Is grand multiparity associated with an increased risk of dysglycaemia?

Abstract:

AIMS/HYPOTHESIS:We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. SUBJECTS, MATERIALS AND METHODS:Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]). RESULTS:After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48-0.84]) and 3 to 4 (OR=0.72 [0.53-0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status. CONCLUSIONS/INTERPRETATION:Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG. We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Simmons D,Shaw J,McKenzie A,Eaton S,Cameron AJ,Zimmet P

doi

10.1007/s00125-006-0276-6

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

1522-7

issue

7

eissn

0012-186X

issn

1432-0428

journal_volume

49

pub_type

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