当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy.

Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy.

Abstract：

AIMS/HYPOTHESIS:Maternal Type I (insulin-dependent) diabetes mellitus is associated with an increased risk for fetal malformations and spontaneous abortions. Although the pathogenic mechanism is not fully understood, reactive oxygen species have been shown to contribute to the pathogenesis in experimental studies. By measuring 8-iso-PGF2alpha and protein carbonyls, radical oxygen damage to lipids and proteins can be estimated. The aim of this study was to investigate the status of lipid peroxidation and protein carbonylation in mothers and fetuses in experimental diabetic pregnancy. METHODS:Non-pregnant and pregnant rats with and without streptozotocin-induced diabetes were studied after 4 weeks of diabetes or at gestational day 19, respectively. Gross morphology of the offspring was studied and 24 h urine, plasma, amniotic fluid, maternal and fetal livers were collected. Concentrations of 8-iso-PGF2alpha, 15-keto-DH-PGF2alpha and other oxidative stress variables were measured. RESULTS:Malformation and resorption rates were increased in diabetic litters, whereas fetal weights were decreased in the control rats. There were no statistically significant differences in maternal plasma concentrations of 8-iso-PGF2alpha, but plasma protein carbonyl content was increased in the diabetic groups. Pregnancy increased 24 h urinary excretion of 8-iso-PGF2alpha in diabetic rats but not in the control rats. There was no difference in the amniotic fluid concentration of 8-iso-PGF2alpha between the normal and the diabetic group. However, in the diabetic group there was a correlation between the uterine horn concentration of 8-iso-PGF2alpha and the percentage of resorptions. CONCLUSIONS/INTERPRETATION:In diabetic pregnancy, both diabetes and pregnancy are promoting oxygen radical damage. Fetal oxidative stress markers do not clearly reflect fetal morphology.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Cederberg J,Basu S,Eriksson UJ

doi

10.1007/s001250051686

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

766-74

issue

6

eissn

0012-186X

issn

1432-0428

journal_volume

44

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • The SstI polymorphism of the apo C-III gene is associated with insulin sensitivity in young men.

    abstract：AIMS/HYPOTHESIS:Insulin resistance is considered to be a risk factor for diabetes and coronary heart disease and is determined by the interaction between genetic and environmental factors. The SstI polymorphism in the apolipoprotein C-III gene has been related to the presence of different features of the insulin resist...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-002-0884-8

    authors： Pérez-Jiménez F,López-Miranda J,Gómez P,Velasco MJ,Marín C,Pérez-Martínez P,Moreno JA,Paniagua JA

    更新日期：2002-08-01 00:00:00

  • Blood-based signatures in type 1 diabetes.

    abstract：:Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and ha...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-015-3843-x

    authors： Cabrera SM,Chen YG,Hagopian WA,Hessner MJ

    更新日期：2016-03-01 00:00:00

  • Non-neural tyrosine hydroxylase, via modulation of endocrine pancreatic precursors, is required for normal development of beta cells in the mouse pancreas.

    abstract：AIMS/HYPOTHESIS:Apart from transcription factors, little is known about the molecules that modulate the proliferation and differentiation of pancreatic endocrine cells. The early expression of tyrosine hydroxylase (TH) in a subset of glucagon(+) cells led us to investigate whether catecholamines have a role in beta cel...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3341-6

    authors： Vázquez P,Robles AM,de Pablo F,Hernández-Sánchez C

    更新日期：2014-11-01 00:00:00

  • Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life.

    abstract：AIMS/HYPOTHESIS:An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not pro...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-0118-y

    authors： Finken MJ,Keijzer-Veen MG,Dekker FW,Frölich M,Hille ET,Romijn JA,Wit JM,Dutch POPS-19 Collaborative Study Group.

    更新日期：2006-03-01 00:00:00

  • A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

    abstract：AIMS/HYPOTHESIS:The enzyme hormone-sensitive lipase (HSL) is produced and is active in pancreatic beta cells. Because lipids are known to play a crucial role in normal control of insulin release and in the deterioration of beta cell function, as observed in type 2 diabetes, actions of HSL in beta cells may be critical....

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1191-9

    authors： Fex M,Haemmerle G,Wierup N,Dekker-Nitert M,Rehn M,Ristow M,Zechner R,Sundler F,Holm C,Eliasson L,Mulder H

    更新日期：2009-02-01 00:00:00

  • Circadian variation of serum glucose, C-peptide immunoreactivity and free insulin normal and insulin-treated diabetic pregnant subjects.

    abstract：:To examine differences among pregnant diabetic and nondiabetic subjects, serum glucose, and immunoreactivity of C-peptide, free and total insulin were measured at hourly intervals during a 24--h third trimester metabolic ward evaluation. Six normals, three mild, and four juvenile-onset type diabetics were studied. Die...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00420978

    authors： Lewis SB,Wallin JD,Kuzuya H,Murray WK,Coustan DR,Daane TA,Rubenstein AH

    更新日期：1976-08-01 00:00:00

  • Secular trend for mortality from breast cancer and the association between diabetes and breast cancer in Taiwan between 1995 and 2006.

