当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats.

Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats.

Abstract：

:Islet amyloid polypeptide (IAPP) is overexpressed relative to insulin under several experimental conditions relevant to diabetes mellitus, including the immediate phase (7 days) following induction of streptozotocin diabetes. In the present study, IAPP and insulin gene expression were examined in chronic streptozotocin diabetes (3 weeks) in rats. Quantitative in situ hybridization, determining grain areas and optical densities of mRNA labelling, revealed that IAPP and insulin expression were reduced at the islet level at both low and high streptozotocin doses, partly due to reduced beta-cell mass. In contrast, the cellular levels of IAPP mRNA were either increased or unaffected at the low and high streptozotocin doses, respectively, whereas those of insulin mRNA were unaffected or reduced. When dexamethasone was administered to rats given the low streptozotocin dose, IAPP expression was increased, whereas that of insulin was markedly reduced. Immunocytochemistry revealed that IAPP predominantly occurred in insulin cells and to a lesser extent in somatostatin cells at all treatments examined. Our findings demonstrate that IAPP and insulin gene expression are differentially regulated; the over-expression of IAPP relative to insulin is augmented when the beta-cell insult is aggravated, in our experiments represented by massive beta-cell destruction (high streptozotocin dose) or a combination of moderate beta-cell damage and peripheral insulin resistance (low streptozotocin dose and dexamethasone). An over-expression of IAPP relative to insulin may therefore be involved in diabetes pathogenesis, contributing to its metabolic perturbations, possibly through the capacity of IAPP to restrain insulin release and action and to form islet amyloid.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Mulder H,Ahrén B,Sundler F

doi

10.1007/BF00418536

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

649-57

issue

6

eissn

0012-186X

issn

1432-0428

journal_volume

39

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population.

    abstract：AIMS/HYPOTHESIS:Single nucleotide polymorphisms (SNPs) in G6PC2 have been reported to be associated with fasting plasma glucose level in several populations of European descent. However, whether G6PC2 variants have a similar effect in other ethnic groups is unknown. The aim of this study was to investigate the effect o...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1241-3

    authors： Hu C,Zhang R,Wang C,Ma X,Wang C,Fang Q,Bao Y,Xiang K,Jia W

    更新日期：2009-03-01 00:00:00

  • Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis.

    abstract：AIMS/HYPOTHESIS:It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue. METHODS:Immunohistological analysis was used to determine the distribution of proinsulin and insulin in t...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05115-6

    authors： Leete P,Oram RA,McDonald TJ,Shields BM,Ziller C,TIGI study team.,Hattersley AT,Richardson SJ,Morgan NG

    更新日期：2020-06-01 00:00:00

  • Assessment of glucose regulation in pregnancy after gastric bypass surgery.

    abstract：AIMS/HYPOTHESIS:Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. METHODS:Sixty-three...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4437-6

    authors： Göbl CS,Bozkurt L,Tura A,Leutner M,Andrei L,Fahr L,Husslein P,Eppel W,Kautzky-Willer A

    更新日期：2017-12-01 00:00:00

  • Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people: a longitudinal study.

    abstract：AIMS/HYPOTHESIS:The aims of the study were to examine whether type 2 diabetes mellitus is associated with greater brain atrophy and cognitive decline, and whether brain atrophy mediates associations between type 2 diabetes and cognitive decline. METHODS:Participants without dementia aged 55-90 years from the Cognition...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-018-4778-9

    authors： Callisaya ML,Beare R,Moran C,Phan T,Wang W,Srikanth VK

    更新日期：2019-03-01 00:00:00

  • Taq I polymorphism of the vitamin D receptor and risk of severe diabetic retinopathy.

    abstract：AIMS/HYPOTHESIS:Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-001-0769-2

    authors： Taverna MJ,Sola A,Guyot-Argenton C,Pacher N,Bruzzo F,Slama G,Reach G,Selam JL

    更新日期：2002-03-01 00:00:00

  • Differences in trends in estimated incidence of myocardial infarction in non-diabetic and diabetic people: Monitoring Trends and Determinants on Cardiovascular Diseases (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) registry.

