Abstract:
:In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, and glisoxepide, which were all alike in terms of the relationship between first and second phases of insulin release.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Gotfredsen CFdoi
10.1007/BF00420977subject
Has Abstractpub_date
1976-08-01 00:00:00pages
339-42issue
4eissn
0012-186Xissn
1432-0428journal_volume
12pub_type
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