Reduction of plasma 1,5-anhydroglucitol (1-deoxyglucose) concentration in diabetic patients.

abstract：AIMS/HYPOTHESIS:Monogenic diabetes (MD) might be misdiagnosed as type 1 diabetes. The prevalence of MD among children with apparent type 1 diabetes has not been established. Our aim was to estimate the prevalence of common forms of MD in childhood diabetes. METHODS:We investigated 2,756 children aged 0-14 years with n...

journal_title：Diabetologia

authors： Irgens HU,Molnes J,Johansson BB,Ringdal M,Skrivarhaug T,Undlien DE,Søvik O,Joner G,Molven A,Njølstad PR

更新日期：2013-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:As one of the key adipokines, retinol binding protein 4 (RBP4) is suggested to positively correlate with insulin resistance; however, not all clinical studies support this association. Although some explanations are proposed for this discrepancy, the temporal aspect of RBP4 secretion has not been consid...

journal_title：Diabetologia

authors： Ma X,Zhou Z,Chen Y,Wu Y,Liu Y

更新日期：2016-02-01 00:00:00

abstract：:Ciglitazone is orally active in preventing and reversing the hyperglycaemic syndrome in C57BL/6J-ob/ob mice and it is only mildly and transiently hypoglycaemic in lean littermates (C57BL/6J-+/?). Its effect on glucose disposal in vivo was estimated by injecting glucose-6-3H/14C and following the specific activity of r...

journal_title：Diabetologia

authors： Chang AY,Gilchrist BJ,Wyse BM

更新日期：1983-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate molecular mechanisms of glucose-induced changes in islets of Langerhans by analysing global changes in protein patterns of islets exposed to elevated glucose concentrations. METHODS:Islets were isolated from C57BL/6J mice and used either directly or after exposu...

journal_title：Diabetologia

authors： Ahmed M,Bergsten P

更新日期：2005-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Adiponectin is an adipokine that exhibits insulin-sensitising, fat-burning and anti-inflammatory properties as well as modulatory effects on oxidative stress. We examined whether adiponectin could be induced in a non-adipose tissue, skeletal muscle, in response to metabolic or oxidative aggression both ...

journal_title：Diabetologia

authors： Delaigle AM,Senou M,Guiot Y,Many MC,Brichard SM

更新日期：2006-06-01 00:00:00

abstract：:Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and ha...

journal_title：Diabetologia

authors： Cabrera SM,Chen YG,Hagopian WA,Hessner MJ

更新日期：2016-03-01 00:00:00

abstract：:The glucose phosphorylating enzyme glucokinase plays an important role in the regulation of glucose homeostasis. Studies in rodents indicate that pancreatic Beta cells and hepatocytes express different isoforms of this protein as a consequence of the presence of tissue-specific promoters and exon 1 sequences which are...

journal_title：Diabetologia

authors： Nishi S,Stoffel M,Xiang K,Shows TB,Bell GI,Takeda J

更新日期：1992-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity and fatty liver are commonly associated with type 2 diabetes, but the genetic and functional bases linking fatty liver with obesity and diabetes are largely unknown. Our aim was to investigate the association of fatty liver with obesity and other diabetes-related phenotypes and to define the gen...

journal_title：Diabetologia

authors： Itoi-Babaya M,Ikegami H,Fujisawa T,Ueda H,Nojima K,Babaya N,Kobayashi M,Noso S,Kawaguchi Y,Yamaji K,Shibata M,Ogihara T

更新日期：2007-08-01 00:00:00

abstract：:We performed i.v. insulin tolerance test in 30 non-obese (BMI < 30 male and < 28 female) non-diabetic (by oral glucose tolerance test) subjects and subdivided them into three groups of 10 subjects each, according to their insulin sensitivity (K(itt) values). Then we compared the tyrosine-kinase activity of immunopurif...

journal_title：Diabetologia

authors： Grasso G,Frittitta L,Anello M,Russo P,Sesti G,Trischitta V

更新日期：1995-01-01 00:00:00

abstract：:Diabetic patients exhibit a higher incidence of post-surgical sepsis, as well as a higher rate of mortality from sepsis, than their non-diabetic counterparts. This may be a result of cardiovascular deterioration associated with diabetes mellitus. This study was designed to characterize the cardiovascular sequelae asso...