    abstract：AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1204-8

    authors： Tseng CH,Chong CK,Tai TY

    更新日期：2009-02-01 00:00:00

  • Effect of interferon on encephalomyocarditis virus infection of cultured mouse pancreatic B cells.

    abstract：:The M variant of encephalomyocarditis virus (EMC) produces a disease similar to human insulin-dependent diabetes mellitus in some but not all strains of mice. This diabetogenic M variant was found to induce fivefold more interferon than non-diabetogenic strains of EMC in cultures of mouse L 929 fibroblasts. When inter...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00275945

    authors： Wilson GL,Bellomo SC,Craighead JE

    更新日期：1983-01-01 00:00:00

  • Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases.

    abstract：:The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies ...

    journal_title：Diabetologia

    pub_type： 传,历史文章,杂志文章,评审

    doi：10.1007/BF00400826

    authors： Hutton JC

    更新日期：1994-09-01 00:00:00

  • Transition of metabolic phenotypes and risk of subclinical atherosclerosis according to BMI: a prospective study.

    abstract：AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05116-5

    authors： Lin L,Zhang J,Jiang L,Du R,Hu C,Lu J,Wang T,Li M,Zhao Z,Xu Y,Xu M,Bi Y,Ning G,Wang W,Chen Y

    更新日期：2020-07-01 00:00:00

  • Persistent poor glycaemic control in individuals with type 2 diabetes in developing countries: 12 years of real-world evidence of the International Diabetes Management Practices Study (IDMPS).

    abstract：AIMS/HYPOTHESIS:We evaluated the secular trend of glycaemic control in individuals with type 2 diabetes in developing countries, where data are limited. METHODS:The International Diabetes Management Practices Study provides real-world evidence of patient profiles and diabetes care practices in developing countries in ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-05078-3

    authors： Aschner P,Gagliardino JJ,Ilkova H,Lavalle F,Ramachandran A,Mbanya JC,Shestakova M,Chantelot JM,Chan JCN

    更新日期：2020-04-01 00:00:00

  • Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.

    abstract：AIMS/HYPOTHESIS:New genetic variants associated with susceptibility to type 2 diabetes mellitus have been discovered in recent genome-wide association (GWA) studies. The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM). METHODS:The stud...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1196-4

    authors： Cho YM,Kim TH,Lim S,Choi SH,Shin HD,Lee HK,Park KS,Jang HC

    更新日期：2009-02-01 00:00:00

  • Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties. METHODS:Male par...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-010-1910-x

    authors： Broekhuizen LN,Lemkes BA,Mooij HL,Meuwese MC,Verberne H,Holleman F,Schlingemann RO,Nieuwdorp M,Stroes ES,Vink H

    更新日期：2010-12-01 00:00:00

  • Sulfate metabolism in the alloxan-diabetic rat: relationship of altered sulfate pools to proteoglycan sulfation in heart and other tissues.

    abstract：:The incorporation of [35S]sulfate into heart proteoglycans has been studied in normal and alloxan-diabetic rats by perfusion and in vivo administration of the isotope; in the latter situation, comparison was also made of radiolabeled sulfate utilization by several other tissues (kidney, liver, lung, muscle, testes and...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00270425

    authors： Spiro MJ

    更新日期：1987-04-01 00:00:00

  • Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation.

    abstract：:Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 d...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00587632

    authors： Comi G,Galardi G,Amadio S,Bianchi E,Secchi A,Martinenghi S,Caldara R,Pozza G,Canal N

    更新日期：1991-08-01 00:00:00

  • Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes.

    abstract：AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1036-6

    authors： Rozo AV,Vijayvargia R,Weiss HR,Ruan H

    更新日期：2008-08-01 00:00:00

  • In vitro insulin action on erythrocyte glucose metabolism in normal and diabetic rats.

    abstract：:Alloxan-induced diabetes in rats significantly impaired the capacity of the erythrocytes to metabolise glucose in vitro to either lactic acid or CO2. Both these metabolic activities were initially insensitive to insulin in normal as well as in diabetic animals; but became responsive when these cells were subjected to ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00279133

    authors： Agarwal VR,Rastogi AK,Sagar P

    更新日期：1988-01-01 00:00:00

  • Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. METHODS:Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two trainin...

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-007-0783-0

    authors： Eriksen L,Dahl-Petersen I,Haugaard SB,Dela F

    更新日期：2007-11-01 00:00:00

  • Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.

    abstract：AIMS/HYPOTHESIS:Insulin resistance is frequently associated with hypertension and type 2 diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the direct contribution of e...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4260-0

    authors： Gangadhariah MH,Dieckmann BW,Lantier L,Kang L,Wasserman DH,Chiusa M,Caskey CF,Dickerson J,Luo P,Gamboa JL,Capdevila JH,Imig JD,Yu C,Pozzi A,Luther JM

    更新日期：2017-06-01 00:00:00

  • Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value for the development of type 1 (insulin-dependent) diabetes mellitus. A 10-year follow-up study.

