Radiologic abnormalities and autonomic neuropathology in the digestive tract of the ketonuric diabetic Chinese hamster.

abstract：AIMS/HYPOTHESIS:To study if people with Type I (insulin-dependent) or Type II (non-insulin-dependent) diabetes mellitus have increased risk of hip fracture. METHODS:The study population consisted of 35,444 people 50 years of age and older, attending a health screening in a Norwegian county. They were followed up with ...

journal_title：Diabetologia

authors： Forsén L,Meyer HE,Midthjell K,Edna TH

更新日期：1999-08-01 00:00:00

abstract：:The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD. Situations in which proteomics could be applied in clinical practice include the identif...

journal_title：Diabetologia

authors： Pena MJ,Mischak H,Heerspink HJ

更新日期：2016-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Few data are available about intakes and food sources of trans-fatty acids (TFAs) or their associations with cardiometabolic outcomes in Asian people who consume a prudent diet but are experiencing rapid nutritional transitions. We aimed to investigate the relationships between TFA biomarkers and type 2...

journal_title：Diabetologia

authors： Yu DX,Sun Q,Ye XW,Pan A,Zong G,Zhou YH,Li HX,Hu FB,Lin X

更新日期：2012-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1), a polypeptide hormone secreted by the l-cells in the gastrointestinal tract, has shown promising effects as a new treatment modality for patients with Type II (non-insulin-dependent) diabetes mellitus. However, the pharmacokinetic profile of native GLP-1 with a rapid eli...

journal_title：Diabetologia

authors： Agersø H,Jensen LB,Elbrønd B,Rolan P,Zdravkovic M

更新日期：2002-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cerebral oedema complicating diabetic ketoacidosis (DKA) remains the major cause of morbidity and mortality in children with type 1 diabetes, but its aetiology remains unknown. Our objective was to determine the impact of baseline biochemical factors and of treatment-related variables on risk of the dev...

journal_title：Diabetologia

authors： Edge JA,Jakes RW,Roy Y,Hawkins M,Winter D,Ford-Adams ME,Murphy NP,Bergomi A,Widmer B,Dunger DB

更新日期：2006-09-01 00:00:00

abstract：:T cells taken from normal rats treated with an exogenous source of bacterial superantigen in vivo specifically failed to proliferate following re-stimulation with the same superantigen in vitro. Responsiveness was restored following the addition of an exogenous source of interleukin-2 indicating that the T cells had b...

journal_title：Diabetologia

authors： Sellins KS,Gold DP,Bellgrau D

更新日期：1996-01-01 00:00:00

abstract：:Using 3H-thymidine labeling techniques, we found that rates of DNA synthesis in islet cells doubled when mouse pancreatic islets were cultured for 1 week with 10 mmol/l nicotinamide, a potent poly(ADP-ribose) synthetase inhibitor. Culture with nicotinamide partially inhibited glucose-stimulated insulin release, wherea...

journal_title：Diabetologia

authors： Sandler S,Andersson A

更新日期：1986-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the relationship between benign prostatic hyperplasia (BPH) and arteriosclerosis shown in a model of type 2 diabetes in a trans-sectional population study using contrast-enhanced colour Doppler ultrasound for exact assessment of prostatic blood flow. METHODS:Contra...

journal_title：Diabetologia

authors： Berger AP,Deibl M,Halpern EJ,Lechleitner M,Bektic J,Horninger W,Fritsche G,Steiner H,Pelzer A,Bartsch G,Frauscher F

更新日期：2005-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Identifying the metabolite profile of individuals with normal fasting glucose (NFG [<5.55 mmol/l]) who progressed to type 2 diabetes may give novel insights into early type 2 diabetes disease interception and detection. METHODS:We conducted a population-based prospective study among 1150 Framingham Hea...

journal_title：Diabetologia

authors： Merino J,Leong A,Liu CT,Porneala B,Walford GA,von Grotthuss M,Wang TJ,Flannick J,Dupuis J,Levy D,Gerszten RE,Florez JC,Meigs JB

更新日期：2018-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptory (PPARgamma). We hypothesized that the anti-diabetic mechanism of thia...