    abstract：AIMS/HYPOTHESIS:One major objective of the St Vincent Declaration was to reduce the excess risk of myocardial infarction in patients with diabetes mellitus. We estimated the trend of the incidence and relative risk of myocardial infarction in the diabetic and non-diabetic populations in southern Germany from 1985 to 20...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1434-4

    authors： Icks A,Dickhaus T,Hörmann A,Heier M,Giani G,Kuch B,Meisinger C

    更新日期：2009-09-01 00:00:00

  • Changes in short- and long-term cardiovascular risk of incident diabetes and incident myocardial infarction--a nationwide study.

    abstract：AIMS/HYPOTHESIS:We assessed secular trends of cardiovascular outcomes following first diagnosis of myocardial infarction (MI) or diabetes in an unselected population. METHODS:All Danish residents aged > or = 30 years without prior diabetes or MI were identified by individual-level linkage of nationwide registers. Indi...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-010-1783-z

    authors： Norgaard ML,Andersen SS,Schramm TK,Folke F,Jørgensen CH,Hansen ML,Andersson C,Bretler DM,Vaag A,Køber L,Torp-Pedersen C,Gislason GH

    更新日期：2010-08-01 00:00:00

  • A prospective study of the effect of 12 months treatment on serum lipids and apolipoproteins A-I and B in Type 2 (non-insulin-dependent) diabetes.

    abstract：:Serum high density lipoprotein cholesterol, total cholesterol, triglyceride and apolipoproteins A-I and B were studied at diagnosis and after 12 months conventional treatment in a group of Type 2 (non-insulin-dependent) diabetic patients. No significant deleterious effect on serum lipids and apolipoproteins was seen i...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00254300

    authors： Taylor KG,John WG,Matthews KA,Wright AD

    更新日期：1982-12-01 00:00:00

  • Risk stratification systems for diabetic foot ulcers: a systematic review.

    abstract：AIMS/HYPOTHESIS:Several risk stratification systems have been proposed for predicting development of diabetic foot ulcer. However, little has been published that assesses their similarities and disparities, diagnostic accuracy and evidence level. Consequently, we conducted a systematic review of the existing stratifica...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-010-2030-3

    authors： Monteiro-Soares M,Boyko EJ,Ribeiro J,Ribeiro I,Dinis-Ribeiro M

    更新日期：2011-05-01 00:00:00

  • Height and glucose tolerance in adult subjects.

    abstract：:In a prospective study concerning the pathogenesis of impaired glucose tolerance and Type 2 (non-insulin-dependent) diabetes mellitus, 346 subjects with no clinical history of diabetes were given a standard 75 g oral glucose tolerance test. The expected positive associations between 120-min plasma glucose concentratio...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00403292

    authors： Brown DC,Byrne CD,Clark PM,Cox BD,Day NE,Hales CN,Shackleton JR,Wang TW,Williams DR

    更新日期：1991-07-01 00:00:00

  • Epidemiology of childhood IDDM in Northern Ireland 1989-1994: low incidence in areas with highest population density and most household crowding. Northern Ireland Diabetes Study Group.

    abstract：:During the period 1989-1994, 462 cases of insulin-dependent diabetes mellitus were registered among children from Northern Ireland aged under 15 years. The estimated completeness of the register was 98.8% (95% confidence interval (CI) 97.7%, 99.9%). A standardised rate of 19.6 (95% CI 17.8, 21.4) per 100 000 person ye...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400655

    authors： Patterson CC,Carson DJ,Hadden DR

    更新日期：1996-09-01 00:00:00

  • Lipolysis and cyclic AMP levels in epididymal adipose tissue of obese-hyperglycaemic mice.

    abstract：:Glycerol release from epididymal fat fragments of young adult (3-month old) ob/ob mice was three times lower than normal, on a tissue weight basis. Dose-response curves in response to isoproterenol and ACTH-(1--24) indicated that the capacity of the lipolytic process was reduced. However, the sensitivity to both hormo...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01236307

    authors： Dehaye JP,Winand J,Christophe J

    更新日期：1977-12-01 00:00:00

  • Interaction of human endothelial cells with elevated glucose concentrations and native and glycosylated low density lipoproteins.

