Is grand multiparity associated with an increased risk of dysglycaemia?


AIMS/HYPOTHESIS:We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. SUBJECTS, MATERIALS AND METHODS:Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]). RESULTS:After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48-0.84]) and 3 to 4 (OR=0.72 [0.53-0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status. CONCLUSIONS/INTERPRETATION:Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG. We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.






Simmons D,Shaw J,McKenzie A,Eaton S,Cameron AJ,Zimmet P




Has Abstract


2006-07-01 00:00:00












  • Metformin and the gastrointestinal tract.

    abstract::Metformin is an effective agent with a good safety profile that is widely used as a first-line treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy and side effects remain poorly understood. Although the liver is recognised as a major site of metformin pharmacodynamics, rece...


    pub_type: 杂志文章,评审


    authors: McCreight LJ,Bailey CJ,Pearson ER

    更新日期:2016-03-01 00:00:00

  • Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment.

    abstract::Glomerular basement membrane thickness (GBMT) has been measured in streptozotocin diabetic rats treated with insulin. The study included 3 groups of 8 rats each: 1) a 'well-controlled' group of diabetic rats under insulin treatment with a plasma glucose level reasonable close to normal values, 2) a 'poorly-controlled'...


    pub_type: 杂志文章


    authors: Rasch R

    更新日期:1979-05-01 00:00:00

  • Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes.

    abstract:AIMS/HYPOTHESIS:The aim of this work was to estimate the life expectancy (LE) and disability-free life expectancy (DFLE) for adults with and without diabetes. METHODS:The Chiang method and the adapted Sullivan method were used to estimate LE and DFLE by age and sex. Mortality data in 2011 were available from the Natio...


    pub_type: 杂志文章


    authors: Huo L,Shaw JE,Wong E,Harding JL,Peeters A,Magliano DJ

    更新日期:2016-07-01 00:00:00

  • Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study.

    abstract:AIMS/HYPOTHESIS:The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS:We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL acc...


    pub_type: 杂志文章


    authors: van der Berg JD,Stehouwer CD,Bosma H,van der Velde JH,Willems PJ,Savelberg HH,Schram MT,Sep SJ,van der Kallen CJ,Henry RM,Dagnelie PC,Schaper NC,Koster A

    更新日期:2016-04-01 00:00:00

  • Association of CREBRF variants with obesity and diabetes in Pacific Islanders from Guam and Saipan.

    abstract:AIMS/HYPOTHESIS:Variants in CREBRF (rs12513649 and rs373863828) have been strongly associated with increased BMI and decreased risk of type 2 diabetes in Polynesian populations; the A allele at rs373863828 is common in Polynesians but rare in most other global populations. The aim of the present study was to assess the...


    pub_type: 杂志文章


    authors: Hanson RL,Safabakhsh S,Curtis JM,Hsueh WC,Jones LI,Aflague TF,Duenas Sarmiento J,Kumar S,Blackburn NB,Curran JE,Mahkee D,Baier LJ,Knowler WC,Nelson RG

    更新日期:2019-09-01 00:00:00

  • A novel role for vitamin D: modulation of expression and function of the local renin-angiotensin system in mouse pancreatic islets.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function. METHODS:Isolated islets cultured ex vivo under high- or low-glucose conditions and treated with or witho...


    pub_type: 杂志文章


    authors: Cheng Q,Li YC,Boucher BJ,Leung PS

    更新日期:2011-08-01 00:00:00

  • The high prevalence of diabetes mellitus on a Central Pacific Island.

    abstract::A diabetes prevalence study on an isolated urbanized Central Pacific Island has established a prevalence rate of 34.4% in individuals aged 15 years and over. Of these, 10.4% had previously known diabetes; in the others the diagnosis was made on the basis of a plasma glucose level of at least 160 mg/100 ml 2h after a 7...


    pub_type: 杂志文章


    authors: Zimmet P,Taft P,Guinea A,Guthrie W,Thoma K

    更新日期:1977-04-01 00:00:00

  • Renal proteinases and kidney hypertrophy in experimental diabetes.

    abstract::IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulo-interstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three...


    pub_type: 杂志文章


    authors: Schaefer L,Schaefer RM,Ling H,Teschner M,Heidland A

    更新日期:1994-06-01 00:00:00

  • Peptides in metabolic autonomic nerves.

    abstract::Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...


    pub_type: 杂志文章


    authors: Uvnäs-Wallensten K

    更新日期:1981-03-01 00:00:00

  • Thermoregulatory responses to hyperinsulinaemic hypoglycaemia and euglycaemia in IDDM.

    abstract::In healthy subjects hypoglycaemia causes a fall in body temperature through increased sweating and limb blood flow, and despite increased metabolic heat production. We studied thermoregulatory responses to hyperinsulinaemic (100 mU.m-2.min-1) (a) hypoglycaemia (2.5 mmol/l) and (b) euglycaemia (4.5 mmol/l) in insulin-d...