journal_title：Diabetologia

authors： Tanaka T,Itoh H,Doi K,Fukunaga Y,Hosoda K,Shintani M,Yamashita J,Chun TH,Inoue M,Masatsugu K,Sawada N,Saito T,Inoue G,Nishimura H,Yoshimasa Y,Nakao K

更新日期：1999-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The gut hormone glucagon-like peptide-1 (GLP-1) decreases beta cell apoptosis in a protein kinase B (PKB)-dependent fashion, and increases islet cell mass and function in vivo. In contrast, cytokines induce beta cell apoptosis, leading to decreased islet mass and type 1 diabetes. In the present study we...

journal_title：Diabetologia

authors： Li L,El-Kholy W,Rhodes CJ,Brubaker PL

更新日期：2005-07-01 00:00:00

abstract：:In a prospective study concerning the pathogenesis of impaired glucose tolerance and Type 2 (non-insulin-dependent) diabetes mellitus, 346 subjects with no clinical history of diabetes were given a standard 75 g oral glucose tolerance test. The expected positive associations between 120-min plasma glucose concentratio...

journal_title：Diabetologia

authors： Brown DC,Byrne CD,Clark PM,Cox BD,Day NE,Hales CN,Shackleton JR,Wang TW,Williams DR

更新日期：1991-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperlipidaemia is an independent risk factor for the progression of diabetic nephropathy, but its molecular mechanism remains elusive. We investigated in mice how diabetes and hyperlipidaemia cause renal lesions separately and in combination, and the involvement of Toll-like receptor 4 (TLR4) in the pr...

journal_title：Diabetologia

authors： Kuwabara T,Mori K,Mukoyama M,Kasahara M,Yokoi H,Saito Y,Ogawa Y,Imamaki H,Kawanishi T,Ishii A,Koga K,Mori KP,Kato Y,Sugawara A,Nakao K

更新日期：2012-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sulphonylureas stimulate insulin secretion by closing ATP-sensitive potassium (KATP) channels in the pancreatic beta-cell membrane. KATP channels are also found in other tissues, including heart and smooth muscle, where they link cellular metabolism to electrical activity. The sulphonylurea gliclazide b...

journal_title：Diabetologia

authors： Lawrence CL,Proks P,Rodrigo GC,Jones P,Hayabuchi Y,Standen NB,Ashcroft FM

更新日期：2001-08-01 00:00:00

abstract：:We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thro...

journal_title：Diabetologia

authors： Ishizuka T,Taniguchi O,Yamamoto M,Kajita K,Nagashima T,Takeda N,Inouye H,Yasuda K,Miura K

更新日期：1994-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glomerular hyperfiltration is a well-established phenomenon occurring early in some patients with type 1 diabetes. However, there is no consistent answer regarding whether hyperfiltration predicts later development of nephropathy. We performed a systematic review and meta-analysis of observational studi...

journal_title：Diabetologia

authors： Magee GM,Bilous RW,Cardwell CR,Hunter SJ,Kee F,Fogarty DG

更新日期：2009-04-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) is overexpressed relative to insulin under several experimental conditions relevant to diabetes mellitus, including the immediate phase (7 days) following induction of streptozotocin diabetes. In the present study, IAPP and insulin gene expression were examined in chronic streptozotoci...

journal_title：Diabetologia

authors： Mulder H,Ahrén B,Sundler F

更新日期：1996-06-01 00:00:00

abstract：:Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with centra...

journal_title：Diabetologia

authors： Nogueiras R,Sabio G

更新日期：2021-02-01 00:00:00

abstract：:The intraperitoneal route may offer more physiological insulin delivery through absorption of a proportion of the dose into the portal circulation. We have compared 1-h square-wave and bolus supplemental infusions of a fixed dose of 10 U of intraperitoneal insulin in 6 C-peptide negative insulin-dependent diabetic pat...

journal_title：Diabetologia

authors： Jimenez JT,Walford S,Home PD,Hanning I,Alberti KG

更新日期：1985-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...