journal_title：Diabetologia

authors： Law WR,Moriarty MT,McLane MP

更新日期：1991-10-01 00:00:00

abstract：:The effect of endogenous hyperinsulinaemia, produced by syngeneic transplantation of rat insulinoma at an extrapancreatic site, on pancreatic insulin and pancreatic polypeptide has been examined by radioimmunoassay and immunohistochemistry. Twenty days after subcutaneous transplantation, tumour-bearing rats exhibited ...

journal_title：Diabetologia

authors： O'Hare MM,Shaw C,Swanston-Flatt SK,Marcelli M,Buchanan KD,Flatt PR

更新日期：1985-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the current study, the effect of a highly specific peptide inhibitor of glycogen synthase kinase 3 (GSK3) (L803-mts) on glucose metabolism and BP was examined in a high-fat (HF) fed mouse model of diabetes. METHODS:C57/BL6J mice were placed on an HF diet for 3 months and treated with L803-mts for 20...

journal_title：Diabetologia

authors： Rao R,Hao CM,Redha R,Wasserman DH,McGuinness OP,Breyer MD

更新日期：2007-02-01 00:00:00

abstract：:Glycogen phosphorylase regulates the breakdown of glycogen into glucose, but as previous studies have demonstrated, the control of glycogen metabolism becomes deregulated in diabetes mellitus. Messenger RNA levels encoding several different proteins are altered in skeletal muscle biopsies of patients with insulin-depe...

journal_title：Diabetologia

authors： Reynet C,Kahn CR,Loeken MR

更新日期：1996-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single nucleotide polymorphisms (SNPs) in WFS1 have been reproducibly associated with type 2 diabetes. We therefore examined the effects of these variants on diabetes i...

journal_title：Diabetologia

authors： Florez JC,Jablonski KA,McAteer J,Sandhu MS,Wareham NJ,Barroso I,Franks PW,Altshuler D,Knowler WC,Diabetes Prevention Program Research Group.

更新日期：2008-03-01 00:00:00

abstract：:The objective of the present study was to assess the prevalence of familial aggregation of Type 1 (insulin-dependent) diabetes mellitus among Danish families with a diabetic child aged 20 years or less and to compare epidemiological data for familial and sporadic cases. We attempted to identify all patients with Type ...

journal_title：Diabetologia

authors： Pociot F,Nørgaard K,Hobolth N,Andersen O,Nerup J

更新日期：1993-09-01 00:00:00

abstract：AIM/HYPOTHESIS:A strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant et al. We ai...

journal_title：Diabetologia

authors： van Vliet-Ostaptchouk JV,Shiri-Sverdlov R,Zhernakova A,Strengman E,van Haeften TW,Hofker MH,Wijmenga C

更新日期：2007-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess whether the diabetogenicity of areca nut (Areca catechu or 'betel-nut'), which has previously been demonstrated experimentally in mice, independently contributes to the risk of hyperglycaemia or type 2 diabetes in men in Taiwan, where the habit has become established ...

journal_title：Diabetologia

authors： Tung TH,Chiu YH,Chen LS,Wu HM,Boucher BJ,Chen TH,Keelung Community-based Integrated Screening programme No. 2.

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hypertension, obesity, impaired glucose tolerance and dyslipidaemia are metabolic abnormalities that often cluster together more often than expected by chance alone. Since these metabolic variables are highly heritable and are at least partially genetically determined, the clustering of defects in these...

journal_title：Diabetologia

authors： Chiu YF,Chuang LM,Kao HY,Ho LT,Ting CT,Hung YJ,Chen YD,Donlon T,Curb JD,Quertermous T,Hsiung CA

更新日期：2007-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin-mediated glucose transport and utilisation are decreased in skeletal muscle from type 2 diabetic and glucose-intolerant individuals because of alterations in insulin receptor signalling, GLUT4 translocation to the plasma membrane and microvascular blood flow. Catalytic activity of the muscle-spe...

journal_title：Diabetologia

authors： Mezghenna K,Leroy J,Azay-Milhau J,Tousch D,Castex F,Gervais S,Delgado-Betancourt V,Gross R,Lajoix AD

更新日期：2014-01-01 00:00:00

abstract：:Structural alterations in arterial extracellular matrix components have been suggested to play a role in the development of arterial disease among patients with diabetes mellitus. This study examines the quantity and quality of collagenous components in aortas from diabetic patients. In order to obtain data about the ...

