in Shanghai, China, who had no prior ...

journal_title：Diabetologia

authors： Villegas R,Gao YT,Yang G,Li HL,Elasy T,Zheng W,Shu XO

更新日期：2008-02-01 00:00:00

abstract：:Glucagon-like peptide-1 and glucagon-like peptide-2 are encoded by the m-RNA of pancreatic preproglucagon. They show high conservation in different species and substantial sequence homology to glucagon. Because no definite biological activity of these peptides has been reported, we investigated the effect of synthetic...

journal_title：Diabetologia

authors： Schmidt WE,Siegel EG,Creutzfeldt W

更新日期：1985-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial. METHODS:In 62 non-diabetic women and men (age 24-69 years, BMI 21-39 kg/m2), we measured VAT and subcutaneous ...

journal_title：Diabetologia

authors： Gastaldelli A,Sironi AM,Ciociaro D,Positano V,Buzzigoli E,Giannessi D,Lombardi M,Mari A,Ferrannini E

更新日期：2005-10-01 00:00:00

abstract：:Pancreatic beta cells differ in terms of glucose responsiveness, insulin secretion and proliferative capacity; however, the molecular pathways that regulate this cellular heterogeneity are unknown. We have identified the Wnt-planar cell polarity (PCP) effector Flattop (FLTP) as a biomarker that identifies mature beta ...

journal_title：Diabetologia

authors： Migliorini A,Roscioni SS,Lickert H

更新日期：2016-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess and compare risks of having large- or small-for gestational age (LGA and SGA, respectively) infants born to women with gestational diabetes mellitus (GDM) from ten racial/ethnic groups. METHODS:LGA and SGA were defined as birthweight >90th and <10th percentile, respe...

journal_title：Diabetologia

authors： Xiang AH,Black MH,Li BH,Martinez MP,Sacks DA,Lawrence JM,Buchanan TA,Jacobsen SJ

更新日期：2015-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study aimed to investigate whether baseline physical activity protects against the occurrence of type 2 diabetes during a 28 year follow-up, after controlling for childhood environment and genetic predisposition. METHODS:At baseline in 1975 same-sex twin pairs born in Finland before 1958 were sent ...

journal_title：Diabetologia

authors： Waller K,Kaprio J,Lehtovirta M,Silventoinen K,Koskenvuo M,Kujala UM

更新日期：2010-12-01 00:00:00

abstract：:The influence of sex on pancreatic islet B cell susceptibility to streptozotocin was studied in mice given multiple low doses of streptozotocin. Male C3 D2 F1 mice developed a steadily increasing blood glucose level after a lag period of about 3 weeks, in contrast to females who were resistant. Spleen cells from strep...

journal_title：Diabetologia

authors： Kromann H,Christy M,Lernmark A,Nedergaard M,Nerup J

更新日期：1982-03-01 00:00:00

abstract：:The plasma concentration of 1,5-anhydro-D-glucitol(AG)(1-deoxyglucose) is known to decrease in diabetic patients. In order to evaluate the usefulness of this polyol as a diabetic marker, we examined the specificity of the plasma AG reduction in various diseases: the plasma AG level was determined in 108 newly diagnose...

journal_title：Diabetologia

authors： Yamanouchi T,Akanuma H,Nakamura T,Akaoka I,Akanuma Y

更新日期：1988-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Oxidative stress is associated with diabetes, hypertension and atherosclerosis. Insulin resistance is implicated in the development of these disorders. We tested the hypothesis that oxidative stress induces insulin resistance in rats, and endeavoured to identify mechanisms linking the two. METHODS:Buth...

journal_title：Diabetologia

authors： Ogihara T,Asano T,Katagiri H,Sakoda H,Anai M,Shojima N,Ono H,Fujishiro M,Kushiyama A,Fukushima Y,Kikuchi M,Noguchi N,Aburatani H,Gotoh Y,Komuro I,Fujita T

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. METHODS:Sixty-three...

journal_title：Diabetologia

authors： Göbl CS,Bozkurt L,Tura A,Leutner M,Andrei L,Fahr L,Husslein P,Eppel W,Kautzky-Willer A

更新日期：2017-12-01 00:00:00

abstract：:Measurement of insulin autoantibodies (IAA) with a novel micro radiobinding assay which requires only 20 microl of serum was compared with that in a conventional radiobinding assay which uses 600 microl of serum. IAA were measured with both assays in samples from 94 new onset insulin-dependent diabetes mellitus (IDDM)...

journal_title：Diabetologia

authors： Naserke HE,Dozio N,Ziegler AG,Bonifacio E

更新日期：1998-06-01 00:00:00

abstract：:The aim of the present study was to determine whether short-term appropriate insulinization of Type 1 (insulin-dependent) diabetic patients in long-term poor glycaemic control (HbA1C > 9.5%) was associated with an adaptive regulation of the activity and gene expression of key proteins in muscle glycogen storage and gl...