    abstract：:We have investigated whether and how the elevated glucose concentrations characteristic of diabetes may alter the interaction of endothelial cells with low-density lipoproteins (LDL). Protracted exposure of cultured human endothelial cells to 20 mmol/l glucose failed to affect either the relationship between the degre...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00252411

    authors： Lorenzi M,Cagliero E,Markey B,Henriksen T,Witztum JL,Sampietro T

    更新日期：1984-03-01 00:00:00

  • Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90β/eNOS complex.

    abstract：AIMS/HYPOTHESIS:Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is significantly upregulated in the serum of individuals with obesity and diabetes. However, whether elevated PEDF levels contribute to DMED remains unknown. This stu...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05147-y

    authors： Che D,Fang Z,Yan L,Du J,Li F,Xie J,Feng J,Yin P,Qi W,Yang Z,Ma J,Yang X,Gao G,Zhou T

    更新日期：2020-09-01 00:00:00

  • Differential binding of sulphated insulin to adipocytes and hepatocytes.

    abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00273803

    authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

    更新日期：1984-08-01 00:00:00

  • Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring.

    abstract：:Many mutagenic nitroso compounds are also diabetogenic. Betel-nut (Areca catechu) chewing populations have an increased incidence of foregut cancers related to betel-nut nitrosamines which suggests that betel consumption could be diabetogenic. Young adult CD1 mice with a low spontaneous incidence of diabetes were fed ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00428777

    authors： Boucher BJ,Ewen SW,Stowers JM

    更新日期：1994-01-01 00:00:00

  • Glycosylated haemoglobin and plasma glycoprotein assays by affinity chromatography.

    abstract：:A rapid chromatography method for separating glycosylated protein from non-glycosylated protein, using a boronate-agarose affinity medium which selectively binds the cis-diol groups of glycoproteins, was used to quantitate plasma glycoprotein as well as glycohaemoglobin. The results were found to be independent of: (1...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00253503

    authors： Willey DG,Rosenthal MA,Caldwell S

    更新日期：1984-07-01 00:00:00

  • Effect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato study.

    abstract：AIMS/HYPOTHESIS:Measurement of plasma apolipoprotein (Apo) B may improve prediction of cardiovascular risk, as it provides a measure of the total number of atherogenic particles. The aim of this population-based study was to compare the association of non-HDL-cholesterol, ApoB and the ApoB:ApoA-I ratio with cardiovascu...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00125-006-0195-6

    authors： Bruno G,Merletti F,Biggeri A,Bargero G,Prina-Cerai S,Pagano G,Cavallo-Perin P

    更新日期：2006-05-01 00:00:00

  • Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association be...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-0970-7

    authors： Vella A,Bouatia-Naji N,Heude B,Cooper JD,Lowe CE,Petry C,Ring SM,Dunger DB,Todd JA,Ong KK

    更新日期：2008-05-01 00:00:00

  • Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes.

    abstract：AIMS/HYPOTHESIS:Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal and insulin sensitivit...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3269-x

    authors： Hamilton DL,Findlay JA,Montagut G,Meakin PJ,Bestow D,Jalicy SM,Ashford ML

    更新日期：2014-08-01 00:00:00

  • Direct effect of GLP-1 infusion on endogenous glucose production in humans.

    abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, independently of the hormonal changes, is controversial. We tested whether an exogenous GLP-1 infusio...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00125-012-2738-3

    authors： Seghieri M,Rebelos E,Gastaldelli A,Astiarraga BD,Casolaro A,Barsotti E,Pocai A,Nauck M,Muscelli E,Ferrannini E

    更新日期：2013-01-01 00:00:00

  • Expression of insulin regulatable glucose transporters in skeletal muscle from type 2 (non-insulin-dependent) diabetic patients.

    abstract：:A prominent feature of Type 2 (non-insulin-dependent) diabetes mellitus is the inability of insulin to appropriately increase the transport of glucose into target tissue. In adipocytes from individuals with Type 2 diabetes, insulin resistance has been shown to be associated with a depletion of glucose transporters. Si...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400207

    authors： Handberg A,Vaag A,Damsbo P,Beck-Nielsen H,Vinten J

    更新日期：1990-10-01 00:00:00

  • Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease.