    pub_type: 杂志文章


    authors: Maggs DG,Macdonald IA,Tattersall RB

    更新日期:1994-07-01 00:00:00

  • A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.

    abstract::Cyclic adenosine 5'diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2+. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly...


    pub_type: 杂志文章


    authors: Yagui K,Shimada F,Mimura M,Hashimoto N,Suzuki Y,Tokuyama Y,Nata K,Tohgo A,Ikehata F,Takasawa S,Okamoto H,Makino H,Saito Y,Kanatsuka A

    更新日期:1998-09-01 00:00:00

  • A prospective study of endometriosis and risk of type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:The objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes. METHODS:We used data from the Nurses' Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazard...


    pub_type: 杂志文章


    authors: Farland LV,Degnan WJ,Harris HR,Tobias DK,Missmer SA

    更新日期:2021-01-05 00:00:00

  • The potential contribution of endothelin-1 to neurovascular abnormalities in streptozotocin-diabetic rats.

    abstract::Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rats. After 6 weeks of...


    pub_type: 杂志文章


    authors: Cameron NE,Dines KC,Cotter MA

    更新日期:1994-12-01 00:00:00

  • Insulin receptors in lizard brain and liver: structural and functional studies of alpha and beta subunits demonstrate evolutionary conservation.

    abstract::Specific insulin receptors are present in the liver and brain of the lizard Anolis carolinesis. In this study, the specific binding of 125I-insulin to the receptors showed time, temperature and pH dependency. Specific binding to crude membranes prepared from brain was 1-2% of the total radioactivity added compared to ...


    pub_type: 杂志文章


    authors: Shemer J,Penhos JC,LeRoith D

    更新日期:1986-05-01 00:00:00

  • Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance.

    abstract:AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...


    pub_type: 杂志文章


    authors: Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

    更新日期:2012-06-01 00:00:00

  • Functional studies in patients with the glucagonoma syndrome.

    abstract::Four patients with glucagon-producing tumours of the pancreas were investigated. Fasting plasma glucagon concentrations ranged from 209--625 pmol/l. Plasma insulin concentrations were normal except in one patient, where the tumour also produced insulin (558 pmol/l). Intravenous glucose (25 g/m2) depressed the glucagon...


    pub_type: 杂志文章


    authors: Holst JJ,Helland S,Ingemannson S,Pedersen NB,von Schenck H

    更新日期:1979-09-01 00:00:00

  • A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker.

    abstract:AIMS/HYPOTHESIS:Non-invasive imaging of the pancreatic beta cell mass (BCM) requires the identification of novel and specific beta cell biomarkers. We have developed a systems biology approach to the identification of promising beta cell markers. METHODS:We followed a functional genomics strategy based on massive para...


    pub_type: 杂志文章


    authors: Flamez D,Roland I,Berton A,Kutlu B,Dufrane D,Beckers MC,De Waele E,Rooman I,Bouwens L,Clark A,Lonneux M,Jamar JF,Goldman S,Maréchal D,Goodman N,Gianello P,Van Huffel C,Salmon I,Eizirik DL

    更新日期:2010-07-01 00:00:00

  • Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

    abstract:AIMS/HYPOTHESIS:In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS:Wom...


    pub_type: 杂志文章,随机对照试验


    authors: d'Emden MC,Jenkins AJ,Li L,Zannino D,Mann KP,Best JD,Stuckey BG,Park K,Saltevo J,Keech AC,FIELD Study Investigators.

    更新日期:2014-11-01 00:00:00

  • Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway.

    abstract::It has been suggested that bradykinin stimulates glucose uptake in experiments in vivo and in cultured cells. However, its mechanism has not yet been fully elucidated. In this study, the effects of bradykinin on the insulin signalling pathway were evaluated in isolated dog adipocytes. The bradykinin receptor binding s...


    pub_type: 杂志文章


    authors: Isami S,Kishikawa H,Araki E,Uehara M,Kaneko K,Shirotani T,Todaka M,Ura S,Motoyoshi S,Matsumoto K,Miyamura N,Shichiri M

    更新日期:1996-04-01 00:00:00

  • The diabesity epidemic in the light of evolution: insights from the capacity-load model.

    abstract::The global nutrition transition, which embraces major changes in how food is produced, distributed and consumed, is associated with rapid increases in the prevalence of obesity, but the implications for diabetes differ between populations. A simple conceptual model treats diabetes risk as the function of two interacti...


    pub_type: 杂志文章,评审


    authors: Wells JCK

    更新日期:2019-10-01 00:00:00

  • Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease.

    abstract::Variations in the coding regions of the insulin receptor substrate-1 (IRS-1) gene have recently been suggested to contribute to the susceptibility of non-insulin-dependent diabetes mellitus (NIDDM). The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) an...


    pub_type: 杂志文章


    authors: Hitman GA,Hawrami K,McCarthy MI,Viswanathan M,Snehalatha C,Ramachandran A,Tuomilehto J,Tuomilehto-Wolf E,Nissinen A,Pedersen O