    abstract：:To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibodies and high titre...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00299020

    authors： Betterle C,Presotto F,Pedini B,Moro L,Slack RS,Zanette F,Zanchetta R

    更新日期：1987-05-01 00:00:00

  • Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:Circulating levels of adiponectin are negatively associated with multiple indices of insulin resistance, and the concentration is reduced in humans with insulin resistance and type 2 diabetes. However, the mechanisms by which adiponectin improves insulin sensitivity remain unclear. SUBJECTS AND METHODS...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0240-5

    authors： Højlund K,Frystyk J,Levin K,Flyvbjerg A,Wojtaszewski JF,Beck-Nielsen H

    更新日期：2006-06-01 00:00:00

  • The clinical and hormonal (C-peptide and glucagon) profile and liability to ketoacidosis during nutritional rehabilitation in Ethiopian patients with malnutrition-related diabetes mellitus.

    abstract：:Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabso...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00404800

    authors： Abdulkadir J,Mengesha B,Welde Gebriel Z,Keen H,Worku Y,Gebre P,Bekele A,Urga K,Taddesse AS

    更新日期：1990-04-01 00:00:00

  • Elevated plasma insulin-like growth factor binding protein-1 levels in type 1 (insulin-dependent) diabetic patients with peripheral neuropathy.

    abstract：:Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00399934

    authors： Crosby SR,Tsigos C,Anderton CD,Gordon C,Young RJ,White A

    更新日期：1992-09-01 00:00:00

  • Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance that does not develop diabetes. MATERIALS AND METHODS:NEFA augmen...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0305-5

    authors： Nolan CJ,Leahy JL,Delghingaro-Augusto V,Moibi J,Soni K,Peyot ML,Fortier M,Guay C,Lamontagne J,Barbeau A,Przybytkowski E,Joly E,Masiello P,Wang S,Mitchell GA,Prentki M

    更新日期：2006-09-01 00:00:00

  • Cardiovascular risk assessment scores for people with diabetes: a systematic review.

    abstract：:People with type 2 diabetes have an increased risk of cardiovascular disease (CVD). Multivariate cardiovascular risk scores have been used in many countries to identify individuals who are at high risk of CVD. These risk scores include those originally developed in individuals with diabetes and those developed in a ge...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-009-1454-0

    authors： Chamnan P,Simmons RK,Sharp SJ,Griffin SJ,Wareham NJ

    更新日期：2009-10-01 00:00:00

  • Identification of four trp1 gene variants murine pancreatic beta-cells.

    abstract：:Insulin secretion is stimulated by glucose, hormones and neurotransmitters. Both activation of a non-selective cation current and activation of a Ca2+ current in response to depletion of intracellular Ca2+ stores have been suggested to play a role in this stimulation. The properties of these currents resemble those re...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050711

    authors： Sakura H,Ashcroft FM

    更新日期：1997-05-01 00:00:00

  • Effects of an acute decrease in non-esterified fatty acid levels on muscle glucose utilization and forearm indirect calorimetry in lean NIDDM patients.

    abstract：:The aim of the study was to evaluate an acute decrease in NEFA levels during an oral glucose tolerance test and its effects on glucose tolerance, muscle glucose uptake and muscle indirect calorimetry in ten lean non-insulin-dependent diabetic subjects. Two 75-g oral glucose tolerance tests were performed in random ord...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00400420

    authors： Piatti PM,Monti LD,Davis SN,Conti M,Brown MD,Pozza G,Alberti KG

    更新日期：1996-01-01 00:00:00

  • Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.

    abstract：AIMS/HYPOTHESIS:We conducted genome-wide association studies (GWASs) and expression quantitative trait loci (eQTL) analyses to identify and characterise risk loci for type 2 diabetes in Mexican-Americans from Starr County, TX, USA. METHOD:Using 1.8 million directly interrogated and imputed genotypes in 837 unrelated t...

    journal_title：Diabetologia

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00125-011-2188-3

    authors： Below JE,Gamazon ER,Morrison JV,Konkashbaev A,Pluzhnikov A,McKeigue PM,Parra EJ,Elbein SC,Hallman DM,Nicolae DL,Bell GI,Cruz M,Cox NJ,Hanis CL

    更新日期：2011-08-01 00:00:00

  • Heart glucose transport and transporters in rat heart: regulation by insulin, workload and glucose.

    abstract：:Aspects of the regulation of the glucose transport by perfused hearts of normal rats have been studied by measuring glucose transport (via the efflux of labelled 3-O-methyl-D-glucose) and glucose transporters (via the labelled cytochalasin B binding assay). Similarly to what is observed with insulin, increasing worklo...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00395557

    authors： Zaninetti D,Greco-Perotto R,Jeanrenaud B

    更新日期：1988-02-01 00:00:00

  • High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail.

    abstract：AIMS/HYPOTHESIS:A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between environmental pollution and both prediabetes and diabetes. METHODS:Associations of serum levels of five persistent organic pollutants (POPs), namely polychlorinated biphen...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-010-1683-2

    authors： Ukropec J,Radikova Z,Huckova M,Koska J,Kocan A,Sebokova E,Drobna B,Trnovec T,Susienkova K,Labudova V,Gasperikova D,Langer P,Klimes I

    更新日期：2010-05-01 00:00:00