    abstract：AIMS/HYPOTHESIS:Type 2 diabetes is a major risk factor for CHD. We hypothesised that diabetes genetic susceptibility variants might be associated with increased CHD risk. METHODS:We examined the individual and cumulative effect of 38 common genetic variants previously reported to be associated with type 2 diabetes on ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-011-2206-5

    authors： Pfister R,Barnes D,Luben RN,Khaw KT,Wareham NJ,Langenberg C

    更新日期：2011-09-01 00:00:00

  • Diabetic background retinopathy is associated with impaired coronary vasoreactivity in people with Type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:We examined whether diabetic background retinopathy is associated with reduced coronary vasoreactivity in people with Type 1 diabetes. METHODS:A total of 21 men with Type 1 diabetes were investigated, including 9 men with background retinopathy and 12 men without retinopathy. In addition, 12 non-diabet...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00125-004-1340-8

    authors： Sundell J,Janatuinen T,Rönnemaa T,Raitakari OT,Toikka J,Nuutila P,Knuuti J

    更新日期：2004-04-01 00:00:00

  • Exercise-induced conduction velocity increment: a marker of impaired peripheral nerve blood flow in diabetic neuropathy.

    abstract：:Severe microvascular disease exists at the stage of clinical diabetic neuropathy. A non-invasive test that will identify those diabetic subjects who will eventually develop neuropathy is essential for early intervention. Sural sensory conduction velocity was recorded (x3) in 12 non-neuropathic diabetic subjects, 15 di...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00402548

    authors： Tesfaye S,Harris ND,Wilson RM,Ward JD

    更新日期：1992-02-01 00:00:00

  • Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men.

    abstract：AIMS/HYPOTHESIS:Individuals with diabetes have increased mortality rates compared with the general population. In patients with type 2 diabetes depression further contributes to the increased mortality. Depression and mortality rates in patients with type 1 diabetes are an understudied phenomenon. We therefore studied ...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00125-011-2347-6

    authors： Ahola AJ,Harjutsalo V,Saraheimo M,Forsblom C,Groop PH,FinnDiane Study Group.

    更新日期：2012-01-01 00:00:00

  • Effect of glipizide treatment on postprandial lipaemia in patients with NIDDM.

    abstract：:The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metabolism of triglyceride-rich lipoproteins of intestinal origin was assessed by measuring the retinyl palmitate c...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00404335

    authors： Jeppesen J,Zhou MY,Chen YD,Reaven GM

    更新日期：1994-08-01 00:00:00

  • A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control.

    abstract：AIMS/HYPOTHESIS:Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of metabolic dysregulations across multiple biofluids and over varying timescales of glycaem...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3636-2

    authors： Yousri NA,Mook-Kanamori DO,Selim MM,Takiddin AH,Al-Homsi H,Al-Mahmoud KA,Karoly ED,Krumsiek J,Do KT,Neumaier U,Mook-Kanamori MJ,Rowe J,Chidiac OM,McKeon C,Al Muftah WA,Kader SA,Kastenmüller G,Suhre K

    更新日期：2015-08-01 00:00:00

  • Nitrative stress and poly(ADP-ribose) polymerase activation in healthy and gestational diabetic pregnancies.

    abstract：AIMS/HYPOTHESIS:Increased oxidative-nitrosative stress, poly(ADP-ribose) polymerase (PARP) activation and subsequent cellular damage play important roles in the complications of both diabetes mellitus and pregnancy. Our aim was to investigate nitrative stress and PARP activity levels during normal and gestational diabe...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1435-3

    authors： Horváth EM,Magenheim R,Kugler E,Vácz G,Szigethy A,Lévárdi F,Kollai M,Szabo C,Lacza Z

    更新日期：2009-09-01 00:00:00

  • Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice.

    abstract：AIMS/HYPOTHESIS:We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes. METHODS:Adult male Akita mice (12 weeks old) were treated with insu...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-2910-4

    authors： Abdo S,Lo CS,Chenier I,Shamsuyarova A,Filep JG,Ingelfinger JR,Zhang SL,Chan JS

    更新日期：2013-07-01 00:00:00