journal_title：Diabetologia

authors： Walraven I,van 't Riet E,Stehouwer CD,Polak BC,Moll AC,Dekker JM,Nijpels G

更新日期：2013-05-01 00:00:00

abstract：:Isloated rat islets were maintained in vitro in a perifusion system, exposed to alloxan (20 mg/100 ml) for 5 minutes in the presence of agents which affect cAMP metabolism and subsequently stimulated with glucose. The rate of insulin secretion was monitored throughout the period of perifusion. Exposure to alloxan alon...

journal_title：Diabetologia

authors： Lacy PE,McDaniel ML,Fink CJ,Roth C

更新日期：1975-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. SUBJECTS, MATERIALS AND METHODS:Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a ho...

journal_title：Diabetologia

authors： Simmons D,Shaw J,McKenzie A,Eaton S,Cameron AJ,Zimmet P

更新日期：2006-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:This multicentre randomised double-blind placebo-controlled clinical trial assessed the efficacy and safety of a methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib, in individuals with obesity (BMI ≥30 kg/m2) and type 2 diabetes (HbA1c 53-97 mmol/mol [7-11%] and fasting glucose <15.6 mmol/l). ME...

journal_title：Diabetologia

authors： Proietto J,Malloy J,Zhuang D,Arya M,Cohen ND,de Looze FJ,Gilfillan C,Griffin P,Hall S,Nathow T,Oldfield GS,O'Neal DN,Roberts A,Stuckey BGA,Yue D,Taylor K,Kim D

更新日期：2018-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes. METHODS:Finnish national healthcare registers were used to identify individuals with diabetes diagnosed between 1992 and 1996 at 15-39 years of age. ...

journal_title：Diabetologia

authors： Lammi N,Moltchanova E,Blomstedt PA,Tuomilehto J,Eriksson JG,Karvonen M

更新日期：2009-03-01 00:00:00

abstract：:Patients with Type II (non-insulin-dependent) diabetes mellitus manifest abnormalities in insulin action and insulin secretion. It is widely accepted that insulin resistance is an early finding, evident before the onset of hyperglycaemia and predictive of the subsequent development of diabetes. Whether abnormalities i...

journal_title：Diabetologia

authors： Pratley RE,Weyer C

更新日期：2001-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes. METHODS:Within the Europe...

journal_title：Diabetologia

authors： Sluik D,Boeing H,Li K,Kaaks R,Johnsen NF,Tjønneland A,Arriola L,Barricarte A,Masala G,Grioni S,Tumino R,Ricceri F,Mattiello A,Spijkerman AM,van der A DL,Sluijs I,Franks PW,Nilsson PM,Orho-Melander M,Fhärm E,Roland

更新日期：2014-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Statins and niacin (nicotinic acid) reduce circulating LDL-cholesterol (LDL-C) levels by different mechanisms. Yet, both increase the risk of diabetes mellitus. Our objective was to relate blood LDL-C concentrations and a genetic risk score (GRS) for LDL-C to the risk of incident diabetes in individuals...

journal_title：Diabetologia

authors： Andersson C,Lyass A,Larson MG,Robins SJ,Vasan RS

更新日期：2015-12-01 00:00:00

abstract：:The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...

journal_title：Diabetologia

authors： Jones PM,Persaud SJ,Bjaaland T,Pearson JD,Howell SL

更新日期：1992-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:To provide a nonenzymatic sensor for glucose monitoring in subcutaneous tissue. METHODS:A continuously working affinity sensor based on the glucose-dependent viscosity of a sensitive liquid containing dextran and concanavalin A has been designed by arranging a microdialysis probe, two flow-resisting ca...

journal_title：Diabetologia

authors： Beyer U,Schäfer D,Thomas A,Aulich H,Haueter U,Reihl B,Ehwald R

更新日期：2001-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes. METHODS:Adult male Akita mice (12 weeks old) were treated with insu...

journal_title：Diabetologia

authors： Abdo S,Lo CS,Chenier I,Shamsuyarova A,Filep JG,Ingelfinger JR,Zhang SL,Chan JS

更新日期：2013-07-01 00:00:00