Abstract:
:The activation of glycogen synthase after addition of glucose to isolated hepatocytes became impaired in BB rats after the development of insulin-dependent diabetes. This defect was associated with a decreased hepatic synthase phosphatase activity. Both features correspond closely to previous observations on alloxan-diabetic rats. In contrast, in hyperinsulinaemic db/db mice with a similarly increased plasma glucose concentration (non-insulin-dependent diabetes), the synthase phosphatase activity was essentially normal. We conclude that the decreased hepatic synthase phosphatase activity in insulin-dependent diabetes in rodents is due to the lack of insulin, rather than to the increased intrahepatic glucose concentration.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Bollen M,Keppens S,Stalmans Wdoi
10.1007/BF00278757subject
Has Abstractpub_date
1988-09-01 00:00:00pages
711-3issue
9eissn
0012-186Xissn
1432-0428journal_volume
31pub_type
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