    更新日期:1995-04-01 00:00:00

  • The effect of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: a systematic review and meta-analysis.

    abstract:AIMS/HYPOTHESIS:The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. METHODS:MEDLINE, EMBASE and the Cochrane L...


    pub_type: 杂志文章,评审


    authors: Bock PM,Telo GH,Ramalho R,Sbaraini M,Leivas G,Martins AF,Schaan BD

    更新日期:2021-01-01 00:00:00

  • GAD autoantibody affinity in schoolchildren from the general population.

    abstract:AIMS/HYPOTHESIS:Subtyping GAD autoantibody (GADA) responses using affinity measurement allows the identification of GADA-positive children with a family history of type 1 diabetes who are at risk of developing diabetes. Here, we asked whether GADA affinity is a useful marker to stratify the risk of type 1 diabetes in G...


    pub_type: 杂志文章


    authors: Bender C,Schlosser M,Christen U,Ziegler AG,Achenbach P

    更新日期:2014-09-01 00:00:00

  • VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.

    abstract:AIMS/HYPOTHESIS:Rho GTPases (Ras-related C3 botulinum toxin substrate 1 [Rac1] and cell division cycle 42 [Cdc42]) have been shown to regulate glucose-stimulated insulin secretion (GSIS) via cytoskeletal remodelling, trafficking and fusion of insulin-secretory granules with the plasma membrane. GTP loading of these G p...


    pub_type: 杂志文章


    authors: Veluthakal R,Tunduguru R,Arora DK,Sidarala V,Syeda K,Vlaar CP,Thurmond DC,Kowluru A

    更新日期:2015-11-01 00:00:00

  • Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans.

    abstract:AIMS/HYPOTHESIS:We sought to evaluate if the cellular localisation and molecular species of diacylglycerol (DAG) were related to insulin sensitivity in human skeletal muscle. METHODS:Healthy sedentary obese controls (Ob; n = 6; mean±SEM age 39.5 ± 2.3 years; mean ± SEM BMI 33.3 ± 1.4 kg/m(2)), individuals with type 2 ...


    pub_type: 杂志文章


    authors: Bergman BC,Hunerdosse DM,Kerege A,Playdon MC,Perreault L

    更新日期:2012-04-01 00:00:00

  • CNS modulation of pancreatic endocrine function : Multiple modes of expression.

    abstract::The involvement of the CNS in pancreatic hormone release has been studied. 1.) It has been shown that one source of vagal efferent fibers capable of facilitating insulin secretion originated in the rostral half of the nucleus ambiguus. 2.) Acute lesions of the ventromedial hypothalamus resulted in hyperinsulinaemia th...


    pub_type: 杂志文章


    authors: Bereiter DA,Rohner-Jeanrenaud F,Berthoud H-,Jeanrenaud B

    更新日期:1981-03-01 00:00:00

  • The increase in albuminuria induced by exercise is not associated with preferential excretion of glycated albumin in type 1 (insulin-dependent) diabetic patients.

    abstract::The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...


    pub_type: 杂志文章


    authors: Cavallo-Perin P,Chiambretti A,Calefato V,Tomalino M,Urbino R,Cecchini G,Pagano G

    更新日期:1991-11-01 00:00:00

  • Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes.

    abstract:AIMS/HYPOTHESIS:In Type II (non-insulin-dependent) diabetes mellitus, amyloid depletes islet mass. We previously found that 81% of male human islet amyloid polypeptide (IAPP) transgenic mice but only 11% of female mice developed islet amyloid, suggesting that either testosterone promotes or ovarian products protect aga...


    pub_type: 杂志文章


    authors: Kahn SE,Andrikopoulos S,Verchere CB,Wang F,Hull RL,Vidal J

    更新日期:2000-10-01 00:00:00

  • Electron microscopy of renal and ocular changes in virus-induced diabetes mellitus in mice.

    abstract::The eyes, kidneys and pancreas of mice (SJL/J) infected with encephalomyocarditis virus were examined by light and electron microscopy. Diabetic mice with the longest duration (6 months) of diabetes showed marked renal and ocular alterations. Fasting blood glucose levels were 17.8-21.9 mmol/l and glycosuria was presen...


    pub_type: 杂志文章


    authors: Rodrigues M,Currier C,Yoon J

    更新日期:1983-04-01 00:00:00

  • Target tissue production and axonal transport of neurotrophin-3 are reduced in streptozotocin-diabetic rats.

    abstract::Neurotrophin-3 (NT-3) acts as a target-derived neurotrophic factor for large calibre sensory neurones and plays a role in the maintenance of the adult phenotype of proprioceptive and mechanoreceptive fibres. Large fibre sensory neuropathy is common in diabetes mellitus and the aim of this study was to determine whethe...


    pub_type: 杂志文章


    authors: Fernyhough P,Diemel LT,Tomlinson DR

    更新日期:1998-03-01 00:00:00