journal_title：Diabetologia

authors： Rasmussen LM,Ledet T

更新日期：1993-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperglycaemia, a key feature of diabetes, is associated with non-enzymatic glycation of plasma proteins. We have shown previously that the reactive alpha-oxoaldehyde, methylglyoxal, non-enzymatically glycates apolipoprotein (Apo)A-I, the main apolipoprotein of HDL, and prevents it from activating lecit...

journal_title：Diabetologia

authors： Nobécourt E,Zeng J,Davies MJ,Brown BE,Yadav S,Barter PJ,Rye KA

更新日期：2008-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabo...

journal_title：Diabetologia

authors： Tomita Y,Cagnone G,Fu Z,Cakir B,Kotoda Y,Asakage M,Wakabayashi Y,Hellström A,Joyal JS,Talukdar S,Smith LEH,Usui Y

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...

journal_title：Diabetologia

authors： Hauge-Evans AC,Anderson RL,Persaud SJ,Jones PM

更新日期：2012-07-01 00:00:00

abstract：:The nerve fibre loss, atrophy and injury of diabetic peripheral polyneuropathy and their responses to metabolic intervention have been studied by morphometric analysis of sural nerve biopsies. The magnitudes and sources of intra- and inter-individual variation in these morphometric measures have not been investigated ...

journal_title：Diabetologia

authors： Sima AA,Brown MB,Prashar A,Chakrabarti S,Laudadio C,Greene DA

更新日期：1992-06-01 00:00:00

abstract：:Following prolonged administration of tolbutamide the DNA- and protein content per islet was enhanced but the IRI content per islet was diminished. Glucose-induced (2.0, 8.0 or 16.6 mM) and leucine-induced (12.5 or 25.0 mM) IRI release from isolated islets, as well as 14C02-production from U-14C glucose, were decrease...

journal_title：Diabetologia

authors： Schauder P,Frerichs H

更新日期：1975-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We studied the gene therapy efficacy of diabetes-associated wound healing disorder with an adeno-associated virus (AAV) vector expressing the 165-amino acid isoform of human vascular endothelial growth factor-A (VEGF-A) by using an incisional skin-wound model produced on the back of female diabetic C57B...

journal_title：Diabetologia

authors： Galeano M,Deodato B,Altavilla D,Cucinotta D,Arsic N,Marini H,Torre V,Giacca M,Squadrito F

更新日期：2003-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study estimated the economic efficiency (1) of intensive blood glucose control and tight blood pressure control in patients with type 2 diabetes who also had hypertension, and (2) of metformin therapy in type 2 diabetic patients who were overweight. METHODS:We conducted cost-utility analysis based...

journal_title：Diabetologia

authors： Clarke PM,Gray AM,Briggs A,Stevens RJ,Matthews DR,Holman RR,UKPDS 72 United Kingdom Prospective Diabetes Study.

更新日期：2005-05-01 00:00:00

abstract：:Non-insulin-dependent diabetic (NIDDM) patients were studied during a modified euglycaemic state when fasting hyperglycaemia was normalized by a prior (-210 to -150 min)--and later withdrawn (-150-0 min)--intravenous insulin infusion. Glucose metabolism was assessed in NIDDM patients (n = 10) and matched control subje...

journal_title：Diabetologia

authors： Vaag A,Alford F,Henriksen FL,Christopher M,Beck-Nielsen H

更新日期：1995-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine risk factors for, and differences in, renal failure in diabetic patients from 10 centres. METHODS:Risk factors for renal failure were examined in 3,558 diabetic patients who did not have renal disease at baseline in the WHO Multinational Study of Vascular Disease in Diabetes (WHO MS...

journal_title：Diabetologia

authors： Colhoun HM,Lee ET,Bennett PH,Lu M,Keen H,Wang SL,Stevens LK,Fuller JH

更新日期：2001-09-01 00:00:00

abstract：:Thiazolidinediones are potent antidiabetic compounds, which act by enhancing peripheral insulin sensitivity. They are also activators of the peroxisome proliferator activated receptor gamma in adipose tissue. Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat and hence the capacity of...

journal_title：Diabetologia

authors： Hallakou S,Foufelle F,Doaré L,Kergoat M,Ferré P

更新日期：1998-08-01 00:00:00