journal_title：Diabetologia

authors： Vestergaard H,Andersen PH,Lund S,Vedel P,Pedersen O

更新日期：1994-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS:We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL acc...

journal_title：Diabetologia

authors： van der Berg JD,Stehouwer CD,Bosma H,van der Velde JH,Willems PJ,Savelberg HH,Schram MT,Sep SJ,van der Kallen CJ,Henry RM,Dagnelie PC,Schaper NC,Koster A

更新日期：2016-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to elucidate whether excess glucocorticoids and increased dietary lipids act synergistically to impair glucose tolerance and, if so, whether activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has an adverse or beneficial effect on glucose tolerance. METHODS:Dexamethaso...

journal_title：Diabetologia

authors： Holness MJ,Smith ND,Greenwood GK,Sugden MC

更新日期：2005-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional s...

journal_title：Diabetologia

authors： Perez-Alcantara M,Honoré C,Wesolowska-Andersen A,Gloyn AL,McCarthy MI,Hansson M,Beer NL,van de Bunt M

更新日期：2018-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Tenascin-C (TN-C) is an extracellular matrix glycoprotein highly expressed in inflammatory and cardiovascular (CV) diseases. Serum TN-C has not yet been specifically studied in individuals with type 2 diabetes, a condition associated with chronic low-grade inflammation and increased CV disease risk. In ...

journal_title：Diabetologia

authors： Gellen B,Thorin-Trescases N,Thorin E,Gand E,Sosner P,Brishoual S,Rigalleau V,Montaigne D,Javaugue V,Pucheu Y,Gatault P,Piguel X,Hadjadj S,Saulnier PJ,SURDIAGENE Study group.

更新日期：2020-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Currently, three categories of measures are used to assess cardiovascular autonomic dysfunction: measures of the Ewing-test, measures of heart-rate variability, and measures of baroreflex sensitivity. We studied the determinants of these measures obtained from cardiovascular autonomic function tests in ...

journal_title：Diabetologia

authors： Gerritsen J,Dekker JM,TenVoorde BJ,Bertelsmann FW,Kostense PJ,Stehouwer CD,Heine RJ,Nijpels G,Heethaar RM,Bouter LM

更新日期：2000-05-01 00:00:00

abstract：:Insulin action and insulin specific binding to erythrocytes were examined in ten recipients of a pancreatic segment and renal graft (Group 1), in nine non-diabetic kidney recipients (Group 2) and in ten age- and weight-matched healthy control subjects (Group 3). All transplant recipients were normoglycaemic without ne...

journal_title：Diabetologia

authors： Saudek F,Pelikánová T,Bartos V,Reneltová I,Kazdová L,Kovár J,Karasová L

更新日期：1991-08-01 00:00:00

abstract：:Amylin is a 37-amino acid pancreatic polypeptide, probably involved in the pathophysiology of Type 2 (non-insulin-dependent) diabetes mellitus. We have determined amylin in human plasma by extraction-based radioimmunoassay (Sep-Pak C18). Of 23 healthy control subjects plasma amylin was determined as 11.9 +/- 3.5 ng/l....

journal_title：Diabetologia

authors： Hartter E,Svoboda T,Ludvik B,Schuller M,Lell B,Kuenburg E,Brunnbauer M,Woloszczuk W,Prager R

更新日期：1991-01-01 00:00:00

abstract：:Aspects of the regulation of the glucose transport by perfused hearts of normal rats have been studied by measuring glucose transport (via the efflux of labelled 3-O-methyl-D-glucose) and glucose transporters (via the labelled cytochalasin B binding assay). Similarly to what is observed with insulin, increasing worklo...

journal_title：Diabetologia

authors： Zaninetti D,Greco-Perotto R,Jeanrenaud B

更新日期：1988-02-01 00:00:00

abstract：:In this study, we found that the ratio of proinsulin to total immunoreactive insulin was much higher in 22 patients with Type 2 (non-insulin-dependent) diabetes mellitus than in 28 non-diabetic control subjects of similar age and adiposity (32 +/- 3 vs 15 +/- 1%, p less than 0.001). In addition, the arginine-induced a...

journal_title：Diabetologia

authors： Ward WK,LaCava EC,Paquette TL,Beard JC,Wallum BJ,Porte D Jr

更新日期：1987-09-01 00:00:00

abstract：:Muscle glycogen synthase (GYS1) is a key enzyme of non-oxidative pathway of glucose metabolism that has been reported to be related to insulin resistance in non-insulin-dependent diabetic (NIDDM) patients. We scanned the GYS1 gene for mutation by single strand conformational polymorphism in 244 non-obese Japanese NIDD...

journal_title：Diabetologia

authors： Shimomura H,Sanke T,Ueda K,Hanabusa T,Sakagashira S,Nanjo K

更新日期：1997-08-01 00:00:00