Differences in liver glycogen-synthase phosphatase activity in rodents with spontaneous insulin-dependent and non-insulin-dependent diabetes.

Abstract:

:The activation of glycogen synthase after addition of glucose to isolated hepatocytes became impaired in BB rats after the development of insulin-dependent diabetes. This defect was associated with a decreased hepatic synthase phosphatase activity. Both features correspond closely to previous observations on alloxan-diabetic rats. In contrast, in hyperinsulinaemic db/db mice with a similarly increased plasma glucose concentration (non-insulin-dependent diabetes), the synthase phosphatase activity was essentially normal. We conclude that the decreased hepatic synthase phosphatase activity in insulin-dependent diabetes in rodents is due to the lack of insulin, rather than to the increased intrahepatic glucose concentration.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Bollen M,Keppens S,Stalmans W

doi

10.1007/BF00278757

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

711-3

issue

9

eissn

0012-186X

issn

1432-0428

journal_volume

31

pub_type

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